Centering Cataract Surgery on the Visual Axis
Transcript of Centering Cataract Surgery on the Visual Axis
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Centering Cataract Surgery on the
Visual Axis
Vance Thompson, MDFounder, Vance Thompson Vision
Professor of Ophthalmology, University of South Dakota, Sanford School of MedicineSioux Falls, South Dakota, USA
65th Rochester Ophthalmology Conference
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Financial DisclosuresAlcon Laboratories: Consultant/Research
Allotex: Consultant/Advisor
Allergan: Consultant/Research
AcuFocus: Consultant/Research
Avsi: Consultant/Research
Bausch Lomb: Consultant/Advisor/Research
BVI Consultant/Advisor/Research
Carl Zeiss Meditec: Consultant/Research
Equinox: Consultant/Investor
Euclid Systems: Consultant/Advisor
Novartis Pharmaceuticals: Research
Vivor AG: Advisor/Research
Keratonics/Advisor/Consultant
Johnson and Johnson: Consultant/Research
Oculeve: Consultant/Advisor, Equity Owner
OPHTEC: Consultant/Advisor/Research
Precision Lens: Consultant/Advisor
Treehouse Eyes: Consultant/Investor
Tarsus Rx: Consultant
EyeBrain Medical Inc: Equity Owner
Imprimis: Consultant/Advisor
Centricity: Consultant/Advisor/Research
EyeGate Pharmaeuticals: Consultant/Research
RxSight: Consultant/Research
TearClear: Consultant/Advisor, Equity Owner
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Financial DisclosuresAlcon Laboratories: Consultant/Research
Allotex: Consultant/Advisor
Allergan: Consultant/Research
AcuFocus: Consultant/Research
Avsi: Consultant/Research
Bausch Lomb: Consultant/Advisor/Research
BVI Consultant/Advisor/Research
Carl Zeiss Meditec: Consultant/Research
Equinox: Consultant/Investor
Euclid Systems: Consultant/Advisor
Novartis Pharmaceuticals: Research
Vivor AG: Advisor/Research
Keratonics/Advisor/Consultant
Johnson and Johnson: Consultant/Research
Oculeve: Consultant/Advisor, Equity Owner
OPHTEC: Consultant/Advisor/Research
Precision Lens: Consultant/Advisor
Treehouse Eyes: Consultant/Investor
Tarsus Rx: Consultant
EyeBrain Medical Inc: Equity Owner
Imprimis: Consultant/Advisor
Centricity: Consultant/Advisor/Research
EyeGate Pharmaeuticals: Consultant/Research
RxSight: Consultant/Research
TearClear: Consultant/Advisor, Equity Owner
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Implant
Anatomic and Optical Goal
1. IOL centered
2. 360° overlap of anterior capsule
over the optic
Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
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Implant
Anatomic and Optical Goal
1. IOL centered
2. 360° overlap of anterior capsule
over the optic
Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
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Automated CapsulotomyFemtosecond Laser
From: Assessment of Lens Center Using Optical Coherence Tomography, Magnetic Resonance Imaging, and Photographs of the Anterior Segment of the Eye
Invest. Ophthalmol. Vis. Sci.. 2015;56(9):5512-5518. doi:10.1167/iovs.15-17454
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Manual Capsulotomy
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Automated CapsulotomyZepto
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Implant
Anatomic and Optical Goal
1. IOL centered
2. 360° overlap of anterior capsule
over the optic
Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
Need to center boththe IOL
andthe Capsulotomy
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Implant
Anatomic and Optical Goal
1. IOL centered
2. 360° overlap of anterior capsule
over the optic
Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
Prevent/MinimizePCO Induced
IOL tilt and/or
Decentration
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Cornea
Iris
Lens
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Cornea
Iris
Lens
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Cornea
Iris
Lens
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Cornea
Iris
Lens
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• Pearl-type PCO• Fibrosis-type PCO
Less aggressiveMore aggressive
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…apposition of the anterior capsule edge onto the posterior capsule near the posterior surface of the IOL optic may be dangerous.
…an increased incidence of cases of fibrosis-type PCO in cases of ciliary sulcus fixation, where the cut edge of the anterior capsule was placed in direct apposition to the posterior capsule near the optic.
…an apposition of the anterior and posterior capsules places the eye at higher risk for the fibrosis-type PCO.
Apple DJ, et al: Posterior Capsule Opacification. Surv Ophthalmol. 1992 Sept-Oct;37(2): 73-116.
Tan DT, Chee SP: Early central posterior capsular fibrosis in sulcus-fixated biconvex intraocular lenses. J Cataract Refract Surg. 1993 Jul;19(4):471-80.
Nagamoto T, et. al: Lens epithelial expansion rate onto the posterior capsule (Video). Presented at the annual meeting of the Americal Society of Cataract and Refractive Surgery, San Diego, Calitornia, April, 1992
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Early central posterior capsular fibrosis in sulcus-fixated biconvex intraocular lenses
Donald T.H. Tan, F.R.C.S., F.C.Ophth., Soon Phaik Chee, F.R.C.S., F.C.Ophth., M.Med.
PCO•Elschnig Pearls
•Fibrotic PCO
J Cataract Refract Surg 19,JULY 1993
Risk factors for developing this aggressive form of opacification were close apposition of peripheral anterior and posterior capsules …..occurred most often in cases of haptic fixation in the ciliary sulcus.
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Incomplete capsule overlap of the optic: allow capsular fusion peripheral to the optic with progressive adherence. This fusion can produce IOL decentration from the edge of the capsulorhexis.
Carlson et al: Surv Ophthalmol 42 (5) March–April 1998
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Incomplete capsule overlap of the optic: allow capsular fusion peripheral to the optic with progressive adherence. This fusion can produce IOL decentration from the edge of the capsulorhexis.
Carlson et al: Surv Ophthalmol 42 (5) March–April 1998
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Incomplete capsule overlap of the optic: allow capsular fusion peripheral to the optic with progressive adherence. This fusion can produce IOL decentration from the edge of the capsulorhexis.
Carlson et al: Surv Ophthalmol 42 (5) March–April 1998
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Capsular Fusion Syndrome
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The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999 Vol. 128, No. 3, pg 271-79
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METHODS: In this prospective study 75 patients underwent standardized phacoemulsification with capsulorhexis and in-the-bag placement of a 5.5-mm polymethylmethacrylate intraocular lens implant. The patients were randomly assigned to receive either a small capsulorhexis of 4.5 to 5 mm to lie completely on the intraocular lens optic or a large capsulorhexis of 6 to 7 mm to lie completely off the lens optic. Patients were examined at days 1, 14, 30, 90, and 180 and at year 1 with logMAR visual acuity assessment, Pelli-Robson contrast sensitivity testing, anterior chamber flare and cell measurement, and high-resolution digital retroillumination imaging of the posterior capsule. The pattern of posterior capsular opacification was determined, and the percentage area of posterior capsular opacification was calculated for each image with dedicated image analysis software.
RESULTS: Large capsulorhexes were associated with significantly more wrinkling of the posterior capsule and worse posterior capsular opacification than small capsulorhexes. At 1 year the average percentage area of posterior capsular opacification was 32.7% for small capsulorhexes (95% confidence interval, 19.8 to 45.6) and 66.2% for large capsulorhexes (95% confidence interval, 57.7 to 74.6) (P 5 .0001). The patients with large capsulorhexes had significantly poorer visual acuities and a trend toward worse contrast sensitivities.
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999 Vol. 128, No. 3, pg 271-79
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
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METHODS: In this prospective study 75 patients underwent standardized phacoemulsification with capsulorhexis and in-the-bag placement of a 5.5-mm polymethylmethacrylate intraocular lens implant. The patients were randomly assigned to receive either a small capsulorhexis of 4.5 to 5 mm to lie completely on the intraocular lens optic or a large capsulorhexis of 6 to 7 mm to lie completely off the lens optic. Patients were examined at days 1, 14, 30, 90, and 180 and at year 1 with logMAR visual acuity assessment, Pelli-Robson contrast sensitivity testing, anterior chamber flare and cell measurement, and high-resolution digital retroillumination imaging of the posterior capsule. The pattern of posterior capsular opacification was determined, and the percentage area of posterior capsular opacification was calculated for each image with dedicated image analysis software.
RESULTS: Large capsulorhexes were associated with significantly more wrinkling of the posterior capsule and worse posterior capsular opacification than small capsulorhexes. At 1 year the average percentage area of posterior capsular opacification was 32.7% for small capsulorhexes (95% confidence interval, 19.8 to 45.6) and 66.2% for large capsulorhexes (95% confidence interval, 57.7 to 74.6) (P 5 .0001). The patients with large capsulorhexes had significantly poorer visual acuities and a trend toward worse contrast sensitivities.
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999 Vol. 128, No. 3, pg 271-79
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
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FIGURE 1. A large capsulorhexis in a 75-year-old man. (Top left) One day postoperatively, its edge is almost completely off the lens optic except for a small lip touching the optic rim superiorly (arrow). (Top right) At 2 weeks postoperatively there is extensive fine wrinkling of the posterior capsule. (Bottom left) By 6 months after surgery the wrinkling has increased with early lens epithelial cell infiltration. (Bottom right) By 1 year postoperatively the wrinkling and lens epithelial cells remain with Elschnig pearl formation superiorly (arrows)
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999
Vol. 128, No. 3, pg 271-79
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FIGURE 2. Example of a small capsulorhexis lying completely on the implant surface in a 69-year-old man. (Top left) One day after surgery there are two tension lines in the posterior capsule caused by the contact of the lens haptic with the equatorial capsular bag. (Top right) Two weeks after surgery the capsular folds have disappeared. (Bottom left) By 6 months postoperatively fibrosis and remodeling of the anterior capsule rim can be seen with a fine reticular pattern of lens epithelial cells on the posterior capsule. (Bottom right) A fine lens epithelial cell membrane can be seen on the posterior capsule (arrows).
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999
Vol. 128, No. 3, pg 271-79
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FIGURE 4. The percentage of patients with each grade of wrinkling at 3 months postoperatively for small and large capsulorhexis groups (P 5 .0001).
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999
Vol. 128, No. 3, pg 271-79
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FIGURE 5. Graph demonstrating the mean percentage area of posterior capsular opacification (PCO) for small and large capsulorhexis groups (error bars represent 95% confidence intervals) (P 5 .0001).
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999
Vol. 128, No. 3, pg 271-79
Small CCC with overlap of the optic
Large CCC outside of the optic
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FIGURE 3. The logMAR visual acuities for small and large capsulorhexis (CCC) groups over the year (error bars represent 95% confidence intervals) (P 5 .025).
The Effect of Capsulorhexis Size on Posterior Capsular Opacification: One-Year Results of a Randomized Prospective Trial
EMMA J. HOLLICK, BA, FRCOPHTH, DAVID J. SPALTON, FRCP, FRCS, FRCOPHTH, AND WILL R. MEACOCK, BSC, FRCOPHTH
AMERICAN JOURNAL OF OPHTHALMOLOGY SEPTEMBER 1999
Vol. 128, No. 3, pg 271-79
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Cornea
Iris
Lens
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Cornea
Iris
Lens
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Cornea
Iris
Lens
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Specular reflection
Specular reflection, also known as regular reflection, is the mirror-like reflection of waves, such as light, from a surface.
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Johann Evangelist Purkinje18 December 1787 – 28 July 1869
Czech anatomist and physiologist
Louis Joseph SansonFrench surgeon
and ophthalmologist
Purkinje ImagesOr
Purkinje-Sanson Images
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Patient Fixating Their Unique
P1/P4 relationshipEquals
Visual Axis
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Optical Axes and Angles
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P 1
The Purkinje Light Reflexes
P 2
P 3
P 4
Image Orientation
P1-upright
P2-upright
P3- upright
P4- inverted
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P 1
The Purkinje Light Reflexes
P 2
P 3
P 4
Image Orientation
P1-upright
P2-upright
P3- upright
P4- inverted
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P 1
The Purkinje Light Reflexes
P 2
P 3
P 4
Image Orientation
P1-upright
P2-upright
P3- upright
P4- inverted
P1P4
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P 1
The Purkinje Light Reflexes
P 2
P 3
P 4
Image Orientation
P1-upright
P2-upright
P3- upright
P4- inverted
P1P4
Useful for Centering Cataract Surgery• The capsulotomy• The implant
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Manual Capsulotomy Automated CapsulotomyZepto
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Automated CapsulotomyZepto
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Zepto®Capsulotomy System Design
Control Console
CapsulotomyTip
Disposable Handpiece
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Clinical Feature Capsulotomy Tip
Soft, clear
suction cup
6.1mm diam
Nitinol 4.4mm
capsulotomy ring
1.18mm height
Un-obstructed
view for visual axis
centration
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Clinical Features
Suction pulls capsule against capsulotomy ring
Electrical energy applied to ring for 4 milliseconds
Phase transition of water molecules (Zepto does not coagulate or cauterize)
Precision Pulse Capsulotomy
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Bottom edge ofnitinol ring
Lens capsule
Precise, Microscale Cutting Mechanism
Precision Pulse Capsulotomy
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Bottom edge ofcapsulotomy ring
Lens capsule at rest
Precision-Pulse Capsulotomy
Layer of trapped water molecules
Increased tensile stress
Suction applied, capsulepulled against ring edge
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Bottom edge ofcapsulotomy ring
Lens capsule at rest
Precision-Pulse Capsulotomy
Suction applied, capsulepulled against ring edge
Increased tensile stress
Trapped water molecules
Cross-section through device and capsule
Multipulse energy discharges
Rapid phase transition ofwater molecules
Capsule membrane cleaved precisely
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ACut edge
Schematic
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Scanning Electron Microscopy (SEM)
ACut edge
Functional edgeduring surgery
D CCC
B ZEPTOSchematic
C ZEPTO
20 microns
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Edge Strength – CCC vs ZeptoTM
CCC
ZEPTO
16 mN
60 mN
Tear Strength
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Edge Strength ZeptoTM vs Femto & CCC
0
20
40
60
80
100
120
140
160
180
200
Pair9 Pair10 Pair11 Pair12 Pair13 Pair14 Pair15 Pair16
EdgeTearStreng
th(m
N)
PrecisionPulseCapsulotomy
CCC
Wilcoxon matched-pairssigned-ranks test P = 0.012
Paired cadaver eyes
Wilcoxon matched-pairssigned-ranks test P = 0.012
ZeptoFemtosecond Laser
ZeptoCCC
Thompson, Berdahl, Solano, Chang 2016 Ophthalmology81
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Edge Strength ZeptoTM vs Femto & CCC
0
20
40
60
80
100
120
140
160
180
200
Pair9 Pair10 Pair11 Pair12 Pair13 Pair14 Pair15 Pair16
EdgeTearStreng
th(m
N)
PrecisionPulseCapsulotomy
CCC
Wilcoxon matched-pairssigned-ranks test P = 0.012
Paired cadaver eyes
Wilcoxon matched-pairssigned-ranks test P = 0.012
ZeptoFemtosecond Laser
ZeptoCCC
Thompson, Berdahl, Solano, Chang 2016 Ophthalmology82
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Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
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Thompson, V. (2018). Journal of Cataract & Refractive Surgery, 44(5), 528-533.
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Pupil Center
Visual Axis
Optic Center
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• First Ever “Patient Trial’ of final
outcome
• Patient previews different
refractions
Interactive Post-Op Process
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Femto vs. Zepto?
No
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Femto vs. Zepto vs. Manual?
No
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Centering Cataract Surgery on the Visual Axis
Vance Thompson, MDFounder, Vance Thompson Vision
Professor of Ophthalmology, University of South Dakota, Sanford School of MedicineSioux Falls, South Dakota, USA
Thank You!
65th Rochester Ophthalmology Conference