logy Lecture Chapter 1 - Pathology of the Respiratory Tract 2010-2011
Chapter 30cv pathology
Transcript of Chapter 30cv pathology
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Alterations of Cardiovascular FunctionChapter 30
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Diseases of the Arteries and Veins Arteriosclerosis
Chronic disease of the arterial system Abnormal thickening and hardening of the vessel
walls Smooth muscle cells and collagen fibers migrate to
the tunica intima
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Arteriosclerosis
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Diseases of the Arteries and Veins Atherosclerosis
Form of arteriosclerosis Thickening and hardening is caused by
accumulation of lipid-laden macrophages in the arterial wall
Plaque development
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Diseases of the Arteries and Veins Atherosclerosis
Progression Inflammation of endothelium Cellular proliferation Macrophage migration LDL oxidation (foam cell formation) Fatty streak Fibrous plaque Complicated plaque
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Atherosclerosis
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Atherosclerosis
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Diseases of the Arteries and Veins Hypertension
Primary hypertension Essential or idiopathic hypertension Genetic and environmental factors Affects 90% to 95% of individuals with hypertension
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Primary Hypertension
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Diseases of the Arteries and Veins Secondary hypertension
Caused by a systemic disease process that raises peripheral vascular resistance or cardiac output
Isolated systolic hypertension Elevations of systolic pressure are caused by
increases in cardiac output, total peripheral vascular resistance, or both
Complicated hypertension Malignant hypertension
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Diseases of the Arteries and Veins Complicated hypertension
Chronic hypertensive damage to the walls of systemic blood vessels
Smooth muscle cells undergo hypertrophy and hyperplasia with fibrosis of the tunica intima and media
Malignant hypertension Rapidly progressive hypertension Diastolic pressure is usually >140 mm Hg
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Treatment for Hypertension
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Diseases of the Arteries and Veins Orthostatic (postural) hypotension
Decrease in both systolic and diastolic blood pressure upon standing
Lack of normal blood pressure compensation in response to gravitational changes on the circulation
Acute orthostatic hypotension Chronic orthostatic hypotension
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Diseases of the Arteries and Veins Aneurysm
Local dilation or outpouching of a vessel wall or cardiac chamber
True aneurysms Fusiform aneurysms Circumferential aneurysms
False aneurysms Saccular aneurysms
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Aneurysm
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Aneurysm
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Diseases of the Arteries and Veins Thrombus formation
Blood clot that remains attached to the vessel wall
Thromboembolus Thrombophlebitis Arterial thrombi Venous thrombi
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Diseases of the Arteries and Veins Embolism
Bolus of matter that is circulation in the bloodstream Dislodged thrombus, air bubble, amniotic fluid,
aggregate of fat, bacteria, cancer cells, or a foreign substance
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Diseases of the Arteries and Veins Peripheral artery disease
Atherosclerotic disease of the arteries that perfuse the limbs
Intermittent claudication Obstruction of arterial blood flow in the iliofemoral
vessels resulting in pain with ambulation
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Peripheral Artery Disease Thromboangiitis obliterans (Buerger disease)
Occurs mainly in young men who smoke Inflammatory disease of peripheral arteries
resulting in the formation of nonatherosclerotic lesions Digital, tibial, plantar, ulnar, and palmar arteries
Obliterates the small and medium-sized arteries
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Peripheral Artery Disease Thromboangiitis obliterans (Buerger disease)
Causes pain, tenderness, and hair loss in the affected area
Symptoms are caused by slow, sluggish blood flow
Can often lead to gangrenous lesions
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Peripheral Artery Disease Raynaud phenomenon and Raynaud disease
Episodic vasospasm in arteries and arterioles of the fingers, less commonly the toes
Raynaud phenomenon is secondary to other systemic diseases or conditions Collagen vascular disease (scleroderma), smoking, pulmonary
hypertension, myxedema, and environmental factors (cold and prolonged exposure to vibrating machinery)
Raynaud disease is a primary vasospastic disorder of unknown origin
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Diseases of the Veins Varicose veins
A vein in which blood has pooled Distended, tortuous, and palpable veins Caused by trauma or gradual venous distention
Chronic venous insufficiency Inadequate venous return over a long period due
to varicose veins or valvular incompetence Venous stasis ulcers
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Diseases of the Veins Deep venous thrombosis
Obstruction of venous flow leading to increased venous pressure
Factors Venous stasis Venous endothelial damage Hypercoagulable states
Post-thrombotic syndrome (PTS)
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Coronary Artery Disease Any vascular disorder that narrows or occludes the
coronary arteries Atherosclerosis is the most common cause Risk factors
Dyslipidemia Hypertension Cigarette smoking Diabetes mellitus Obesity/sedentary lifestyle
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Coronary Artery Disease Nontraditional risk factors
Markers of inflammation and thrombosis C-reactive protein, fibrinogen, protein C, and
plasminogen activator inhibitor Hyperhomocysteinemia Infection
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Coronary Artery Disease Myocardial ischemia
Local, temporary deprivation of the coronary blood supply
Stabile angina Prinzmetal angina Silent ischemia Angina pectoris
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Myocardial Ischemia
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Myocardial Ischemia
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Coronary Artery Disease Acute coronary syndromes
Transient ischemia Unstable angina Sustained ischemia Myocardial infarction Myocardial inflammation and necrosis
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Myocardial Infarction
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Coronary Artery Disease Myocardial infarction
Sudden and extended obstruction of the myocardial blood supply
Subendocardial infarction Transmural infarction
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Myocardial Infarction Cellular injury Cellular death Structural and functional changes
Myocardial stunning Hibernating myocardium Myocardial remodeling
Repair
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Disorders of the Heart Wall Disorders of the pericardium
Acute pericarditis Pericardial effusion
Tamponade Constrictive pericarditis
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Pericarditis
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Disorders of the Myocardium Cardiomyopathies
Dilated cardiomyopathy (congestive cardiomyopathy)
Hypertrophic cardiomyopathy Asymmetrical septal hypertrophy Hypertensive (valvular hypertrophic) cardiomyopathy
Restrictive cardiomyopathy
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Cardiomyopathy
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Disorders of the Endocardium Valvular dysfunction
Valvular stenosis Aortic stenosis Mitral stenosis
Valvular regurgitation Aortic regurgitation Mitral regurgitation Tricuspid regurgitation
Mitral valve prolapse syndrome
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Valvular Dysfunction
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Valvular Dysfunction
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Acute Rheumatic Fever and Rheumatic Heart Disease Rheumatic fever
Diffuse, inflammatory disease caused by a delayed immune response to infection by the group A β-hemolytic streptococci
Febrile illness Inflammation of the joints, skin, nervous system, and
heart If left untreated, rheumatic fever causes
rheumatic heart disease
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Acute Rheumatic Fever and Rheumatic Heart Disease Rheumatic fever
Carditis Polyarthritis Chorea Erythema marginatum
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Acute Rheumatic Fever and Rheumatic Heart Disease
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Infective Endocarditis Inflammation of the endocardium Agents
Bacteria, viruses, fungi, rickettsiae, and parasites Pathogenesis
“Prepared” endocardium Blood-borne microorganism adherence Proliferation of the microorganism
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Infective Endocarditis
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Cardiac Complications of AIDS Myocarditis Endocarditis Pericarditis Cardiomyopathy
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Heart Failure General term used to describe several types of
cardiac dysfunction that result in inadequate perfusion of tissues with blood-borne nutrients
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Heart Failure Congestive heart failure
Systolic heart failure Inability of the heart to generate adequate cardiac
output to perfuse tissues Diastolic heart failure
Pulmonary congestion despite normal stroke volume and cardiac output
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Congestive Heart Failure
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Heart Failure Right heart failure
Most commonly caused by a diffuse hypoxic pulmonary disease
Can result from an increase in left ventricular filling pressure that is reflected back into the pulmonary circulation
High-output failure Inability of the heart to supply the body with blood-borne
nutrients, despite adequate blood volume and normal or elevated myocardial contractility
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Right Heart Failure
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Dysrhythmias Disturbance of the heart rhythm Range from occasional “missed” or rapid beats to
severe disturbances that affect the pumping ability of the heart
Can be caused by an abnormal rate of impulse generation or abnormal impulse conduction
Examples: Tachycardia, flutter, fibrillation, bradycardia, premature
ventricular contractions (PVCs), premature atrial contractions (PACs), asystole