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Centro de Química da Madeira

2005 Scientific Report

2005 Relatório de actividades científicas

Madeira Chemistry Research Centre is a research associated to:

The unit has financial support from:

FUNCHAL, UNIVERSIDADE DA MADEIRA

Fevereiro/ February 2006


2005 Scientific report

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Summary

2005 was the second year of activity of the Centro de Química da Madeira (CQM) covered by

the financial support of FCT and the main objective defined in the initial project was the

stabilization of the research activities and the consolidation of the research lines by the

attraction of young PhD and post-doc students. This main objective was fully achieved

considering the fact that 1 PhD project was approved in 2004 and 4 were granted in 2005 (to

be started in January 2006). In consequence, the CQM will have in 2006 six permanent PhD

students (1 project is expected to finish during 2006). Another PhD student is actually

working at the University of Bordeaux (France). The actual number of post-doc students is 4

(0 in 2004). The increasing number of post docs was foreseen and represents an important

addition to our planning and working capacity. This is a major issue in the evolution of the

research team.

In terms of research projects, an important work was carried out in order to assure the

integration of CQM in the National networks for NMR and MS. The project (CHEMIA) was

approved in 2004 and the networks were formed under the supervision of FCT during the year

of 2005. In consequence, the CQM is expecting to receive a 400MHz NMR and a LCMSMS until

the end of 2006 (total investment of about 500000€, financed by FCT). Three new research

projects started during the year of 2005, involving a total amount of about 1300000€

(Financial support from FCT and FEDER). It must be stressed that two of these projects are

headed by CQM. With these three projects, members of CQM were involved in financed

projects totalizing more than 2000000€ in the last three years. The important number of

projects running in our facilities requires special attention on the attraction of PhD students,

but essentially post-docs due the associated scientific autonomy that they can bring to the

team.

During 2005, three important international meetings were held in Funchal under the

organization of members of CQM. The VI Conference on Inorganic Chemistry, from 31 March -

3 April 2005, involved about 110 attendees (30 of them from abroad). The Matrix-2005 Low

Temperature Spectroscopy and Matrix Isolation, was held in Funchal from July 24-29 and

involved more than 100 attendees and the congress of the Phytochemistry Society of Europe –

Phytotherapy 2005, held in Funchal from November 1-5.

An important issue was the regular emission of the CQM newsletter, Memento, as an

important tool for the spreading of information concerning our current activities. This is well

expressed by the people that accessed the web page of CQM during the year of 2005: 18031

(+16% than 2004). CQM was also involved in the activities planed for the National week for

Science and Technology (November) and received 8 undergraduate students for a two weeks

training period in our research labs (July).



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In what concerns the number of papers published in international journals, the number is

lower (7) than expected (12). This number does not reflect the work carried out has three

others papers appeared in the first 2006 issue (January) and other 9 were accepted for

publication. They will be published along the first semester of 2006. To these figures, 3 book

chapters and 40 presentations in several meeting must be added.

The financial results show a rather low use of the amount supplied by FCT. Two main reasons

can justify this fact: an important amount was reserved for the needs not covered by the

project CHEMIA, in order to add flexibility in the optimization of the internal conditions for

the installation and use of the NMR and LCMS; and the contract of a lab technician foreseen

for these equipments. The fact that both equipments were not acquired in 2005, the good

use of these amounts was delayed and will be applied during the year of 2006. FCT has

already agreed with this request.

Reminding the main objectives for 2004-2005:

1. The stabilization of the current research activities and the consolidation of the

research lines – Natural Products and Materials research areas will be developed

having in view an increased integration and equilibrium between applied and

innovative chemistry, as suggested by the unit evaluation panel;

2. To increase the scientific production of the team; it is expected to publish an average

number of at least two papers per PhD per year by the end of the period;

3. To reinforce the collaboration with regional entities as well as national and

international research groups in order to increase the involvement in research

activities and full recognition by our pairs;

4. To attract young and good PhD and Post-doc students in order to increase the human

potential of the group.

Considering the above, the main objectives defined for the CQM for the period 2004-2005

were achieved and the adequate conditions were prepared for the next three year period.

We believe that these results show that young and new research teams can advantageously be

supported, if an ambitious but feasible project is outlined. We do hope to maintain the high

levels of expectancy created with the current projects and justify the confidence received

from FCT and the evaluation panel.



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Unit identification

Identificação da unidade Designação da unidade Centro de Química da Madeira Área científica Química Coordenador Científico José Carlos Antunes Marques Endereço da unidade Departamento de Química da Universidade da Madeira, Campus Universitário da Penteada 9000-390 Funchal Telefone Fax 291705100 291705149 Email Endereço na internet (URL) [email protected] http://cqm.uma.pt Instituição de acolhimento Universidade da Madeira Largo do Município - Colégio dos Jesuítas 9000-081 Funchal NIF: 680041982 Instituição de gestão Universidade da Madeira Largo do Município - Colégio dos Jesuítas 9000-081 Funchal NIF: 680041982 Linhas de investigação / Research lines Produtos naturais / Natural products Materiais /msterials Palavras chave / Keywords Enologia / enology fitoquímica / phytochemistry materiais / materials biomateriais / biomaterials



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2005 Research team

2005 Equipa de investigação Integrados [9 registos]

Nome completo Grau académico

Categoria profissional

%tempo

Fracçãoelegível

Helena Maria Pires Gaspar Tomas Doutoramento Professor Auxiliar 60 1,00

Helena Paula de Freitas Caldeira Araújo Doutoramento Professor Auxiliar 60 1,00

Joao Manuel Cunha Rodrigues Doutoramento Professor Auxiliar 60 1,00

Jose Carlos Almeida Mesquita Doutoramento Professor Auxiliar 60 1,00

Jose Carlos Antunes Marques Doutoramento Professor Associado 60 1,00

José de Sousa Câmara Doutoramento Professor Auxiliar 60 1,00

Miguel Xavier Jesus Josefat Fernandes Doutoramento Professor Auxiliar 60 1,00

Paula Cristina Machado Ferreira Castilho Doutoramento Professor Associado 60 1,00

Pedro Filipe Duarte Louzeiro Pires Doutoramento Professor Auxiliar 60 1,00

Bolseiros [7 registos]



%tempo

Fracçãoelegível

Cezar Florin Catrinescu Doutoramento Não aplicável (bolseiro) 100 1,00

Visvaldas Kairys Doutoramento Não aplicável (bolseiro) 100 1,00

Wojciech Czardybon Doutoramento Não aplicável (bolseiro) 100 1,00

Zsolt Csok Doutoramento Não aplicável (bolseiro) 100 1,00

César Esmeraldo Fernandes PAPCC Assistente 100 0,00

Ana Lina Fernandes Licenciatura Não aplicável (bolseiro) 100 0,00

José Luis da Silva Santos Licenciatura Não aplicável (bolseiro) 100 0,00

Colaboradores [12 registos]



%tempo

Fracçãoelegível

Agata Renata Czardybon Doutoramento Outra 100 0,00

Maria do Ceu Goncalves da Costa Doutoramento Investigador Auxiliar 40 0,00

Pedro Luis Ryberg Mousinho Figueiredo Doutoramento Outra 40 0,00

Carla Sophia Brazão Andrade Sousa Alves Mestrado Outra 100 0,00



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Catia Cristina Capelo Ornelas Licenciatura Não aplicável (bolseiro) 20 0,00

Maria Helena da Silva Oliveira Figueira da Silva Licenciatura Assistente Convidado 60 0,00

Rosa Maria De Sá Perestrelo Licenciatura Estagiário de Investigação 100 0,00

Sandra Cristina Gonçalves Gouveia Licenciatura Estagiário de Investigação 100 0,00

Vanda Nulita Gomes Pereira Licenciatura Estagiário de Investigação 100 0,00

João Luís Camacho Baptista Figueira Ensino Secundário Estagiário de Investigação 100 0,00

Manuel Gonçalves Jardim Ensino Secundário Estagiário de Investigação 100 0,00

Marisela Cátia Fernandes Pontes Ensino Secundário Estagiário de Investigação 100 0,00



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2005 Relatório científico

Main unit projects approved in the 2004-2005 period involve the acquisition of large equipment

(CHEMIA) and CQM2005 submited to FEDER for the support of the research unit. Two important

international research projects were approved in 2005 (Antivinmac e Biopolis) financed by FEDER,

Interreg IIIB. Due to the importance for the sustainable growth of the research team the PhD project

started in 2005 and the 4 new grants (Projects to be started in 2006) deserve special attention. In

complement, 4 post-doc projects have been granted and the involved foreign students reveal the

confidence on the work under run in the group and the recognition by other international groups.

GENERAL PROJECTS

1. CHEMIA - CHEMISTRY ENHANCEMENT IN MADEIRA BY INSTRUMENTAL ANALYSIS”, submitted

by CQM-Centro de Química da Madeira – Universidade da Madeira to the "Programa de Re-

Equipamento Científico" launched by FCT, EEQ/876/2001, Funding requested: € 898425. (2004-

Approved); CQM was integrated in the national networks of NMR and MS and a 400MHz NMR

and a LCMSMS are expected to be installed in our labs until the end of 2006.

2. CQM2005; submitted to FEDER for the financial support of the research Unit, funding

requested €42300.

RESEARCH PROJECTS

1. ANTIVINMAC - Determinação do potencial antioxidante, aminoácidos e aminas biogénicas

em vinhos de castas comuns a Canárias, Açores e Madeira; financed by FEDER - INTERREG

IIIB 2005-2006 (headed by CQM/Universidade da Madeira)

2. CARVINMAC- Caracterização dos vinhos elaborados com castas autóctones da Madeira,

Açores e Canárias; financed by FEDER - INTERREG IIIB, 2003-2005 (headed by CQM; finished

September 2005)

3. IMPACT - Impacto das tecnologias de Produção na qualidade do Vinho Madeira, financed by

ADI - Agência de Desenvolvimento e Inovação (2003-2006)

4. CLAYCATS - Modified Porto Santo Clays as catalysts for liquid phase organic reaction

(CQM leader) with the Materials Research Institute, Sheffield Hallam Univ, UK, and Évora

University, Portugal, 2004-2007, POCTI/CTM/47619/2002



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5. Regularity and Stability of Ordered Mesoporous Materials Containg Alumínium and Titanium

- with Èvora Univ. (leader) and ITN and IST, Lisbon, 2004-2007, POCTI/CTM/45859/2002

6. Phytochemical Study of Compounds from Arboreal Species of Eco-Etno-Pharmacological

Importance in the “Laurissilva” Forest –Luso-French Integrated Actions, F-41/03, 2003-2005

with Université de Corse

7. CYTED – Subprogramme X: Química Fina e Farmacêutica, Projecto X.9 Monografias de Calidad,

Seguridad y Eficacia de Plantas Medicinales Iberoamericanas (PROMFI) 2002-2005 e Red X.A.

: Red Iberoamericana de Productos Naturales de Uso Medicinal (RIPRONAMED), 2003-2006

8. CYTED – Subprogramme X: Química Fina e Farmacêutica, Projecto X.11 Proyecto

Iberoamericano de Búsqueda y Evaluación de Agentes Naturales Antituberculosos

(PIBATUB), (2003-2007)

9. BIOPOLIS – Construindo uma bio-região europeia. INTERREG IIIB aprovado na IV convocatória

(2006-2008)

10. -“Molecular Interactions in Liquids and Liquid Mixtures”- POCTI/EQU/60963/2004, (2005-

2007). Funding requested to FCT: € 96910. (Funded by FCT: € 76500), Starting date: 1/7/2005.

(headed by Universidade da Madeira/CQM)

11. "In vitro study of the interactions between bone cells and collagen type I", Acordo

ICCTI/ASCR -2003/2005, em colaboração com o Instituto de Fisiologia da Academia de Ciências

da República Checa

12. “Cytocompatibility evaluation of the alloy Ti-6Al-7Nb after spark-anodization surface

treatment”; Estágio da Lic. Lucina Sousa da UNESP/Brasil (September 2005 - January 2006)

13. 6-"Construção e Caracterização de Dendrímeros Organometálicos para Aplicações em Óptica

Não Linear", BILATERAL PROJECT: granted by the PROGRAMA PESSOA 2005-2006 -Acções

integradas LUSO-FRANCESAS -GRICES - EGIDE, with the Groupe de Nanosciences Moleculaires et

Catalyse of Prof. Dider Astruc, University of Bordeaux I, France

14. "Novel Polarised Molecular Wires Based on Transition Metal Complexes of di(4-

pyridyl)heterocycles Spacers Bridging Ligands", – POCTI/CTM/41495/2001, (2003-2006).

Funding requested to FCT: € 85504. (Funded by FCT: € 85504), Starting date: 1/4/2003.

(CITMA/CQM)

15. Synthesis and Study of New Organometallic Dendrimers for Nonlinear Applications", -

POCTI/QUI/41814/2001, (2003-2005). Funding requested to FCT: € 92467. (Approved by FCT:

€ 72300), Starting date: 1/4/2002. (headed by Universidade da Madeira/CQM) (finished

October 2005)

16. BILATERAL AGREEMENT SOCRATES programme”: HIGHER EDUCATION (ERASMUS) 2003-2006-

student and teaching staff mobility:



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a) UNIVERSITÉ BORDEAUX I, France – Metallodendrimers – Prof. Didier Astruc

b) UNIVERSITY OF JYVÄSKYLÄ, Finland – Dendrimers – Prof. Kari Rissanen;

17. Caracterização Estrutural por Difracção de Raios-X", submitted by Centro de Química

Estrutural do IST to the contest "Programa de Re-Equipamento Científico" launched by FCT,

2001 (2004-Approved)

OTHER PROJECTS SUBMITTED

1. Study of the translocation mechanism of macromolecules by the peptide carrier PEP-1

delivered into human cells”; POCTI/QUI/59820/2004. Universidade da Madeira/CQM. (Not

funded)

2. USE OF DENDRIMERS AS VECTORS FOR GENE THERAPY, POCTI/SAU-MMO/56318/2004, (2004-

2007). Funding requested to FCT: € 84228. Universidade da Madeira/CQM. (Not funded)

3. Design of selective inhibitors for human pro-coagulant proteases, POCTI/SAU-

FCF/57343/2004. Funding requested to FCT: € 82992. Universidade da Madeira/CQM. (Not

funded)

PhD PROJECTS

1. Efeito do processo de estufagem nos níveis de compostos furânicos presentes nos Vinhos

Madeira; Vanda Pereira under the supervision of José C. Marques (Universidade da Madeira)

and Juan Cacho (Universidade da Saragoça); financed by FCT, to be started in 2006

2. Isolamento e caracterização de princípios activos de plantas para o combate à Tuberculose;

Sandra Gouveia under the supervision of Paula Castilho; financed by FCT, to be started in 2006

3. Avaliação fitoquímica e farmacológica de algumas plantas aromáticas da família das

Labiatae; Tatiana Weinhold, under the supervision of Paula Castilho; financed by FCT, to be

started in 2006

4. DINÂMICA CONFORMACIONAL DO PÉPTIDO TRANSLOCADOR DE CÉLULAS PEP-1 EM SISTEMAS

MODELO DE MEMBRANAS: ESTUDOS DE SIMULAÇÃO COMPUTACIONAL E

ESPECTROSCÓPICOS”, Carla Alves under the supervisiono f Miguel Fernandes, financed by FCT,

to be started in 2006

5. BONE TISSUE ENGINEERING VIA LOCAL GENE DELIVERY”; José Luís Santos under the

supervision of Helena Tomás, financed by CT SFRH/BD/19450/2004/NG2H); started in 2005



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6. RUTHENIUM MOLECULAR WIRES USING 1,4-DIETHYNILBENZENE DERIVATIVES AS SPACER

LIGANDS; João Luís Camacho Baptista Figueira (Universidade da Madeira). PhD. Grant Proposal

(SFRH/BD/24108/2005) (Not funded).

POST DOC PROJECTS

1. Modified Porto Santo Clays as catalysts for liquid phase organic reactions; Cezar Catrinescu,

Romenia (January 2005).

2. Itegration of genomic and structural information to choose new therapeutical targets and

develop new drugs against malária; Visvaldas Kairys (Latvia), Post-doc Grant Proposal

(SFRH/BPD/20716//2005). (June 2005)

3. Effect of Chirality on the Conductivity Efficiency of Metallomolecular Wires Based on EDOT

Derivatives; Agata Renata Czardybon (Silesian University of Technology, Gliwice, Poland).

Post-doc Grant Proposal (SFRH/BPD/25423/2005). (Evaluation 4.3; minimum 4.4, Not funded)

4. Development of a Novel Family of Pt (II) and Pd(II) Metallomolecular Wires Using 1,4-

diethynylbenzene Derivatives as Spacers Ligands; Wojciech Czardybon, Poland (October

2005).

5. Synthesis and Structural Characterization of a New Metallodendrimers Family Using

Ruthenium, Platinum and Palladium Complexes as Building Blocks; Zsolt Csok, Hungary

(October 2005).

INTERNAL PROJECTS

1. Caracterização química do aroma dos vinhos da casta TINTA NEGRA MOLE – Perfil

hierárquico dos compostos mais odorantes; Rosa Perestrelo, under the supervision of José

Câmara

2. Efeito do processo de estufagem nos níveis de compostos furânicos presentes nos Vinhos

Madeira; Vanda Pereira, under the supervison of José C. Marques

3. Determinação do teor de aminoácidos nos Vinhos Madeira – Avaliação do seu

comportamento durante o processo de estufagem; Marisela Pontes, under the supervision of

José C. Marques

4. Implementação de Técnicas de Análise aos mostos e Vinhos na Adega de São Vicente; Magna

Fernandes, under the supervision of José Carlos Marques



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5. Extracção e caracterização do óleo de sementes de anona, para produção de biodiesel;

Juan Ferreira, under the supervision of Paula Castilho

6. Estudos fitoquímicos de subespécies de Helichrysum endémicas da Madeira; Emanuel

Camacho, under the supervision of Paula Castilho

7. Isolamento e Quantificação da Artemisinina extraída de Artemisia annua; Sandra Gouveia,

under the supervision of Paula Castilho

8. Caracterização e Extracção de Subprodutos de Grainha de Uva das castas de Vinho Madeira:

Óleos e Procianidinas; Daniel Maia, under the supervision of Paula Castilho

9. Simulação e caracterização termodinâmica de substâncias puras e misturas simples; Nuno

Freitas, under the supervision of Pedro Pires

10. Ruthenium Molecular wires using 1,4-diethylnylbenzene derivatives as spacers ligands; João

Figueira, under the supervision of João Rodrigues

11. Preparation and characterization of poly(propylene imine) nitrile ruthenium dendrimer;

Manuel Jardim, under the supervision of João Rodrigues

Organised Meetings:

Three important international meetings were held in Funchal during 2005 under the organization of

CQM members. Team members were also involved in small regional meeting associated with the

projects under run or with vistors. Other than the attendees to the 3 international meetings, The CQM

received in 2005 visitors from the University of Zaragoza, University of La Laguna, University of Azores,

University of Lisbon, University of Compiegne and University of Reading and Czech Academy of

Sciences.

1. VI Conference on Inorganic Chemistry – Sociedade Portuguesa de Química – Mar 2005; about

110 attendees

2. Vinho Madeira: os desafios da Investigação – June 2005; Instituto do Vinho Madeira; about 40

participants

3. MATRIX 2005 - Low Temperature Spectroscopy and Matrix Isolation, Funchal, 24-29 July,

2005; about 100 attendees

4. 2as. Jornadas de Enologia - Vinho Madeira: a colaboração na Investigação. Setembro de

2005; Universidade da Madeira; about 40 participants

5. PHYTOTHERAPY – the role of an Ancient Tradition in Modern Times, Funchal, 1-5 November

2005; about 100 attendees



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OTHER ACTIVITIES

CQM and the Chemistry Department of the University of Madeira were pioneers in the introduction in

Portugal of science events for academic and non-academic general public. A Química é divertida

(Chemistry is fun) is organized regularly since 1995. Since late 90’s we use to regularly include planed

activities in the Science and Technology National Week (November). The 2005 event included a

scientific meeting and a visit to the research labs, including fun lab experiments. In July, 8 under

graduate students, from a secondary school (Calheta), were received and integrated in the research

projects for two weeks.

In the regular collaboration with regional authorities a protocol on the area of Natural Products was

established with SDM (Sociedade de Desenvolvimento da Madeira) and 3 students received financial

support (1500€) in order to pursuit research activities.

CQM has also de coordination of a post-graduate course on Occupational Safety and Hygiene (21

students were graduated in 2005 and 28 started a new course).

Members of CQM were also involved in the preparation of the new graduate courses, following the

adoption of the Bologna Protocol by the Portuguese National Authorities.

HUMAN RESOURCES

The number of full members of CQM is the same as in 2004 but the team changed dramatically during

2005 with the arrival of the new post-doc students and the launching of the new PhD projects, as

expected. The CQM has the purpose to engage an increasing number of Chemistry students in current

activities in order to increase the experimental skills and interest for scientific activities.

Several students were sent to other research unit in Finland, France, Spain and mainland Portugal.

We also expect to include regional technicians in the team despite the fact that the number of PhD

working outside the University is small. However, the interaction with regional entities will also

increase with the installation of large scale equipment (NMR and LCMS) together with the expected

increase of PhD and post-doc students and also well known researchers in sabbatical leave.



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2005 Expected indicators

2005 Indicadores previstos Indicadores Previstos Expected indicators (Unidade: em número) (Unit: number)

2005 foreseen

2005 realized

Publicações Publications 14 10

Livros / Capítulos de livros Books / books chapters

0 3

Artigos em revistas internacionais Papers in internacional journals 12 7

Artigos em revistas nacionais Papers in national journals

2 0

Comunicações Communications

27 53

Em encontros científicos internacionais In internacional meetings

6 30

Em encontros científicos nacionais In national meetings

8 10

Relatórios Reports

9 8

Organização de seminários e conferencias Organization of seminars and conferences

4 5

Formação avançada Advanced training

6 4

Teses de Doutoramento PhD theses

1 0

Teses de Mestrado Master theses

0

Outras Others

5 4

Outros indicadores Other indicators

0 0

Modelos Models

0 -

Aplicações computacionais Software 0 -

Instalações piloto Pilot plants

0 -

Protótipos laboratoriais Prototypes 0 -

Patentes Patents

0 -

Outros Others 0 -



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2005 Published communications

2005 Publicações realizadas

Despite the fact that the objective for the publication of 12 papers in international journals was not

achieved (7 were published), it must be stressed that 12 other papers were accepted for publication

during the year of 2005 (3 of them were published in the first issues of 2006). Considering that 9 other

papers were submitted and are under evaluation, we believe that the objective was fully achieved.

This shows that an average value of about 1.5 papers / full member can be maintained in the near

future. Unfortunately no papers were published in national journals, also because the number of

national journals covering our research area is limited and were substituted by international options.

The PhD thesis foreseen for 2005 will be presented during 2006.

The number of oral and poster presentations (40) is significantly higher that expected which would

reflect the large amount of work done and will turn to an important number of papers to be published

in 2006.

Reflecting the high amount of work carried out within the team, two important prices were won by

CQM members. The first, PREMIO ZARCO, is attributed every two years to the most recognised work on

science and culture in Madeira. Two candidates were CQM members and the price was won by: Helena

Caldeira with her PhD thesis: Purines, creatine, defective methylation and their biochemical and

clinical relationship. The work was carrtied out under the supervision of Marinus Duran (University of

Amsterdam), Isabel Almeida (University of Lisbon) and Helena Tomás (member of CQM, University of

Madeira).

A smaller but rather important price was won by Rosa Perestrelo, as the best poster presentation in the

Chromatography National Meeting, December 2005) covering the work carried out for the chemistry

degree, under the supervision of José Câmara (CQM member, University of Madeira).

We believe that with the new Post-doc and PhD students and with the equipment expected to be

installed during 2006 the team can maintain the high levels of performance and justify the confidence

placed on the group by the evaluation committee in 2003.

PUBLISHED PAPERS IN INTERNATIONAL JOURNALS

1. Direct Identification and Quantitative Determination of Costunolide and

Dehydrocostuslactone in Laurus novocanariensis Fixed Oil using 13C-NMR

Spectroscopy”Ferrari, B.; Castilho, P.C.; Tomi, F.; Rodrigues, AI.; Costa, M.C. and Casanova,

J. “ Phytochemical Analysis 16 (2): 104-107, 2005



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2. Characterization of Laurus spp. fruit oil from Madeira Island, Portugal, Castilho, PC, Costa,

MC, Rodrigues AI, Partidário, A “ J. Am. Chem. Oil Soc. 82: 863–868, 2005

3. New Synthesis of (-)-Thioambrox; Maria C. Costa, Susana G. Teixeira, Cristina Rodrigues,

Pedro Ryberg Figueiredo, Maria J. Marcelo Curto, Tetrahedron, 61, 4403-4407, 2005.

4. THERMOPHYSICAL AND THERMODYNAMIC PROPERTIES OF IONIC LIQUIDS OVER AN EXTENDED

PRESSURE RANGE: [BMIM][Ntf2] AND [HMIM][Ntf2], R. Gomes de Azevedo, J. M. S. S.

Esperança, J. Szydlowski, Z. P. Visak, P. F. Pires, H. J. R. Guedes, L. P. N. Rebelo, J. Chem.

Thermodynamics, 2005, 37, 888–899.

5. Guanidinoacetate methyltransferase deficiency identified in mentally retarded adults;

Caldeira Araújo, H., Smit, W., Verhoeven, N.M., Salomons, G., Silva, S., Vasconcelos, R.,

Tomás, H., Tavares de Almeida, I., Jakobs, C., Duran, M., Am. J. Med. Genet., 2005, 133A,

122–127.

6. Synthesis, Characterization and X-ray Structure of Bimetallic Cyano-bridged [(η5-

C5H5)(PPh3)2Ru(µ-CN)Ru(PPh3)2(η5-C5H5)]PF6; Cátia Ornelas, Cláudia Gandum, José Mesquita,

João Rodrigues, M. Helena Garcia, Nelson Lopes, M. Paula Robalo, Kalle Nättinen, Kari

Rissanen, Inorg. Chim. Acta, 2005, 358, 2482-2488

7. Ruthenium Molecular Wires With Potential Applications in Nanotechnology; João Rodrigues,

João Figueira, Viatcheslav Vertlib and Kari Rissanen, Proceedings of Twelfth International

Conference on Composites/Nano Engineering (ICCE-12), Tenerife, Spain, 1-6 August, 2005.

ACCEPTED PAPERS IN INTERNATIONAL JOURNALS

1. Development of a HS-SPME/GC-MS methodology for analysis of terpenoid compounds in

Madeira Wines; J.S. Câmara, M. Arminda Alves, J.C. Marques, Anal. Chimica Acta, 2005.

2. “Application of multivariate analysis for classification and differentiation Madeira wines

according the main grape varieties.” J. S. Câmara, M. A. Alves; J. C. Marques, Talanta,

2005

3. Changes in volatile composition of Madeira wines during their oxidative aging, J.S.

Câmara, M.A. Alves, J.C. Marques, Anal. Chimica Acta, 2005

4. Analytical Characterization of the Aroma of Tinta Negra Mole Wine. Identification of

Odorants Compounds; Rosa Perestrelo, José C. Marques, José S. Câmara, Anal. Chimica

Acta, 2005.

5. Composition and acaricidal activity of Laurus novocanariensis and Laurus nobilis essential

oils against Psoroptes cuniculi; F. Macchioni, P.L. Cioni, I. Morelli, P.C. Castilho, S. Perrucci

accepted in J. Essential Oil Research



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6. Synthesis of Ambergris-Type Ketal from Rosin; M. Céu Costa, Susana P. Alves, M. Eduarda

Correia, M. Regina Tavares, M. João Marcelo-Curto, Synthesis, accepted October 2005.

7. Composition and Antimicrobial Screening of the Essential Oil of Acantholippia deserticola

(Phil.ex F. Phil.); L. Rojo, J. Benites, A. Rodrigues, F.Venancio, L.Ramalho, A.Teixeira, S.

Feio, M.C. Costa, Moldenke, JEOR, accepted August 2005

8. From Simple Monopyridine Clusters [Mo6Br13(Py-R)6][n-Bu4N] and Hexapyridine Clusters

[Mo6X8(Py-R)6][OSO2CF3]4 (X = Br or I) to Cluster-cored Organometallic Stars, Dendrons

and Dendrimers; Denise Méry, Lauriane Plault, Cátia Ornelas, Jaime Ruiz, Sylvain Nlate, Didier

Astruc, Jean-Claude Blais, João Rodrigues, Stéphane Cordier, Kaplan Kirakci, and Christiane

Perrin, (Accepted for publication in the Inorganic Chemistry)

9. Lipidic-membrane induced optimization for ligand-receptor docking. Recent tools and

insights for the “membrane catalysis” model; M.A.R.B. Castanho, M.X. Fernandes,

(Accepted for publication in the European Biophysical Journal)

10. Electrochemical characterization of titanium biomaterials using the mini-cell system;

Nascimento, M.L., Mueller, W.-D., Carvalho, A.C., Tomás, H., (Accepted for publication in the

J. Mater.Sci.Mater.Med.)

11. Ruthenium Metallodendrimers Based on Poly(propylene imine) Nitriles; Cátia Ornelas,

Viatcheslav Vertlib, João Rodrigues, and Kari Rissanen, (Accepted for publication in the

European Journal of Inorganic Chemistry)

12. -Mo6Br8-CLUSTER-CORED ORGANOMETALLIC STARS AND DENDRIMERS; Denise Méry, Catia

Ornelas, Marie-Christine Daniel, Jaime Ruiz, João Rodrigues, Didier Astruc, Stéphane Cordier,

Kaplan Kiraki, Christiane Perrin; Accepted for publication in the special issue of Comptes

Rendud Chimie on "New Molecular Architectures Built From Metallic Nanoclusters".) 2005 ,

8, 1789-1797

SUBMITTED PAPERS

1. Headspace SPME analysis to estimate the terpenoid patterns in Boal, Malvazia, Sercial

and Verdelho wines; J.S. Câmara, M.A. Alves; J.C. Marques, submitted to Anal Bioanal.

Chemistry

2. Composition and antimicrobial activity of Clinopodium ascendens (Jordan) Sampaio from

Madeira; P. C. Castilho, K. Liu, A. I. Rodrigues, S. Feio, F. Tomi, and J. Casanova, submitted

to Flavour and Fragrances J.

3. Screening drug-like compounds by docking to homology models: a systematic study; V.

Kairys, M.X. Fernandes, M.K. Gilson, Submitted to the Journal of Chemical Information and

Modeling



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4. Osteoblastic differentiation over an adsorbed collagen layer, over the surface of collagen

gels and inside collagen gels – a comparative study; Tomás, H., Fernandes, L.F., Calabretta,

A., Pereira, J.A., Costa, M.A., Fernandes, M.H., submitted to Biomaterials

5. Gel systems of collagen type I, proteoglycans and TGF-β1 – in vitro fibrillogenesis and

growth factor release; Tomás, H., Fernandes, L.F., Marques, J.C., Costa, M.A., Fernandes,

M.H., submitted to the J.Mater.Sci.Mater.Med.

6. Electrochemical characterization of cobalt-based alloys using the mini-cell system;

Nascimento, M.L., Mueller, W.-D., Carvalho, A.C., Tomás, H., submitted to the Dental

Materials

7. Urinary uric acid / creatinine ratio as a screening tool for creatine biosynthesis defects;

Caldeira Araújo, H., Tomás, H., Silva, S., Vasconcelos, R., Smit, W., Tavares de Almeida, I.,

Duran, M., submitted to the Ann. Clin. Biochem.

8. Uric acid and creatinine levels in two groups of school children; Caldeira Araújo, H., Silva,

H., Ornelas, R., Tomás, H., Tavares de Almeida,I., Duran, M., submitted to the Ped. Nephrol.

9. A new solid-phase extraction procedure for purine and pyrimidine analysis; Caldeira

Araújo, H., Silva, H., Tomás, H., Tavares de Almeida, I., Duran, M. submitted to the J.

Chromat. B.

BOOKS / BOOKS CHAPTERS

1. Acid Activated Serra de Dentro Bentonite: Chemical, Structural, Textural and Catalytic

Properties; C. Fernandes, C. Catrinescu, P. Castilho, P. Russo, M. Carrott, C. Breen in

Materiales arcillosos: de la geología a las nuevas aplicaciones Ed. M. Suárez, M. A. Vicente, V.

Rives y M. J. Sánchez Salamanca, 2005 p. 111-122

2. Catalytic wet peroxide oxidation of reactive azo dyes over iron-containing pillared

beidellite catalyst; Cezar Catrinescu, Mariana Neamtu, Jocelyne Miehe-Brendlé, Martí Gich

Garcia and Antonius Kettrup in Materiales arcillosos: de la geología a las nuevas aplicaciones

Ed. M. Suárez, M. A. Vicente, V. Rives y M. J. Sánchez Salamanca, 2005 p. 87-98

3. Valorização de mono-, di- e tri- terpenos de recursos naturais de interesse em Portugal;

M.C. Costa, S. Ramos, S. P. Alves, S. Teixeira e I. Eleutério, " in Plantas Iberoamericanas como

Fuente de Terpenoides Útiles en Química Fina, CYTED, Ed. Alejandro Fernández Barrero,

Universidad de Granada, 2005

ABSTRACTS/SCIENTIFIC MEETINGS

1. Caracterização química do aroma dos vinhos Madeira; CÂMARA José S., ALVES Maria A.C.,



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MARQUES José C.A. 7º Encontro de Química dos Alimentos. Viseu, Abril de 2005

2. Análise de precursores em uvas de castas produtoras de vinho Madeira; FERNANDES Ana

L., CÂMARA José S., PEREZ Juan P., MARQUES José C. 7º Encontro de Química dos

Alimentos. Viseu, Abril de 2005

3. Determinação do teor em aminoácidos em Vinhos Madeira e evolução durante o

processo de estufagem; PONTES Marisela, ALBUQUERQUE Francisco M., FERREIRA António

C., CÂMARA José S., MARQUES José C. 7º Encontro de Química dos Alimentos. Viseu, Abril

de 2005

4. Determinação de 5-hidroximetilfurfural em Vinho Madeira produzido a partir de uvas

da casta Malvazia; PEREIRA Vanda, CÂMARA José S., PEREZ Juan P., MARQUES José C., 7º

Encontro de Química dos Alimentos. Viseu, Abril de 2005

5. Determinación de precursores de aroma en uvas y vinos eleborados com las variedades

blancas Gual, Malvasia y Verdello” J.J. Rodriguez Bencomo, H.M. Cabrera Valido, J.E.

Conde, J.P. Perez Trujillo, J. Câmara, J. C. Marques, J.C., V. Ferreira, J. Cacho, VIII

Jornadas Científicas de los Grupos de Investigación Enológica. Palencia, Valladolid, June

2005

6. Analytical Characterization of the Aroma of Tinta Negra Mole Wine. Identification of

Odorants Compounds” Rosa Perestrelo, José C. Marques, José S. Câmara, In Vino Analytica

Scientia 2005. Montpellier, July 2005

7. The Evolution of Volatile Compounds During Madeira Wines aging; José S. Câmara, A.C.

Silva Ferreira, M. Arminda Alves, José C. Marques, In Vino Analytica Scientia 2005.

Montpellier, July 2005.

8. Effect of the heating process in the levels of furanic compounds present in Madeira

Wines; Vanda Pereira, Francisco Albuquerque, José S. Câmara, Juan P. Perez, José C.

Marques”, In Vino Analytica Scientia 2005. Montpellier, July 2005

9. Effect of the heating process in the levels of amino acids compounds present in Madeira

Wines; MARISELA, Pontes, Francisco Albuquerque, José S. Câmara, Juan P. Perez, José C.

Marques, In Vino Analytica Scientia 2005. Montpellier, July 2005

10. Influence of the making technology in the volatile composition of Tinta Negra Mole red

wines; Rosa Perestrelo, José C. Marques, José S. Câmara, 11as Jornadas de Analisis

Instrumental, JAI 2005. Barcelona, November 2005

11. Caracterização química dos constituintes voláteis dos vinhos Madeira; CÂMARA, José S.;

ALVES, Maria A.C.; MARQUES, José C.A., 4º Encontro de Nacional de Cromatografia. Évora,

December 2005 (oral communication)

12. The influence of the heating and ageing processes in the volatile composition of TNM



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red wines; Rosa Perestrelo, José C. Marques, José S. Câmara, 4º Encontro de Nacional de

Cromatografia. Évora, December 2005

13. Chemical, structural and catalytic properties of a portuguese pillared bentonite;

Fernandes, C., Castilho, P. & Breen, C. 6th Conference on Inorganic Chemistry, Funchal, 31

March - 2 April, 2005

14. Acid Activated Serra de Dentro Bentonite: Chemical, Structural, Textural and Catalytic

Properties; Fernandes C., C. Catrinescu, P. Castilho, P. Russo, M. Carrott, C. Breen XIX

Reunión Científica de la Sociedad Española de Arcillas, Salamanca 26-28 September 2005

15. METHOD FOR ANALYSIS OF VOLATILE CONSTITUENTS OF WHISKEYS USING GAS

CHROMATOGRAPHY WITH FLAME IONISATION DETECTION; Michael Caldeira, Freddy

Rodrigues, Paulo Andrade, Lino Oliveira, José C. Marques, José S. Câmara, 4º Encontro de

Nacional de Cromatografia. Évora, December 2005

16. Isolamento e identificação de constituintes de um extracto de Parastrephta

lepidophylla (Webb.) Cabrera; A.L. Balão, A.I. Rodrigues, M.C. Costa; 6º Encontro

Nacional de Química Orgânica, Universidade do Minho, Julho de 2005

17. Pesquisa de marcadores em leites de animais alimentados com forragem de Lupinus

luteus por HPLC-MS J.C.D. Chaves, A.I. Rodrigues, I. Macedo, M.C. Costa, P.C. Branco; 6º

Encontro Nacional de Química Orgânica, Universidade do Minho, Julho de 2005

18. Estudo da composição química da carqueja por HPLC-ESIMSn. P.C. Branco, A.I. Rodrigues,

C. Borges, A. Paulo, M.C. Costa, A. Teixeira; 6º Encontro Nacional de Química Orgânica,

Universidade do Minho, Julho de 2005

19. Synergistic antituberculosis activity of Lactones from Laurus spp J. Luna- Herrera,

P.C. Castilho, M.C. Costa, A.I. Rodrigues, E .Reyes-Rodriguez; Phytotherapy; Funchal 2005

(oral communication)

20. Essential Oils and Herbal Extracts from Red Clover Flowers and Artemisia species; D.

Lopes, J.C. Marques, M.N. Marianchuk and P.P. Kolodziejczyk Phytotherapy; Funchal 2005

(oral communication)

21. Evaluation of the free radical scavenging activity of Laurus spp fruit extracts

S.C. Gouveia,; P.C. Castilho,; A.I. Rodrigues, Phytotherapy; Funchal 2005

22. Proanthocyanidin composition and radical scavenging capacity of Madeira’s grapeseeds

D. Maia, P.C. Castilho, P.C. Branco, A.I. Rodrigues, Phytotherapy; Funchal 2005

23. Antimicrobial activity and chemical composition of the essential oil of Clinopodium

ascendens from Madeira; P. Castilho; K. Liu, A.i. Rodrigues, S.Feio, F. Tomi; J.

Casanova; Phytotherapy; Funchal 2005

24. Acaricidal activity of Laurus novocanariensis and Laurus nobilis leaf essential oil



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against Psoroptes caniculi; F. Macchioni, P. C. Castilho; F. Cecchi, P.Cioni, I. Morelli, S.

Perrucci, Phytotherapy; Funchal 2005

25. Analgesic and anti-inflammatory activity of Laurus novocanariensis fruit oil; M.C. Costa,

P.C. Castilho, A. Rodrigues, M.M. Souza, M.J. Curto, V. Cechinel Filho, Phytotherapy;

Funchal 2005

26. New data on biological activity in Hypericum L. taxa from Portugal; T. Nogueira, M.C.

Costa, C. Moiteiro, A. Medeiros, S. Feio, M.J. Marcelo-Curto, A. Arellanes, E. Reye, and J.

Luna-Herrera, Phytotherapy; Funchal 2005

27. Antioxidant Activity of Water Infusions from Lampaya medicinalis Phil; J. Benites, L.

Rojo, C. Calderón, M. Rojas, R. Leoncini, P. Diaz, E. Pastene; M.C. Costa. Phytotherapy;

Funchal 2005

28. Evidence for the antidiabetic potential of isoquercitrin from Pterospartum

tridentatum; Paulo, S. Martins, P. C. Branco, C. Borges, A. I. Rodrigues, M.C. Costa, A.

Teixeira, H. M.Filipe, Phytotherapy; Funchal 2005

29. Antimycobacterial activity of a new friedelanyl trisaccharide; Eleutério, S.S. Ramos,

M.C. Costa, W. B. Motherwell, P. Almeida, J. Luna, A. Jimenez; R. Schmidt, Phytotherapy;

Funchal 2005

30. Designing specificity into ligands with molecular docking; Miguel Fernandes, in

Biophysical Chemistry meets Molecular Medicine, Sesimbra, Portugal, June, 2005 (oral

communication)

31. Ruthenium Molecular Wires With Potential Applications in Nanotechnology" João

Rodrigues, João Figueira, Viacheslav Vertlib and Kari Rissanen, Twelfth International

Conference on Composites/Nano Engineering (ICCE-12), Tenerife, Spain, 1-6 August, 2005.

(Session 6d - Magnetic Composites and Nano-Thin Films) (oral communication)

32. New Functional Ruthenium Metallodendrimers; João Rodrigues, CERC3 YOUNG CHEMISTS

WORK SHOP on “Functional Molecular Nanostructures (Fun-MONA), Karlsruhe, Germany, 2-

4 May, 2005. (oral communication)

33. Dendrimeres-clusters en Etoile de MO6 ; Cátia Ornelas, Denise Méry, Marie-Christine

Daniel, Jaime Ruiz, João Rodrigues, Didier Astruc, Journées de la Division de Chimie de

Coordination de la SFC, Versailles, 13-14 Janvier, 2005(oral communication)

34. Construction de Géants Metallodendrimeres Redox ; Cátia Ornelas, Jaime Ruiz, Jean-

Claude Blais, Colette Belin, João Rodrigues, Didier Astruc, Journées de la Division de

Chimie de Coordination de la SFC, Versailles, 13-14 Janvier, 2005. (oral communication)

35. PAMAM dendrimers as vectors for gene delivery into human primary osteoblastic cells –

preliminary cytotoxicity studies; Santos, J.L., Tomás, H., Granja, P.L., 13th Annual



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Congress of the European Society of Gene Therapy, Prague, 29Oct.-01Nov. 2005.

36. New bone cements capable of setting at low temperatures – specific cytocompatibility

studies, Tomás, H., Barros, J.N, Fernandes, L.F., Müller W.-D., Berger, G., VIª Conferência

de Química Inorgânica da Divisão de Química Inorgânica da SPQ/6th Conference on

Inorganic Chemistry, Inorganic Chemistry Division Meeting, March 31 – April 2, Funchal,

PORTUGAL, 2005.

37. Synthesis and Structural Characterization of a New Metallodendrimer Family Using

Ruthenium Complexes as Building Blocks”; Zs. Csok, C. Gandum, J. Mesquita, J.

Rodrigues, M. Helena Garcia, M. Paula Robalo and K. Rissanen, VIª Conferência de

Química Inorgânica da Divisão de Química Inorgânica da SPQ/6th Conference on Inorganic

Chemistry, Inorganic Chemistry Division Meeting, March 31 – April 2, Funchal, PORTUGAL,

2005

38. 3-“New Ligands for the Preparation of Ruthenium Based Molecular Wires; V. Vertlib, J.

C. Mesquita, J. Rodrigues, M. Paula Robalo, K. Nättinen and K. Rissanen, VIª Conferência

de Química Inorgânica da Divisão de Química Inorgânica da SPQ/6th Conference on

Inorganic Chemistry, Inorganic Chemistry Division Meeting, March 31 – April 2, Funchal,

PORTUGAL, 2005

39. New Cyano-bridged ruthenium Complexes for Non-linear Optics; P. Craveiro, V. Vertlib,

J. C. Mesquita, J. Rodrigues, M. Helena Garcia, M. Paula Robalo, K. Nättinen and K.

Rissanen, VIª Conferência de Química Inorgânica da Divisão de Química Inorgânica da

SPQ/6th Conference on Inorganic Chemistry, Inorganic Chemistry Division Meeting, March

31 – April 2, Funchal, PORTUGAL, 2005

40. Degradation of organic dyes by TiO2 nanoparticules under Visible artificial light or

natural solar iRradiation; José Luís S. Santos and João Rodrigues, VIª Conferência de

Química Inorgânica da Divisão de Química Inorgânica da SPQ/6th Conference on Inorganic

Chemistry, Inorganic Chemistry Division Meeting, March 31- April 2, Funchal, PORTUGAL,

2005.

ADVANCED TRAINING

CQM Members were involved in the supervision of 4 advanced training projects:

1. Cytocompatibility evaluation of the alloy Ti-6Al-7Nb after spark-anodization surface

treatment”, Lucina Sousa (UNESP - Brasil) – (Setembro 2005 - Janeiro 2006), under the

supervision of Helena Tomás

2. Three final projects included in the post-graduate course on Occupational Safety and

Higiene, under the supervision of José Carlos Marques



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OTHER COMMUNICATIONS

1. Nanomateriais – Uma viagem Maravilhosa; João Rodrigues, Escola Secundária do Estreito

de Câmara de Lobos, Câmara de Lobos, 13 de Maio de 2005. (DIVULGAÇÃO)



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Financial report

Relatório financeiro

The financial report involves exclusively the amount sent by FCT for the unit – project CQM2005. No

expenses involved in the research projects are included.

As indicated above, the planed expenses were only partially executed due to the fact that the planed

acquisition of the NMR and MS (National networks) was delayed and the equipments will be installed in

2006. Thus, the reserved amount for the lab technician was not used. As agreed with FCT, the unused

amounts can be used until the end of 2006. The decision of careful use of the amount sent by FCT for

this period was conditioned by the need of extra expenses to be carried out for the new equipment as

most demands were covered by the approved projects. Other than the technician and the reserved

amount for maintenance, CQM intends and is prepared to spend an important amount in a new

corporate image (including logo and web page), large printing plotter and auxiliary equipment

(foreseen for the beginning of 2006). Part of the available amount will used for the invitation of well

recognised researchers (not foreseen for 2005, but requested for 2006).

As no indication was given until this moment about the financial support for the next three years, the

use of the available amount will be conditioned until complete information is received from FCT.

Rubricas 2005 foreseen

2005

executed

Recursos Humanos 9.500,00 Aquisição de Serviços e manutenção 3.000,00 Missões 3.000,00 1.451,13 Consultores 0,00 Despesas Gerais 0,00 Outras Despesas Correntes * 10.000,00 7.305,73 Total - Despesas Correntes 25.500,00 8.756,86

Equipamento 3.850,00 5.618,44 Total 29.350,00 14.375,30



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The unit receives financial support from:

Funchal, February 15, 2006 CQM/JCM

Centro de Química da Madeira - Universidade da … · training period in our research labs ......

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