ChemInform Abstract: Synthesis and Regioselective Deacylation Studies on Peracylated 2′-Azido...

ChemInform 2010, 41, issue 17 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Nucleic acids U 0700 DOI: 10.1002/chin.201017204 Synthesis and Regioselective Deacylation Studies on Peracylated 2'-Azido arabino- and ribo-Thymine Nucleosides: Towards 5'-O,2'-N-Linked Oligonucleotides. — Title nucleosides such as (I) and (III) are selectively deacylated in 5-position using lipase-B (Candida antarctica) immobilized on polyacrylate (Novozym 435). The result- ing 3'-O-acylated azidonucleosides may be used as key precursors for the synthesis of title oligonucleotides. — (SHARMA, D.; KHANDELWAL, A.; SHARMA, R. K.; BHATIA, S.; REDDY, L. C.; OLSEN, C. E.; WENGEL, J.; PARMAR, V. S.; PRASAD*, A. K.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 12, 1712-1720; Dep. Chem., Univ. Delhi, Delhi 110 007, India; Eng.) — H. Haber 17- 204

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Transcript of ChemInform Abstract: Synthesis and Regioselective Deacylation Studies on Peracylated 2′-Azido...

Page 1: ChemInform Abstract: Synthesis and Regioselective Deacylation Studies on Peracylated 2′-Azido arabino- and ribo-Thymine Nucleosides: Towards 5′-O,2′-N-Linked Oligonucleotides.

www.cheminform.wiley-vch.de

Nucleic acidsU 0700 DOI: 10.1002/chin.201017204

Synthesis and Regioselective Deacylation Studies on Peracylated 2'-Azido arabi-no- and ribo-Thymine Nucleosides: Towards 5'-O,2'-N-Linked Oligonucleotides. — Title nucleosides such as (I) and (III) are selectively deacylated in 5-position using lipase-B (Candida antarctica) immobilized on polyacrylate (Novozym 435). The result-ing 3'-O-acylated azidonucleosides may be used as key precursors for the synthesis of title oligonucleotides. — (SHARMA, D.; KHANDELWAL, A.; SHARMA, R. K.; BHATIA, S.; REDDY, L. C.; OLSEN, C. E.; WENGEL, J.; PARMAR, V. S.; PRASAD*, A. K.; Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem. 48 (2009) 12, 1712-1720; Dep. Chem., Univ. Delhi, Delhi 110 007, India; Eng.) — H. Haber

17- 204

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