ChemInform Abstract: Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene.

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ChemInform 2009, 40, issue 01 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Halogenation O 0235 Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene. — A simple procedure allows the bromination of mono-, di- and trimethylated arenes and hetarenes with NBS under photochemical conditions. Generally, AIBN is used as catalyst. However, the halogenation can also be carried in the presence of ACN or Bz-O-O-Bz. In the case of substrate (XII), the transformation is successful with Br2 in the absence of any catalyst. — (SUAREZ, D.; LAVAL, G.; TU, S.-M.; JIANG, D.; ROBINSON, C. L.; SCOTT, R.; GOLDING*, B. T.; Synthesis 2009, 11, 1807-1810; Sch. Chem., Univ. Newcastle, Newcastle upon Tyne NE1 7RU, UK; Eng.) — Mais 43- 035

Transcript of ChemInform Abstract: Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene.

Page 1: ChemInform Abstract: Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene.

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HalogenationO 0235 Benzylic Brominations with N-Bromosuccinimide in (Trifluoromethyl)benzene.

— A simple procedure allows the bromination of mono-, di- and trimethylated arenes and hetarenes with NBS under photochemical conditions. Generally, AIBN is used as catalyst. However, the halogenation can also be carried in the presence of ACN or Bz-O-O-Bz. In the case of substrate (XII), the transformation is successful with Br2 in the absence of any catalyst. — (SUAREZ, D.; LAVAL, G.; TU, S.-M.; JIANG, D.; ROBINSON, C. L.; SCOTT, R.; GOLDING*, B. T.; Synthesis 2009, 11, 1807-1810; Sch. Chem., Univ. Newcastle, Newcastle upon Tyne NE1 7RU, UK; Eng.) — Mais

43- 035

ChemInform 2009, 40, issue 01 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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Rhodium-catalyzed direct alkylation of benzylic amines using ......Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides 1311 3 Conclusion We∎demonstrated∎that∎alkyl∎bromides∎can∎be∎used∎as∎ole-∍n∎precursors∎in∎the∎direct∎alkylation∎of∎C(sp3)–H∎bonds∎Cited

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