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CCenter for Oncological Research (CORE) Antwerp · 2017. 10. 16. · FOCUS ON BIOMARKERS, TARGETED...
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FOCUS ON BIOMARKERS, TARGETED THERAPY & THE TUMOR MICROENVIRONMENT We focus on the development of new therapeutic strategies to treat cancer, more specifically on targeted therapy and combination therapies. We study the influence of hypoxia on therapeutic outcome and we put efforts in the identification of biomarkers for personalized medicine. Therapeutic targets: e.g. CD70, EGFR, p53 and PLK1 Tumor types: e.g. cervix, colon, head & neck, lung and pancreas Techniques: cell culture, hypoxia cabinet, radiotherapy, Western blot, immunohistochemistry, immunofluorescence, flow cytometry, liquid biopsies, PCR-based techniques such as ddPCR RESEARCH STAFF Prof. Dr. Filip Lardon, Head Research Laboratory, CORE Prof. Dr. Evelien Smits, Coordinator Solid Tumor Immunology Group, CORE Prof. Dr. An Wouters, Coordinator Targeted and Combination Therapy Team, CORE Prof. Dr. Marc Peeters, Multidisciplinary Oncologic Center Antwerp, UZA & CORE Prof. Dr. Patrick Pauwels and Prof. Dr. Martin Lammens, Department of Pathology, UZA & CORE Prof. Dr. Guy Van Camp, Coordinator Oncogenetics Group, CORE & Center of Medical Genetics, UAntwerp & UZA Prof. Dr. Steven Van Laere, Dr. Luc Dirix and Dr. Peter Vermeulen, Coordinators Translational Cancer Research Unit, CORE & GZA Postdocs : Dr. Christophe Deben, Dr. Ken Op de Beeck, Dr. Christel Vangestel, Dr. Gert Van den Eynden Labtechnicians : Katrien Coen, Christophe Hermans, Hilde Lambrechts, Céline Merlin, Christel Verbrugge PhD students: Elien Augustus, Hasan Baysal, Matthias Beyens, Nele Boeckx, Gitta Boons, Anja Brouwer, Lieselot Croes, Sven De Bruycker, Bram De Laere, Ines De Pauw, Jorrit De Waele, Tal Flieswasser, Laurie Freire Boullosa, Marieke Hylebos, Julie Jacobs, Elly Marcq, Steffi Oeyen, Pablo Reclusa, Charlotte Rypens, Vaso Siozopoulou, Laure Sorber, Jonas Steenbrugge, Laure-Anne Teuwen, Jonas Van Audenaerde, Christophe Van Berckelaer, Kaat Van Casteren, Pieter-Jan Van Dam, Jolien Van den Bossche, Jinthe Van Loenhout, Timon Vandamme FOCUS ON IMMUNOTHERAPY FOCUS ON ONCOGENETICS Central theme: developing novel combination therapies by coupling immune stimulation to inhibition of immune suppression in order to boost antitumor immunity Key words: innate immune cells, immune checkpoints, hypoxia, plasma, stroma, Toll-like receptors Tumor types: colorectal cancer, glioblastoma, lung cancer, melanoma, mesothelioma, pancreatic cancer The research on breast cancer and metastasis comprises three topics: (1) Inflammatory breast cancer; (2) Liquid biopsy: circulating tumor cells (CTCs); (3) Liver metastases, focusing on growth patterns Techniques: CellSearch for CTC detection, DEParray for single cell isolation, whole genome amplification, next-generation sequencing, PCR-based techniques, cell culture, flow cytometry, xCELLigence The research on oncogenetics focuses on the identification of genetic susceptibility factors contributing to tumor initiation. A common central theme is the study and identification of biomarkers leading to therapeutic resistance. Techniques: cell culture, next generation sequencing, real time PCR, Western blot, methylation analysis, microarray technology, ... Seimetz, J Cancer 2011 The Center for Oncological Research (CORE) is a joint oncology research platform of the University of Antwerp, gathering research lines and experts in the field of basic, translational and clinical cancer research. The CORE lab is operational on three sites: the Antwerp University Campus Drie Eiken, Wilrijk; the Antwerp University Hospital, Edegem; and the GZA Hospital Sint-Augustinus, Wilrijk. University of Antwerp – Faculty of Medicine and Health Sciences Campus Drie Eiken, T4 – Universiteitsplein 1, 2610 Wilrijk, Belgium Contact: [email protected] C Center for Oncological Research (CORE) Antwerp FOCUS ON BREAST CANCER AND METASTASIS Marcq et al, Cancer Treatment Reviews 2015 Contact: [email protected]
Transcript of CCenter for Oncological Research (CORE) Antwerp · 2017. 10. 16. · FOCUS ON BIOMARKERS, TARGETED...
FOCUS ON BIOMARKERS, TARGETED THERAPY & THE TUMOR MICROENVIRONMENT
We focus on the development of new therapeutic strategies to treat cancer, more specifically on targeted therapy and combination therapies. We study the influence of hypoxia on therapeutic outcome and we put efforts in the identification of biomarkers for personalized medicine.
Therapeutic targets: e.g. CD70, EGFR, p53 and PLK1
Tumor types: e.g. cervix, colon, head & neck, lung and pancreas
Techniques: cell culture, hypoxia cabinet, radiotherapy, Western blot,
immunohistochemistry, immunofluorescence, flow cytometry,
liquid biopsies, PCR-based techniques such as ddPCR
RESEARCH STAFF
Prof. Dr. Filip Lardon, Head Research Laboratory, COREProf. Dr. Evelien Smits, Coordinator Solid Tumor Immunology Group, COREProf. Dr. An Wouters, Coordinator Targeted and Combination Therapy Team, COREProf. Dr. Marc Peeters, Multidisciplinary Oncologic Center Antwerp, UZA & COREProf. Dr. Patrick Pauwels and Prof. Dr. Martin Lammens, Department of Pathology, UZA & COREProf. Dr. Guy Van Camp, Coordinator Oncogenetics Group, CORE & Center of Medical Genetics, UAntwerp & UZAProf. Dr. Steven Van Laere, Dr. Luc Dirix and Dr. Peter Vermeulen, Coordinators Translational Cancer Research Unit, CORE & GZA
Postdocs: Dr. Christophe Deben, Dr. Ken Op de Beeck, Dr. Christel Vangestel, Dr. Gert Van den Eynden
Labtechnicians: Katrien Coen, Christophe Hermans, Hilde Lambrechts, Céline Merlin, Christel Verbrugge
PhD students: Elien Augustus, Hasan Baysal, Matthias Beyens, Nele Boeckx, Gitta Boons, Anja Brouwer, Lieselot Croes, Sven De Bruycker, Bram De Laere, Ines De Pauw, Jorrit De Waele, Tal Flieswasser, Laurie Freire Boullosa, Marieke Hylebos, Julie Jacobs, Elly Marcq, Steffi Oeyen, Pablo Reclusa, Charlotte Rypens, Vaso Siozopoulou, Laure Sorber, Jonas Steenbrugge, Laure-Anne Teuwen, Jonas Van Audenaerde, Christophe Van Berckelaer, Kaat Van Casteren, Pieter-Jan Van Dam, Jolien Van den Bossche, Jinthe Van Loenhout, Timon Vandamme
FOCUS ON IMMUNOTHERAPY FOCUS ON ONCOGENETICS
Central theme: developing novel combination therapies by coupling immune stimulation to inhibition of immune suppression in order to boost antitumor immunity Key words: innate immune cells, immune checkpoints, hypoxia, plasma, stroma, Toll-like receptorsTumor types: colorectal cancer, glioblastoma, lung cancer, melanoma, mesothelioma, pancreatic cancer
The research on breast cancer and metastasis comprises three topics:
(1) Inflammatory breast cancer;
(2) Liquid biopsy: circulating tumor cells (CTCs);
(3) Liver metastases, focusing on growth patterns
Techniques: CellSearch for CTC detection, DEParray for single cell isolation, whole genome amplification, next-generation sequencing, PCR-based techniques, cell culture, flow cytometry, xCELLigence
The research on oncogenetics focuses on the identification of genetic susceptibility factors contributing to tumor initiation. A common central theme is the study and identification of biomarkers leading to therapeutic resistance.
Techniques: cell culture, next generation sequencing, real time PCR, Western blot, methylation analysis, microarray technology, ...
Seimetz, J Cancer 2011
The Center for Oncological Research (CORE) is a joint oncology research platform of the University of Antwerp, gathering research lines and experts in the field of basic, translational and clinical cancer research. The CORE lab is operational on three sites: the Antwerp University Campus Drie Eiken, Wilrijk; the Antwerp University Hospital, Edegem; and the GZA Hospital Sint-Augustinus, Wilrijk.
University of Antwerp – Faculty of Medicine and Health SciencesCampus Drie Eiken, T4 – Universiteitsplein 1, 2610 Wilrijk, Belgium
Contact: [email protected]
CCenter for Oncological Research (CORE) Antwerp
FOCUS ON BREAST CANCER AND METASTASISMarcq et al, Cancer Treatment Reviews 2015
Contact: [email protected]
