Cell-Cell Interactions · AP Biology Interactions between cells Gap junction Desmosome Tight...
Transcript of Cell-Cell Interactions · AP Biology Interactions between cells Gap junction Desmosome Tight...
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AP Biology
Cell-Cell Interactions
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AP Biology
Tissues
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AP Biology
Levels of Organization
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AP Biology
Cells stick together to form tissue
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AP Biology
Levels of Organization How do individual cells “connect” to
form tissue?
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AP Biology
Interactions between cells
Gap junction Desmosome Tight junction Which is anchoring and why?
Which is involved in permeability between cells and how is that permeability mediated?
Which is a communication junction?
Which is most similar to the plasmodesmata (in plants) and why?
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AP Biology
Plasma membranes can join together to form tight junctions
Adherens junctions membranes “glued” together by proteins
- pass through both membranes and attach to cytoskeletons
Desmosomes proteins “button” two membranes together
Transport across membranes
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AP Biology
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AP Biology
Cells of the proximal renal tubule of the kidney where filtration often takes place have few
fusion sites to allow for leakability, whereas, cells of the urinary bladder (that must hold
urine and not allow it to leak out) contains numerous fusion sites or tight junctions to form
a seal to prevent the flow of materials between epithelial cells.
Tight Junctions Zonulae Occludens
forms a band completely around
the cell fusing cells together and
closing off intercellular space
Fusion site #
often correlates to “leakiness” Fewer fusion sites greater
permeability to water and solutes
More fusion sites less permeable…
How would the # Of fusion sites
Affect permeability?
In what organs would you
expect few fusion sites?
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AP Biology
Tight Junctions Proteins interact
to form tight
junctions
You do not need to know these specific proteins.
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AP Biology
Gap Junctions A gap between neighboring cell membranes
Gap Junction (communicating junction)
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AP Biology
Gap Junctions
Connexin surrounds the pore,
- acts like a hydrophilic ion channel between cells
Individual unit of the gap junction = connexon
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AP Biology
Desmosome Anchoring junctions
Does not surround cell
Adhesion is strengthened by
intermediate filaments (keratin)
Hemidesmosome = half a desmosome
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AP Biology
Plant Cell Wall
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AP Biology
Plasmodesmata Intercellular connections between
adjacent plant cells
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AP Biology
Plasmodesmata
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AP Biology
Summary Adhering junctions:
Desmosome & hemidesmosome
Impermeable junctions:
Tight junctions
Communicating junctions:
Gap junctions (and in plants, plasmodesmata)