Cell Signaling

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CELL SIGNALING

description

Cell Signaling. “Real Life” Cell Communication: Flight or Fight Response. While watching the movie clip, record at least TWO responses cells have to signals. . Pathways with Friends. Handout Diagram. Steps of Cell Signaling. Reception Signal Transduction Cellular Response. Reception. - PowerPoint PPT Presentation

Transcript of Cell Signaling

Page 1: Cell Signaling

CELL SIGNALING

Page 2: Cell Signaling

“Real Life” Cell Communication: Flight or Fight Response While watching the movie clip,

record at least TWO responses cells have to signals.

Page 3: Cell Signaling

Pathways with Friends

Handout

Diagram

Page 4: Cell Signaling

Steps of Cell Signaling

1. Reception

2. Signal Transduction

3. Cellular Response

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Reception

1. G-Protein

2. Tyrosine Kinase

3. Ligand-Gated Ion Channel

4. Intracellular Receptor

Online Simulation:http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&B

1. Molecule the receptor binds to?

2. Action of the receptor?

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Signal Transduction

Second Messengers

a. Cyclic AMP

b. Calcium ions

c. Protein kinases

Online Simulation:http://media.pearsoncmg.com/bc/bc_campbell_biology_7/media/interactivemedia/activities/load.html?11&C

1. Receptor/s the messenger works with

2. Action of the messenger

Page 7: Cell Signaling

Cellular ResponsesExamples

a. Testosterone (intracellular receptors)

b. Cell Reproduction/Cancer (kinase messengers)

c. Cholera, Viagra (cAMP secondary messengers)

d. Muscle Contraction (Ca2+ secondary messengers)

Online Simulation:

http://media.pearsoncmg.com/bc/bc_c

ampbell_biology_7/media/interactive

media/activities/load.html?11&D

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Cell Cycle

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Regulation of Mitosis

Cyclins - Their levels in the cell rise and fall with the stages of the cell cycle.

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Cyclin-dependent kinases (Cdks) G1 (Cdk4)  S-phase (Cdk2)  M-phase (Cdk1)

- Levels in the cell remain fairly stable, but each must bind the appropriate cyclin (whose levels fluctuate) in order to be activated.

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Anaphase-promoting complex (APC) or cyclosome (APC/C) allows the sister chromatids to separate degrades the mitotic cyclins

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Role of Cyclin & Cdks

Protein kinase + Cyclin = Cdks (Cyclin Dependent Kinases)

Advance the cell at G1 and G2 stages MPF is a type of Cdk + Cyclin

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1. MPF signals mitosis to begin

2. Cyclin begins

to degrad

e

3. Mitosis ends

4. Cdk portion recycled

5. Cyclins build up

and trigger mitosis again

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Cancer

HHMI Video Clip

http://www.hhmi.org/biointeractive/cancer/lectures.html

p53 gene affects production of Cdk2 and apoptosis