Chapter 17 Amino Acid Catabolism - Illinois State University · •High protein diet? ... cid s...
Transcript of Chapter 17 Amino Acid Catabolism - Illinois State University · •High protein diet? ... cid s...
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Chapter 17
Amino Acid
Catabolism
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Urea
Excretion
as
Conversion to:
pyruvate
acetyl-CoA
citric acid cycle intermediates
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Digestion by
proteases
Digestion by
proteases
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cytosol
mitochondria
NH4+
NH4+
Protein
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Aminotransferases
catalyze transfer of
amino groups
of amino acids to
a-ketoglutarate
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Predict the product
of amino acid catabolism
• Alanine ??
Aspartate ??
Glutamate ??
• Draw the structure of each amino acid and
then predict the product of the transamination
reaction. Hint: count the carbons.
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Prentice Hall c2002 Chapter 16 9
NH3
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Glucose-alanine cycle
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Blood Urea Nitrogen (BUN)
• Blood urea nitrogen (BUN) measures the amount of urea nitrogen, a
waste product of protein metabolism, in the blood. BUN is commonly
monitored in hospitals and nursing homes.
• Adult BUN: 7-20 mg/100 ml; men may be slightly higher
• Predict whether BUN will increase or decrease in the following cases.
• Dehydrated patient? Overhydration?
• Elderly patient? Newborn?
• High protein diet? Malnutrition?
• Intestinal bleeding?
• Pregnancy?
• Kidney failure? Liver failure?
• Impaired nutrient absorption?