Chapter 16 Obj 01

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16.1 General Concepts in Immunity Explain the basic aspects of innate (nonspecific) and adap?ve (specific or acquired) immunity. What are the first lines of defense against pathogens? What are the second lines of defense? What is the third line of defense in the body?

Transcript of Chapter 16 Obj 01

Page 1: Chapter 16 Obj 01

16.1GeneralConceptsinImmunity

Explainthebasicaspectsofinnate(nonspecific)andadap?ve(specificoracquired)immunity.

•  Whatarethefirstlinesofdefenseagainstpathogens?

•  Whatarethesecondlinesofdefense?

•  Whatisthethirdlineofdefenseinthebody?

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ThreeLinesofDefenseintheHumanBody

•  Innateimmunity1st:Barriersatbodysurfaces–external•  Integument&mucousmembranes•  Chemicalsecre?ons•  microflora

•  3rd:Adap?veimmunity:specificimmuneresponses–  Cell‐mediated–  An?body‐mediated

2nd:Nonspecificresponses–internal

•  Phagocy?ccells•  Inflamma?on&fever

•  An?microbialproteins

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InnatevsAdap?ve

•  Innate–Nonspecific– ATributeswehaveatbirth– Defendusfromallpathogens

•  Adap?ve–Acquired–Specific– Notpresentatbirth–  ImmuneresponsesthatdevelopaWerexposure

•  Vaccine,subclinicalinfec?on,clinicalinfec?on– Uniquecellsforeachspecificpathogen