Chapter 6 Gene Prediction: Finding Genes in the Human Genome.
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Transcript of Chapter 6 Gene Prediction: Finding Genes in the Human Genome.
![Page 1: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/1.jpg)
Chapter 6Gene Prediction: Finding Genes
in the Human Genome
![Page 2: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/2.jpg)
Figure 6.1: Map of the human X-chromosome
![Page 3: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/3.jpg)
Figure 6.2: Schematic view of a typical prokaryotic gene and the mRNA transcribed from the gene
![Page 4: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/4.jpg)
Figure 6.3: Transcriptional units in prokaryotes (A) can contain multiple open reading frames; eukaryotic transcriptional units (B) can have only one
ORF each
![Page 5: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/5.jpg)
Figure 6.4: The eukaryotic promoter, defined by an assemblage of interacting protein transcription factors bound to DNA
![Page 6: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/6.jpg)
Figure 6.5: A eukaryotic mRNA is processed by splicing after transcription to remove introns and join exons into a continuous coding sequence
![Page 7: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/7.jpg)
Figure 6.6: Consensus promoter sequences based on a few strong E. coli promoters
![Page 8: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/8.jpg)
Figure 6.7: The six possible reading frames within a short piece of double-stranded DNA
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Figure 6.8: Output from NCBI’s ORF Finder program
Courtesy of ORF/National Center for Biotechnology Information
![Page 10: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/10.jpg)
Figure 6.T1: Promoter sequences recognized by some E. coli sigma factors
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Figure 6.T2: One-letter code for ambiguous nucleotides
![Page 12: Chapter 6 Gene Prediction: Finding Genes in the Human Genome.](https://reader036.fdocuments.in/reader036/viewer/2022081504/56649ddb5503460f94ad2e36/html5/thumbnails/12.jpg)
Figure 6.9: The splicing process and consensus sequences at the exon-intron boundaries and branch site
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Figure 6.T3: Codon usage table for human genes