ChemInform Abstract: Synthesis and Biological Evaluation of Lipid-Soluble Prodrugs of Anethole...

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ChemInform 2011, 42, issue 14 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Dithiole derivatives R 0175 DOI: 10.1002/chin.201114135 Synthesis and Biological Evaluation of Lipid-Soluble Prodrugs of Anethole Dithiolthione. — Compound (Ia) is a potential hepatic protectant which exhibits better bioavailability and potency than anethol trithione. — (GUAN, M.; FAN, W.; QIAN, S.; XIAO, R. Q.; WU*, Y.; Chin. Chem. Lett. 21 (2010) 12, 1427-1429, http://dx.doi.org/10.1016/j.cclet.2010.07.014 ; Key Lab. Drug Targeting, West China Sch. Pharm., Sichuan Univ., Chengdu, Sichuan 610041, Peop. Rep. China; Eng.) — A. Forchert 14- 135

Transcript of ChemInform Abstract: Synthesis and Biological Evaluation of Lipid-Soluble Prodrugs of Anethole...

Page 1: ChemInform Abstract: Synthesis and Biological Evaluation of Lipid-Soluble Prodrugs of Anethole Dithiolthione.

Dithiole derivativesR 0175 DOI: 10.1002/chin.201114135

Synthesis and Biological Evaluation of Lipid-Soluble Prodrugs of Anethole Dithiolthione. — Compound (Ia) is a potential hepatic protectant which exhibits better bioavailability and potency than anethol trithione. — (GUAN, M.; FAN, W.; QIAN, S.; XIAO, R. Q.; WU*, Y.; Chin. Chem. Lett. 21 (2010) 12, 1427-1429, http://dx.doi.org/10.1016/j.cclet.2010.07.014 ; Key Lab. Drug Targeting, West China Sch. Pharm., Sichuan Univ., Chengdu, Sichuan 610041, Peop. Rep. China; Eng.) — A. Forchert

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ChemInform 2011, 42, issue 14 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim