Chapter 23, part C

Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings

PowerPoint® Lecture Slide Presentation prepared by Christine L. Case

Microbiology

B.E Pruitt & Jane J. Stein

AN INTRODUCTIONEIGHTH EDITION

TORTORA • FUNKE • CASE

Chapter 23, part CMicrobial Diseases of the Cardiovascular and

Lymphatic Systems


• Nasopharyngeal carcinoma

• Epstein-Barr virus (Human herpesvirus 4)

• Cancer in immunosuppressed individuals, and malaria and AIDS patients

Burkitt’s Lymphoma


• Epstein-Barr virus (Human herpesvirus 4)

• Childhood infections are asymptomatic

• Transmitted via saliva

• Characterized by proliferation of monocytes

Infectious Mononucleosis


Infectious Mononucleosis

Figure 23.20


• Cytomegalovirus (Human herpesvirus 5)

• Infected cells swell (cyto-, mega-)

• Latent in white blood cells

• May be asymptomatic or mild

• Transmitted across the placenta, may cause mental retardation

• Transmitted sexually, by blood, or by transplanted tissue

Cytomegalic Inclusion Disease


Viral Hemorrhagic Fevers

Classic

Yellow fever Flavivirus Aedes aegypti Monkeys

Dengue & DHF Flavivirus • A. aegypti

• A. albopictus

No known reservoir

Emerging

Marbug Filovirus • Monkeys (?)

Ebola Filovirus • Monkeys (?)

Lassa fever Arenavirus • Rodents

Argentine hemorrhagic fever

Arenavirus • Rodents

Bolivian hemorrhagic fever

Arenavirus • Rodents

Hantavirus pulmonary syndrome

Hantavirus • Rodents


Ebola Virus

Figure 23.21


• Trypanosoma cruzi

• Reservoir

• Rodents, opossums, armadillos

• Vector

• Reduviid bug

American Trypanosomiasis (Chagas’Disease)

Figure 23.22, 12.33d


• Toxoplasma gondii

Toxoplasmosis

Figure 23.23


• Plasmodium vivax, P. ovale, P malariae, P. falciparum

• Anopheles mosquito

Malaria

12.31b


Malaria

Figure 23.25


Malaria

Figure 23.24


Malaria

Figure 12.19


Leishmaniasis

Disease Visceral leishmaniasis

Cutaneous leishmaniasis

Mucocutaneous leishmaniasis

Babesiosis

Fatal if untreated

Papule that ulcerates and scars

Disfiguring Replicates in RBCs

Causative agent

Leishmania donovani

L. Tropica L. Braziliensis Babesia microti

Vector Sandflies Sandflies Sandflies Ixodes ticks

Reservoir Small mammals Small mammals Small mammals Rodents

Treatment Amphotericin B or miltefosine

Amphotericin B or miltefosine

Amphotericin B or miltefosine

Atovaquone + azithromycin

Geographic distribution

Asia, Africa, Southeast Asia

Asia, Africa, Mediterranean, Central America, South America

Rain forests of Yucatan, South America

U.S.


Babesiosis

Figure 12.32


Schistosomiasis

Figure 23.28


• Tissue damage (granulomas) in response to eggs lodging in tissues

Schistosomiasis

• S. haemotobium Granulomas in urinary bladder wall

Africa, Middle East

• S. japonicum Granulomas in intestinal wall East Asia

• S. mansoni Granulomas in intestinal wall African, Middle East, South American, Caribbean

• Swimmer’s itch Cutaneous allergic reaction to cercariae

U.S. parasite of wildfowl


Schitstosomasis

Figure 23.27a

(a) Male and female schitosomes.


Schitstosomasis

Figure 23.27b

Chapter 23, part C

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Transcript of Chapter 23, part C