CENTER FOR PROCESS

ANALYTICAL CHEMISTRY UNIVERSITY OF WASHINGTON, SEATTLE

Provides a Global Forum for Multi-disciplinary

and Multi-University Participation in

Developments in Process Analytical Technology

The Objective of the Center is to Address

Challenges in Real-Time Analysis and Process

Optimization

CPAC is a Consortium of Multi-Industry

Sponsors, and Government Agencies

CPAC is Multidisciplinary

Chemistry

Electrical Engineering

Applied Physics

Forest Resources

Computer Sciences

Chemical Engineering

Food Sciences

Health Sciences

Biochemistry

With 30 industry sponsors,

CPAC presently supports 15

research projects at 3

Universities involving 15

Principal Investigators (Faculty

and Research Scientists) and

28 graduate students and post

docs

Since 1984, 150 PhD graduates

have been associated with CPAC

CPAC Activities

• Semiannual Sponsor Meetings (May & Nov)

• Tutorials and Technical Workshops

• Summer Institute – Seattle (July)

• Satellite Workshop – Rome, Italy (March)

• Industry Driven Initiatives

• Graduate Education

• IFPAC, FACSS, AIChE, Pittcon, etc.

• FDA (PAT, QbD), USP

Today’s Key Industrial Topics include:

Quality by Design - QbD

Process Analytical Technology - PAT

Food Quality and Safety

Bio-Processing

Green Chemistry

Nanotechnology

Micro-instrumentation

Process Control and Data Handling

What CPAC is interested in:

The Development and Application

of New Technology Tools for

Enhancing:

Quality by Design (QbD), Process

Analytical Technology (PAT),

Process Intensification, and

Greener Processing

What is Quality by Design?

Systematic approach to

development

• Begins with predefined

objectives

• Emphasizes product and

process understanding and

process control

• Based on sound science and

quality risk management

PAT Tools

• PAT tools can be categorized as:

– Process analyzers

– Process control tools

– Multivariate tools for design, data

acquisition and analysis

– Continuous improvement and

knowledge management tools

• PAT is more than just an analyzer!

Core Research Areas

Chemometrics

Sensors

Spectroscopy / Imaging

Chromatography

CPAC RESEARCH PROJECTS

• SELF ASSEMLED SENSOR PLATFORMS BASED ON RFID

• ADAPTIVE OPTICS TO VISUALIZE DYNAMIC PROCESSES

• SMALL NMR SYSTEMS

• VAPO CHROMIC BASED SENSORS

• DIELECTRIC SPECTROSCOPY SENSORS

• DATA MINING AND DATA FUSION

CPAC RESEARCH PROJECTS

• RAMAN SPECTROSCOPY

• GC / GC

• SMALL LC

• LIBS

• SURFACE PLASMON RESONANCE BASED BIO-SENSORS

• MEMBRANES FOR SEPARATION AND CONCENTRATION OF LIGNOCELLUOSES

• MICRO-REACTORS AND NeSSI

CPAC INITIATIVES INCLUDE:

- BIO-PROCESSING IMPROVEMENTS

- MICRO-INSTRUMENTATION FOR HIGH THROUGHPUT EXPERIMENTATION AND PROCESS OPTIMIZATION

- NEW SAMPLING AND SENSOR INITIATIVE (NeSSI)

- CHEMOMETRICS ON-LINE INITIATIVE

- MEASUREMENT TOOLS FOR FOOD QUALITY AND SAFETY

Some of the Current Initiatives at CPAC that

are Keys to the Future of Process Analytics

• Micro-instrumentation for high throughput,

development, and process optimization

(Micro-Analytical)

• New sampling system

approaches (NeSSI™)

CPAC LEGACY

• CREATING FORUMS FOR PROMOTING ADVANCES IN PAT AND IN GLOBAL APPROACHES TO TECHNICAL COOPERATION IN PAT

• ACADEMIC PROGRAMS TO EDUCATE STUDENTS

• MULTI-DISCIPLINARY, MULTI-INDUSTRY

CPAC Activities

IMTeC – June 2010

Summer Institute – July 2010

IFPAC Europa – September 2010

Corning / Oggi Chemist – October 2010

PPAR – October 2010

Members meeting – Nov. 2010

IFPAC – January 2011

Satellite Workshop - Rome – March 2011

CPAC SUMMER INSTITUTES • THE DEVELOPMENT OF ENABLING

TECHNOLOGIES FOR THE PROCESSING INDUSTRIES

• MICRO-INSTRUMENTATION FOR HIGH THROUGHPUT EXPERIMENTATION AND PROCESS INTENSIFICATION

• A TOOL FOR PAT

• EMPHASIS ON BIO-PROCESSING

• JULY 20-22, 2011 SEATTLE

40

CPAC SATELLITE WORKSHOP

(Winter Institute)

• MICRO-REACTORS AND

MICRO-ANALYTICAL

• PROCESS OPTIMIZATION

• UW ROME CENTER

• MARCH 2006 – 2010

• MARCH 22-24, 2011

50

Global Approach to Create a Reference

BENEFITS OF CONSORTIA

MEMBERSHIP

New Technology Peer Communication

Students

Deliverables

PEER COMMUNICATION

BENCHMARKING

CLEARING HOUSE

FOCUS GROUPS

CENTERS ENHANCE

ACADEMIC PROGRAMS

MULTIDISCIPLINARY

SHOWCASE EMERGING TECHNOLOGIES

PROVIDE PRACTICAL FOCUS

COMPETE WELL FOR SCARCE RESOURCES