ChemInform Abstract: A Synthetic Approach to Kingianin A Based on Biosynthetic Speculation.
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ChemInform 2012, 43, issue 05 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Other natural products U 0800 DOI: 10.1002/chin.201205221 A Synthetic Approach to Kingianin A Based on Biosynthetic Speculation. — Synthetic investigations toward the structurally complex dimer kingianin A are report- ed. The protecting group free synthesis of the proposed monomeric precursor pre-kingianin A (VI) and its isomer (V) is achieved using a tandem Stille coupling and electrocyclization process of alkenyl bromide (I) and stannane (II). However, prelimi- nary studies of the key dimerization indicate that the process is not spontaneous, raising questions as to the origin of this natural product. — (SHARMA, P.; RITSON, D. J.; BURNLEY, J.; MOSES*, J. E.; Chem. Commun. (Cambridge) 47 (2011) 38, 10605-10607, http://dx.doi.org/10.1039/c1cc13949e ; Sch. Chem., Univ. Nottingham, Nottingham NG7 2RD, UK; Eng.) — M. Paetzel 05- 221
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Transcript of ChemInform Abstract: A Synthetic Approach to Kingianin A Based on Biosynthetic Speculation.
Other natural productsU 0800 DOI: 10.1002/chin.201205221
A Synthetic Approach to Kingianin A Based on Biosynthetic Speculation. — Synthetic investigations toward the structurally complex dimer kingianin A are report-ed. The protecting group free synthesis of the proposed monomeric precursor pre-kingianin A (VI) and its isomer (V) is achieved using a tandem Stille coupling and electrocyclization process of alkenyl bromide (I) and stannane (II). However, prelimi-nary studies of the key dimerization indicate that the process is not spontaneous, raising questions as to the origin of this natural product. — (SHARMA, P.; RITSON, D. J.; BURNLEY, J.; MOSES*, J. E.; Chem. Commun. (Cambridge) 47 (2011) 38, 10605-10607, http://dx.doi.org/10.1039/c1cc13949e ; Sch. Chem., Univ. Nottingham, Nottingham NG7 2RD, UK; Eng.) — M. Paetzel
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ChemInform 2012, 43, issue 05 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
