Case Study (FULL)

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TABLE OF CONTENT

CONTENT PAGETable of content 1Acknowledgement 2Objective 3Methodolog !"e#$lt and %i#c$##ion &'11Concl$#ion 12A((endice# 13'1)"efe*ence# 1+

ACKNOWLEDGEMENT

,e a*e *eall g*atef$l beca$#e we managed to com(lete o$* ca#e #t$d the

-dentification of -mida.ole 2/!2 and 2/!3 $#ing 0(ect*o#co(ic Method within the time

given b the lect$*e %*/ 0a.linda inti ama*$.aman/Thi# ca#e #t$d cannot be

com(leted witho$t the effo*t and co'o(e*ation f*om o$* g*o$( membe* 0ee an Teng4

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Tan 5$e 6ing4 Chong 6in Mei4 Cha*le# Maigol and 0lve#te* Awoh/ ,e al#o

#ince*el thank o$* lect$*e* %*/ Emilia inti Malek fo* the g$idance and

enco$*agement in fini#hing thi# ca#e #t$d/ 7a#t b$t not lea#t4 we wo$ld to e8(*e##

o$* g*atit$de to o$* f*iend who involved and hel( $# to #olve thi# ca#e #t$d/

OBJECTIVES

1/ To inte*(*et and identif two imida.ole 2/!2 and 2/!3 $#ing -nf*a*ed4 N$clea*

Magnetic "e#onance and Ma## #(ect*omet*/

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2/ To diffe*entiate between two imida.ole 2/!2 and 2/!3 and t(e of chemical

(*e#ent/

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METHODOLOGY

-n o*de* to #olve the ca#e #t$d given4 we have ca**ied o$t #ome (*acticable

method#/

9i*#tl4 we have (aid a vi#it to %*/ 0a.linda and %*/ Emilia d$*ing thei* office

ho$*#/ -nitiall4 all g*o$( membe*# we*e not clea* whethe* we need to #how o$t the

e8act #te(# to de#c*ibe the wa# we identified the (*od$ct# o* we can #t*aight awa

$#ing the method of com(a*i#on with the data (*ovided4 to fig$*e o$t the (*od$ct

2/!2 and (*od$ct 2/!3/ 5oweve*4 we able to clea* o$* do$bt# abo$t the :$e#tion and

ta#k that we #ho$ld (*e(a*ed4 afte* we *efe**ed to %*/ 0a.linda and %*/Emilia/

0econdl4 we have taken #ome book *efe*ence# in o*de* to make #$*e the

anal#i# we ca**ied o$t wa# co**ect/ -n addition4 the book# (*ovided a lot of

knowledge that we need in doing anal#i#/ 9o* e8am(le4 the knowledge incl$ded fo*

o$* g*o$(;# ca#e #t$d we*e -nf*a*ed


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-n o*de* to identif #t*$ct$*e (*e#ent in imida.ole 2/!2 and imida.ole 2/!34

#(ect*o#co(ic method #$ch a# -nf*a*ed


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Table 1

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Imidazole


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Table 1 #how# the *e#$lt# that a*e obtained fo* 2 #(ect*o#co(ic method that

a*e $#ed to detect the (*od$ct of imida.ole 2/!2/ 9o* -" #(ect*o#co(4 we can detect

the (*e#ence of C'N g*o$( and C>C a*omatic g*o$( f*om the waven$mbe* given/ C'

N #t*etch can be fo$nd $nde* waven$mbe* of 13+3cm'1and 12?1cm'1/ 9o* C>C

a*omatic #t*etch4 val$e# of 1!+)cm'14 1!!2cm'1and 1!21cm'1a*e fo$nd whe*ea#

val$e# of 1)?!cm'1and 1&23cm'1indicate the (*e#ence of C>C a*omatic bending/

9o* (*oton


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doe# not ca$#e m$ch effect on the ca*bon atom/ The #econd mo#t #hielded C atom

i# at 52 and 53 with val$e of !&/?((m/ -t# neighbo$*ing atom i# mo*e de#hielded b

elect*onegative nit*ogen atom and the (*e#ence of (i bond/ On the othe* hand4 C'12

and C'1 have val$e# of 113/?((m and 11/+((m *e#(ectivel/ The #mall deviation in

chemical #hift# a*e d$e to the facto* of elect*onegative N atom nea*e* to C'1

com(a*ed to C'12/ Ne8t4 fo* the ben.ene *ing4 ca*bon NM" contained have a val$e#

of 132/?((m4 12!/D((m4 12)/+((m and 12D/&((m/ The bl$e colo$* of C atom ha# a

highe* chemical #hift of 12D/&((m beca$#e it i# bonded and nea*e* to imida.ole

g*o$( which ca$#e# it to be mo*e de#hielded com(a*ed to o*ange colo$* C'+ atom

which i# fa* awa f*om bonded atom/ The mo#t de#hielded C atom


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Table 2

Acco*ding to the -" #(ect*$m in table 2 fo* imida.ole 2/!34 the*e i# a mode*ate

(eak (*e#ent in the waven$mbe* of 1)?!cm'1 and 1!)cm'1and a weak (eak (*e#ent

in the waven$mbe* of 1&32cm'1/ The#e (eak# a*e located at the *ange of 1)??'1&D&

cm'1 and 1&??'1!?? cm'1/ 0o4 a*omatic f$nctional g*o$( i# (*e#ent in thi# imida.ole

/The*e i# a medi$m (eak (*e#ent in the waven$mbe* of 1!2+cm'1/Thi# #hown that

C'5 bending i# (*e#ent in thi# molec$le a# the waven$mbe* i# in the *ange of 1!+?'1!&?cm'1 / 0ome (eak# a*e (*e#ent in the wavelength of 13Dcm'1


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#hielded hd*ogen com(a*ed to othe*# like 52and 53 which ha# the #ame amo$nt

of hd*ogen attache# to it fo* it ha# a g*eate* di#tant f*om nit*ogen which act a# an

elect*onegative element/ A# fo* the 52 and 534 the have chemical #hift at !/1?((m

with 2 hd*ogen atom# and co$(ling con#tant 6 of +/+/ The a*e mo*e de#hielded

than 51 and 512 a# the a*e nea*e* to the elect*onegative element4 N/ The chemical

#hift that i# )/1&((m with 1 hd*ogen


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othe*/ The a*e mo*e de#hielded than ca*bon that ha# 5) and 5D attached to it/ The

chemical #hift fo* ca*bon that contain# 5) and 5D a*e 12)/+((m/The mo#t #hielded

ca*bon in a*omatic *ing i# ca*bon that ha# 5+ attached to it with chemical #hift of

12!/+((m/ The mo#t de#hielded ca*bon atom in thi# molec$le i# the ca*bon with no

hd*ogen and i# attached to two nit*ogen atom# that ($ll the elect*on den#it towa*d

them#elve# with the chemical #hift of 1!3/((m/ The chemical #hift of 11/&((m and

11!/+((m belong to ca*bon with 51? and ca*bon with 511/The a*e mo*e de#hielded

than tho#e attached to two hd*ogen atom# b$t mo*e #hielded than tho#e do not

have an hd*ogen atom a# the have one hd*ogen that i# attached to them/

The*e a*e #ome wa# to diffe*entiate imida.ole 2/!2 and imida.ole 2/!3/The

diffe*ence between imida.ole 2/!2 and 2/!3 i# d$e to the (o#ition of do$ble bond a#

both of them a*e i#ome*#/ The 15 #hift fo* imida.ole 2/!2 which i# 51?and 511have

the val$e of 3/&!'3/)?((m i# mo*e de#hielded than 51and 512 in imida.ole 2/!3 with

2/)?'2/)&((m/Thi# i# beca$#e the 51? and 511 in imida.ole 2/!2 a*e nea*e* to two

nit*ogen atom# which act a# elect*onegative element# /A# fo* imida.ole 2/!34 the

val$e of chemical #hift fo* 51and 512 a*e 2/??'2/)&((m/ 51 and 512 in imida.ole

2/!3 a*e mo*e #hielded than the 51? and 511in imida.ole 2/!2 beca$#e the a*e nea*

e* to one nit*ogen #o le## elect*on den#it a*e ($lled towa*d# elect*onegativeelement4 that i# nit*ogen/

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CONCLUSION

The conden#ation *eaction of lactam 2/3) give# two majo* (*od$ct# which i#

imida.ole 2/!2 and imida.ole 2/!3/ The we*e identified and inte*(*eted $#ing th*ee

diffe*ent #(ect*omet* techni:$e# which i# inf*a*ed #(ect*omet*


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APPENDICES

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REFERENCES

1= %onald 7/ Pavia4 Ga* M/ 7am(man H Geo*ge 0/ *i.4 6ame# "/ Ivan/

Case Study (FULL)

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