Atoms, Molecules, and Ions Chapter 2 Atoms, Molecules, Ions.
Chapter 2 Atoms, Ions, and Molecules · Atoms, Ions, and Molecules • At its simplest level of...
Transcript of Chapter 2 Atoms, Ions, and Molecules · Atoms, Ions, and Molecules • At its simplest level of...
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Chapter 2 Atoms, Ions, and Molecules Sections Covered 2.1 Atomic Structure 2.2 Ions and Ionic Compounds 2.3 Covalent Bonding, Molecules, and Molecular Compounds 2.4 Molecular Structure and Properties of Water 2.5 Acidic and Basic Solutions, pH, and Buffers 2.7 Biological Macromolecules
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Atomic Structure
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Atoms, Ions, and Molecules
• At its simplest level of organization, the human body is composed of chemical structures: – Atoms – Ions – Molecules
• A basic understanding of chemical concepts is necessary to understand physiological processes
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Atoms, Ions, and Molecules: Matter, Atoms, Elements, and the Periodic Table
• Human body is composed of matter – Three forms:
• solid (e.g., bone) • liquid (e.g., blood) • gas (e.g., oxygen)
• Matter is composed of atoms – Atom, smallest particle that exhibits the chemical properties of
an element
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Atoms, Ions, and Molecules: Matter, Atoms, Elements, and the Periodic Table
• Elements organized into chart form in the periodic table of elements
• Elements called major, lesser, or trace based on percentage by weight in the body – Six major elements, over 98% total – Six minor elements, less than 1% total
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Periodic Table of Elements
H
K
1 3 1.008
6.941 Li
11
Na 22.99
37
Rb 85.47 55
Cs 132.9
87
Fr 223.0
IA
19
39.10
4 Be 9.012 12
Mg 24.31
20
Ca 40.08
38
Sr 87.62 56
Ba 137.3
88
Ra 226.0
Y 21
Sc 44.96
39
88.91 57
La 138.9
89
Ac 227.0
22
Ti 47.87
40
Zr 91.22 72
Hf 178.5
104
Rf 267.0
V 23
50.94
41
Nb 92.91
Ta 73
180.9
105
Db 268.0
W 24
Cr 52.00
42
Mo 95.94 74
183.8
106
Sg 271.0
25
Mn 54.94
43
Tc 98.00 75
Re 186.2
107
Bh 272.0
26
Fe 55.85
44
Ru 101.1 76
Os 190.2
108
Hs 270.0
27
Co 58.93
45
Rh 102.9 77
Ir 192.2
109
Mt 276.0
28
Ni 58.69
46
Pd 106.4 78
Pt 195.1
110
Ds 281.0
29
Cu 63.55
47
Ag 107.9 79
Au 197.0
111
Rg 274
30
Zn 65.38
48
Cd 112.4 80
Hg 200.6
112
277 Uub
B 5 10.81
13
Al 26.98
31
Ga 69.72 49
In 114.8 81
Tl 204.4
112
277 Uut
14
Si 28.09
32
Ge 72.64
50
Sn 118.7 82
Pb 207.2
114
Uuq 289.0
12.01 C 6
15
P 30.97
33
As 74.92
51
Sb 121.8 83
Bi 209.0 115
Uup 288.0
14.01 N 7
O S 8
15.99
16
2.07
34
Se 78.96
52
Te 127.6 84
Po 209.0
116
293.0 Uuh
I
F 9 19.00
17 Cl 35.45
35
Br 79.90
53
126.9 85
At 210.0
117
292.0 Uus
2 He 4.003 10
Ne 20.18
18
Ar 39.95
36
Kr 83.80
54
Xe 131.3 86
Rn 222.0
118
294.0 Uuo In
crea
sing
ele
ctro
nega
ativ
ity
Increasing electronegativity
1 H Atomic number
Element symbol Atomic mass number
58 59 60 61 62 63 64 65 66 67 68 69 70 71
Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu 140.1 140.9 144.2 145.0 150.4 152.0 157.3 158.9 162.5 164.9 167.3 168.9 173.0 175.0
90 91 92 93 94 95 96 97 98 99 100 101 102 103
U Th Pa Np Pu Am Cm Bk Cf Es Fm Md No Lr 232.0 231.0 238.0 237.0 244.0 243.0 247.0 247.0 251.0 252.0 257.0 258.0 259.0 262.0
IIA IIIA IVA VA VIA VIIA VIIIA
1.008
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Most Common Elements of the Human Body
Major elements (collectively compose more than 98% of body weight)
Lesser elements (collectively compose less than 1% of body weight)
P Ca N H C O Symbol % Body weight
Oxygen
Carbon
Hydrogen
Phosphorus
Calcium
Nitrogen
1.0
1.5
3.0
10.0
18.0
65.0
Symbol % Body weight
S K
Fe
Mg
Na
Cl
Sulfur
Potassium
Iron
Magnesium
Chlorine
Sodium
0.25
0.20
0.15
0.15
0.05
0.006
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Atoms, Ions, and Molecules: Matter, Atoms, Elements, and the Periodic Table
The components of an atom • Atoms composed of three subatomic particles:
– Protons • mass of one atomic mass unit (amu) • positive charge of one (+1)
– Neutrons • mass of one amu • no charge
– Electrons • 1/1800th mass of a proton or neutron • negative charge of one (-1) • located at varying distance from the nucleus in regions called orbitals
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The periodic table • Elements differ in number of subatomic particles • Periodic table displays:
– Chemical symbol • unique to each element • usually identified by first letter, or first letter plus an additional letter
– e.g., C is carbon – Atomic number
• number of protons in an atom of the element • located above symbol name • elements arranged by anatomic number within rows
– Average atomic mass • mass of both protons and neutrons • shown below the element’s symbol on the table
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Atoms, Ions, and Molecules: Matter, Atoms, Elements, and the Periodic Table
Determining the number of subatomic particles • Proton number = atomic number • Neutron number = atomic mass – atomic number
• neutron number = (p + n) – p • neutron number of Na = 23 – 11 = 12
• Electrons number = proton number
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Atoms, Ions, and Molecules: Matter, Atoms, Elements, and the Periodic Table
Diagramming Atomic Structures • An atom has shells of electrons
surrounding the nucleus – Each shell with a given energy
level – Each shell holding a limited
number of electrons – Innermost shell two electrons,
second shell up to eight – Shells close to the nucleus: must be
filled first
Shell model
(b)
Nucleus: Proton (+)
Neutron (no charge)
8 electrons
8 protons 8 neutrons
Energy shell
Electron shells: Electron (–)
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Atoms, Ions, and Molecules: Isotopes
• Isotopes are different atoms of the same element – Have same number of protons and electrons – Have different numbers of neutrons – Exhibit essentially identical chemical characteristics – One usually predominant
• Carbon exists in three isotopes: – carbon-12, with 6 neutrons
• most prevalent type – carbon-13, with 7 neutrons
– carbon-14 , with 8 neutrons
Carbon–13 Carbon–14 6 protons 7 neutrons 6 electrons
6 protons 8 neutrons 6 electrons
Carbon–12
6 electrons
6 protons 6 neutrons
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Atoms, Ions, and Molecules: Chemical Stability and the Octet Rule
• Periodic table organized into columns based on number of electrons in outer shell (valence shell) – Column one, with hydrogen, lithium, sodium, potassium
• all with one electron in their outer shell – Each consecutive column with one additional electron in outer shell – Elements in column VIIIA with a full valence shell
• results in chemical stability • helium, neon, etc., chemically inert (noble gases)
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Atoms, Ions, and Molecules: Chemical Stability and the Octet Rule
• Elements tend to lose, gain, or share electrons to obtain complete outer shells with eight electrons – Known as the octet rule
F
1 2 3 4 5 6 7 8
P
N
H
C O
S
K
B
IA IIA IIIA IVA VA VIA VIIA VIIIA
Li
Na
Ca
Ar Cl Si Al
Ne Be
Mg
He
Number of valence electrons
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Ions and Ionic Compounds
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Ions and Ionic Compounds
• Chemical compounds – Stable associations between two or more elements combined in a
fixed ratio – Classified as ionic or molecular
• Ionic compounds are structures composed of ions held together in a lattice of ionic bonds
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Ions and Ionic Compounds: Ions
• Ions – Are groups of atoms with a positive or a negative charge – Are produced from the loss or gain of an electron or
electrons – Are used very commonly in the body with significant
physiological functions • e.g., Na+ for electrical signals in neurons • e.g., Ca2+ for blood clotting and muscle contraction • e.g., Cl- in stomach acid, and many more
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Ions and Ionic Compounds: Ions
Losing electrons and the formation of cations • Sodium can reach stability by donating an electron
– Now satisfies the octet rule – Now has 11 protons and 10 electrons – Charge is +1
• Ions with positive charge called cations
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Ions and Ionic Compounds: Ions
Gaining electrons and the formation of anions • Chlorine can reach stability by gaining an electron
– Now satisfies the octet rule – Now has 17 protons and 18 electrons – Charge is -1
• Ions with negative charge called anions
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Ions and Ionic Compounds: Ionic Bonds
• Cations and anions may bind together in ionic bonds – Salts formed – For example, table salt (NaCl)
• Each sodium atom donates one outer shell electron to a chlorine atom
• Sodium and chlorine ions are held together by ionic bonds in a lattice crystal structure
• This is an ionic compound
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Formation of and Ionic Bond Involving Sodium and Chloride
+ = Na 11p
Cl 17p
Na+
11p Cl–
17p
Cl– Na+ Cl–
Cl– Na+ Na+
Cl– Na+ Cl–
(d) Lattice salt crystal of NaCl (c) Sodium ion (Na+) (a) Sodium atom (Na) (b) Chlorine atom (Cl) Chloride ion (Cl–)
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Covalent Bonding, Molecules, and Molecular Compounds
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Covalent Bonding, Molecules, and Molecular Compounds
• Sharing of electrons between atoms results in a covalently bonded molecule
• Most molecules are composed of two or more different elements – Termed molecular compounds
• examples include carbon dioxide (CO2) but not molecular oxygen (O2)
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
• A covalent bond is formed when atoms share electrons – Occurs when both atoms require electrons – Occurs with atoms that have four to seven electrons in their outer shell
• Four elements of the human body form covalent bonds most commonly: – oxygen (O) – carbon (C) – hydrogen (H) – nitrogen (N)
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Single, double, and triple covalent bonds • Single covalent bond
– One pair of electrons shared • e.g., between two hydrogen atoms
• Double covalent bond – Two pairs of electrons shared
• e.g., between two oxygen atoms
• Triple covalent bond – Three pairs of electrons shared
• e.g., between two nitrogen atoms
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N N
H H
O O
H H
O O
N N
Hydrogen gas (H2) Single bond
Double bond
Triple bond
Nitrogen gas (N2)
Oxygen gas (O2)
Single covalent bond
Double covalent bond
Triple covalent bond
(a)
(b)
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Single, double, and triple covalent bonds (continued) • Carbon needs four electrons to satisfy the octet rule
– Can be obtained in multiple different ways
H H
H H C C
H H H H
H H O O O C C
C O O C H H H C O
H H
C H H H
Methane (CH4) Carbon dioxide (CO2) Ethanol (C2H5OH)
(c) (b) (a)
H H
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Carbon Skeleton Formation • Carbon can bond in straight chains, branched chains,
or rings – Carbon present where lines meet at an angle; additional atoms hydrogen
C C C C C C C C C C C C C C C C C C
C C C C
C C C
Straight chain Branched chain Ring
(a) (b) (c)
CH3
CH3
CH3 H3C
CH3
H3C
C
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Nonpolar and polar covalent bonds • Atoms in a covalent bond may share electrons equally
or unequally – How they share is determined by electronegativity
• the relative attraction of each atom for electrons • high electronegativity = electrons spend more time orbiting the nucleus • determined by the number of protons in the nucleus and the proximity of
valence electrons – Two atoms of the same element have same electronegativities – Share electrons equally in a nonpolar covalent bond
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Nonpolar and polar covalent bonds (continued) • Atoms in a covalent bond may share electrons equally
or unequally – Atoms with different electronegativity share electrons unequally – This results in a polar covalent bond – Exception is the bond between carbon and hydrogen, considered
nonpolar
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Covalent Bonding, Molecules, and Molecular Compounds: Covalent Bonds
Nonpolar and polar covalent bonds (continued) • More electronegative atom develops a partial
negative charge – Less electronegative atom develops a partial positive charge – In a bond between oxygen and hydrogen, oxygen is slightly negative,
hydrogen slightly positive
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Covalent Bonding, Molecules, and Molecular Compounds: Intermolecular Attractions
• Intermolecular attractions – Weak chemical attractions between molecules – Collectively important in maintaining the shape of complex molecules
such as DNA and protein – One type, the hydrogen bond
• forms between polar molecules • attraction between partially positive hydrogen atom and a partially
negative atom • individually weak, collectively strong • influences how water molecules behave
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Molecular Structure and Properties of Water
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Molecular Structure of Water and the Properties of Water: Molecular Structure
• Water – Composes two-thirds of the
human body by weight – Polar molecule composed of
one oxygen atom bonded to two hydrogen atoms
– Oxygen atom with two partial negative charges
– Hydrogen with a single positive charge
– Can form four hydrogen bonds with adjacent molecules
• central to water’s properties
H H O
Water (H2O)
Hydrogen bonds
δ+
δ+
δ+ δ+
δ–
δ–
δ– δ–
(a) (b)
Water is a polar molecule due to unequal sharing of electrons.
Hydrogen bonds form between water molecules.
δ+
δ–
δ+ δ–
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Molecular Structure of Water and the Properties of Water: Properties
Cohesion, surface tension, and adhesion • Cohesion
– The attraction between water molecules due to hydrogen bonding
• Surface tension – The inward pulling of cohesive forces at the surface of water – Causes moist sacs of air in the lungs to tend to collapse
• surfactant (mixture of lipids and proteins) helps prevent this
• Adhesion – The attraction between water molecules and a substance other
than water
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Molecular Structure of Water and the Properties of Water: Properties
High specific heat and high heat of vaporization • Temperature
– The measure of kinetic energy of atoms or molecules within a substance
• Specific heat – The amount of energy required to increase the temperature of 1 gram of
a substance by 1 degree Celsius – Water’s value extremely high due to energy needed to break hydrogen
bonds – Contributes to body temperature constancy
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Molecular Structure of Water and the Properties of Water: Properties
High specific heat and high heat of vaporization (continued)
• Heat of vaporization – The heat required for the release of molecules from a liquid phase into
a gaseous phase for 1 gram of a substance – Water’s value very high due to hydrogen bonding – Why sweating is an effective means of cooling the body
• Excess heat dissipated as water evaporates
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Molecular Structure of Water and the Properties of Water: The Universal Solvent
• Water is the solvent of the body • Substances that dissolve in water are called solutes • Water called the universal solvent because most
substances dissolve in it
• Some polar molecules and other charged substances dissolve (disperse) within water – Substances termed hydrophilic, “water-loving”
• Nonpolar molecules do not dissolve within water – Substances termed hydrophobic, “water-fearing”
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Acidic and Basic Solutions, pH, and Buffers
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Acidic and Basic Solutions, pH, and Buffers: pH, Neutralization, and the Action of Buffers
• The pH is a measure of H+
– The relative amount of H+ in a solution – Expressed as a number between 0 and 14 – The inverse of the log for a given H+ concentration
• greater H+ = lower pH value
• The pH of plain water is 7 – Water dissociates to produce 1/10,000,000 ions per liter
• Moving from one increment to another is a tenfold change
– E.g., a pH of 6 has 10 times greater concentration of H+ than pure water
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Acidic and Basic Solutions, pH, and Buffers: pH, Neutralization, and the Action of Buffers
Interpreting the pH scale • Solutions with equal concentrations of H+ and OH-
– Are neutral – Have a pH of 7
• Solutions with greater H+ than OH- – Are acidic – Have a pH < 7
• Solutions with greater OH- than H+ – Are basic (alkaline) – Have a pH >7
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0 1 2 3 4 5 6 8 9
H+
H+
[H+]
H+ <
Examples pH Value
Sodium hydroxide (NaOH): 14
Household bleach: 12
Household ammonia: 10.5–11
Antacid: 10.5
Seawater: 8
Human blood: 7.4 Pure water: 7 Milk, saliva: 6.3–6.6 Urine: 6
Tomato juice: 4.7
Grapefruit juice: 3 Wine: 2.4–3.5 Lemon juice, stomach acid: 2–3
Hydrochloric acid (HCl): 1
100
10–1
10–2 H+
H+
H+ H+
H+
H+
H+
H+
H+
H+ H+
H+ H+
H+
H+ H+
H+ Decreasing
Increasing
OH–
pH
H+ Concentration
[H+]
H+ > OH–
pH
Basic
Neutral
Acidic
10–3
10–4
10–5
10–6
10–7
10–8
10–9
10–10
10–11
10–12
10–13
10–14 14
13
12
11
10
7
Decreasing
Increasing
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Acidic and Basic Solutions, pH, and Buffers: pH, Neutralization, and the Action of Buffers
• Neutralization occurs when an acidic or basic solution is returned to neutral – Acids neutralized by adding base
• e.g., medications to neutralize stomach acid containing base – Bases neutralized by adding acid
• Buffers help prevent pH changes if excess acid or base is added – Act to accept H+ from excess acid or donate H+ to neutralize base
• carbonic acid (weak acid) and bicarbonate (weak base) buffer blood pH • both help maintain pH in a critical range
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Biological Macromolecules
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Biological Macromolecules: General Characteristics
• Organic molecules, molecules that contain carbon – Most are a component of living organisms – Biological macromolecules (biomolecules) are a subset
• Inorganic molecules, all other molecules
• Four classes of biomolecules in living systems: I. Lipids II. Carbohydrates III. Nucleic acids IV. Proteins
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Biological Macromolecules: General Characteristics
Polymers • Molecules made up for repeating subunits, termed
monomers – Monomers identical or similar in chemical structure – Examples are carbohydrates, nucleic acids, proteins
• carbohydrates with sugar monomers • nucleic acids with nucleotide monomers • proteins with amino acid monomers
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Biological Macromolecules: General Characteristics
• Dehydration synthesis (condensation) – Occurs during the synthesis of biomolecules – One subunit looses an –H – Other subunit loses an –OH – New covalent bond formed and water produced
• Hydrolysis reaction – Occurs during the breakdown of biomolecules – An –H added to one subunit – An –OH added to another subunit
Dehydration
H2O
Synthesis
(a)
Hydrolysis
Digestion
(b)
H2O
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• h"ps://www.youtube.com/watch?v=ZMTeqZLXBSo
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Biological Macromolecules: Lipids
I. Lipids – Diverse group of fatty, water-insoluble compounds – Not composed of monomers – Function as stored nutrients, cellular membrane
components, and hormones – Occur in four primary classes:
1) Triglycerides 2) Phospholipids 3) Steroids 4) Eicosanoids
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Biological Macromolecules: Lipids
1) Triglycerides: energy storage – Most common form of lipid in living things – Used for long-term energy storage in adipose tissue – Also used for structural support, cushioning, and insulation – Formed from a glycerol molecule and three fatty acids
• Fatty acids – Are varied in length – Are varied in the number of double bonds
» saturated if they lack double bonds » unsaturated if they have one double bond » polyunsaturated if they have two or more double bonds
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Triglyceride
H C H C
H C H
H C H
H C H
H C H C H
H C H
H C H
H C H
C H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H H
H C H H
H C H
H C H
H C H
H C H C
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H H
H
H
O O C
O O O O
H C H C
H C H
H C H
H C H
H C H C H
H C H
H C H
H C H
C H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H H
H C H H
H C H
H C H
H C H
H C H C
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H
H C H H
H
H
C O C O C O
C C
C
C
Hydroxyl groups Carboxylic acid
OH
H2O
OH
H2O
OH
HO
HO
HO
H2O
Lipogenesis (occurs through dehydration)
Lipolysis (occurs through hydrolysis)
Glycerol Three fatty acids (vary in length and number of double bonds between carbons)
Triglyceride (b)
(a)
Triglyceride
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Biological Macromolecules: Lipids
2) Phospholipids: Membranes – Amphipathic molecules forming cell membranes – Phospholipid structure similar to a triglyceride
• one end of the glycerol with a polar phosphate group with another organic group
• group substitutes for a fatty acid • glycerol, phosphate, and organic group is polar
– known as the hydrophilic head • fatty acid group is nonpolar
– known as the hydrophobic tails
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Biological Macromolecules: Lipids
3) Steroids: ringed structures including some hormones – Composed of hydrocarbons arranged in a multiringed structure – Differ in the side chains extending from their rings – Include cholesterol, steroid hormones (e.g., testosterone), and bile salts
• cholesterol component of membranes • precursor to other steroid synthesis
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Biological Macromolecules: Lipids
4) Eicosanoids: locally acting hormones – Modified 20-carbon fatty acids – Synthesized from arachidonic acid, membrane component – Local signaling molecules – Have functions in the inflammatory response, in the nervous system,
and all body systems – Four classes:
• prostaglandins • prostacyclins • thromboxanes • leukotrienes
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Major Classes of
Lipids
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Biological Macromolecules: Carbohydrates
II. Carbohydrates – An –H and an –OH usually attached to every carbon – Chemical formula is (CH2O)n
• n the number of carbon atoms
– Monosaccharides • simple monomers
– Disaccharides • formed from two monosaccharides
– Polysaccharides • formed from many monosaccharides
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Biological Macromolecules: Carbohydrates
Glucose and Glycogen • Glucose
– Six-carbon carbohydrate – Most common monosaccharide – Primary nutrient supplying energy to cells – Concentration carefully maintained – Bound into the polysaccharide glycogen during glycogenesis
• Liver and skeletal muscle store excess glucose following a meal – Broken down from glycogen during glycogenolysis
• Liver breaks down glucose from glycogen as needed
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O C C
C C C H H
H H
H (b) Glycogen (a) Glucose
OH
HO
CH2OH
OH OH
Glycogenolysis
Glycogenesis
Glucose and Glycogen
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Biological Macromolecules: Carbohydrates
Other types of carbohydrates • Other monosaccharides
– Five carbon monosaccharides (pentose sugars) • ribose and deoxyribose in nucleic acids
• Disaccharides, two sugars bonded together – E.g., sucrose (table sugar), lactose (milk sugar), and maltose (malt
sugar)
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Biological Macromolecules: Carbohydrates
Other types of carbohydrates (continued) • Polysaccharides, three or more sugars bonded
– Glycogen most common in animals – Starch and cellulose found in plants
• plant starch a major nutritional source of glucose • celullose a source of fiber (nondigestible substances)
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Other Simple Carbohydrates
H H H O H
H H H H H
H O
H H HO H
O H
H H
O H
H H H
O
H H H
H O H
H H H
O H O H H
H O
H H H
O H H H
H H O
H H H
O H H O
Monosaccharides
6–carbon sugars (hexose)
CH2OH
5–carbon sugars (pentose)
CH2OH OHCH2 OHCH2
CH2OH CH2OH CH2OH CH2OH CH2OH
(a)
(b)
Galactose Fructose Deoxyribose Ribose
Maltose Lactose Sucrose
OH OH HO
OH OH OH
OH OH
OH OH
OH CH2OH
OH
OH CH2OH OH
HO HO
Disaccharides
HO
OH
OH OH HO
OH CH2OH
OH OH OH
OH OH
HO
*You do NOT have to memorize these structures!
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Biological Macromolecules: Nucleic Acids
III. Nucleic acids – Macromolecules that store and transfer genetic
information in cells – Two classes deoxyribonucleic acid (DNA) and
ribonucleic acid (RNA) • both polymers of nucleotide monomers
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The nucleotide monomer – Three components: sugar,
phosphate group, and a nitrogenous base
• sugar a five-carbon pentose
• phosphate group attached at carbon five
• nitrogenous base attached to same sugar at carbon one
• nitrogenous base with single-ring or double-ring structure
O P O–
–O O O
P N N N Phosphate group
(a) Nucleotide monomer
OH
CH2
Nitrogenous base
NH2
Sugar
OH in RNA
H in DNA
Biological Macromolecules: Nucleic Acids
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Biological Macromolecules: Nucleic Acids
The nucleotide monomer (continued) • Five types of nitrogenous bases
– Single-ring bases: pyrimidines • cytosine, uracil, and thymine
– Double-ring nitrogenous bases: purines • adenine and guanine
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Nucleic Acids Pu
rines
Pyrim
idin
es
NH2 NH2
N C C
N N C
C N C O
O C C
C O O C
O N C C
C N C HC
C O Uracil (U)
(RNA only)
NH2
NH NH HC
Guanine (G) (both DNA and RNA)
Cytosine (C) (both DNA and RNA)
Adenine (A) (both DNA and RNA)
(b) Nitrogenous bases
HC
HC N
CH3
HC N
HC N
Thymine (T) (DNA only)
N
HC
CH
NH
N
H H
H H H
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Biological Macromolecules: Nucleic Acids
Deoxyribonucleic acid (DNA) – Double-stranded nucleic acid – Found in chromosomes in the nucleus and in mitochondria – Has deoxyribose sugar, phosphate, and one of four nitrogenous bases:
• adenine, guanine, cystosine, or thymine • does not contain uracil
– Double-strands held together by hydrogen bonds • form between complementary bases • thymine paired with adenine; guanine paired with cytosine
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Biological Macromolecules: Nucleic Acids
Ribonucleic acid (RNA) – Single-stranded nucleic acid – Found in the nucleus and within cytoplasm of the cell – Has ribose sugar, phosphate, and one of four nitrogenous bases:
• adenine, guanine, cystosine, or uracil • does not contain thymine
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Nucleic Acids
C G A
A
T T P
P
P P
P O A O G
P
P
P
P
O C
O U
P
(c) RNA (single–stranded)
OH
(d) DNA (double–stranded)
Nucleotide
Sugar–phosphate “backbone”
Nitrogenous base
Deoxyribose sugar
Phosphate group
Unique to RNA
Phosphate group
Nitrogenous base
Ribose sugar
Nucleotide
Phosphodiester bonds
Unique to DNA
5′
3′ 3′
5′ Hydrogen bonds
between nitrogenous bases
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Biological Macromolecules: Nucleic Acids
Other important nucleotides • Adenosine triphosphate (ATP)
– Nucleotide composed of nitrogenous bases adenine, ribose sugar, and three phosphate groups
– Covalent bonds between last two phosphate groups • release energy when broken
– Central molecule in chemical energy transfer within cells
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Biological Macromolecules: Proteins
IV. Proteins – serve a vast array of functions – Serve as catalysts (enzymes) in metabolic reactions – Act in defense – Aid in transport – Contribute to structural support – Cause movement – Perform regulation – Provide storage
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71
Protein FuncCons
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Biological Macromolecules: Proteins
General protein structure • Proteins composed of one or more strands of
monomers • Monomers are amino acids
– 20 total in living organisms – Have an amine and a carboxylic acid functional group
• both covalently linked to same carbon atom – Carbon also covalently bonded to a hydrogen and different side chain
structures • referred to as the R group • distinguish different amino acids from one another
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Biological Macromolecules: Proteins
General protein structure (continued) • Amino acids covalently linked by peptide bonds – Formed during dehydration synthesis reaction – Occur between amine group of one amino acid and the carboxylic group of
another • – H lost from the amine group • – OH lost from the carboxylic acid
– N-terminal end has free amine group – C-terminal end has free carboxyl group
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Proteins
A m i n e
R OH C C H N O H H R OH C C H N O H H
R O H C C H N O H H
R C N H H O H C O
R C C H N O N H
C O H R C N H H
R C C O N H
C O H R C N H H
R C C O N H
C O H R C N H H
R C C O N H
R C H C O H H
Amino acid Peptide bond
Peptide bond Amine Carboxylic acid
R group (1 of 20 different structures)
(a)
(c)
N–terminal C–terminal
Polymer protein
Carboxylic acid
H2O
(b)
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Amino Acids N
onpo
lar
Pola
r Sp
ecia
l fun
ctio
ns
Cha
rged
O H C C O H
C C O H
H C C O H C C O H
C C O H
O C C C O H C C O H
O C
C C O H
C C O H S
C C O H S H
O–
C O
O H C C O H C C C O H
O–
O C
C C O H O C
C C O H
C C O H
C C C O H H
C C C O H
C C C O H Glycine (Gly)
Valine (Val)
Isoleucine (Ile)
Leucine (Leu)
Phenylalanine (Phe)
Tryptophan (Trp)
Allows bends in protein chain
Forms disulfide bond
Always the first amino acid in a protein sequence (may be removed following synthesis of protein)
Glutamic acid (Glu)
Lysine (Lys)
Histidine (His)
(–) Charge (+) Charge
Aspartic acid (Asp)
Arginine (Arg)
Tyrosine (Tyr)
Glutamine (Gln)
Asparagine (Asn)
Serine (Ser)
Threonine (Thr)
Methionine (Met)
Proline (Pro)
Cysteine (Cys)
NH2 OH NH2
CH2
CH2
OH
CH2 CH2
HC CH
CH2
CH2
CH2
CH2
OH OH NH2 NH2
NH3+
C C OH NH2
CH2
CH2
CH2
NH
CH2 NH2+
NH2
NH2
CH2
CH2
CH3
CH2
NH2 OH OH
NH2+
CH2
CH2 CH2
CH
NH2 OH
CH2
OH
NH2
OH CH3
CH3
NH2 OH OH
CH2
NH2
OH OH
CH2
CH2
CH2
OH
NH2 OH OH NH2
HN
CH2 CH2
CH2
CH3 CH3 CH3
OH OH NH2 NH2 OH NH2
CH3
CH2 CH3 CH3
CH
OH NH2
NH2
CH3
NH2 NH2
NH2
Alanine (Ala)
O–
N H+
CH2
H N
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Protein Structure: Amino Acid Sequence and Protein Conformation
• Primary structure, linear sequence of amino acids
N H H C C O R N
H H C
C O
R
Primary structure
Linear sequence of amino acids joined by peptide bonds
(a)
Peptide bond
Amino acid
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Protein Structure: Amino Acid Sequence and Protein Conformation
• Secondary structures, structural patterns from hydrogen bonds – Confer unique characteristics – Two types:
• alpha helix, spiral coil • beta sheet, planar pleat
arrangement
R
R
R
R
R
R R
R
R
R
R R
R R
R
R
R R
R R
Secondary structure
Structural patterns within a protein that result from hydrogen bonds formed between amino acids
Hydrogen bonds
(b)
Beta sheet (planar pleats) Alpha helix (spiral coil)
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Protein Structure: Amino Acid Sequence and Protein Conformation
• Tertiary structure, final three-dimensional shape of polypeptide chain – Two categories
distinguished: • globular proteins,
compact shape • fibrous proteins,
extended linear molecules (c)
Globular protein Fibrous protein
Tertiary structure Final 3–dimensional shape of a protein, which
contains repeating secondary structures
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Protein Structure: Amino Acid Sequence and Protein Conformation
• Quaternary structure, present in proteins with two or more polypeptide chains – E.g., hemoglobin
with its four polypeptide chains
(d)
Quaternary structure
Molecule composed of two or more separate proteins
Three fibrous proteins Globular
protein
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