Chapter 12 Autonomic Nervous System

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Chapter 12Autonomic Nervous System

Autonomic or Visceral Reflexes• What They Do: Autonomic reflexes regulate

organ function• Pathway: The sequence is receptor activation,

sensory input ( CNS), motor neuron response, and effector response

Organization and Function of the Autonomic Nervous System

• Divisions of the ANS: There are two divisions.– Sympathetic nervous system, called “Fight or Flight.”– Parasympathetic Nervous System, called “Feed and Breed.”

• Autonomic Terminology and Autonomic Pharmacology– Drugs that affect the sympathetic nervous system are called

sympathomimetic and sympatholytic.– Drugs that affect the parasympathetic nervous system are

called parasympathomimetic and parasympatholytic.

Organization and Function of the Autonomic Nervous System - cont’d

• Autonomic Tone and Vasomotor Tone– Background firing of the ANS causes autonomic

tone.– Background sympathetic stimulation of the blood

vessels causes vasomotor tone.

ANS: Neurons• Numbers and Ganglia– Preganglionic fibers are fibers that extend from

the CNS to the ganglia.– Postganglionic fibers are fibers that extend from

the ganglia to the effector organ.

ANS: Neurons - cont’d

• Neurons of the Sympathetic Nervous System– The SNS is called the thoracolumbar outflow.– The sympathetic ganglia are located in a chain

close to the spinal cord; the chain is called paravertebral ganglia.

– The adrenal medulla secretes hormones that mimic the SNS.


• Neurons of the Parasympathetic Nervous System– The parasympathetic nervous system is called the

craniosacral outflow.– Parasympathetic fibers travel with cranial nerves;

most parasympathetics run with the vagus nerve CN X.

• Naming Fibers and Neurotransmitters– Cholinergic fibers secrete acetylcholine (ACh).– Adrenergic fibers secrete norepinephrine (NE).


• Neurotransmitters: Termination of Activity– ACh is degraded immediately by

acetylcholinesterase.– NE activity is ended primarily by reuptake of the

NE into the nerve terminal and by MAO activity within the nerve terminal.

Receptors of the Autonomic Nervous System

• Cholinergic Receptors– These are activated by ACh.– There are two types: muscarinic and nicotinic

(with subtypes). • Adrenergic Receptors– Activated by NE– There are two types: alpha and beta

(with subtypes).

Receptors of the Autonomic Nervous System - cont’d

• Receptor activation and blockade can be determined by examining Tables 12-1, 12-3, and 12-4.

• Autonomic Receptors: “Doing Autonomic Pharmacology”– Clinical examples where drugs target autonomic

receptors

Introduction• The brain, spinal cord, and peripheral nervous

system act as a vast communication system. The spinal cord transmits information to and from the brain. The peripheral nervous system brings information to the CNS (its sensory role) and delivers information from the CNS to the periphery (its motor role).

What the Spinal Cord Is• The spinal cord is a tubelike structure located

in the spinal cavity, extending from the foramen magnum (occipital bone) to L1

• Arrangement of Nervous Tissue– The gray matter is a centrally located, butterfly-

shaped area.– The white matter is composed of myelinated

fibers arranged in tracts. Ascending tracts are sensory tracts. Descending tracts are motor tracts.

What the Spinal Cord Is - cont’d

• Arrangement of Nervous Tissue—cont’d– Spinal nerves are attached to the spinal cord. All

spinal nerves are mixed (they contain sensory and motor fibers).

– Sensory nerve fibers travel to the cord through the dorsal root. Motor nerve fibers travel in the ventral root.

What the Spinal Cord Does: Functions • The spinal cord relays both sensory and motor

information. • The spinal cord acts as a major reflex center.

Reflexes• A reflex is an involuntary response to a

stimulus.• The four components to a reflex are a sensory

receptor; an afferent (sensory) neuron; an efferent (motor) neuron; and an effector organ.

Peripheral Nervous System• Nerve– A nerve is a group of neurons, blood vessels,

and connective tissue.– There are sensory nerves, motor nerves, and

mixed nerves.

Peripheral Nervous System - cont’d

• Structural Classification of Nerves– A classification of nerves on the basis of structure divides

nerves into cranial nerves and spinal nerves. There are 12 pairs of cranial nerves (Table 11-3) and 31 pairs of spinal nerves (Table 11-5).

– Spinal nerves are sorted out at nerve plexuses. The three major plexuses are the cervical plexus, the brachial plexus, and the lumbosacral plexus.

– A dermatome is the area of skin innervated by each spinal nerve.

Peripheral Nervous System - cont’d

• Functional Classification of Nerves– Somatic afferent nerves carry sensory information

to the CNS.– Somatic efferent nerves carry motor information

to skeletal muscles.– Autonomic nerves carry motor information to the

organs (viscera).

Introduction• The purpose of the nervous system is to bring

information to the central nervous system, interpret the information, and enable the body to respond to the information.

The Nervous System: Overview• Divisions of the Nervous System– The central nervous system (CNS) includes the

brain and the spinal cord.– The peripheral nervous system includes the nerves

that connect the CNS with the rest of the body.

The Nervous System: Overview - cont’d

• Cells That Make Up the Nervous System– Neuroglia (glia) support, protect, and nourish the

neurons.– Neurons conduct the nerve impulse. – The three parts of a neuron are the dendrites,

cell body, and axon.


• Types of Neurons– Sensory, or afferent, neurons carry information

toward the CNS.– Interneurons are located in the CNS

(make connections).– Motor, or efferent, neurons carry information

away from the CNS toward the periphery.


• White Matter and Gray Matter– White matter is due to myelinated fibers.– Gray matter is composed primarily of cell bodies,

interneurons, and unmyelinated fibers.– Clusters of cell bodies (gray matter) are called

nuclei and ganglia.

The Neuron Carrying Information• Nerve Impulse– The electrical signal is called the action potential or

nerve impulse.– The nerve impulse is due to the following changes in

the neuron: polarization, depolarization, and repolarization.

– The nerve impulse is due to flow of ions: polarization (outward flux of K+), depolarization (influx of Na+), and repolarization (outward flux of K+).

The Neuron Carrying Information - cont’d

• Nerve Impulse—cont’d– The refractory period is the unresponsive period

of the neuron.– The nerve impulse jumps from node to node as it

travels along a myelinated fiber. Myelination increases the speed of the nerve impulse.

– The nerve impulse causes the release of a neurotransmitter.

The Neuron Carrying Information - cont’d

• Synapse– The synapse is a space between two neurons.– The nerve impulse of the first (presynaptic)

neuron causes the release of neurotransmitter into the synaptic cleft. The neurotransmitter diffuses across the synaptic cleft and binds to the receptors on the second (postsynaptic) membrane. The activation of the receptors stimulates a nerve impulse in the second neuron.

Brain: Structure and Function• Cerebrum– The right and left hemispheres are joined by the

corpus callosum.– The four main cerebral lobes are the frontal,

parietal, temporal, and occipital lobes. Functions of each lobe are summarized in Table 10-2.

– Large areas of the cerebrum, called association areas, are concerned with interpreting, integrating, and analyzing information.

Brain: Structure and Function - cont’d

• Diencephalon– The thalamus is a relay station for most sensory

tracts traveling to the cerebrum.– The hypothalamus controls many body functions

such as water balance, temperature, and the secretion of hormones from the pituitary gland; it exerts an effect on the autonomic nervous system.


• Brain Stem– Brain stem: midbrain, pons, and medulla

oblongata.– The medulla oblongata is called the vital center

because it controls the heart rate, blood pressure, and respirations (the vital functions).

– The vomiting center is located in the medulla oblongata; it receives input directly and indirectly from activation of the chemoreceptor trigger zone (CTZ).


• Cerebellum– The cerebellum is sometimes called the little

brain.– The cerebellum is concerned primarily with the

coordination of voluntary muscle activity.


• Structures Involving More than One Lobe– The limbic system is sometimes called the

emotional brain.– The reticular formation is concerned with the

sleep/wake cycle. It keeps us conscious and prevents us from slipping into a coma state.

– The “memory areas” handle short-term and long-term memory.

Protection of the CNS• Bone: cranium and vertebral column• Meninges: pia mater, arachnoid, and dura

mater• Cerebrospinal fluid (CSF) that circulates within

the subarachnoid space• Blood-brain barrier

Introduction• The purpose of muscle is to contract and to

cause movement.

Muscle Function: Overview• Types and Functions of Muscles– Skeletal muscle is striated and voluntary; its

primary function is to produce movement.– Smooth (visceral) muscle is nonstriated and

involuntary; it helps the organs perform their functions.

– Cardiac muscle is striated and involuntary; it is found only in the heart and allows the heart to function as a pump.

Muscle Function: Overview - cont’d

• Structure of the Whole Muscle– A large muscle consists of thousands of single

muscle fibers (muscle cells).– Connective tissue binds the muscle fibers (cells)

together (forming compartments in the limbs) and attaches muscle to bone and other tissue (by tendons and aponeuroses).


• Structure and Function of a Single Muscle Fiber– The muscle fiber (cell) is surrounded by a cell

membrane (sarcolemma). The cell membrane penetrates to the interior of the muscle as the transverse tubule (T tubule).

– An extensive sarcoplasmic reticulum (SR) stores calcium.

– Each muscle fiber consists of a series of sarcomeres. Each sarcomere contains the contractile proteins actin and myosin.


• How Muscles Contract– Muscles shorten or contract as the actin and myosin

(in the presence of calcium and ATP) interact through crossbridge formation, according to the sliding filament theory.

– For skeletal muscle to contract, it must be stimulated by a motor nerve. The nerve impulse releases acetycholine (ACh) from the nerve terminal. ACh diffuses across the neuromuscular junction (NMJ), binds to the muscle membrane and causes an electrical signal to form in the muscle membrane.


• How Muscles Contract—cont’d– The electrical signal enters the T-tubular system

and stimulates the SR to release calcium.– Actin, myosin, and ATP interact to form

crossbridges, which cause sliding or shortening.– Calcium is pumped back into the SR and the

muscles relax.


• Responses of a Whole Muscle– A single muscle fiber contracts in an all-or-nothing response; a whole

muscle can contract partially (i.e., not all-or-nothing).

– A whole muscle increases its force of contraction by recruitment of additional muscle fibers.

– Two terms describe the contractile activity of a whole muscle: twitch and tetanus. Tetanus refers to a sustained muscle contraction.

– Energy for muscle contraction can be obtained from three sources: burning fuel aerobically, burning fuel anaerobically, and metabolizing creatine phosphate.


• Terms That Describe Muscle Movement– Origin and Insertion: The attachments of the

muscles.– Prime mover: The muscle most responsible for the

movement achieved by the muscle group – Synergist and Antagonist: Works with, or has an

opposing action.

Muscles from Head to Toe• Skeletal muscles are named according to size,

shape, direction of fibers, location, number of origins, place of origin and insertion, and muscle action.

• See Table 9-1 for a list of the body’s muscles.

Introduction• The skeletal system supports the weight of the

body, supports and protects body organs, enables the body to move, acts as storage site for minerals, and produces blood cells.

Bones: An Overview• Sizes and Shapes

– Bones are classified as long, short, flat, and irregular.– Bone markings function as sites of muscle attachments and passages

for nerves and blood vessels.– A long bone has a diaphysis (shaft) and two epiphyses (ends). Articular

cartilage is found on the outer surface of the epiphyses. – The diaphysis is composed of compact or hard bone. The epiphysis

consists of spongy or soft bone; red marrow is found in the holes of spongy bone.

Bones: An Overview - cont’d

• Bone Formation and Growth– Bones ossify in two ways. In the skull, osteoblasts replace

thin connective tissue membrane, forming flat bones. Other bones form on hyaline cartilage models as osteoblasts replace cartilage with bone.

– Bones grow longitudinally at the epiphyseal disc, to determine height; bones also grow thicker and wider to support the weight of the body.

– Bone growth and reshaping occur throughout life and depend on many factors, including diet, exercise, and hormones.

Divisions of the Skeletal System• The names of the 206 bones of the skeleton

are listed in Table 8-2.

Divisions of the Skeletal System - cont’d

• Axial Skeleton– The axial skeleton includes the bones of the skull

(cranium and face), hyoid bone, bones of the middle ear, bones of the vertebral column, and the thoracic cage.

– The skull of a newborn contains fontanels, which are membranous areas that allow brain growth.

– The skull contains air-filled cavities called sinuses.


• Axial Skeleton—cont’d– The vertebral column is formed from 26 vertebrae,

one sacrum, and one coccyx. The vertebrae are separated by cartilaginous discs. The vertebral column of the adult has four curvatures: cervical, thoracic, lumbar, and sacral.

– The thoracic cage is a bony, cone-shaped cage formed by the sternum, 12 pairs of ribs, and thoracic vertebrae.


• Appendicular Skeleton– The appendicular skeleton includes the bones of

the extremities (arms and legs), and the bones of the hip and shoulder girdles.

– The shoulder girdle consists of the scapula and the clavicle.

– The pelvic girdle is formed by the two coxal bones and is secured to the axial skeleton at the sacrum.

Joints• A joint or articulation is the site where two

bones meet.

Joints - cont’d

• Types of Joints (based on the degree of movement)– Immovable joints. – Slightly movable joints.– Freely movable joints or synovial joints. Structures

within a synovial joint (knee): articular cartilage, the joint capsule, synovial membrane, synovial fluid, bursae, and supporting ligaments.

– The types of freely movable joints include hinge, ball and socket, pivot, gliding, saddle, and condyloid.

Joints - cont’d

• Joint Movement– Freely movable joints are capable of different

types of movement.– Types of movements at freely movable joints

include flexion and extension, abduction and adduction, inversion and eversion, supination and pronation, and circumduction.

Introduction• The integumentary system includes the skin,

which covers the body, protects the internal organs, and plays an important role in the regulation of body temperature.

Structures: Organs of the Integumentary System

• The integumentary system includes the skin, accessory structures, and subcutaneous tissue beneath the skin.

Structures: Organs of the Integumentary System - cont’d

• Skin– The skin is called the cutaneous membrane.– The skin has two layers, an outer layer called the

epidermis and an inner layer called the dermis.– The epidermis has five layers. The stratum

germinativum is the layer in which cell division takes place. The new cells produce keratin (waterproofing) and die as they are pushed toward the surface. The outer layer is the stratum corneum and consists of flattened, dead, keratinized cells.


• Skin—cont’d– The dermis lies on the subcutaneous tissue.– Skin color is determined by many factors: some

genetic, some physiologic, and some due to disease. Melanin causes skin to darken. Carotene causes skin to appear yellow. The amount of blood in the skin affects skin color (e.g., flushing) as does the appearance of abnormal substances such as bilirubin (jaundice) and a low blood oxygen content (cyanosis).


• Accessory Structures of the Skin– Hair is unevenly distributed over the skin. The location of the

hair determines its function. Eyebrows and eyelashes protect the eyes from dust and perspiration.

– The main parts of a hair are the shaft and root.– Hair color is determined by the amount and type of melanin.– Nails are thin plates of stratified squamous epithelial cells

that contain a hard form of keratin.– There are two major exocrine glands in the skin: sebaceous

glands and sweat glands.


• Accessory Structures of the Skin—cont’d– The sebaceous glands (oil glands) secrete sebum. The

sebum lubricates hair and skin. In the fetus, these glands secrete vernix caseosa, a cheeselike substance that coats the skin of a newborn.

– The two types of sweat glands (sudoriferous glands) are the apocrine glands and the eccrine glands. The eccrine sweat glands play a crucial role in temperature regulation.

– The mammary glands (which secrete milk) and the ceruminous glands (which secrete ear wax) are modified sweat glands.


• Subcutaneous Tissue– Subcutaneous tissue anchors the dermis to

underlying structures.– Subcutaneous tissue acts as an insulator; it

prevents heat loss.

Regulation of Body Temperature• Heat Production– Heat produced by metabolizing cells constitutes

the body temperature.– Most of the heat is produced by the muscles and

the liver.• Heat Loss– Most of the heat (80%) is lost through the skin.– Heat loss occurs through radiation, conduction,

convection, and evaporation.

Regulation of Body Temperature - cont’d

• Heat Loss—cont’d– Normal body temperature is set by the body’s

thermostat in the hypothalamus. – Heat is lost through sweating and vasodilation.

Heat is conserved by vasoconstriction and produced by shivering.

When Skin Is Burned• Physiological Effects – Short-term effects: fluid and electrolyte losses,

shock, inability to regulate body temperature, infection

– Long-term effects: scarring, loss of function, and cosmetic and emotional problems

• Classification of Burns– Classified according to the thickness of the burn

(partial, full); also first, second, and third degree.– The rule of nines is a way to evaluate burns.

Introduction• Tissues are groups of cells similar to each

other in structure and function. • Membranes are thin sheets of tissue that

cover surfaces, line body cavities, and surround organs.

Types of Tissue • Epithelial Tissue Types – Epithelial tissue covers surfaces, lines cavities, and

engages in secretion/absorption and protective functions.

– Epithelial tissue is classified according to cell shape (squamous, cuboidal, and columnar) and layers (simple and stratified).

– The types and functions are summarized in Table 6-1.

Types of Tissue - cont’d

• Connective Tissue– The primary function of connective tissue is to bind

together the parts of the body. Other functions include support, protection, fat storage, and transport of substances.

– Connective tissue has an abundant intercellular matrix that fills spaces between cells. The intercellular matrix may be liquid, gel-like, or hard. The matrix often contains protein fibers that are secreted by the cells.

– There are three types of loose connective tissue: areolar, adipose, and reticular.


• Connective Tissue—cont’d– Dense fibrous connective tissue forms tendons, ligaments,

capsules, and fascia, and is found in the skin (dermis).– Types of cartilage include: hyaline, elastic, and

fibrocartilage.– Bone (osseous tissue) is connective tissue formed by

osteocytes. Bone cells have a hard intercellular matrix that includes collagen, calcium salts, and other minerals.

– Blood and lymph are types of connective tissue that have a watery intercellular matrix.


• Nervous Tissue– Nervous tissue is found in the peripheral nerves, brain,

and spinal cord.– The two types of nervous tissue are neurons, which

transmit electrical signals, and neuroglia, which support and take care of the neurons.

• Muscle Tissue– Muscle cells contract, thereby causing movement.– The three kinds of muscle are skeletal, smooth, and

cardiac.

Tissue Repair• Tissue Repair by Regeneration – Replacement of tissue by cells that undergo

mitosis• Tissue Repair by Fibrosis – Formation of scar tissue

Membranes• Epithelial Membranes

– The cutaneous membrane is the skin.– Mucous membranes are epithelial membranes that line all body

cavities that open to the exterior of the body.– Serous membranes are epithelial membranes that line the ventral

body cavities, which are not open to the exterior of the body.– Serous membranes form two layers: a parietal layer that lines the

wall of the cavity and a visceral layer that covers the outside of an organ.

– The three serous membranes are the pleura, the pericardium, and the peritoneum.

Membranes - cont’d

• Connective Tissue Membranes– Synovial membranes are connective tissue

membranes.– Other connective tissue membranes are listed in

Table 6-3.

Chapter 12 Autonomic Nervous System

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