Case 2007-1971 Ellen M Binder Presented at SEVPAC 2008 – Permission granted for use on SEVPAC...
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Transcript of Case 2007-1971 Ellen M Binder Presented at SEVPAC 2008 – Permission granted for use on SEVPAC...
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Case 2007-1971
Ellen M Binder
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Signalment & History
Number 20018-month old female brown and white Boer goat
Transported from NC to VA 1 week agoBred within last 2-3 weeks
Vaccinated within last week
Other goats (4) normal
Clinical SignsLethargy, depression
Mucous membranes pale and grey
Pigmenturia
Neurologic Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only
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CBC & ChemistryAnemia
Leukocytosis
Azotemia
Liver and muscle enzymes increased
UrinalysisProteinuriaPigmenturiaHematuria
Fecal Egg Count
Treatment
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Differential Diagnoses
Copper Toxicosis
InfectiousLeptospira
Plant toxicosis
Unknown toxin/infection
Myopoathy
Negative
Copper (serum): 2.6ppmLead (blood): none detected
No methemoglobinemia
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Kidney
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Kidney: H&E (200x)
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Kidney: H&E (400x)
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Kidney: special stainsPrussian Blue Halls
Rhodanine Steiner’sPresented at SEVPAC 2008 – Permission granted
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Kidney: Prussian Blue (+)
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Liver: H&E (100x)
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Liver: H&E (200x)
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Liver: H&E (400x)
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Liver: special stainsPrussian Blue Halls
RhodaninePresented at SEVPAC 2008 – Permission granted
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Liver: Halls (+)
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Liver: Rhodanine (+)
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Morphologic Diagnoses:
Kidney, acute tubular necrosis, diffuse, marked, with hemoglobin tubular casts and multifocal interstitial nephritis.
Liver, hepatitis, periportal and centrilobular, moderate, with copper accumulation, hepatocellular necrosis and cholestasis.
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Copper Toxicosis
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Copper ToxicosisStressor precipitates sudden release of Cu
Hepatic necrosisHemolytic crisis
Other speciesCattlePigsDogs: Bedlington, WHWT, & Skye terriers Siamese cat (single case)Humans (Wilson disease)
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COPPER TOXICOSIS IN A DAIRY GOAT HERD.
Cornish J, Angelos J, Puschner B, Miller G, George L., 2007
400 mixed breed dairy goats
Decrease in milk production and increased mortality rate
9 deaths within a 1 month period
Clinical signs only in lactating goats
Anorexia, recumbency, neurologic abnormalities and death
AST, GGT and Total bilirubin: elevated
No evidence of hemolysis
Had been fed mineral mix containing 3,050 ppm copper for the past 9 months
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Acknowledgments
Histology technicians
Co-authors:Natalie Crawford, D Phillip Sponenberg, Rachel Tan, Flavia Lepene
References
1. Adam SEI, Wasfi LA, Chronic copper toxicity in Nubian goats. J Comp Pathol 1977;87:623-627.
2. Cornish J, Angelos J, Puschner B, Miller G, George L. Copper toxicosis in a dairy goat herd. JAVMA 2007; 231,4:586-589.
3. Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. Ed. M Grant Maxie. Saunders Ltd. 2:379-381.
4. Solaiman SG, Maloney MA, Qureshi MA, et al. Effects of high copper supplements on performance, health, plasma copper and enzymes in goats. Small Rumin Res 2001;41:127-139.
5. Soli NE, Nafstad I. Effects of daily oral administration of copper to goats. Acta Vet Scand 1978; 19:561-568.
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