ChemInform Abstract: N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the...
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Transcript of ChemInform Abstract: N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the...
2002 benzothiazole derivatives
benzothiazole derivativesR 0270
09 - 134N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the2-Alkynylbenzothiazolium Functionality in DNA Cleavage. — Fourcompounds of type (V) and compound (VII) are prepared and tested as DNAcleavage agents. While compounds (V) are shown to be modest DNA agents,DNA cleavage is also observed with (VII). The structural requirements for DNAcleavage and the correlation of DNA cleavage efficiency with the propensityof these compounds to undergo nucleophilic addition by methanol support aproposed DNA cleavage mechanism involving DNA alkylation by appropriate2-alkynyl-substituted benzothiazolium salts. — (KUMAR, DALIP; DAVID,WENDI M.; KERWIN, SEAN M.; Bioorg. Med. Chem. Lett. 11 (2001) 22,2971-2974; Med. Chem. Div., Coll. Pharm., Univ. Tex., Austin, TX 78712,USA; EN)
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