CardioSense3DIntroduction

H. Delingette

Intermediate Evaluation of the CardioSense3D Research Action

Agenda of the day

Start End Topic Speaker

9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette

9h55 10h25Research Activity of the Asclepios Team within CardioSense3D

( with 5mn questions)Hervé Delingette

Maxime Sermesant

10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D

( with 5mn questions)Michel Sorine

10h55 11h10 Coffee Break  

11h10 11h40Research Activity of the Macs Team within CardioSense3D

( with 5mn questions)Dominique Chapelle

11h40 12h10Research Activity of the Reo Team within CardioSense3D

( with 5mn questions)Jean-Frédéric

Gerbeau

12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez

12h30 13h45 Lunch Break  

13h45 16h00 Discussion with the evaluation committee All

16h00 17h00 Discussion within the evaluation committee  

Introduction to CardioSense3D

•Scientific Objectives and Positioning

•Partnership and organization

What is CardioSense3D ?

An INRIA Large Initiative Action on cardiac modeling :

• Started (officially) in May 2005

• 4 ans duration (evaluated after 2 years)

• Transversal to 4 INRIA project teams :

– ASCLEPIOS (Medical Image Analysis and Simulation) N. Ayache

– MACS (Biomechanics and Numerical Analysis) : D. Chapelle

– REO (Fluid Mechanics) : J-F. Gerbeau

– SISYPHE (Contrôle and Modeling) : M. Sorine

• Supervisor : H. Delingette,

• Co-Supervisor : M. Fernandez

Cardiac data

solid mechanics

Clinical applications

Diagnosis

Therapy planning

blood flowPersonalization

electro-physiology

perfusion & metabolism

CardioSense3D Research Topics

Cardiac modeling

anatomy

Objectives

• Build a patient specific heart simulator

• Estimate the parameters of this model from observations of the

cardiac function,

• Develop clinical applications (Cardiac Resynchronisation

Therapy, radiofrequency ablation,..).

Propose models having a low number of parameters

State of the art

Computational Cardiac Models

• ElectroPhysiology : Noble et al. (Oxford),

S. Panfilov et al. , O. Dössel (Karlsruhe),

Y. Rudy et al. (Wash. Univ. St Louis),

Colli-Franzone (Univ. Pavia)

• Flow-Biomechanics : C. Peskin (NYU),

Quarteroni (EPFL),…

• Electro-mechanics : Peter Hunter et al.

(Physiome project; Auckland); Andrew

McCulloch et al. (UCSD)

anatomy

electro-physiology

solid mechanicsblood flow

perfusion & metabolism

Cardiac modeling

State of the art

Cardiac Image Analysis (Geometrical approaches)

• Elliott McVeigh et al. (JHU+NIH)

• D. Rueckert et al. (Imperial College) and R. Razavi et al.

(KCL + Guy’s hospital)

• Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas

(Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi

(Hongkong Univ.)

Cardiac data

State of the art

Therapy planning

Clinical applications

Diagnosis

Therapy planning (Generic Models)• D. Noble (Oxford)

• A. Mc Culloch (UCSD)

• O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah)

Positioning of CardioSense3D

•Integrate/Couple 4 physiological phenomena :Electrophysiology, Contraction/Relaxation Mechanics,

Arterial Circulation, Perfusion

•To propose models having a low number of parameters in order to estimate them from clinical data.

•Develop clinical applications (CRT, RF Ablation) based on personalized models

CardioSense3D : Academic / Clinical / Industrial Partnership

Physiology/Control• Sisyphe/Sosso, INRIA

Numerical Analysis • Macs, INRIA

• Reo, INRIA

• Geometrica, INRIA

• Gamma, INRIA

• Univ. de Nantes

• Pzlen Univ. (Czech Rep.)

• LIRMM (Montpellier)

Imaging/Simulation• Asclepios, INRIA

• UCL / King’s College (London)

• Creatis, CNRS

Clinical Sites• Guy’s Hospital (London)

• NIH (Washington)

• HEGP, U678 (Paris)

• Hopital Henri Mondor (Créteil)

• Sunnybrook Health Sciences Center

• InParys, Clinique George Bizet

• Hopital Bicêtre + Paris XI U. +INSERM (Paris)

Industrial Partners• Philips Research France

• ELA Medical

• (Siemens)

First Circle Members of CS3DTeam ASCLEPIOS Team MACS Team SOSSO2 Team REO

N. Ayache D. Chapelle M. Sorine J-F. Gerbeau H. Delingette P. Moireau Q. Zhang M.A. Fernández M. Sermesant M. Vidrascu Y. Papelier M. ThirietJM. Peyrat J. Sainte-Marie T. M. Laleg I. Vignon-Clémentel F. Billet E. Phe K. Djabella M. Boulakia D. Lepiller R Djafri N. ZemzemiT. Mansi A. Illanes-Manriquez M. AstorinoN. Toussaint C. Grandmont

•Sophia-Antipolis

•Rocquencourt

Two different INRIA Research Units :

INRIA Support

Recruitment of :

• P. Moireau (Détachement X-Corps des Telecoms) in 2005

• 4 Phd Thesis :

– R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi

– M. Astorino (Reo) from Janvier. 2007 bourse Cordi

– F. Billet (Asclepios) from Oct 2006

– R. Djafri (Sisyphe) from 2007

• 3 Engineers :

– M. Alba (Macs) 2005-2006 Ingénieur Associé

– E. Phe (Macs-REO) 2006-2008 Ingénieur Associé

– N. Toussaint (Asclepios) : 2006-2008 Ingénieur Associé

External Support

National Scholarship :• PhD of N. Zemzemi

Philips Medical Systems Paris (Suresnes):• PhD of D. Lepiller (Asclepios)

ELA Medical :• Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard

Siemens Corporate Research• PhD of JM Peyrat

European Health eChild• PhD of T. Mansi

European RTN HaeModel• Phd of N. Diniz Dos Santos

Industrial contracts • PhD of M. Laleg and K. Djabella

Software

Current Development based on 3 software packages :• LifeV (Reo) (www.lifev.org) for CFD and electrophysiology

• OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics

• Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/)

Software developed within CardioSense3D :• CardioViz3D (Asclepios)

• Heartlab (Macs)

Dissemination Activity

• “Digital Heart” DVD (20mn)

Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau,

Maxime Sermesant

Dissemination Activity

• “Digital Heart” Movie

• Public release of Software (CardioViz3D) and database (DTI atlas)

• Involvements in Conferences (NIH-INRIA workshop)

• General Audience Articles (La Recherche, Ercim News)

Dissemination Activity

• “Digital Heart” DVD

• Public release of Software (CardioViz3D) and database (DTI atlas)

• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)

• General Audience Articles (La Recherche, Ercim News)

• CardioSense3D seminars with Paris V university

Dissemination Activity

• “Digital Heart” DVD

• Public release of Software (CardioViz3D) and database (DTI atlas)

• Involvements in Conferences (ISBI’07, NIH-INRIA workshop)

• General Audience Articles (La Recherche, Ercim News)

•CardioSense3D seminars with Paris V university

•Organisation of workshops (summer school) and conferences (FIMH’09 in Nice)

•Apple ARTS Award

Agenda of the day

Start End Topic Speaker

9h30 9h55 Introduction of CardioSense3D ( with 5mn questions) Hervé Delingette

9h55 10h25Research Activity of the Asclepios Team within CardioSense3D

( with 5mn questions)Hervé Delingette

Maxime Sermesant

10h25 10h55Research Activity of the Sisyphe Team within CardioSense3D

( with 5mn questions)Michel Sorine

10h55 11h10 Coffee Break  

11h10 11h40Research Activity of the Macs Team within CardioSense3D

( with 5mn questions)Dominique Chapelle

11h40 12h10Research Activity of the Reo Team within CardioSense3D

( with 5mn questions)Jean-Frédéric

Gerbeau

12h10 12h30 Perspectives of CardioSense3D ( with 5mn questions) Miguel Fernandez

12h30 13h45 Lunch Break  

13h45 16h00 Discussion with the evaluation committee All

16h00 17h00 Discussion within the evaluation committee  

Cardiac data

solid mechanics

Clinical applications

Diagnosis

Therapy planning

blood flowPersonalization

electro-physiology

perfusion & metabolism

CardioSense3D Research Topics

Cardiac modeling

anatomy