Cardiovascular effects of anti-hyperglycemic

therapy

Edoardo Mannucci

Diabetes AgencyCareggi teaching hospital,

Firenze, Italy

ADVANCE

MACE

CV mort.

Effects of intensified glycemic control on CV mortality

MYOCARDIAL ISCHEMIA

Adrenercic activation could have a negative impact on the

prognosis of

MACE

Secondary prevention of macrovascular events in patientswith type 2 diabetes:The PROACTIVE Study

Dormandy JA et al., Lancet 2005; 366: 1279

Relative risk SU vs other therapies

vs. Conventional

vs. Insulin

vs. Metformin

Mortality 0.96 1.03 1.53

MI 0.83 0.91 1.24

Stroke 1.19 1.40 2.12

Effect of SU on MACE

Monami M, Ganovese S, Mannucci E – 2013 [in press]

Effect of SU on mortality

Monami M, Ganovese S, Mannucci E – 2013 [in press]