Cervical paraganglioma esso 32 slides 2 2012
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MANAGEMENT OF ADOLESCENT CERVICAL
PARAGANGLIOMA: 13 CASES
FOUAD A.FOUADAssistant professor of surgical oncology
National Cancer Institute (NCI)
Cairo University
04/14/2023 1Fouad Abdelshaheed [NCI]
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INTRODUCTION
• A paraganglioma is a rare neuroendocrine tumor.
• 75% of paragangliomas are sporadic. • 25% are hereditary .• 90% adrenal (pheochromocytoma).• 10% extra-adrenal .
04/14/2023 2Fouad Abdelshaheed [NCI]
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INTRODUCTION
• Extra-adrenal– 85% abdomen– 12% thorax– 3% head and neck:
• Carotid body most common(CBT)• Vagal(VP)• Jugulotympanic(JP;TP)• Other
• Cervical paragangliomas [CP] generally present in mid-adult life.
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TREATMENT
• The different therapeutic options include:
Surgical resection. Conventional radiotherapy . Stereotactic radio surgery In selected cases a ‘wait and scan’ Foote RL,
et al.[2002]
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AIM OF THIS STUDY
• The aim to review our experience at NCI in management of cervical paraganglioma in the adolescent age as regard:
Surgical treatment Functional results.
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MATERIAL AND METHODS
• During the period 2002–2011, thirteen patients with cervical paragangliomas have been presented to NCI, Cairo university for surgical treatment.
• All patients were adolescents with mean age 17.2 years (range, 13 to 21 years).
• Complete surgical resection was possible in all cases in this study
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PREOPERATIVE DATA
Percentage No; of the patients Item
84.6%:15.4% 11/2 Female/male
17.2±2.3 Mean Age(Years)
69.2%23%7.6%69.2%:30.8%
9/133/131/139:4
Main symptom: Lateral neck mass Mixed symtomatology Headache Lt. /Rt.
15.1±9.4 Duration of symptoms (mean in months)
23%53.1%23%
3/137/133/13
Size of the tumor >2 cm 2-4cm >4 cm
15.3% 2/13 Pre op. biopsy
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Accidental pre-operative biopsy
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04/14/2023 9Fouad Abdelshaheed [NCI]
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Pre-operative investigation
• Ultrasonography (US) • Computerized tomography (CT)• Magnetic Resonance Imaging (MRI)
[seven out of 13 (53.8%) ]
• Digital subtraction angiography (DSA) {All cases}
• Balloon test occlusion (BTO) [three cases with large tumors more than 4 cm]
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In all cases
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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CP-IMAGING
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Preoperative selective embolization
• Remains a matter of debate as major complications such as cerebrovascular accidents might occur.
• For some authors, allows safer surgical excision of the paraganglioma
• In our series, no patient underwent selective embolization
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OPERATIVE TECHNIQUE
• Incision along the anterior border of the sternocleidomastoid
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OPERATIVE TECHNIQUE
• Proximal exposure of the CCA.• The branches from the ECA were ligated
and divided near the tumor border . • The dissection was performed in the
relatively a vascular subadventitial plane between the artery and the tumor called “white line”.
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OPERATIVE TECHNIQUE
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POST OPERATIVE SPECIMEN
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OPERATIVE TECHNIQUE
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POST OPERATIVE SPECIMEN
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OPERATIVE TECHNIQUE
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OPERATIVE TECHNIQUE
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POST OPERATIVE SPECIMEN
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OPERATIVE DATA
• The mean operative time was 84.7 ±36.4 ml minutes;
• Mean blood loss was 98.07±39 ml.• Mean size of the resected tumors was
3.6±1.5 cm (range 1.8–6.8 cm).
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POST-OPERATVE DIAGNOSIS
Percentage Number Type of the tumor
61.7% 8
2 [25%]5 [62.5]1 [12.5%]
CBTShamblin 1971 class:
• I [Localized] • II [Adherent Partially ]• III [Encasing]
23% 3 VP
15.3% 2 JP
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Vascular and neurological injuries
Cranial nerves injuries Carotid arteries injuries
Item
XII XI X IX ICA injury
ECA injury
2(15%) 1(7.6%) 3(23%) CBPs
3(23%) 1(7.6%) VPs
1(7.6%) 2(15.3%) JPs
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MORBIDITY AND MORTALITY
• Post operative difficulty in deglutition in 3 patients.
• No transient ischemic attack or stroke was noticed in any patient .
• No perioperative mortality was documented
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CONCLUSION• Cervical paragangliomas in the adolescent
age are a rare entity • More predominant in females• Carotid body tumors are the most common
head and neck CP in adolescent age.• Best treated by proper surgical resection.
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CONCLUSION• Early management of patients and expert
surgeons minimize neurovascular complications
• Cranial nerve deficits were more common in patients with JP and VP relative to those with CBT but all improved rapidly in that young age.
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THANK YOU