CCTS Town Hall&

Information SessionAugust 15, 2013

Philip A. Kern, MDCCTS Director/CTSA PI

CCTS Town Hall & Information Session

CCTS Needs Assessment & Satisfaction Survey!

We hear you!!

If you have used one CCTS service, you know about one CCTS service.

91% of 333 respondents reporting utilization of CCTS services or support over the past 12 months also report that their research has benefited from that support.

61%

39%

During the past 12 months, did you uti-lize any CCTS services or receive any CCTS

support?

No

Yes

CCTS Utilization

15%

40%

34%

11%

Overall, has your research benefited in any way from the CCTS resources or services in

the past 12 months?

Not At AllYes, somewhatYes, significantlyI do not know

39%

8%17%

4%

12%

4%

16%

If you did NOT use CCTS resources or services in the past 12 months, why not? (N=106)

I did not know what services are available

I did not know how to access these services

Resources are available to me from another source

CCTS resources are too costly

CCTS resources are not appropriate/adequate for my needs

CCTS resources take too much time to obtain

Other (please specify)

CCTS PilotsCCTS Portal/Web pageBiomedical Informatics

Biostatistics/Research DesignClinical Services

Courses and Programs Biochemical Analysis Laboratory

Ethics/Regulatory SupportFunding for Career Development

Functional Assessment and Body Composition LabFiscal/Grant Management Services

Participant Recruitment ServicesMentor Training/Matching

Career Development and SupportDrug Discovery and Development

Staff TrainingResearch Concierge

Community Engagement ConsultationStudy Coordination at Centers for Rural Health

Novel Methodology Consultation

0.0% 10.0% 20.0% 30.0% 40.0% 50.0% 60.0% 70.0%

CCTS Services you were not aware of until now

CCTS Town Hall & Information Session

Outline

Presentation: Services, Pilot Awards, Education Programs

Intros: CCTS Core Directors/Co-Directors/Key Staff

Q & A Session

Info Session & Reception in Chandler Hospital Atrium

CCTS Timeline1985: General Clinical Research Center (GCRC): 5 renewals to 3/31/08

2002:  UK Clinical Research Organization (UKCRO)

2006: Center for Clinical and Translational Science (CCTS) 

2007-09: 4 CTSA Submissions – Jan & Nov 2007, Oct 2008, Oct 2009 

2009:   Consolidation of GCRC/CRO → (CR-DOC)

2010:   5th CTSA Submission:  Oct 2010

2011:  CTSA awarded June 1, 2011 – member of CTSA Consortium

2013: CTSA Project Year 3 (March 1 – February 28)

CCTS Key Functions, aka Cores Portal (Website & Research Concierge) Clinical Services Core (now CSC, was GCRC, UKCRO, CR-DOC) Regulatory Support & Research Ethics Biostatistics, Epidemiology & Research Design (BERD) Biomedical Informatics (BMI) Pilot & Collaborative Studies Novel Clinical & Translational Methodologies Drug Discovery & Development (DDD) Translational Technologies (Biospecimens Core) Training, Education & Mentoring (TEAM) Community Engagement & Research and

Appalachian Translational Research Network (ATRN) Risk-related Behaviors & Substance Abuse Marshall University Partnership

CCTS Services: Access

Research Concierge: Elodie Elayi, MS

Contact: elodie.elayi@uky.edu, 859-323-7939

CCTS Website: http://www.ccts.uky.edu/

Consultations, Services, Resources, Tools for: Designing a Study Setting up a Study Conducting a Study Closing out a Study

Clinical Services Core (CSC) Inpatient (5 North)/Outpatient (C-300 UKMC)

Nursing, Study Coordination

Marketing/Participant Recruitment o Clinical Research Opportunities Wildcat Databaseo ResearchMatch

Biochemical Analysis & Body Composition Labs

Financial Management – industry contracts

Regulatory – IRB submissions, QA/QI audits, DSMB

Access: Submit CSC Service Request Form at www.ccts.uky.edu

Biostatistics, Epidemiology & Research Design (BERD)

Consultations on study design – pre-study initiation preferred!!o Clinical Trialso Community-based Participatory Researcho Population-based (epidemiologic) Studies

Quantitative data analysis

Protocol review

For: Pilot Studies, Grant Submissions, Publications

Info: Pizza & Pilots (at lunchtime the last Monday of each month)

OR: Email request to: Catherine.Starnes@uky.edu

Biomedical Informatics (BMI) Enterprise Data Trust (clinical data warehouse)

o Datasets: UKHC inpatient data, Markey Cancer Center, Kentucky Cancer Registry, KY Medicaid, Social Security Death Master File

o Data extractions: On request

Consultations with faculty in Division of Biomedical Informaticso Expertise: Bioinformatics, data mining, database design, data visualizations,

imaging informatics, natural language processing, social network analysis Informatics Tools

o REDCap: data collection & surveyso i2b2: quick aggregate counts on available patient populationso Request account: http://www.ccts.uky.edu/BIC/InformaticsTools.aspx

Info: Tamela Harper, MHA Project Director

Contact: Tamela.harper@uky.edu; 859-257-9384

Novel Development 1 Biospecimens Core

o Blood, urine, fingernails of 102 women in Kentucky Women’s Health Registryo Expansion to Appalachian Kentuckyo Assistance with access to biospecimens collections at UK, other institutionso Coming soon: Enhanced biobank/tissue bank!

Access: biospecimens@uky.edu

Drug Discovery & Development (DDD)o Therapeutic Advisory Panel – experts on drug developmento Medicinal chemistry, assessment of HERG channel interaction,

virtual screening & predictive toxicologyo Pilot awards in drug discovery & development

Info: To schedule a consultation, email Charolette Garland cawgarland@uky.edu,

Novel Development 2 Community Engagement & Research

o Consultations to facilitate community-oriented research& research collaborations

o Training for community-oriented researcho Seed grants for community partnerso Study Coordinators & Clinical Liaisons in Hazard and

Morehead to support research activities

Appalachian Translational Research Network (ATRN)o Research collaborations & new avenues to address

health challenges and health disparities in Appalachiao UK, OSU, Ohio U, WVU, U of Cincinnati, Marshall, U. of Pikeville

Info: Carol White, MPH Program Manager

Contact: crwhit3@email.uky.edu; 859-218-0588

University of Cincinnati

Ohio State University

West VirginiaUniversity

Ohio University

MarshallUniversity

University of Pikeville

University of Kentucky

Appalachian TranslationalResearch Network

Center for Rural Health,Morehead

Center for Excellence in Rural Health,

Hazard

Pilot Awards Program 32 Awards since CTSA initiation for total of $1,102,988

11 NIH awards ($6.9M) from CCTS pilots since 2007 program initiation

January RFA: Joint pilots – UK Centers & CCTS Partners, Community Engagement, Drug Development

July RFA: All other pilot programs

New RFA in 2013: Novel Device Development

Standing Pilot Review Committee

Info: Elodie Elayi, MS Research Development Director

Contact: elodie.elayi@uky.edu, 859-323-7939

Junior Investigator Award: $25,000 High Impact and Innovative Award: $50,000 Community Engagement Award: $25,000 Drug Development Award: $50,000 CCTS Partners (OSU, UC, WVU) Collaborative Awards: $50,000 CCTS Centers (BB, SB, MCC, SCoBIRC) Collaborative Awards: $50,000 Community Engagement Mini Grant Awards: $2,500 Marshall University Partnership: $25,000 Novel Methodology Awards: $15,000

Categories Of Pilot Funding

Training, Education & Mentoring (TEAM)KL2 Career Development Program for 6 Junior Faculty 75% release time, research support, mentoring, career development 3 KL2 Scholars awarded NIH grants

Brandon Fornwalt, MD, PhD, Pediatric Cardiology

Brian Noehren, PT, PhD, Rehabilitation Sciences

Qing-Bai She, PhD, Markey Cancer Center

TL1 Institutional Training Program for Pre-doctoral Students Stipend, tuition, health insurance for 4 pre-doctoral students

Professional Student Mentored Research Fellowship (PSMRF) Introduction to Clinical Research Course/Workshop 1-year mentored research ($3,000) for 25-30 professional students

Training, Education & Mentoring (TEAM)Certificate and Degree Programs Graduate Certificate in Clinical and Translational Science Graduate Certificate in Clinical Research Skills MS in Medical Sciences – Clinical & Translational Science

Pathway PhD in Clinical and Translational Science

Info: Victoria King, PhDResearch & Leadership Development Director

Contact: vicky.king@uky.edu; 859-323-1225

Other Career Development Activities One-on-one Coaching & Mentoring K Club for KL2 Scholars, Pilot Awardees CTS Seminar for TL1, Certificate, PSMRF, MD/PhD Students Coordinator 101 & Clinical Research Updates for Clinical Researchers

8th Annual CCTS Spring Conference: April 8, 2013

5 ConferencesCCTS Spring ConferenceCommunity Faculty/PBRN ConferenceResearch Day: Dentistry, Neuroscience,

Public Health648 attendees; 251 oral/poster presentations

Keynote: Chris Austin, MD, Director, National Center for Advancing Translational Science (NCATS)

9th Annual CCTS Spring Conference: Thursday, March 27, 2014 CCTS Spring Conference ATRN Annual Meeting Research Day: Dentistry, Health Sciences, Neuroscience, Nursing

Cite! Campaign: Cite UL1TR000117

When to cite: UL1TR000117 Research with CCTS $$

o CCTS Pilot Awardso CCTS Seed Grants and Mini-grantso KL2/TL1 support o CCTS subsidized research projects and protocols

Faculty/staff funded by CCTS where research benefited

Research utilizing CCTS services, resources, facilities, tools, equipment

Less direct CCTS funding but still appropriate for citation:o Technical assistanceo Faculty/staff funding contributed to researcho Assistance with collaborations, research development

Benefits of citing the CTSA – UK Basketball Tickets 2 sets of 2 basketball tickets – pre-SEC & SEC

Who is eligible: First, Last, Corresponding Author on publications citing CTSA: UL1TR000117, KL2TR000116, TL1TR000115

How to enter: o Watch for email announcement on CCTS listservo We will solicit entries from PubMed search for citationso Eligible author to send publication citing CTSA to Barb Ramseyo Drawings in late fall, early winter

Winner of tickets may determine who gets them, e.g., other member of research team! NOTE: Tickets may not be sold!

Any questions?

• BERD• Biospecimens• BMI• Community Engagement• ATRN• CSC

• MCL• NCTM• Pilot/Research Concierge• Regulatory• TEAM

Q & A Session• Dick Kryscio, Heather Bush, Catherine Starnes• Ken Campbell• Todd Johnson, Tamela Harper• Nancy Schoenberg, Kevin Pearce, Carol White• Patrick Kitzman• Peter Sawaya, Marietta Barton-Baxter ,

Linda Rice, Brian Raisler• Susan Foster-Harper• Greg Gerhardt, Eric Grulke• Elodie Elayi• Ada Sue Selwitz, Marietta Barton-Baxter• Tom Kelly, Vicky King