Cell Signaling
description
Transcript of Cell Signaling
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CELL SIGNALING
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“Real Life” Cell Communication: Flight or Fight Response While watching the movie clip,
record at least TWO responses cells have to signals.
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Pathways with Friends
Handout
Diagram
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Steps of Cell Signaling
1. Reception
2. Signal Transduction
3. Cellular Response
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Reception
1. G-Protein
2. Tyrosine Kinase
3. Ligand-Gated Ion Channel
4. Intracellular Receptor
Online Simulation:http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&B
1. Molecule the receptor binds to?
2. Action of the receptor?
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Signal Transduction
Second Messengers
a. Cyclic AMP
b. Calcium ions
c. Protein kinases
Online Simulation:http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&C
1. Receptor/s the messenger works with
2. Action of the messenger
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Cellular ResponsesExamples
a. Testosterone (intracellular receptors)
b. Cell Reproduction/Cancer (kinase messengers)
c. Cholera, Viagra (cAMP secondary messengers)
d. Muscle Contraction (Ca2+ secondary messengers)
Online Simulation:
http://media.pearsoncmg.com/bc/bc_c
ampbell_biology_7/media/interactive
media/activities/load.html?11&D
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Cell Cycle
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Cell Cycle Animations
1) Stages of the Cell Cycle
2) Mitosis Movie
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Regulation of Mitosis
Cyclins - Their levels in the cell rise and fall with the stages of the cell cycle.
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Cyclin-dependent kinases (Cdks) G1 (Cdk4) S-phase (Cdk2) M-phase (Cdk1)
- Levels in the cell remain fairly stable, but each must bind the appropriate cyclin (whose levels fluctuate) in order to be activated.
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Anaphase-promoting complex (APC) or cyclosome (APC/C) allows the sister chromatids to separate degrades the mitotic cyclins
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Role of Cyclin & Cdks
Protein kinase + Cyclin = Cdks (Cyclin Dependent Kinases)
Advance the cell at G1 and G2 stages MPF is a type of Cdk + Cyclin
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1. MPF signals mitosis to begin
2. Cyclin begins
to degrad
e
3. Mitosis ends
4. Cdk portion recycled
5. Cyclins build up
and trigger mitosis again
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Cancer
HHMI Video Clip
http://www.hhmi.org/biointeractive/cancer/lectures.html
p53 gene affects production of Cdk2 and apoptosis