Chap3 calculation
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Transcript of Chap3 calculation
Chapter 3: Objectives Describe instruments for volumetric
measurement and characterize their differences in application and accuracy.
Describe the correct procedure when using a pharmaceutical balance.
Define sensitivity requirement and apply it in calculations.
Perform calculations by the aliquot method.
Demonstrate an understanding of percentage of error in pharmaceutical measurement.
Vocabulary Compound or Compounding
Sensitivity Requirement (SR)
Aliquot
Percentage of Error
Measurement of Volume
Measurement of Volume
Measurement of Weight
Measurement of Weight
Weighing by the AliquotMethod
Preliminary Step: Calculate the smallest quantity of a substance that can be weighed on the balance with the desired precision.
Step 1: Select a multiple of the desired quantity that can be weighed with the required precision.
Step 2: Dilute the multiple quantity with an inert substance.
Step 3: Weigh the aliquot portion of the dilution that contains the desired quantity.
Preliminary Step Calculate the smallest quantity of a
substance that can be weighed on the balance with the desired precision.
Preliminary Step Calculate the smallest quantity of a
substance that can be weighed on the balance with the desired precision.
Preliminary Step Calculate the smallest quantity of a
substance that can be weighed on the balance with the desired precision.
Step One Select a multiple of the desired quantity that
can be weighed with the required precision.
Step Two Dilute the multiple quantity with an inert
substance.
Step Three Weigh the aliquot portion of the dilution that
contains the desired quantity.
Step Three Weigh the aliquot portion of the dilution that
contains the desired quantity.
Weighing by the AliquotMethod
Weighing Accuracy
Least Weighable Quantity Method of
Weighing Step1: Weigh an amount of the drug
substance that is equal to or greater than the least weighable quantity.
Step2: Dilute the drug substance with a calculated quantity of inert diluent such that a predetermined quantity of the drug-diluent mixture will contain the desired quantity of drug.
Least Weighable Quantity Method of
Weighing Example:
Least Weighable Quantity Method of
Weighing Example:
Least Weighable Quantity Method of
Weighing Example:
Least Weighable Quantity Method of
Weighing Example:
Percent Error
Percent Error Example:
Percent Error Example:
Percent Error Example:
