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ChemInform Abstract: Catalyzing the Erlenmeyer Ploechl Reaction: Organic Bases versus Sodium...
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ChemInform 2010, 41, issue 28 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Oxazole derivatives R 0220 DOI: 10.1002/chin.201028126 Catalyzing the Erlenmeyer Ploechl Reaction: Organic Bases versus Sodium Ace- tate. — The preparation of 4-arylidene-2-aryl-5(4)-oxazolones, of interest as interme- diates for fine chemicals and biologically active molecules, is studied in the presence of Huenig's base and NaOAc. In all cases, the products are formed in good yields. Fi- nally, conditions A) are found to be the most efficient ones since they render possible a clean reaction with fewer by-products and can be applied to gram scale synthesis, what is especially of interest in connection with the desired target compound (VI). — (CLEARY, T.; RAWALPALLY, T.; KENNEDY, N.; CHAVEZ*, F.; Tetrahedron Lett. 51 (2010) 12, 1533-1536; Pharm. Process Dev., Roche Carolina Inc., Florence, SC 29506, USA; Eng.) — Mais 28- 126
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Transcript of ChemInform Abstract: Catalyzing the Erlenmeyer Ploechl Reaction: Organic Bases versus Sodium...
www.cheminform.wiley-vch.de
Oxazole derivativesR 0220 DOI: 10.1002/chin.201028126
Catalyzing the Erlenmeyer Ploechl Reaction: Organic Bases versus Sodium Ace-tate. — The preparation of 4-arylidene-2-aryl-5(4)-oxazolones, of interest as interme-diates for fine chemicals and biologically active molecules, is studied in the presence of Huenig's base and NaOAc. In all cases, the products are formed in good yields. Fi-nally, conditions A) are found to be the most efficient ones since they render possible a clean reaction with fewer by-products and can be applied to gram scale synthesis, what is especially of interest in connection with the desired target compound (VI). — (CLEARY, T.; RAWALPALLY, T.; KENNEDY, N.; CHAVEZ*, F.; Tetrahedron Lett. 51 (2010) 12, 1533-1536; Pharm. Process Dev., Roche Carolina Inc., Florence, SC 29506, USA; Eng.) — Mais
28- 126
ChemInform 2010, 41, issue 28 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
