ChemInform Abstract: Studies on the Novel Antistaphylococcal Compound Nematophin.
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2000 benzimidazole derivatives benzimidazole derivatives R 0200 45 - 141 Studies on the Novel Antistaphylococcal Compound Nematophin. — Compounds (V) and (VII) are tested for their antibacterial activity. The most potent active compound in inhibiting methicillin resistant Staphylococcus aureus is found to be derivative (Va). This activity seems to be dependent on the introduction of the 2-phenyl group which diminishes the influence of the inactive benzimidazole moiety (no yields given). — (KENNEDY, GOR- DON; VIZIANO, MONICA; WINDERS, JOHN ALEXANDER; CAVALLINI, PALMINA; GEVI, MONICA; MICHELI, FABRIZIO; RODEGHER, PAMELA; SENECI, PIERFAUSTO; ZUMERLE, AURELIA; Bioorg. Med. Chem. Lett. 10 (2000) 15, 1751-1754; Med. Res. Cent., Glaxo Wellcome S.p.A., I-37100 Verona, Italy; EN) 1
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Transcript of ChemInform Abstract: Studies on the Novel Antistaphylococcal Compound Nematophin.
2000 benzimidazole derivatives
benzimidazole derivativesR 0200
45 - 141Studies on the Novel Antistaphylococcal Compound Nematophin.— Compounds (V) and (VII) are tested for their antibacterial activity. Themost potent active compound in inhibiting methicillin resistant Staphylococcusaureus is found to be derivative (Va). This activity seems to be dependenton the introduction of the 2-phenyl group which diminishes the influence ofthe inactive benzimidazole moiety (no yields given). — (KENNEDY, GOR-DON; VIZIANO, MONICA; WINDERS, JOHN ALEXANDER; CAVALLINI,PALMINA; GEVI, MONICA; MICHELI, FABRIZIO; RODEGHER, PAMELA;SENECI, PIERFAUSTO; ZUMERLE, AURELIA; Bioorg. Med. Chem. Lett.10 (2000) 15, 1751-1754; Med. Res. Cent., Glaxo Wellcome S.p.A., I-37100Verona, Italy; EN)
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