Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact;...
Transcript of Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact;...
![Page 1: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/1.jpg)
Cell Injury
DEPARTMENT OF PATHOLOGICAL PHYSIOLOGY– 2018
![Page 2: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/2.jpg)
Cell adaptation reactions
![Page 3: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/3.jpg)
![Page 4: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/4.jpg)
![Page 5: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/5.jpg)
Necrosis and Apoptosis
![Page 6: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/6.jpg)
Necrosis and Apoptosisproperties Necrosis Size
Cell size Enlarged (swelling) Reduced (shrinkage)
Nucleus Pyknosis>Karyorhexis-> Karyolysis Fragmentation into nucleosome
size fragments
Plasma membrane Disrupted Intact, altered structures- lipids
Cellular content Enzymatic digestion , leak out of
cell
Intact; formation of apoptotic
bodies
Adjacent Inflammation Frequent No
Physiological and pathological
role
Pathologic (culmination of
irreversible cell injury)
Often physiological, leads to
the elimination of unwanted
cells; may be pathological after
some forms of cell injury,
especially DNA damage
![Page 7: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/7.jpg)
Apoptosis
![Page 8: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/8.jpg)
![Page 9: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/9.jpg)
![Page 10: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/10.jpg)
Calcium mechanism of injury
![Page 11: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/11.jpg)
![Page 12: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/12.jpg)
„Vicious circle “ in the pathogenesis of cell
injury
АТP depletion Lipid peroxydation
Damage of cell membrane
Increasing of intracellular Са 2+
![Page 13: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/13.jpg)
Defense system of organism
during cell injury
Antioxidant system
Antimutation system
Detoxification system
Synthesis of Chaperones and HSP
The buffer system
![Page 14: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/14.jpg)
Antioxidant system
Antioxidants of enzymatic origin - superoxide
dismutase (SOD), catalase, glutathione
antioxidant system
Antioxidants of non-enzymatic origin - vitamins
E, C, A, ferritin, serulloplazmin, ubiquinone,
steroid hormones, cysteine, flavonoids
![Page 15: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/15.jpg)
Free radicals and antioxidant system
![Page 16: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/16.jpg)
Antimutation system
Helycase, endonuclease, exonuclease,
DNA-polymerse,nucleosidase,
insertase, ligase
![Page 17: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/17.jpg)
Detoxycation system
Cytochrome Р450 and glutathione –S-
transferase
![Page 18: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/18.jpg)
HSP- heat shock proteins and synthesis
of chaperones
![Page 19: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/19.jpg)
Buffer system
Carbonate
Phosphate
Protein
Hemoglobin
![Page 20: Cell Injury - Azərbaycan Tibb Universiteti. Cell injury and... · 2019. 1. 18. · cell Intact; formation of apoptotic bodies Adjacent Inflammation Frequent No Physiological and](https://reader035.fdocuments.in/reader035/viewer/2022071217/604b7c9a9bbeeb284c36b434/html5/thumbnails/20.jpg)
Principles of correction
Etiological (antibiotic therapy )
Pathogenetical (Са++ blockades, inhibitors
of phospholipase)
Sanogenetical (antioxydants )