Catalyzing ways of thinking. Ferocious Beauty: Genome Liz Lerman Dance Exchange World Premiere...
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Transcript of Catalyzing ways of thinking. Ferocious Beauty: Genome Liz Lerman Dance Exchange World Premiere...
Ferocious Beauty: Genome
Liz Lerman Dance Exchange
World Premiere
February 3, 2006
Wesleyan University
Biological Processes
Viewing c.f. Describing c.f. Modeling
Representations?Levels of organization?
Units? Rules?
Choreography?
Science Choreography
• Viewing a biological process
• Describing a biological process– Component identification / parts lists– Initial superficial understanding
• Modeling a biological process– Deep understanding– Relationships between parts– Choreography
Molecular biology concepts from informatics perspective
• Biological machine– What does this mean ?– Examples ?– What does this mean physically ?– Choreograph a biological machine
Molecular biology concepts from informatics perspective
• Algorithm in biology– What does this mean ?– Examples ?– Local rules ?– Emergent behavior– Choreograph a biological algorithm
Key concept in molecular biology and bioinformatics
• Base pairing– Why key?
• Choreograph base pairing– Key properties?– C.f. covalent
Molecular biology concepts from informatics perspective
• Consensus sequence– What does this mean ?– Examples ?– What does this mean physically ?– Choreograph recognition of consensus
sequence by biological machine
Zipping and Unzipping
Central to biology• DNA replication• RNA transcription
Central to molecular biology technologies• Southern, Northern, PCR, microarrays