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Chapter 10Lecture
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BIOL 2064: Anatomy & Physiology 1Chapter 10
Edited by Brenda Holmes
MSN/Ed, RN
Associate Professor
South Arkansas Community College
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Hole’s Human Anatomyand Physiology
Twelfth Edition
Shier Butler Lewis
Chapter 10
Nervous System I: Basic Structure and Function
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
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10.1: Introduction
• Cell types in neural tissue:• Neurons• Neuroglial cells (also known as neuroglia, glia, and glial)
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Dendrites
Cell body
Axon
Nuclei ofneuroglia
© Ed Reschke
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Divisions of the Nervous System
• Central Nervous System (CNS)• Brain• Spinal cord
• Peripheral Nervous System (PNS)• Cranial nerves• Spinal nerves
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Brain
(a)
Spinalcord Spinal
nerves
Cranialnerves
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Divisions of Peripheral Nervous System
• Sensory Division• Picks up sensory information and delivers it to the CNS
• Motor Division• Carries information to muscles and glands
• Divisions of the Motor Division:• Somatic – carries information to skeletal muscle• Autonomic – carries information to smooth muscle, cardiac muscle, and glands
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Divisions Nervous SystemCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Sensory division Sensory receptors
Motor division
Skeletal muscle
Brain
(a) (b)
Spinalcord Spinal
nerves
Cranialnerves
Central Nervous System(brain and spinal cord)
Peripheral Nervous System(cranial and spinal nerves)
Smooth muscleCardiac muscleGlands
AutonomicNervousSystem
SomaticNervousSystem
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10.1 Clinical Application
Migraine
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10.2: General Functions of the Nervous System
• The three general functions of the nervous system:• Receiving stimuli = sensory function• Deciding about stimuli = integrative function• Reacting to stimuli = motor function
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Functions of Nervous System
• Sensory Function• Sensory receptors gather information• Information is carried to the CNS
• Integrative Function• Sensory information used to create:
• Sensations• Memory• Thoughts• Decisions
• Motor Function• Decisions are acted upon • Impulses are carried to effectors
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10.3: Description of Cells of the Nervous System
• Neurons vary in size and shape
• They may differ in length and size of their axons and dendrites
• Neurons share certain features:
• Dendrites
• A cell body
• An axon
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Neuron StructureCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Cell body
Neurofibrils
Nucleus
Nucleolus
Dendrites
Impulse
Nodes of Ranvier
Myelin (cut)
Axon
Axon
Chromatophilicsubstance(Nissl bodies)
Axonalhillock
Portion of acollateral
Schwanncell
Nucleus ofSchwann cell
Synaptic knob ofaxon terminal
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Myelination of Axons
• White Matter• Contains myelinated axons• Considered fiber tracts
• Gray Matter• Contains unmyelinated structures• Cell bodies, dendrites
Dendrite
Node of Ranvier
Myelinated region of axon
Axon
(a)
Unmyelinatedregion of axon
Neuroncell body
Neuronnucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
(c)
EnvelopingSchwann cell
Schwanncell nucleus
Unmyelinatedaxon
Longitudinalgroove
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10.2 Clinical Application
Multiple Sclerosis
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10.4: Classification of Neurons and Neuroglia
• Neurons vary in function
• They can be sensory, motor, or integrative neurons
• Neurons vary in size and shape, and in the number of axons and dendrites that they may have
• Due to structural differences, neurons can be classified into three (3) major groups:
• Bipolar neurons
• Unipolar neurons
• Multipolar neurons
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Classification of Neurons: Structural Differences
• Bipolar neurons• Two processes• Eyes, ears, nose
• Unipolar neurons• One process• Ganglia of PNS• Sensory
• Multipolar neurons• 99% of neurons• Many processes• Most neurons of CNS
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Dendrites
Axon Axon
AxonDirectionof impulse
(a) Multipolar
Centralprocess
Peripheralprocess
(c) Unipolar(b) Bipolar
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Classification of Neurons: Functional Differences
• Sensory Neurons• Afferent• Carry impulse to CNS• Most are unipolar• Some are bipolar
• Interneurons• Link neurons• Aka association neurons or internuncial neurons• Multipolar• Located in CNS• Motor Neurons• Multipolar• Carry impulses away from CNS• Carry impulses to effectors
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Central nervous system Peripheral nervous system
Cell body
Interneurons
Dendrites
Axon
Axon
Sensory (afferent) neuron
Motor (efferent) neuron
Cell body
Axon(central process)
Axon(peripheral process)
Sensoryreceptor
Effector(muscle or gland)
Axonterminal
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Types of Neuroglial Cellsin the PNS
1) Schwann Cells• Produce myelin found on peripheral myelinated neurons• Speed up neurotransmission
2) Satellite Cells• Support clusters of neuron cell bodies (ganglia)
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Types of Neuroglial Cellsin the CNS
2) Astrocytes• CNS• Scar tissue• Mop up excess ions, etc.• Induce synapse formation• Connect neurons to blood vessels
3) Oligodendrocytes• CNS• Myelinating cell
4) Ependyma or ependymal• CNS• Ciliated• Line central canal of spinal cord• Line ventricles of brain
1) Microglia• CNS• Phagocytic cell
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Types of Neuroglial CellsCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Microglial cell
Axon
Oligodendrocyte
Astrocyte
Capillary
Neuron
Myelinsheath (cut)
Node ofRanvier
Ependymalcell
Fluid-filled cavityof the brain orspinal cord
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Regeneration of A Nerve AxonCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
AxonSite of injury Schwann cells
(a)
(b)
(c)
(d)
(e)
Changesover time
Motor neuroncell body
Former connectionreestablished
Schwann cellsproliferate
Schwann cellsdegenerate
Proximal end of injured axon regenerates into tube of sheath cells
Distal portion ofaxon degenerates
Skeletalmuscle fiber
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10.5: The Synapse
• Nerve impulses pass from neuron to neuron at synapses, moving from a pre-synaptic neuron to a post-synaptic neuron.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Dendrites
Impulse
Impulse
Impulse
Synapticcleft
Axon ofpresynapticneuron
Cell body of postsynaptic neuron
Axon of postsynaptic neuron
Axon ofpresynapticneuron
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Synaptic Transmission
• Neurotransmitters are released when impulse reaches synaptic knob
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Mitochondrion
Synaptic knob
(a)
Synaptic cleft
Neurotransmitter
Axon
Ca+2
Presynaptic neuron
Direction ofnerve impulse
Synapticvesicles
Cell body or dendriteof postsynaptic neuron
Synapticvesicle
Vesicle releasingneurotransmitter
Axonmembrane
Polarizedmembrane
Depolarizedmembrane
Ca+2Ca+2
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Animation:Chemical Synapse
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10.6: Cell Membrane Potential
• A cell membrane is usually electrically charged, or polarized, so that the inside of the membrane is negatively charged with respect to the outside of the membrane (which is then positively charged).
• This is as a result of unequal distribution of ions on the inside and the outside of the membrane.
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Distribution of Ions
• Potassium (K+) ions are the major intracellular positive ions (cations).• Sodium (Na+) ions are the major extracellular positive ions (cations).• This distribution is largely created by the Sodium/Potassium Pump (Na+/K+ pump).• This pump actively transports sodium ions out of the cell and potassium ions into the cell.
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Resting Potential
• Resting Membrane Potential (RMP):
• 70 mV difference from inside to outside of cell• It is a polarized membrane• Inside of cell is negative relative to the outside of the cell• RMP = -70 mV• Due to distribution of ions inside vs. outside• Na+/K+ pump restores
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
AxonCell body
Low Na+
Axon terminalLow K+
High K+
High Na+
(a)
+
+
––
+
+
––
+
+
–+–
–+–+
–
+–
+–
+–
+–
+–
+–
+–
+–
+ –
–70 mV
(b)
+
+
––
+
+
––
+
+
–+–
–+–+
–
+–
+–
+ –
+–
+–
+–
+–
–70 mV
Low Na+
Low K+ High K+
High Na+
Na+
K+
(c)
Pump
Impermeantanions
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Local Potential Changes
• Caused by various stimuli:• Temperature changes• Light• Pressure
• Environmental changes affect the membrane potential by opening a gated ion channel
• Channels are 1) chemically gated, 2) voltage gated, or 3) mechanically gated
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Gatelike mechanism Protein
(b) Channel open(a) Channel closed
Cellmembrane
Fatty acidtailPhosphatehead
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Local Potential Changes
• If membrane potential becomes more negative, it has hyperpolarized
• If membrane potential becomes less negative, it has depolarized
• Graded (or proportional) to intensity of stimulation reaching threshold potential
• Reaching threshold potential results in a nerve impulse, starting an action potential
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Local Potential ChangesCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
–62 mV
Na+
Na+
Neurotransmitter
(a)
–55 mV
Na+Na+ Na+ Na+
Na+
Trigger zone
(b)
Chemically-gatedNa+ channel
Presynapticneuron
Voltage-gatedNa+ channel
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Action Potentials
• At rest, the membrane is polarized (RMP = -70)
• Sodium channels open and membrane depolarizes (toward 0)
• Potassium leaves cytoplasm and membrane repolarizes (+30)
• Threshold stimulus reached (-55)
• Brief period of hyperpolarization (-90)
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
(a)
Region of depolarization
(b)
Region of repolarization
(c)
–70
–0
–70
–0
–70
–0K+
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
K+ K+ K+ K+ K+ K+ K+
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
K+ K+ K+ K+ K+ K+ K+ K+
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
K+ K+ K+ K+ K+
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
K+ K+ K+ K+ K+
K+
K+
K+ K+
K+ K+
Na+ Na+ Na+
Na+ Na+ Na+
Thresholdstimulus
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+
K+ K+ K+ K+ K+
K+ K+ K+ K+ K+
Na+ Na+ Na+
Na+ Na+ Na+
K+
K+
K+ K+ K+
K+ K+ K+
Na+ channels openK+ channels closed
K+ channels openNa+ channels closed
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Action Potentials
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Milliseconds
10
0
+20
+40
2 3 4 5 6 7 8
Mem
bra
ne
po
ten
tial
(m
illi
vo
lts)
Action potential
Hyperpolarization
–40
–20
–60
–80
Restingpotential
Resting potentialreestablished
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Action PotentialsCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
(a)
Direction of nerve impulse
+ +
+ +
+
– – – – – – – – –
– – – – –– – – –
– – – – –– – – –
– – – – – – – – –
– – – – – – – – –
– – – – – – – – –
+ + + + + + + +
+ + + + + + + + +
(b)
+ +
+ +
++ + + + + + + +
++ + + + + + + +
(c)
+ +
+ +
++ + + ++ + + +
++ + + ++ + + +
Region ofaction potential
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Animation:Action Potential Propagation
in Myelinated Neurons
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Animation:Action Potential Propagation
in Unmyelinated Neurons
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All-or-None Response
• If a neuron responds at all, it responds completely
• A nerve impulse is conducted whenever a stimulus of threshold intensity or above is applied to an axon
• All impulses carried on an axon are the same strength
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Refractory Period
• Absolute Refractory Period• Time when threshold stimulus does not start another action potential
• Relative Refractory Period• Time when stronger threshold stimulus can start another action potential
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Impulse Conduction
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Animation:The Nerve Impulse
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10.3 Clinical Application
Factors Affecting Impulse Conduction
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10.7: Synaptic Transmission
• This is where released neurotransmitters cross the synaptic cleft and react with specific molecules called receptors in the postsynaptic neuron membrane.
• Effects of neurotransmitters vary.
• Some neurotransmitters may open ion channels and others may close ion channels.
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Synaptic Potentials
• EPSP• Excitatory postsynaptic potential• Graded• Depolarizes membrane of postsynaptic neuron• Action potential of postsynaptic neuron becomes more likely
• IPSP• Inhibitory postsynaptic potential• Graded• Hyperpolarizes membrane of postsynaptic neuron• Action potential of postsynaptic neuron becomes less likely
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Summation of EPSPs and IPSPs
• EPSPs and IPSPs are added together in a process called summation• More EPSPs lead to greater probability of an action potential
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Nucleus
Neuroncell body
Presynapticknob
Presynapticaxon
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Neurotransmitters
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Neurotransmitters
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Neuropeptides
• Neurons in the brain or spinal cord synthesize neuropeptides.
• These neuropeptides act as neurotransmitters.
• Examples include:• Enkephalins• Beta endorphin• Substance P
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10.4 Clinical Application
Opiates in the Human Body
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10.8: Impulse Processing
• Way the nervous system processes nerve impulses and acts upon them
• Neuronal Pools• Interneurons• Work together to perform a common function• May excite or inhibit
• Convergence• Various sensory receptors• Can allow for summation of impulses
• Divergence• Branching axon• Stimulation of many neurons ultimately
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Neuronal Pools
• Groups of interneurons that make synaptic connections with each other
• Interneurons work together to perform a common function
• Each pool receives input from other neurons
• Each pool generates output to other neurons
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Convergence
• Neuron receives input from several neurons
• Incoming impulses represent information from different types of sensory receptors
• Allows nervous system to collect, process, and respond to information
• Makes it possible for a neuron to sum impulses from different sources
1 2
3
(a)
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
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Divergence• One neuron sends impulses to several neurons
• Can amplify an impulse
• Impulse from a single neuron in CNS may be amplified to activate enough motor units needed for muscle contraction
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
(b)
4
5
6
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Important Points in Chapter 10:Outcomes to be Assessed
10.1: Introduction
Describe the general functions of the nervous system.
Identify the two types of cells that comprise nervous tissue.
Identify the two major groups of nervous system organs.
10.2: General Functions of the Nervous System
List the functions of sensory receptors.
Describe how the nervous system responds to stimuli.
10.3: Description of Cells of the Nervous System
Describe the three major parts of a neuron.
Define neurofibrils and chromatophilic substance.
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Important Points in Chapter 10:Outcomes to be Assessed
Describe the relationship among myelin, the neurilemma, and the nodes of Ranvier.
Distinguish between the sources of white matter and gray matter.
10.4: Classification of Neurons and Neuroglia
Identify structural and functional differences among neurons.
Identify the types of neuroglia in the central nervous system and their functions.
Describe the Schwann cells of the peripheral nervous system.
10.5: The Synapse
Define presynaptic and postsynaptic.
Explain how information passes from a presynaptic to a postsynaptic neuron.
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Important Points in Chapter 10:Outcomes to be Assessed
10.6: Cell Membrane Potential
Explain how a cell membrane becomes polarized.
Define resting potential, local potential, and action potential.
Describe the events leading to the conduction of a nerve impulse.
Compare nerve impulse conduction in myelinated and unmyelinated neurons.
10.7: Synaptic Transmission
Identify the changes in membrane potential associated with excitatory and inhibitory neurotransmitters.
10.8: Impulse Processing
Describe the basic ways in which the nervous system processes information.
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Quiz 10
Complete Quiz 10 now!
Read Chapter 11.