PropulsionResearchLaboratoryCHEMICALHYGIENEPLAN

LaboratoryLocation(buildingandroom):_____IndustrialSciences101____________________DepartmentorCampusUnit:___MechanicalandAerospaceEngineering__________________CampusUnitSafetyCoordinator:_____DavidBritt____________________________________PrincipalInvestigator:___StephenA.Whitmore______________________________________ LaboratorySafetyCoordinator:_____________________________________________________(ifdifferentfromPI)Dateofplancompletion:______01/13/2017______________________________________________________Personwhocompletedtheplan:__StephenA.Whitmore________________________________Titleofpersoncompletingtheplan:___Professor______________________________________Annualreview(includinganynecessaryupdating)oftheplanisrequired.OncereviewedandupdateditmustbesenttotheUSUChemicalHygieneCommitteeforapproval,UMC8315.Referencesinthisdocumentaremadetothefollowingtext:PrudentPracticesforHandlingHazardousChemicalsinLaboratories,NationalResearchCouncil,NationalAcademyPress,2011.This manual along with other chemical safety and health references are available online athttp://rgs.usu.edu/ehs/.

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UTAHSTATEUNIVERSITYCHEMICALHYGIENEPLAN

TableofContents

A. GeneralPrinciples

1.MinimizeallChemicalExposures2.AvoidUnderestimationofRisk3.ProvideAdequateVentilation4.InstituteaChemicalHygieneProgram5.ObservethePELsandTLVs6.UnderstandRoutesofExposuretoToxicChemicals7.MaintainReadilyAvailableFilesofMSDSs

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B. ChemicalHygieneResponsibilities1.LaboratoryWorker2.LaboratorySupervisorandPrincipalInvestigator3.CampusUnitSafetyCoordinator4.USUEH&SOfficeandChemicalHygieneOfficer5.DepartmentHeadorCampusUnitDirector6.UniversityAdministration

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C. TheLaboratoryFacility1.Design2.Maintenance3.Usage4.Ventilation

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t t

t

D. ChemicalHygieneinThisLaboratory1.BasicChemicalHygieneRules2.AdditionalRulesSpecifictoThisLaboratory3.ChemicalsPosingSignificantlyHighHazard3.1Allergens3.2ChemicalsofHighAcuteToxicity3.3ReproductiveToxins(includeembryotoxins)3.4ChemicalofHighChronicToxicity(Carcinogens)3.5AnimalWorkwithChemicalsofHighChronicToxicity3.6PhysicalHazards4.ChemicalHygieneStandardOperatingProcedures(SOPs)specifictothelaboratory5.ChemicalProcurement,Distribution,andStorage6.EnvironmentalMonitoring7.HousekeepingandMaintenance8.LaboratoryAudits9.MedicalProgram10.PersonalProtectiveApparelandEquipment

88101111131517202223242425252526

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11.Records12.SignsandLabels13.SpillsandAccidents14.InformationandTraining15.WasteDisposal

2627272728

t E. ChemicalInventory 29t F. SafetyDataSheets(SDS) 29 G. PhysicalHazards 29

t H. LaboratorySafetyTrainingCertificates 29

t SpecificLaboratoryInformationRequired

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A.GENERALPRINCIPLESFORWORKWITHLABORATORYCHEMICAL1. It is prudent tominimize all chemical exposures. Because few laboratory chemicals are

withouthazards,precautionsforhandlingalllaboratorychemicalsshouldbeadopted.Skincontactwithchemicalsshouldbeavoidedasacardinalrule.

2. Avoidunderestimationofrisk.Evenforsubstancesofnoknownhazard,exposureshould

beminimized;forworkwithsubstanceswhichpresenthazards,specialprecautionsshouldbe taken. One should assume that any mixture will be more toxic than its most toxiccomponentandthatallsubstancesofunknowntoxicityaretoxic.

3. Provideadequateventilation.Thebestwaytopreventexposuretoairbornesubstancesisto prevent their escape into theworking atmosphere by use of local exhaust hoods andclosedchemicalcontainers.

4. Instituteachemicalhygieneprogram.TheOSHALaboratoryStandardrequiresachemical

hygiene program be developed and implemented for all laboratories. A mandatorychemical hygiene program designed to minimize exposures is needed, it should be anongoing, continuing effort, notmerely a one-time or short-term activity. Its proceduresshouldbefollowedinacademicteachinglaboratoriesaswellasresearchlaboratories.

5. Observe the PELs and TLVs. The OSHA Permissible Exposure Limits (PEL’s) and the

AmericanConferenceofGovernmental IndustrialHygienistsThresholdLimitValues(TLV’s)shouldnotbeexceeded. Engineering controls shouldbe implemented if action levels areexceeded.

6. UnderstandRoutesofExposuretoToxicChemicals.Toxicchemicalsmayenteryourbody

throughseveralroutes: a. Byinhalationthroughthenoseormouth. b. Byabsorptionthroughtheskin,eyes,andmucousmembranes.

c. Byingestion,viaunwashedhands.d. Byinjectionviabrokenglass,needles,knives,orothersharpinstruments.

7. Proper controlmethods reduce risk of chemical related injury or illness by eliminating

theseroutesofentry.Chemicalhygienecontrolmethodsaredividedintothreecategories: a. EngineeringControls: Localexhaustventilation,gloveboxes,safetyinterlocks b. AdministrativeControls:

StandardOperatingProcedures(SOP’s),RiskAssessment,substitutionofalesstoxicmaterialforamoretoxicmaterial,processorprotocolchanges.

c. PersonalProtectionEquipmentSafety glasses, goggles, face shields, respirators, and protective clothing (e.g.gloves,labcoats,aprons,andetc.)

8. Maintain readily available files of SafetyData Sheets.SafetyData Sheets contain safety

and health information on the hazardous properties and proper handling of chemicals.ChemicalusersshouldmakeanefforttobefamiliarwiththeSDS’sforthechemicalswith

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which theywork. OSHA requires thatworkers have immediate access to SDS’s for eachchemicalintheworkarea.SeesectionFtofindouthowtoobtainSDS’s.

B.CHEMICALHYGIENERESPONSIBILITIESResponsibility for chemical hygiene restswith various individuals and organizations includingthe:1. LaboratoryWorker,whoisresponsiblefor:

a. Knowingandfollowingthechemicalhygienerules . b. Planning and conducting each operation in accordance with the laboratory

specificchemicalhygieneprocedures.c. Developinggoodpersonalchemicalhygienehabits.

2. Principal Investigator and Laboratory Supervisor who have primary responsibility for

chemicalhygieneinthelaboratory,includingresponsibilityto: a. Ensure that workers know and follow the chemical hygiene procedures that

protective equipment is available and inworking order, and that appropriatesafetyandhealthtraininghasbeenprovided.

b. Provide routine, formal chemical hygiene and housekeeping inspection;includinginspectionsofemergencyequipment.

c. Knowthecurrentlegalrequirementsconcerningregulatedsubstances.d.Determinetherequiredlevelsofprotectiveapparelandequipment.e. Ensurethatfacilitiesareadequateandtrainingiscurrentforanymaterialbeing

usedororderedforthelaboratory.3. Campus Unit Safety Coordinator, as assigned by the department head or campus unit

directorwhomust: a. ServeasliaisonbetweenUSUEH&SOfficeandhis/herCampusUnit. b. Knowthecurrentlegalrequirementsconcerningregulatedsubstances. c. See that laboratory personnel are informed and trained, as required by the

standard.4. The EH&S Office (ext. 7-2892) is a resource for improving chemical hygiene in the

laboratoriesandforhelpingyoucomplywithallsafetyandhealthregulations. SomeoftheservicesprovidedbytheEH&SOfficetohelpyoucomplywiththeOSHALabStandardinclude:

a. MakingaboilerplateChemicalHygienePlansavailable. b. ReviewoflaboratoryspecificChemicalHygienePlans. c. Conductgenerallabsafetytrainingandprovidechemicalhygieneinformation. d. Annualinspectionsoflabhoods. e. Environmentalmonitoringwhenhighexposurestochemicalsaresuspected. f. Periodicsafetyauditsoflabfacilities. g. ConsultationindevelopingStandardOperatingProcedures.

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5. TheCampusChemicalHygieneOfficerwillbefromtheEnvironmentalHealthandSafety

Officestaffasassignedbythedirectorandwill:a. Work with administrators and other employees to develop and implement

appropriatechemicalhygienepoliciesandpractices.b. Provide information relating to procurement, use, and disposal of chemicals

usedinthelab.c. Seethatappropriateauditsareperformed.d. Helpprojectdirectorsidentifyappropriateequipmentandadequatefacilities.e. Knowthecurrentlegalrequirementsconcerningregulatedsubstances.f. Seekwaystoimprovethechemicalhygieneprogram.

6. DepartmentHeadorotherCampusUnitDirector,whoisresponsibleforoverallchemical

hygieneinthatunit.7. President of Utah State University, the Vice-president for Research and other

administrators who have ultimate responsibility for chemical hygiene within theinstitution and must, with other administrators, provide continuing support forinstitutionalchemicalhygiene.

C.THELABORATORYFACILITY1. Design.Thelaboratoryfacilityshouldhave:

a. Anappropriategeneralventilationsystemwithairintakesandexhaustslocated

soastoavoidintakeofcontaminatedair. b. Adequate,well-ventilatedchemicalstoragerooms. c. Properlyfunctioninglaboratoryhoodsandsinks. d. Othersafetyequipmentincludingeyewashfountainsanddrenchshowers. e. Arrangementsforwastedisposal.2. Maintenance. Chemical-hygiene-related equipment (hoods, incinerator, etc.) should be

evaluatedroutinely.

3. Usage.Theworkconductedandtowhatextenttheworkisconductedmustbeappropriatefor the physical facilities available and, especially, to the availability and quality ofventilation.

4. Ventilation.

a. Generallaboratoryventilation.Thissystemshould:i. Provideasourceofairforbreathingandforinputtolocalventilation

devices.ii. Itshouldnotbereliedonforprotectionfromtoxicsubstancesreleasedinto

thelaboratory.

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iii. Ensurethatlaboratoryairiscontinuallyreplacedwithacceptablelevelsoffreshair,therebypreventingincreasedconcentrationsoftoxicsubstancesduringtheworkingday.

iv. Directairflowintothelaboratoryfromnon-laboratoryareasandouttotheexteriorofthebuilding.

b. Hoods.Alaboratoryhoodwith2.5linearfeetofhoodspaceperpersonshould

beprovidedforevery2workers if theyspendmostof their timeworkingwithchemicals. Each hood should have a continuous monitoring device to allowconvenientconfirmationofadequatehoodperformancebeforeuse.Ifthisisnotpossible,workwithsubstancesofunknowntoxicityshouldbeavoidedorothertypes of local ventilation devices should be provided. Questions related tochemicalhoodadequacy,need,etc.shouldbedirectedtoEnvironmentalHealthandSafety.

c. Other local ventilation devices. Ventilated storage cabinets, canopy hoods,

snorkels, etc. should be provided as needed. Each canopy hood and snorkelshouldhaveaseparateexhaustduct.

d. Special ventilation areas. Exhaust air from glove boxes and isolation rooms

shouldbepassedthroughscrubbersorother treatmentdevicesbeforereleaseinto the regular exhaust system. Cold rooms and warm rooms should haveprovisionsforrapidescapeandforescapeintheeventofelectricalfailure.

e. Modifications. Anyalterationoftheventilationsystemshouldbemadeonly if

thoroughtestingindicatesthatworkerprotectionfromairbornetoxicsubstanceswillcontinuetobeadequate.

f. Performance. Rate:4-12roomairchanges/hour isnormallyadequategeneral

ventilation,forlaboratories,iflocalexhaustsystemssuchashoodsareusedastheprimarymethodofcontrol.

g. Quality. General air flow should not be turbulent and should be relatively

uniformthroughoutthelaboratory,withnohighvelocityorstaticareas.Airflowintoandwithin thehoodshouldnotbeexcessively turbulent. Ideally thehoodface velocities should be 100 fpm (feet perminute) +/-25 fpm at theworkingsashheight(generally16").

h. Evaluation. Quality and quantity of ventilation should be evaluated on

installation, regularly monitored, and reevaluated whenever a change in thelocal ventilation devices is made. EH&S Office personnel monitor hood flowratesregularlyandareavailableforotherventilationmonitoringandadvice.

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D.CHEMICALHYGIENEINTHELABORATORYLaboratoryworkerswill knowand follow the rules, procedures and recommendations in thisChemicalHygienePlan.1. BasicChemicalHygieneRulesThefollowingwillbeusedforessentiallyalllaboratoryworkwithchemicals:

a. Accidentsandspills:

i.EyeContact: Promptlyflusheyeswithwaterforaprolongedperiod(15

minutes)andseekmedicalattention.

ii.Ingestion: Encouragethevictimtodrinklargeamountsofwater.RefertotheSafetyDataSheet.

iii.SkinContact: Promptlyflushtheaffectedareawithwaterandremoveany

contaminatedclothing.Ifsymptomspersistafterwashing,seekmedicalattention.

iv.Clean-up: Promptlycleanupspills,usingappropriateprotective

apparelandequipmentandproperdisposal.

b. Avoidance of "routine" exposure: Develop and encourage safe habits. Avoidunnecessaryexposuretochemicalsbyanyroute.

i. Donotsmellortastechemicals. ii. Vent any apparatus which may discharge toxic chemicals (vacuum

pumps,distillationcolumns,andetc.)intolocalexhaustdevices. iii. Inspectglovesandotherpersonalprotectiveequipmentbeforeuse. iv. Donotallowreleaseoftoxicsubstancesincoldroomsandwarmrooms,

sincethesecontainre-circulatedatmospheres.

c. Choice of chemicals: Use only those chemicals for which the quality of theavailableventilationsystemisappropriate.

d. Eating,smoking,etc.:Donoteat,drink,smoke,chewgum,orapplycosmeticsin

areaswhere laboratory chemicals are present.Wash hands before conductingtheseactivities.Donotallowstorage,handling,preparation,orconsumptionoffoodandbeveragesinareaswhichareusedforlaboratoryoperations.

e. Equipmentandglassware:Handleandstore laboratoryglasswarewithcare to

avoiddamage.Donotusedamagedglassware.UseextracarewithDewarflasksandotherevacuatedglassapparatus;shieldorwrapthemtocontainchemicalsand fragments should implosion occur. Use equipment only for its designedpurpose.

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f. Exiting:Thoroughlywashareasofexposedskinbeforeleavingthelaboratory.g. Horseplay:Avoidpracticaljokesorotherbehaviorwhichmightconfuse,startle,

ordistractanotherworker.

h. Mouthsuction:Donotusemouthsuctionforpipettingorstartingasiphon.

i. Personalapparel:Confinelonghairandlooseclothing.Wearshoesatalltimesin the laboratory.Sandals,perforatedoropen-toedshoesshouldnotbeworn.Alwayswearlongpants,notskirtsorshortpants.Wearalabcoat.

j. Personal housekeeping: Keep the work area clean and uncluttered, with

chemicalsandequipmentbeingproperlylabeledandstored.Cleanuptheworkareaoncompletionofanoperationorattheendofeachday.

k. Personal protection: Assure that appropriate eye protection is worn by all

persons, including visitors, where chemicals are stored or handled. Wearappropriate gloves when the potential for contact with toxic materials exists;inspect the gloves before each use, wash them before removal, and replacethemperiodically.Useappropriaterespiratoryequipmentwhenaircontaminantconcentrationsarenotsufficientlyrestrictedbyengineeringcontrols,inspectingtherespiratorbeforeuse.Useanyotherprotectiveandemergencyapparelandequipmentasappropriate.Avoiduseofcontactlensesinthelaboratoryunlessnecessary; if they are used, inform supervisor so special precautions can betaken.Removelaboratorycoatsimmediatelyonsignificantcontamination.

l. Planning: Seek information and advice about hazards, plan appropriate

protectiveprocedures,andplanpositioningofequipmentbeforebeginninganynewoperation.

m. Unattendedoperations:Leavelightson,placeanappropriatesignonthedoor,

andprovideforcontainmentoftoxicsubstancesintheeventoffailureofautilityservice(suchascoolingwater)toanunattendedoperation.

n. Useofhood:Usethehoodforoperationswhichmightresultinreleaseoftoxic

chemical vapors or dust. In general, use the hoodwhenever feasible to limitexposureto laboratoryworkers. Asaruleofthumb,useahoodorother localventilationdevicewhenworkingwithanyappreciablyvolatilesubstancewithaTLVoflessthan50ppm.Confirmadequatehoodperformancebeforeuse;keephood closed at all times except when adjustments within the hood are beingmade;keepmaterialsstoredinhoodstoaminimumanddonotallowthemtoblockventsorairflow.Leavethehood"on"whenitisnotinactiveuse,iftoxicsubstances are stored in it or if it is uncertain whether adequate generallaboratoryventilationwillbemaintainedwhenitis"off".

o. Vigilance: Be alert to unsafe conditions and see that they are correctedwhen

detected.

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p. Waste disposal: Assure that each laboratory operation includes plans and

training for waste disposal. Deposit chemical waste in appropriately labeledchemicallycompatiblereceptaclesandfollowUSUHazardousWasteGuidelines.Thefollowingchemicalswillnotbedischargedtothesewer:concentratedacidsor bases, toxic, flammable substances, reactive materials, malodorous,lachrymatory, explosive, or any substances which might interfere with thebiological activity of waste water treatment plants, create fire or explosionhazards,causestructuraldamage,orobstructflow.ConsulttheEH&SOfficeifyouhavedisposalquestionsonaparticularchemicalwaste.

q. Working alone: Avoid working alone in a building. Do not work alone in a

laboratoryiftheproceduresbeingconductedarehazardous.

r. Chemicalswithunknownhazards:Chemicalswhosehazardouspropertieshavenot been evaluated (no SDS available) will be considered highly toxic andhandledassuch.(Seesections3.4and3.5ofthisCHP)

2.AdditionalRulesspecifictothislaboratory a. Aim:Toassurethathazardsspecifictothelabareaddressed. Examplesofadditionalrules: i.Requirementthatvisitorscheck-inatofficeandweareyeprotection. ii.Requirementthatcabinetdoorstochemicalstoragebekeptclosed.

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3.Chemicalsposingsignificantlyhighhazards3.1WorkwithAllergensAllergensorsensitizers.Achemicalallergyisanadversereactionbytheimmunesystemtoachemical. Such allergic reactions result from previous sensitization to that chemical or astructurallysimilarchemical.Oncesensitizationoccurs,allergicreactionsresultfromexposuretoextremelylowdosesofthechemical.Individualsdifferwidelyintheirtendencytobecomesensitized to allergens. Examples of chemical substances that cause that cause allergicreactionsinsomeindividualsinclude:diazomethane,dicyclohexylcarbodiimide,formaldehydeandphenol derivatives, various isocyanates, benzylic and allylic halides, acid anhydrides, andmetalssuchasnickel,beryllium,platinum,cobalt,tin,andchromium.

a. Wear suitable gloves to prevent hand contact with allergens of substances of

unknownallergenicactivity.Thoroughlywashhands immediatelyafterworkingwiththesematerials.

b. Utilizechemicalhoodsorotherlocalexhaustventilationtolimitexposure.c. Review each use of these materials with the research supervisor and review

ongoingusesannuallyorwheneveraproceduralchangeismade.

d. Storethesesubstances,properlylabeled,inanadequatelyventilatedareainanunbreakablesecondarycontainer.

e. Notify supervisors of all incidents of exposure or spills; consult a qualified

physicianwhenappropriate.

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f. Listofallergens(sensitizers)usedinthislab:

ChemicalName CASnumber Manufacturer (ifknown)

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3.2WorkwithChemicalsofHighAcuteToxicityAcute toxicity is the ability of a chemical to cause a harmful effect after a single exposure.Acutely toxic agents cause local toxic effects, systemic toxic effects, or both. This class oftoxicants includes corrosive chemicals, irritants, and allergens. Examples include:diisopropylfluorophosphate,hydrofluoricacid,andhydrogencyanide.

a. Aim: To minimize exposure to these toxic substances by any route using all

reasonableprecautions.

b. Applicability: Theseprecautionsareappropriate for substanceswithmoderatechronicorhighacutetoxicityusedinsignificantquantities.

c. Location:Useandstorethesesubstancesonlyinareasofrestrictedaccesswith

specialwarningsigns.

i. Always use an approved hood or other containment device forprocedures which may result in the generation of aerosols orvaporscontainingthesubstance.

ii. Trap released vapors to prevent their discharge with the hoodexhaust.

e. Personalprotection:Alwaysavoidskincontactbyuseofglovesandlongsleeves

(and other protective apparel as appropriate). Always wash hands and armsimmediatelyafterworkingwiththesematerials.

f. Records:Maintainrecordsoftheamountsofthesematerialsonhand,amounts

used,andthenamesoftheworkersinvolved.

g. Preventionofspillsandaccidents:Bepreparedforaccidentsandspills.Assurethatatleast2peoplearepresentatalltimesifacompoundinuseishighlytoxicorofunknowntoxicity.

i. Store breakable containers of these substances in chemically

resistanttrays.Also,workandmountapparatusabovesuchtraysor cover work and storage surfaces with removable, absorbent,plasticbackedpaper.

ii. Ifamajorspilloccursoutsidethehood,evacuatetheareaandcall

9-1-1.

h. Waste:Followingusethoroughlydecontaminateclothingorshoes. Ifpossible,chemically decontaminate by chemical conversion. Store waste or othercontaminatedobjectsinclosed,suitablylabeled,imperviouscontainers.DisposeofinaccordancewithUSUHazardousWasteguidelines.

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i. Listingofchemicalsinthislabconsideredtobeofhighacutetoxicity:ChemicalName CASnumber Manufacturer (ifknown)

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3.3WorkwithReproductiveToxinsReproductive Toxins aredefinedby theOSHA Laboratory Standard as substances that causechromosomal damage (mutagens) and substances with lethal or teratogenic (malformation)effectsonfetuses. Thesesubstanceshaveadverseeffectsonvariousaspectsofreproductionincluding: fertility,gestation, lactation,andgeneral reproductiveperformance. Reproductivetoxinscanaffectbothmenandwomen.Embryotoxins or teratogens are chemicals that are harmful to a developing fetus at aconcentration that may have no effect on the mother (examples: organomercurials, leadcompounds,formamide). Embryotoxinshavethegreatest impactduringthefirsttrimesterofpregnancy. Becauseawomanoftendoesnotknowthatsheispregnantduringthisperiodofhighsusceptibility,womenofchildbearingpotentialareadvisedtobeespeciallycautiouswhenworkingwithchemicals,especiallythoserapidlyabsorbedthroughtheskin.Ifyouareawomanof childbearing age, handle these substancesonly in a hoodwhose satisfactory performancehas been confirmed, using appropriate protective apparel (especially gloves) to prevent skincontact. a. Review each use of these materials with the research supervisor and review

ongoingusesannuallyorwheneveraproceduralchangeismade.

b. Storethesesubstances,properlylabeled,inanadequatelyventilatedareainanunbreakablesecondarycontainer.

c. Notify supervisors of all incidents of exposure or spills; consult a qualified

physicianwhenappropriate.

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d. ListingofchemicalsinthislabconsideredtobeReproductivetoxins:ChemicalName CASnumber Manufacturer (ifknown)

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3.4WorkwithChemicalsofHighChronicToxicity(Carcinogens)A carcinogen is a substance capable of causing cancer. Carcinogens are chronically toxicsubstances; that is, they cause damage after repeated or long-duration exposure and theireffects may become evident only after a long latency period. Carcinogens are particularlyinsidioustoxinsbecausetheymayhavenoimmediateapparentharmfuleffects.Compoundsthatareknowntoposethegreatestcarcinogenichazardarereferredtoasselectcarcinogens. A select carcinogen isdefined in theOSHALaboratoryStandardasa substancethatmeetsoneofthefollowingcriteria: 1.ItisregulatedbyOSHAasacarcinogen. 2. It is listedasknown tobeacarcinogen in the latestAnnualReportonCarcinogens

issuedbytheNationalToxicologyProgram(NTP). 3. It is listed underGroup I (carcinogenic to humans) by the International Agency for

ResearchforCancer(IARC). 4. It is listedunder IARCGroup2A (probably carcinogenic tohumans) or 2B (possibly

carcinogenic to humans), or under the category “reasonably anticipated to be acarcinogen”bytheNTP.

Examples: dimethyl mercury and nickel carbonyl, benzo-a-pyrene, N-nitrosodiethylamine,formaldehyde,andotherhumancarcinogensorsubstanceswithhighcarcinogenicpotency inanimals.

a. Access: Conduct all transfers andworkwith these substances in a"designatedandcontrolledarea".

i. Controlledareasinclude:arestrictedaccesschemicalhood,glovebox, or portion of a lab designated for use of highly toxicsubstances.

ii. These restricted areas will be posted with warning signs, toensure that people with access to the lab are aware of thesubstancesbeingusedandnecessaryprecautions.

iii. Thesesubstanceswillbestoredseparatelywithaccessrestricted.

b. Signsandlabels:Assurethatthedesignatedandcontrolledareaisconspicuouslymarkedwithwarningandrestrictedaccesssignsandthatallcontainersofthesesubstancesareappropriatelylabeledwithidentityandwarninglabels.

c. Approvals:Prepareaplanforuseanddisposalofthesematerialsandobtainthe

approvalofthelaboratorysupervisor.

d. Non-contamination/Decontamination: i. Protect vacuum pumps against contamination by scrubbers or

HEPAfiltersandventthemintothehood. ii. Decontaminate vacuum pumps or other contaminated

equipment, including glassware, in the hood before removingthemfromthecontrolledarea.

iii. Decontaminate the controlled area before normal work isresumedthere.

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e. Exiting:Onleavingacontrolledarearemoveanyprotectiveapparel(placingitin

anappropriate, labeledcontainer)and thoroughlywashhands, forearms, face,andneck.

f. Housekeeping:UseawetmoporavacuumcleanerequippedwithaHEPAfilter

insteadofdrysweepingifthetoxicsubstancewasadrypowder.g. Medical surveillance: If using toxicologically significant quantities of such a

substance on a regular basis (e.g., 3 times per week), consult a qualifiedphysicianconcerningdesirabilityofregularmedicalsurveillance.

h. Records:Keepaccuraterecordsoftheamountsofthesesubstancesstoredand

used,thedatesofuse,andnamesofusers.

i. Spills: Assure that contingency plans, equipment, and materials to minimizeexposuresofpeopleandpropertyincaseofaccidentareavailable.

j. Storage:Storecontainersofthesechemicalsonlyinaventilated,limitedaccess

area in appropriately labeled, unbreakable, chemically resistant, secondarycontainers.

k. Gloveboxes:Foranegativepressureglovebox,ventilationratemustbeatleast

2volumechanges/hourandpressureatleast0.5inchesofwater.Forapositivepressureglovebox,thoroughlycheckfor leaksbeforeeachuse. Ineithercase,trap theexit gasesor filter them throughaHEPA filter and then release themintothehood.

l. Waste: Use chemical decontamination whenever possible; ensure that

containersofcontaminatedwaste(includingwashingsfromcontaminatedflasks)are transferred from the controlled area in a secondary container under thesupervisionofauthorizedpersonnel. Disposeofwaste inaccordancewithUSUHazardousWasteguidelines.

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p. List of chemicals in this lab considered to be of high chronic toxicity

(Carcinogens):ChemicalName CASNumber Manufacturer (ifknown)

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3.5AnimalWorkwithChemicalsofHighChronicToxicity(Carcinogens) a. Access: For large scale studies, special facilities with restricted access are

preferable. b. Administrationofthetoxicsubstance:Whenpossible,administerthesubstance

byinjectionorgavageinsteadofinthediet.Ifadministrationisinthediet,useacagingsystemundernegativepressureorunderlaminarairflowdirectedtowardHEPAfilters.

c. Aerosolsuppression:Deviseprocedureswhichminimizeformationanddispersal

ofcontaminatedaerosols, includingthosefromfood,urine,andfeces(e.g.,useHEPA filtered vacuum equipment for cleaning,moisten contaminated beddingbeforeremovalfromthecage,mixdietsinclosedcontainersinahood).

d. Personalprotection:Whenworking intheanimalroom,wearplasticorrubber

gloves, fully buttoned laboratory coat or jumpsuit and, if needed because ofincomplete suppression of aerosols, other apparel and equipment (shoe andheadcoverings,respirator).

e. Waste disposal: Dispose of contaminated animal tissues and excreta by

incinerationiftheavailableincineratorcanconvertthecontaminanttonon-toxicproducts; otherwise, package the waste appropriately and dispose of wasteaccordingtoUSUHazardousWasteGuidelines.

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f. List of chemicals of high chronic toxicity (carcinogens) involved with animalworkinthislab:

ChemicalName CASnumber Manufacturer (ifknown)

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3.6WorkwithMaterialsthatposeasignificantPhysicalHazardOSHAdefinesaphysicalhazardsasachemicalforwhichthereisscientificallyvalidevidencethatitisacombustibleliquid,acompressedgas,explosive,flammable,anorganicperoxide,anoxidizer,pyrophoric,unstable(reactive),orwater-reactive.Otherphysicalhazardsinclude:CryogensElectrichazardsHighpressurereactionsMagneticfieldsRadiofrequency,microwave,ultraviolet,andinfraredradiationVacuumworkCutting,sawing,orgrindingLabspecificSOPsforPhysicalHazardsshouldbedevelopedandinsertedhere.

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4.StandardOperatingProcedures(SOPs)specifictothislaboratory a. Aim:toassurethathazardousoperationsspecifictothelabareconductedina

prudentlysafemanner. b. Content: Chemical Hygiene SOPs may be incorporated into general lab

proceduralprotocolsormaybewrittenupseparately.TheseSOPscontain1)themajorhazardsassociatedwithataskand/orchemicalsand2)controlstoavoidexposure.ExamplesofSOPscanbefoundinPrudentPractices,chapters1B,1Cand 1D. A guide to preparing Chemical Hygiene SOPs is available from theCampusEH&SOffice.

ExamplesofproceduresortasksthatsupportimplementationofSOPs.

1)Useofperchloricacid.

2)Endofdayclean-upprocedures.3) Mixing of acrylamide gels-will be conducted in a "controlled area", withlocal exhaust (i.e. a lab hood) and measures taken to limit exposureincludingpreventingskincontact.4)UseofEthidiumBromide-similartonumber3above.

c. InsertanySOPsspecifictothelabafterthispage.

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5.ChemicalProcurement,Distribution,andStorage a. Procurement:Before a substance is received, information on proper handling,

storage,anddisposalwillbeknowntothosewhowillbeinvolved.Nocontainerwillbeacceptedwithoutanadequateidentifyinglabel.

b. Stockrooms/storerooms: i. Incompatible substances will be segregated in a well-identified

areawithlocalexhaustventilation. ii. Chemicals which are highly toxic or other chemicals whose

containers have been opened will be in unbreakable secondarycontainers.

iii. Storedchemicalswillbeexaminedperiodically(atleastannually)forreplacement,deterioration,andcontainerintegrity.

iv. Chemicalswithsensitiveshelflives,suchasperoxideformers,willbedatedandusedordisposedofproperlywithinsuggestedshelflifeperiod.

v. Stockrooms/storerooms will not be used as preparation orrepackagingareas,willbeopenduringnormalworkinghours,andwillbecontrolledbyoneperson.

c. Distribution:Whenchemicalsarehandcarried, thecontainerwillbeplaced in

suitable secondary containment (e.g. an outside container or bucket).Freight-onlyelevatorswillbeusedifpossible.

d. Laboratorystorage: i. Amountspermittedwillbeassmallaspractical.Storageonbench

topsandinhoodsisinadvisable. ii. Exposuretoheatordirectsunlightwillbeavoided. iii. Periodic inventories will be conducted, with unneeded items

beingdiscarded, returnedto thestoreroom/stockroom,ormadeavailabletootherusers.

iv. Carewillbetakentoprotect the integrityofchemicals, (preventcontaminationetc.)sothatthechemicalscanbeofusetoothers.

v. Properstoragewillensurethatincompatiblechemicalsarestoredseparately.

vi. Chemicals referred to in 3.1, 3.2, 3.3, 3.4, 3.5, and 3.6 will bestoredinareasofrestrictedaccess.

6.EnvironmentalMonitoring a. Regular instrumental monitoring of airborne concentrations is not usually

justified or practical in laboratories but may be appropriate when testing orredesigninghoodsorotherventilationdevicesorwhenahighlytoxicsubstanceisstoredorusedregularly(e.g.3times/week).

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7.HousekeepingandMaintenance

a. Cleaning:Floorswillbecleanedregularly.

b. Maintenance: i. Eyewash fountains should be inspected by users at intervals of

notlessthan3months. ii. All labswillhavereadyemergencyaccesstoaneyewashstation

anddrenchshower,andthelocationwillbecommunicatedtoallworkers.

iii. Respirators for routine use will be inspected periodically. Allrespirator userswill be enrolled in theUSURespirator Program,willbetrained,andfittested.

iv. Othersafetyequipmentwillbeinspectedregularly(e.g.,every3-6months)andpriortouse.

v. Procedurestopreventrestartingofout-of-serviceequipmentwillbeestablished.

c. Passageways:Stairwaysandhallwayswillnotbeusedasstorageareas.Access

toexits,emergencyequipment,andutilitycontrolswillneverbeblocked.d. Aisles and Walkways: Aisles and walkways will be kept clear and free of

obstruction. Boxes,bottlesof chemical,waste containers, labequipment, andothermaterialsshouldnotbestoredonthefloorinaislesorwalkways.

8.LaboratoryAudits a. Frequency:Formalhousekeepingandchemicalhygieneauditsofthelaboratory

willbeheldatleastquarterly. b. Documentation:Datedcopiesofthecompletedquarterlyauditswillbefiledat

theendofthisplan.AcopyoftheSafetyAuditwillbesenttotheEH&SOffice. c. Informalinspectionsshouldbecontinual.9.MedicalProgram

a. Compliancewithregulations:Regularmedicalsurveillancewillbeestablishedtotheextentrequiredbyregulations.

b. Routine surveillance: Anyone whose work involves regular and frequent

handling of toxicologically significant quantities of a chemical will consult aqualified physician to determine on an individual basis whether a regularscheduleofmedicalsurveillanceisdesirable.

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c. Firstaid: i. Personnel trained in first aid will be available during working

hours. ii. Incaseofamedicalemergencycall911. Tellthedispatcher:

• Locationofthepatient(building&roomnumber)• Name and condition of the patient (alert, conscious,

breathing iv. USU employees with non-life threatening injuries should be

evaluatedatIHCWorkMed,412North200East,435-713-2700. v. Supervisorsmustbenotifiedofanyworkrelatedinjuryorillness.

Supervisors are required to fill out appropriate worker’scompensationformsavailableontheHRwebsite.

vi. All laboratory injuries or illnesses must be reported to theChemicalHygieneOfficer.

10.ProtectiveApparelandEquipmentThesewillincludeforeachlaboratory:

a. Protective apparel compatible with the required degree of protection forsubstancesbeinghandled.

b. Aneasilyaccessibledrench-typesafetyshower. c. Aneyewashfountain. d. Afireextinguisher. e. Respiratory Protection - Anyworker issued a respiratormust be trained in its

appropriateuseandundergomedicaldeterminationoffitness.Thisisasimpleprocess,throughwhichEH&Scanguideyou.Foradditionalinformation,contactEH&Sat797-2892.

f. Firealarmandtelephoneforemergencyusewillbeavailablenearby. g. OtheritemsdesignatedbythelaboratorySafetyCoordinator.11.Records

a. Accidentrecordswillbewrittenandretained. b. ChemicalHygienePlanrecordswilldocumentthatthefacilitiesandprecautions

arecompatiblewithcurrentknowledgeandregulations. c. Inventoryandusagerecordsforhigh-risksubstanceswillbekept.

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d. Medical records will be retained by the institution in accordance with the

requirementsofstateandfederalregulations.12.SignsandLabelsProminentsignsandlabelsofthefollowingtypeswillbeposted:

a. Emergency telephone numbers including: emergency personnel/facilities,

supervisors,laboratorypersonnel,andotherpertinentcontactpersons.b. Chemical container labels showing contents of containers (including waste

receptacles)andassociatedhazards.Allcontainersmusthavealegiblelabel. c. Location signs for safety showers, eyewash stations, other safety and first aid

equipment,exitsandareaswherefoodandbeverageconsumptionandstoragearepermitted.Foodandbeverageswillnotbeallowedinareaswherechemicalsarestoredorhandled

d. Warningsatareasorequipmentwherespecialorunusualhazardsexist. Thisincludescontrolledareasforuseofchemicalsdescribedin3.1,3.2,3.3,3.4,

3.5,and3.6.13.SpillsandAccidents

a. Spillresponseplanwillbeestablishedandcommunicatedtoallpersonnel.Itwillincludeproceduresfor: ventilationfailure,evacuation,medicalcare,reporting,prevention,containment,cleanup,anddrills.

b. Therewillbeanalarmsystemtoalertpeopleinallpartsofthefacilityincluding

isolationareassuchascoldrooms.

c. All accidents or near accidents will be carefully analyzed with the resultsdistributedtoallwhomightbenefit.Allchemicalspillsmustbereportedtothesupervisor.

d. Forquestionsonspillclean-upproceduresconsulttheSDSorcallEH&Sat797-

2892. e. Intheeventofachemicalspillemergency,dial911.14.InformationandTrainingProgram

a. Aim: To assure that all individuals at risk are adequately informed about the

workinthelaboratory,itsrisks,andwhattodoifanaccidentoccurs.LaboratorySafetyTrainingseminarsareavailablethroughEH&S.

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b. EmergencyandPersonalProtectionTraining:Everylaboratoryworkerwillknowthe location and proper use of available protective apparel, emergencyequipmentandprocedures.

Suchtrainingaswellasfirstaid instructionwillbeavailabletoandencouragedforeveryonewhomightneedit.FirstaidcoursesareofferedthroughthelocalRedCrossChapter.

c. Handling: Receiving and stockroom/storeroom personnel will know about

hazards,handlingequipment,protectiveapparel,andrelevantregulations.d. Frequency of Training: The training and education programwill be a regular,

continuingactivity-notsimplyanannualpresentation.Alllaboratorypersonnelare required to attend the Laboratory Safety Initial training course offered byEH&S. PeriodicLabSafetyRefreshertrainingcanbescheduledfor laboratoriesand/ordepartments.AvarietyoftrainingmaterialsareavailablefromtheEH&Soffice.

e. Literature/Consultation: Literature and consultation concerning chemical

hygiene is readily available to laboratory personnel, through EH&S 797-2892.Laboratorypersonnelareencouragedtousetheseinformationresources.

15.WasteDisposalProgram

a. Aim:Toassurethatthepotentialminimalharmtopeopleandtheenvironmentresultingfromthedisposalofchemicalwasteisminimized.

b. Content:Chemicalwasteandradioactivewastedisposal requestscanbemade

onlineathttp://rgs.usu.edu/ehs/htm/hazardous-waste-pickup. c. Discarding Chemical Stocks: Designate chemicals that are no longer need as

waste.Everypossibleeffortshouldbemadebylaboratorypersonneltoidentifyexactly or generally chemicals contained in any unlabeled containers. In theeventwastechemicalsmaybepotentiallyexplosive(e.g.picricacid,ethersetc.)theymustnotbeopenedormovedbylaboratorypersonnel.

Alldepartingemployees, includingfaculty,students,andstaffmustensurethat

all chemicals inhis/herworkareaareproperlydistributed. All chemicalsmustbediscarded,returnedtostorage,orgiventoafellowresearcher.

d. Frequency of Disposal: Waste must be stored in a secure place within the

laboratoryandremovedataregularinterval.

e. MethodofDisposal:Alldiscardedchemicalsareshippedoff-siteandhandledatapproved disposal facilities. USU personnel should not attempt to minimizechemical waste through practices such as elementary neutralization, chemical

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reactions, dilution, or evaporation, unless these practices are part of theexperiment. Disposal by pouring waste chemicals down the drain isunacceptable.

E.ChemicalInventoryInsertLabSpecificChemicalInventoryHereorAttachasanAppendixtothisdocument.F.SafetyDataSheetsSafety Data Sheets contain information on the hazardous properties and proper handling ofchemicals. OSHA requires chemical handlers be familiarwith the chemicalswithwhich theywork. OSHAalsorequiresthatworkershavereadyaccesstoanSDSforeachchemical inthework area. You will receive a SDS with or shortly after the arrival of an ordered chemicalproduct.RequestacopyoftheSDSforeachproductyoupurchase.SDSsshouldbemaintainedin a notebook or file that is easily accessible to employees in the lab. Most chemicalmanufacturersanddistributorshaveSDSsavailableontheirwebsites.G.PhysicalHazardsNumerousphysicalhazardsmaybepresentinthelaboratory.Physicalhazardsareresponsiblefor the majority of workplace injuries. Many of the above recommendations are directedprimarilytowardpreventionoftoxicexposureandrelatedhealtheffectsratherthanpreventionofphysical injury. However,failuretotakeprecautionsagainstphysical injurywilloftenhavethesecondaryeffectofcausingtoxicexposures.Pleasenotethatthemostcurrentversionofthe USU Chemical Hygiene Plan (2013) has been modified to specifically address physicalhazardsinsection3.6.Belowaresomeofthemajorcategoriesofphysicalhazardswhichalsohaveimplicationsforchemicalhygiene:

1.Compressedgases2.Electricallypoweredlaboratoryequipment3.Firesorexplosions4.Proceduresinvolvingtemperatureextremes(bothlowandhigh)5.Pressurizedandvacuumoperations(includinguseofcompressedgascylinders)

6.Slipperysurfacesortrippinghazards 7.Useofpowertools(cutting,sanding,grinding) 8.SharpsTheFireMarshal'sOfficeoffersadviceon fireandelectrical safety, and sponsorsahandsonextinguishertrainingsession.TheUSULabSafetyAuditFormincludessectionsonbasiccontrolmethodsforbothphysicalandhealthhazardsinlaboratories.H.LabSafetyTrainingCertificates