ChemInform Abstract: Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy- (or...
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1998 nucleic acids nucleic acids U 0700 01 - 242 Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy- (or Azido)-5,6-dihydro-2’-deoxyuridine Diastereomers as Potential Pro- drugs to 5-Ethyl-2’-deoxyuridine. — Starting from the known potent HSV- inhibitor (I) some derivatives are prepared in a simple procedure. Among them nucleosides (III) and (IV) are found to be more potent than the parent compound (I) besides low cell cytotoxicity. — (KUMAR, R.; WIEBE, L. I.; KNAUS, E. E.; Arch. Pharm. (Weinheim, Ger.) 330 (1997) 8, 259-263; Fac. Pharm. Pharm. Sci., Univ. Alberta, Edmonton, Alberta T6G 2N8, Can.; EN) 1
Transcript of ChemInform Abstract: Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy- (or...
1998 nucleic acids
nucleic acidsU 0700
01 - 242Synthesis and Antiviral Activity of 5-Ethyl-5-halo-6-alkoxy- (orAzido)-5,6-dihydro-2’-deoxyuridine Diastereomers as Potential Pro-drugs to 5-Ethyl-2’-deoxyuridine. — Starting from the known potentHSV- inhibitor (I) some derivatives are prepared in a simple procedure. Amongthem nucleosides (III) and (IV) are found to be more potent than the parentcompound (I) besides low cell cytotoxicity. — (KUMAR, R.; WIEBE, L. I.;KNAUS, E. E.; Arch. Pharm. (Weinheim, Ger.) 330 (1997) 8, 259-263; Fac.Pharm. Pharm. Sci., Univ. Alberta, Edmonton, Alberta T6G 2N8, Can.; EN)
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