Changes of Presenile Cataracts Changes of Presenile Cataracts that had been Operated over 10 years that had been Operated over 10 years

in Korea in Korea

Sung Kun Chung, M.D. ; Eun-Jung Jun, M.D. Sung Kun Chung, M.D. ; Eun-Jung Jun, M.D. Hyun Seung Kim.Hyun Seung Kim.

Department of Ophthalmology and Visual Department of Ophthalmology and Visual Science, Science, The Catholic University of KoreaThe Catholic University of Korea

No author has any financial or proprietary No author has any financial or proprietary interest in any materials or methods mentionedinterest in any materials or methods mentioned

IntroductionIntroduction Many studies about senile cataractMany studies about senile cataract

: aged more than 60 years old: aged more than 60 years old

: age is one of the most important risk factors of cataract: age is one of the most important risk factors of cataract

Presenile cataract patients may display different Presenile cataract patients may display different characteristics from senile cataract patientscharacteristics from senile cataract patients

PurposePurpose To investigate the long-term characteristics To investigate the long-term characteristics

and changes of presenile cataracts that had and changes of presenile cataracts that had been operated in Korea.been operated in Korea.

Materials & MethodsMaterials & Methods

Inclusion criteria Inclusion criteria

① ① aged from 30 to 50 years aged from 30 to 50 years

② ② underwent cataract surgeries underwent cataract surgeries at St. Mary’s hospital at St. Mary’s hospital from 1995 to 2004(n=976) from 1995 to 2004(n=976)

Exclusion criteriaExclusion criteria

① ① patients with histories of ocular patients with histories of ocular trauma or uveitis trauma or uveitis

② ② those received combined surgeries those received combined surgeries

Retrospective review of Retrospective review of medical recordsmedical records

AnalyzeAnalyze

① ① age & sex : 31-40, 41-50 groupage & sex : 31-40, 41-50 group

② ② their histories of diabetes and their histories of diabetes and hypertension hypertension

③ ③ types of lens opacities types of lens opacities

④ ④ preoperative and preoperative and postoperative visual acuities postoperative visual acuities

•Lens opacity grading : LOCSⅢLens opacity grading : LOCSⅢ (Lens Opacity Classification System III)(Lens Opacity Classification System III)

• Statistical analysis Statistical analysis : Cochran-Armitage proportion trend test: Cochran-Armitage proportion trend test

ResultsResults

30-39 years 40-49years Total

Mean age 36.2 45.3 41.7

Male 299(38.8%) 472(61.2%) 771(79.0%)

Female 81(39.5%) 124(60.5%) 205(21.0%)

History of diabetes 20(20.0) 78(80.0) 98(10.0%)

History of

hypertension

16(21.1%) 60(78.9%) 76(7.8%)

ResultsResults

ResultsResults

Anterior polar

Opacity

Posterior subcapsular opacity

(PSCO)

Anterior polar opacity +PSCO

Cortical opacity

Nuclearopacity

30-39years

n(%)

147(42.2%)

104(30.3%)

34(50%)

12(20.3%)

16(30.2%)

40-49years

n(%)

201(57.8%)

239(69.7%)

34(50%)

47(79.7%)

37(69.8%)

Totaln

(%)348

(35.7%)343

(35.1%)68

(7.0%)59

(6.0%)53

(5.4%)

Lens opacities in each age group (LOCSⅢ)

Region of study

Sample size, race

Methods of evaluation

Age Group(yrs)

Prevalence(%) Prevalence(%)Cortical Nuclear PSC Male Female

Beijing,China

4439,Chinese

slit-lamp c AREDS

≥ 40 0.3 82.2 4.3 No statistically significantdifference in gender

Shih-Pai,Taiwan

1361,Chinese

Slit-lampc LOCSⅢ

≥ 65 21.9 38.9 9.2 Femalepredominance

Singapore

1717,Chinese

Slit-lampc LOCSⅢ

40-79 23.9 22.6 7.0 No statistically significant difference in gender

Sumatra,Indonesia

919,Indonesian

Slit-lampc LOCSⅢ

≥ 21 4 5.7 Femalepredominanceexcept cortical cat.

Victoria,Australia

4433,Australian

Slit-lampc WCGS

≥ 40 11.3 12.6 4.08 Femalepredominance

Korea 976,Korean

Slit-lampc LOCSⅢ

30-49 6.0 5.4 35.1 Male predominance

ResultsResults

*PSC : posterior subcapsular*c : with*AREDS : Age-related Eye disease Study*LOCSⅢ : Lens Opacities Classification System Ⅲ*cat. : cataract*JCCESG : Japanese Cooperative Cataract Epidemiology Study Group*WCGS : Wilmer cataract grading scheme

ResultsResults

Eyes that had surgeries for presenile cataracts displayed Eyes that had surgeries for presenile cataracts displayed

statistically significant decrease(p = 0.0002, CI 95%)statistically significant decrease(p = 0.0002, CI 95%)

Presenile cataracts with diabetes showed no significant Presenile cataracts with diabetes showed no significant

trend with the passage of time(p = 0.4767, CI 95%) trend with the passage of time(p = 0.4767, CI 95%)

Presenile cataracts with hypertension showed Presenile cataracts with hypertension showed

statistically significant increase (p = 0.0049, CI 95%) statistically significant increase (p = 0.0049, CI 95%)

ConclusionConclusion

Presenile cataract patients had different Presenile cataract patients had different

characteristics from senile cataract patients. characteristics from senile cataract patients.

Men consisted of the majority of the presenile cataract Men consisted of the majority of the presenile cataract

patients. patients.

Anterior polar opacity was the most common type of Anterior polar opacity was the most common type of

lens opacity. lens opacity.

Cataracts with hypertension showed overall increase Cataracts with hypertension showed overall increase

over 10 years.over 10 years.