Rome, March 12/14, 2019

Venue: Ergife Palace HotelLargo Lorenzo Mossa

CARDIONEPHROLOGY 2019

Cover:Rome, Castel Sant’Angelo or Hadrian’s Tomb.

ENDORSEMENTERA-EDTA’s endorsement is for thepromotion of education in general,therefore the specific content of the eventis the responsibility of the organiser

ENDORSEMENT REQUESTEDHigh Patronage of the President of the Republic

Italian Society of Artificial NutritionItalian Society Metabolism Diabetes Obesity

Italian Society of Cardiovascular Ultrasound System

SCIENTIFIC ADVISORSLuca Di Lullo, Antonio Bellasi

PRESIDENTSClaudio Ronco, Alberto Santoboni, Antonio De Pascalis

HONORARY PRESIDENTPeter McCollough

ORGANIZING SECRETARIATFenicia Events & Communicationinfo@fenicia-events.euFenicia Events

&Communication 3

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WELCOME LETTER

Cardiovascular and renal disease are closely linked through differentmechanisms such as chronic inflammation, dyslipidemia, calcium-phos-phorus metabolism abnormalities, or comorbid conditions such as arte-rial hypertension, coronary artery disease and diabetes which may affectthe heart and the kidneys at the same or in different times. At the sametime, different hereditary (such as Policystic kidney disease) and/or rare(such as Fabry’s disease) diseases also may impair simultaneously renaland cardiovascular functions.The fourth edition of the CardioNephrology meeting will review comor-bidities and metabolic abnormalities from the cardiorenal syndrome tothe metabolic consequences of chronic kidney and heart disease thatoccur as the glomerular filtration rate decreases and link kidney and car-diovascular diseases.The key features of the CardioNephrology 2019 are represented by thescientific sessions dedicated to the close interactions between heart, kid-ney and lung together with nutritional aspects in cardio – renal patients.Heart failure will be discussed both in acute and chronic kidney diseasepatients. Lectures dedicated to imaging will underscore potentials andlimits of available diagnostic tools. Young cardionephrologists will bealso specifically involved in vasculitis – dedicated as far as in poster ses-sion.CardioNephrology 2019 will also focus on specific educational coursesdedicated to critical appraisal, interventional nephrology, electrocardiog-raphy and blood gas analysis.The meeting is arranged on several scientific sessions (some of themjoined with other eminent scientific societies) and selected plenary lec-tures with eminent national and international speakers.Finally, Meeting will close with World Kidney Day 2019 with severalactivies directly linked to this special issue.Enjoy CardioNephrology 2019 with usLuca Di Lullo, Antonio Bellasi, Claudio Ronco, Antonio De Pascalis, AlbertoSantoboni, Peter Mc Cullough

DAY ONE - Tuesday March 12th 2019

LEPTIS MAGNA 2-4 ROOMChairmen: P. Conti (Grosseto), A. Santoboni (Colleferro)

9.00 Coronary angiography e and contrast-induced nephropathy riskG.P. Talarico (Rome)

9.15 Folic acid and cardiovascular preventionG. Cianciolo (Bologna)

9.30 Sleep disturbances in CKD diabetic patientsTBA

9.45 Fluid assessment in heart failure patients with chronic kidneydisease: the role of telehealth an telemedicineA. Martino (Rome)

10.00 Cardiorenal involvement in adrenocortical failureA. Falorni (Perugia)

10.15 Left atrial appendage occlusion in end-stage renal diseasepatients: an alternative to oral anticoagulant approachG. Patti (Rome)

10.35 Pain therapy in cardio-renal patientsTBA

10.50 Cardiovascular interventional proceedings in end-stage renaldisease patientsA. Granatelli (Tivoli)

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11.05 Cardiovascular risk factors in CKD patients: the roleof bioequivalent drugs R. Pontremoli (Genoa)

11.25 Hypertonic solutions for peritoneal dialysis patientsV. Barbera (Colleferro

11.45 Cardiorenal anemia management: the role of biosimilar ery-thropoiesis-stimulating agents (ESA)M. Morosetti (Rome)

12.05 CKD, Cardiorenal syndrome and dyslipidemia: an unsolvedpuzzleP. Terrosu (Sassari)

12.20 When to start anticoagulant therapy in cardioembolic stroke?S. Anticoli (Rome)

12.40 Cardio and renal update on new treatment’s perspectives inFabry’s diseaseF. Pieruzzi (Monza)

13.00 Light Lunch

14.00 OPENING PLENARY LECTUREThe link between chronic inflammation and cardiovascular diseasein CKDP. Raggi (Edmonton - Canada)Introducing: C. Ronco (Vicenza)

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I SESSIONCARDIOVASCULAR RISK FACTORS IN CHRONICKIDNEY DISEASE PATIENTS (CKD): NEWTHERAPEUTIC APPROACHESChairmen: A. Granatelli (Tivoli), P. Menè (Rome)

14.30 Cardiorenal anemia syndrome: what’s new?F. Locatelli (Lecco)

15.00 Anti PCSK9 antibodies in dyslipidemic patients with CKD:from clinical trials to real world evidencesA. Zambon (Padua)

15.30 Xanthine oxidase inhibitors and novel uricosuric agents for uricacid-related cardionephropathy treatmentL. Di Lullo (Colleferro), L. Gesualdo (Bari)

16.10 Antiplatelet vs Anticoagulant therapy in acute coronarysyndrome patients with renal involvementJ.A. Barrabes (Barcelona)

16.30 Pharmacological treatment and cardiovascular safety in obesepatientsF. Muratori (Como)

II SESSIONINTEGRATED MEDICINE ANDCARDIONEPHROLOGYChairmen: S. Castellino (Taormina), A. Gorini (Rome)

17.00 Immune system involvement in cardiorenal diseasesM. Del Prete (Milan)

17.15 Herbal extracts as metabolic interferences: potential clinical usesG. Occhionero (Perugia)

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17.30 Biophysical integrated approach on cardionephrolgy: anemerging clinical perspectiveA. Foletti (Lugano - Switzerland)

17.45 Stem cells as treatment option in cardiac diseases: availableresultsC. Castellitto (Bologna)

18.00 Discussion

III SESSIONCLINICAL HISTORY OF CARDIO-RENALSYNDROMEChairmen: S. Radenkovic (Nis - Serbia), R. Rivera (Monza)

18.15 Post-AKI kidney functional recoveryC. Ronco (Vicenza)

18.30 Progression of kidney disease: from AKI to CKDG. Grandaliano (Foggia)

18.45 Sepsis-related kidney damageV. Cantaluppi (Novara)

19.00 The role of renal functional reserveC. Ronco (Vicenza)

19.15 Discussion

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LEPTIS MAGNA 1 ROOM No Translation Tool available for this Session

9.00 ECG Educational CourseDiscussant: A. De Pascalis (Lecce), R. Rivera (Monza)

13.00 Light Lunch

I SESSIONDIRECT ORAL ANTICOAGULANTS (DOACs) ANDCHRONIC KIDNEY DISEASE: A THREE-STEPSFLOW-CHARTChairmen: S. Caramiello (Rome), A. Mugnolo (Legnago)

FIRST STEP: Management14.30 Fragile patients and anticoagulant therapy between guidelines

and real lifeL. Di Lullo (Colleferro)

14.45 Two dosages for the same drug: two sides of the same coin?R. Pola (Rome)

15.00 Emergencies management in DOACs treated patientsD. Toni (Rome)

SECOND STEP: Appropiateness15.15 DOACs prescriptive appropiateness in atrial fibrillation patients

with CKDL. De Luca (Tivoli)

15.30 DOACs therapy according to patients phenotypes: a matter ofsafety? Anything else?M. Ciavolella (Frascati)

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15.45 DOACs and advanced CKD stagesL. Di Lullo (Colleferro)

THIRD STEP: Complexity16.00 Direct oral anticoagulant therapy in patients with active cancer:

between atrial fibrillation and deep venous thromboembolismI. Bisceglia (Rome)

16.15 Direct oral anticoagulant therapy once daily treatment andthromboembolic prophylaxis in CKD patientsS. Radicchia (Perugia)

16.30 Efficacy and safety profile of direct oral anticoagulant therapy inold and fragile patientsM. Ciaburri (Rome)

16.45 Discussion

II SESSIONLUNG, KIDNEY AND HEART AXISChairmen: N. Di Daniele (Rome), A. Pinna (Oristano)

17.00 Kidney, heart and lung: three sides of the same pictureZ. Ricci (Rome)

17.15 Chronic obstructive lung disease, right heart failure and kidneydiseaseS. Di Simone (Colleferro)

17.30 New anti-cholinergic agents for chronic obstructive lungdisease: safety profile in cardiorenal patientsTBA

17.45 Primary and secondary pulmonary hypertension in CKDM.P. Cicini (Rome)

18.00 Discussion

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III SESSIONCARDIAC ARRHYTMIAS AND CHRONIC KIDNEYDISEASEChairmen: M. Mennuni (Colleferro), M. Rebecchi (Rome)

18.15 Pathophysiology of arrhythmias in CKD patientsD. Grieco (Rome)

18.30 Heart rhytmn impairment: the silent killerS. Mennuni (Rome)

18.45 Atrial fibrillation: prevention and treatment in renalreplacement treatment’s patientsA. Politano (Rome)

19.00 Atrial fibrillation: anticoagulation and hemodialysisM. Sgueglia (Rome)

19.15 Discussion

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TARRAGONA ROOM No Translation Tool available for this Session

9.00 Blood gas analysis educational courseDiscussant: M.T. Sciarrone Alibrandi (Milan), U. Tulli (Tivoli)

13.00 Light Lunch

I SESSIONCARDIOVASCULAR FEATURES OF KIDNEYTRANSPLANT PATIENTSChairmen: G. Grandaliano (Foggia), G. Otranto (Colleferro)

14.30 Which cardiologic evaluation for kidney transplatation patients’waiting list?L. Potena (Bologna)

15.00 Cardiovascular ageing in transplant patients: immune responseand immunosoppressive treatment rolesG. Stallone (Foggia)

15.30 Cardiovascular involvement in transplant patients: how tomanage?E. Paoletti (Genoa)

16.00 Optimal timing of HCV-related hepatic disease treatment inkidney transplant recipientsG. Taliani (Rome)

16.30 Discussion

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II SESSION17.00 QUESTIONS’ CLINIC WITH THE EXPERTS:

CARDIORENAL SYNDROMEChairman: C. Ronco (Vicenza)

III SESSIONFUNCTIONAL FOODS AND NUTRACEUTICS INCARDIORENAL PATIENTSChairmen: V. Barbera (Colleferro), F. Santoboni (Rome)

18.15 Pharmacological interactions and the treatment of dyslipidemia:how and when to treatR. Volpe (Rome)

18.30 Nutraceutics and dyslipidemia management in cardiorenalpatientsC. Morozzi (Rome)

18.45 Hypercholesterolemia targets in high risk cardiorenal patients:beyond the statinsV. Barbera (Colleferro)

19.00 Iron deficiency and anemia in CKD patients: new therapeuticapproachesN. Marchitto (Terracina)

19.15 Prevention and treatment of nephrolithiasisTBA

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CESAREA ROOM No Translation Tool available for this Session

9.00 Interventional Nephrology Educational CourseDiscussant: A. D’Amelio (Lecce), F. Fiorini (Rovigo)A. Granata (Agrigento), N. Pirozzi (Rome), M. Tozzi (Varese)

13.00 Light Lunch

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THUGGA ROOM No Translation Tool available for this Session

9.00 Critical appraisal in cardionephrologyDiscussant: C. Turin, G. Tripepi (Reggio Calabria)

13.00 Light Lunch

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LEPTIS MAGNA 2-4 ROOM

19.30 OPENING CERIMONYAUTHORITIES’ GREETINGS

20.00 Closing

DAY TWO - Wednesday March 13th 2019

LEPTIS MAGNA 2-4 ROOM

IV SESSIONARTERIAL HYPERTENSIONChairmen: A. Balducci (Rome), G. Reboldi (Perugia)

8.30 ESC/ESH and ACC guidelines: what’s new? What’s different?F. Mallamaci (Reggio Calabria)

8.45 Anti-hypertensive treatment and nephro-protection? Whichtarget to achieve?R. Pontremoli (Genoa)

9.00 Arterial hypertension in hemodialysis patients: how to treat? Andwhich target values to achieve?L. De Nicola (Naples)

9.15 Resistant hypertension and cardiorenal risk: bad compliance orpoor efficacy?F. Viazzi (Genoa)

9.30 Potential new targets for antihypertensive therapyK. Narkiewicz (Gdansk - Poland)

9.45 Discussion

10.00 PLENARY LECTUREManagement of chronic ischemic disease in CKD patientsG. Ferraiuolo (Rome)Introducing: A. Santoboni (Colleferro)

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EXHIBIT HALL

10.30 Coffee Break with the Expert

V SESSIONACUTE KIDNEY INJURYChairmen: V. Barbera (Colleferro), C. Ronco (Vicenza)

11.30 AKI: diagnosis and clinical settingsC. Ronco (Vicenza)

11.45 AKI and heart failureP. Mc Cullough (Dallas, Texas - USA)

12.00 Cytokines removal and cardiac surgeryV. Cantaluppi (Novara)

12.15 Endotoxins and type - 1 cardorenal syndromeG.M. Virzì (Vicenza)

12.30 AKI and Sepsis: sequential extracorporeal treatmentsC. Ronco (Vicenza)

12.45 Renal replacement treatments in AKI patientsC. Ronco (Vicenza)

13.00 Discussion

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LUNCHEON SYMPOSIUMPERITONEAL DIALYSIS IN CARDIORENALPATIENTSChairmen: C. Crepaldi (Vicenza), A.R. Rocca (Rome)

13.30 Clinical studies of PD in cardiorenal syndrome and heart failureA. Kazory (Gainsville - USA)

13.45 Fluids’ balance in peritoneal dialysisO. Heimburger (Stockholm - Sweden)

14.00 The pathophysiology of the cardiorenal syndrome and potentialuse of peritoneal ultrafiltrationJ. Bargman (Toronto - Canada)

14.15 PUF and CHF: the italian experience of a multidisciplinaryapproachG.M. Iadarola (Turin)

14.30 Discussion

VI SESSIONRENIN-ANGIOTENSIN-ALDOSTERONEINHIBITORS (RAASi) ENABLING THERAPIES ANDCHRONIC HYPERKALEMIA MANAGEMENTChairmen: L. De Nicola (Naples), E. Paoletti (Genoa)

15.00 Epidemiology and diagnosis of chronic hyperkalemiaL. De Nicola (Naples)

15.15 Chronic hyperkalemia risk factorsE. Paoletti (Genoa)

15.30 RAAS inhibition and hyperkalemiaG. Pajes (Albano Laziale)

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15.45 Therapeutic strategies for chronic hyperkalemia:a) Dietetic interventionsA. Cupisti (Pisa)b) Pharmacological optionsS. Bianchi (Livorno)

16.15 Discussion

EXHIBIT HALL

16.30 Coffee Break with the Expert

VII SESSIONIRON DEFICIENCY, ANEMIA AND CARDIORENALSYNDROMEChairmen: M. Fusaro (Padua), R. Rivera (Monza)

17.30 Iron deficiency, anemia and heart failure: an up to dateP. Terrosu (Sassari)

17.50 Multidisciplinary Round Table Internal Medicine point of viewD. Girelli (Verona)Nephrologist’s point of viewR. Minutolo (Naples)Cardiologist’s point of viewM. Senni (Bergamo)

18.50 Discussion

19.00 Closing

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LEPTIS MAGNA 1 ROOM

IV SESSIONFABRY’S DISEASEChairmen: S. Feriozzi (Viterbo), F. Graziani (Rome)

8.30 Natural history of Fabry’s diseaseF. Floccari (Civitavecchia)

8.45 Fabry’s disease: from glomerular hyperfiltration to overt CKDA. Pisani (Naples)

9.00 Fabry’s disease: from arterial hypertension to hypertrophiccardiomyopathyC. Autore (Rome)

9.15 Neurologic involvement in Fabry’s diseaseG. Silvestri (Rome)

9.30 Fabry’s disease progression and biomarkersR. Mignani (Rimini)

9.45 Discussion

10.00 PLENARY LECTURECardiorenal AmyloidosisC. Quarta (Bologna)Introducing: C. Ronco (Vicenza)

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EXHIBIT HALL

10.30 Coffee Break with the Expert

V SESSIONHEART FAILURE MANAGEMENT INCARDIORENAL PATIENTSChairmen: E. Ferramosca (Lecce), A. Santoro (Bologna)

11.30 Diuretics, heart failure-related systemic congestion and KarlPopper’s turkeyG. Cice (Naples)

11.45 Neprilisine inhibition in heart failureC. Parisi (Rome)

12.00 Guanylate cyclase stimulators and heart failureA. Fucili (Ferrara)

12.15 Therapeutic strategies for chronic hyperkalemia in heart failurepatientsA. Bellasi (Bergamo)

12.30 Intra and extracorporeal fluids balance in heart failureP. Mc Cullough (Dallas, Texas - USA)

12.45 Extracorporeal’s fluids removal in patients affected bycardiorenal syndromeV. Panichi (Versilia)

13.00 Apheresis and cardio-renal syndromeA. Santoro (Bologna)

13.15 Discussion

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LUNCHEON SYMPOSIUMHEMODIALYSIS TREATMENTS ANDCARDIORENAL PATIENTSChairmen: M. Morosetti (Rome), P. Trambaiolo (Rome)

13.30 Immunoadsorption in heart transplant’s patientsC. Maiello (Naples)

13.50 Electrolytes’balance in Continuous Renal Replacement Therapywith citrateS. Morabito (Rome)

14.10 Immunomodulation in septic patientsG. Paternoster (Potenza)

14.30 Discussion

VI SESSIONAUTOSOMIC DOMINANT POLYCYSTIC KIDNEYDISEASE (ADPKD) AND CARDIO-RENALINVOLVEMENTChairmen: M. Galliani (Rome), P. Peverini (Rieti)

15.00 ADPKD: an up to dateL. Trepiccione (Naples)

15.15 Disease’s progression models:a) ERA-EDTA approachR. Torra (Barcelona - Spain)b) Italian approachF. Scolari (Brescia)

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15.45 Imaging diagnosis in ADPKD patientsA. Granata (Agrigento)

16.00 Therapeutic management of ADPKD patients: real world dataand future perspectivesR. Magistroni (Modena)

16.15 Patient’s interviewF. Floccari (Civitavecchia)

EXHIBIT HALL

16.30 Coffee Break with the Expert

VII SESSIONDIABETIC PATIENT WITH METABOLICSYNDROME: REAL WORLD EVIDENCESChairmen: R. Addesse (Tivoli), V. Toscano (Rome)

17.30 Hypoglicemic, but non-insulinemic therapy, in CKD patients:how collect safety and efficacy in every CKD stagesS. Settembrini (Naples)

17.50 New therapies for dyslipidemia management in cardiorenalpatients: the role of fixed pharmacological associationTBA

18.10 Omega-3 fatty acids and cardiovascular damage’s prevention inCKD patientsA. De Pascalis (Lecce)

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18.30 Statin therapy in dialysis patients: top or flop?S. Andrulli (Lecco)

18.50 Discussion

19.00 Closing

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TARRAGONA ROOM

IV SESSION

JOINT SESSION CARDIONEPHROLOGY STUDYGROUP - ITALIAN SOCIETY OF ARTIFICIALNUTRITION

NUTRITIONAL AND METABOLIC FEATURES INCARDIORENAL PATIENTSChairmen: L. Gianotti (Monza), G. Iapichino (Milan)

8.30 Nutritional status evaluation in kidney disease patientsE. Giaquinto (Cesena)

8.50 Nutritional therapy in CKD patientsA. Cupisti (Pisa)

9.10 Kidney-Intestinal microbiota AxisS. Riso (Novara)

9.30 Artificial nutrition in AKI patientsM. Zanello (Bologna)

9.50 Malnutrition and cardiorenal syndromeD. Radrizzani (Legnano)

10.10 Obesity paradox and acute kidney failureM. Zanetti (Trieste)

EXHIBIT HALL

10.30 Coffee Break with the Expert

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V SESSIONACUTE CORONARY SYNDROME AND CHRONICRENAL FAILUREChairmen: G. Patti (Rome), F. Proietti (Rome)

11.30 Which eGFR equation better predict outcome in patients withacute coronary syndrome?F. Floccari (Civitavecchia)

11.45 Patients with acute coronary syndrome and chronic renal failure:contemporary trends on early treatment strategiesM. Tubaro (Rome)

12.00 Impact of chronic renal failure at early and one-year follow-upafter acute coronary syndrome:a) The bleeding risk outweighs the ischemic risk!V. Pengo (Padua)b) The ischemic risk outweighs the bleeding risk!P. Calabrò (Caserta)

12.30 Acute coronary syndrome and chronic renal failure: which datafrom real-world registries?a) ISAC RegistryR. Bugiardini (Bologna)b) START ANTIPLATELET RegistryR. Marcucci (Florence)

13.00 Long-term antithrombotic therapy in patients with chronicrenal failure and previous acute coronary syndrome: newevidenceG. Di Pasquale (Bologna)

13.15 Discussion

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LUNCHEON SYMPOSIUMHEART FAILURE: POTENTIAL APPROACHESFROM ACUTE TO CHRONIC SETTINGSChairmen: E. Galli (Treviglio), V. La Milia (Milan)

13.30 Continuous ultrafiltration and extracorporea devices: tecniquesand outcomesV. Cantaluppi (Novara)

13.50 Wearable device-based PUF (Peritoneal Ultrafiltration)L. Wrammer (Lund -Sweden)

14.10 Frequent hemodialysis in heart failure patientsM. Napoli (Lecce)

14.30 Discussion

VI SESSIONMETABOLIC SYNDROME: RISK FACTORS ANDINTERVENTIONAL STRATEGIESChairmen: A. Bellasi (Bergamo), R. Rivera (Monza)

15.00 Hypertriglyceridemia as independent cardiovascular risk factor G. Pajes (Albano Laziale)

15.20 Mixed dyslipidemia management in cardiorenal patient M. Uguccioni (Rome)

15.40 Interactive question clinic: metabolic syndrome patient incardiorenal outpatient clinic G. Pajes (Albano Laziale), M. Uguccioni (Rome)

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EXHIBIT HALL

16.30 Coffee Break with the Expert

VII SESSIONCARDIORENAL INVOLVEMENT IN SYSTEMICVASCULITIS AND RARE DISEASESChairmen: V. Montinaro (Tricase), A. Pani (Cagliari)

17.30 Therapeutic perspectives in systemic vasculitisS. Sciascia (Turin)Discussant: A. Mitrotti (Bari)

17.50 Pathogenic classification of MGRSA. Angioi (Cagliari)Discussant: G. Piscopo (Bari)

18.10 Modulation of complement activation in atypical hemolyticuremic syndromeG. Castellano (Bari)Discussant: A. Atzeni (Cagliari)

18.30 Immunopathogenesis of idiopathic membranous nephropathyM. Fiorentino (Bari)Discussant: D. Santoro (Messina)

18.50 Discussion

19.00 Closing

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CESAREA ROOM

13.30 LUNCHEON SYMPOSIUM

Joint Session WITH ITALIAN SOCIETY OF DIABETES,METABOLISM AND OBESITY (SIMDO) ANDINTERNATIONAL OBESITY NETWORK (ION)GLYCEMIC VARIABILITY AND ITS CONTROL INEND – STAGE RENAL DISEASE DIABETICPATIENTSChairmen: A. De Monte (Trieste), G. Fatati (Terni)P.A. Miserendino (Catania)

13.30 LECTUREEvidences from SGLT-2 inhibitors in diabetic patients withCKD: from EMPA-REG to CREDENCE trialsV. Provenzano (Palermo)Introducing: L. Di Lullo (Colleferro), V. Monda (Ferrara)

13.50 Glycemic variabilityG. Crispino (Vibo Valentia)

14.05 Intradialytic glycemic variability: face to facenephrologist/diabetologistR. Mancini, G. Mazzitello (Catanzaro)

14.20 Nutritional therapy in diabetic patients with intradialyticglycemic variabilityA. Curti (Cosenza)

14.35 CSII treatment in diabetic patients with ESRDM. Fleres (Palermo)

14.50 Discussion

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DAY THREE - Thursday March 14th 2019

WORLD KIDNEY DAY

LEPTIS MAGNA 2-4 ROOM

VIII SESSIONFAST AND FURIOUS 1CARDIORENAL ARENA ON CKD-MBDChairman: F. Locatelli (Lecco)

8.30 Burning questions 1

The role of calcimimetic in CKDD. Russo (Naples)

Cinacalcet or etelcalcetide? To whom?A. Bellasi (Bergamo)

Surgical parathyroidectomy?S. Mazzaferro (Rome)

First round: wrap-up and take home messages

9.00 Burning questions 2

Biomarkers: PTH and alkaline phosphataseM.C. Mereu (Cagliari)

The role of bone biopsyM. Fusaro (Padua)

Vascular calcification: does it matter?P. Raggi (Edmonton)

Second round: wrap-up and take home messages

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9.30 Burning questions 3

Bone fractures in CKD patientsM. Di Luca (Pesaro)

Active or native Vitamin D?M. Pasquali (Rome)

New calcium free phosphate bindersM. Cozzolino (Milan)

Third round: wrap-up and take home messages

10.00 Hypoparathyroidism and CKDA. Sandonati (Rome)

10.15 PLENARY LECTUREErythropoietin, chronic kidney disease and cardiovascular outcomes: a30 years historyR. Rivera (Monza)Introducing: A. De Pascalis (Lecce)

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IX SESSIONFAST AND FURIOUS 2CARDIORENAL ARENA ON ATRIAL FIBRILLATIONIN CKDChairmen: P. Pignatelli (Rome), F. Summaria (Rome)

11.15 Burning questions 1 - CKD and Heart Faillure

Fast: Which DOAC should be used?L. Di Lullo (Colleferro)

Furious: Please, do not use DOACsG. Pulignano (Rome)

Neither “Fast” or “Furious”: Vitamin K antagonists and CKD:angel or devil?A. Bellasi (Bergamo)

First round: wrap-up and take home messages

11.45 Burning questions 2 - The Real World

Fast: DOACs and CKD: from clinical trials to real world dataM. Uguccioni (Rome)

Furious: Frail and older patients with CKD: which DOAC?A. Ungar (Florence)

Neither “Fast” or “Furious”: Thromboembolic and hemorragicrisk score calculators in CKDM. Ravera (Genoa)

Second round: wrap-up and take home messages

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12.15 Burning questions 3 - CKD and atrial fibrillation inEmergency Department

Fast: An highway to cardioversionC. Lavalle (Rome)

Furious: Pulmonary embolism preventionM.P. Ruggieri (Rome)

Neither “Fast” or “Furious”: Deep venous thrombosismanagementL. Zuccaro (Rome)

Third round: wrap-up and take home messages

13.00 Anticoagulant therapy and cardiovascular calcificationsprogressionA. De Vriese (Bruges - Belgium)

X SESSIONCARDIOVASCULAR INVOLVEMENT IN PATIENTSWITH HEMODIALYSIS VASCULAR ACCESSChairmen: M. Gallieni (Milan), M. Tozzi (Varese)

13.20 The impact of haemodialysis arteriovenous fistula onhaemodynamic parametersJ. Malik (Prague - Czech Republic)

13.40 Cardiovascular disease and HD: cvc trigger or destinyC. Lomonte (Aquaviva delle Fonti)

13.55 Cardiac implantable electronic devices and vascular access:Strategies to overcome problemsF. Caravati (Varese)

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14.10 High-range FAV and theft syndromes: possible strategiesN. Pirozzi (Rome)

14.25 Graft for low flow VA: an option for patients with heart failureM. Tozzi (Varese)

14.40 Radiological intervention in high flow accessP. Quaretti (Pavia)

14.55 Discussion

15.00 CLOSING REMARKS

FAREWELL PARTY

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LEPTIS MAGNA 1 ROOM

VIII SESSIONDIABETIC NEPHROPATHY 1Chairmen: A. Selvi (Perugia), V. Toscano (Rome)

8.30 Novel association therapies for every step of treatmentR. Buzzetti (Rome)

9.00 SGLT-2 inhibitors and cardiovascular outcomes: lessons fromCVOTs and RWE studiesG. Pugliese (Rome)

9.30 GLP-1 agonists’ impact on cardiovascular mortality andmorbidityS. Settembrini (Naples)

10.00 PLENARY LECTURENew perspectives in the treatment of diabetic nephropathyR. Minutolo (Naples)Introducing: G. La Manna (Bologna)

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IX SESSIONDIABETIC NEPHROPATHY 2Chairmen: G. Del Rosso (Teramo), F. Aucella (S.G. Rotondo)

11.15 Diabetic nephropathy and cardiovascular implicationsM. Ravera (Genoa)

11.30 DPP-IV efficay and safety in CKD patients: new real worlddataN. Napoli (Terracina)

11.45 Diabetic disease’s management in dialysis patientsO. Disoteo (Milan)

X SESSIONNEW TECHNOLOGIES IN CARDIONEPHROLOGYChairmen: N. Rifici (Latina), F. Tulli (Palestrina)

12.00 HFR and cardiovascular outcomeG. La Manna (Bologna)

12.15 Percutaneous coronary intervention in high-risk patients withco-morbidities and multivessel coronary artery diseaseV. Pasceri (Rome)

12.30 HFR and hepcidin removalG. Donati (Bologna)

12.45 Progress in cardiac pacing: which role for the leadless devices?N. Di Belardino (Anzio)

13.00 Discussion

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TARRAGONA ROOM

VIII SESSIONCLINICAL NUTRITION IN NEPHROLOGY: ISSUESOF DAILY CLINICAL PRACTICE IN CKDRelevant nutritional topics for CKD patients, caregivers andclinicians in NephrologyChairmen: V. Bellizzi (Salerno), G. Brunori (Trento)

8.30 IntroductionG. Brunori (Trento)

8.35 What the CKD patients ask to social media on nutritionaltreatment?G. Quintaliani (Perugia)

8.50 Priorities on nutritional treatment in CKD according tostakeholdersV. Bellizzi (Salerno)

9.00 Discussion

Practical renal nutrition issues in the real lifeChairmen: V. Bellizzi (Salerno), B. Di Iorio (Naples)

9.15 Low-proteins/high-carbohydrates or normal-proteins/low-carbohydrates diet in diabetic CKD patients?D. Santoro (Messina)

9.30 Safety of very low-protein/vegetarian diets in CKD: iper-kalemiaB. Di Iorio (Naples)

9.45 Salt intake and autosomal dominant polycystic kidney diseaseF. Scolari (Brescia)

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10.00 Dietary modulation of Gut Microbioma in CKDE. Fiaccadori (Parma)

10.15 Advice or device to improve adherence to nutritional treatmentin CKD?C. D’Alessandro (Pisa)

10.30 Discussion

IX SESSIONAPHERESIS IN CARDIORENAL PATIENTSChairmen: A. Santoro (Bologna), W.D. Valentini (Rieti)

11.15 Lipoprotein (a) - risk marker and therapeutic targetR. Klingel (Cologne - Germany)

11.30 Rheopheresis and microvascular complications in cardiorenalpatientsA. Ramunni (Bari)

11.45 Discussion

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X SESSIONNURSES AND CLINICIANS INTERACTIVE SESSIONON CARDIONEPHROLOGYChairmen: R. Mari (Colleferro), U. Tulli (Tivoli)

12.00 CRRT and nurses. Learming to the job-DowtimeP. Martucci (Rome)

12.15 Central Venous Catheters: guidelines, budle and best practiceA. Fontana (Tivoli)

12.30 CKD patients’ fluids and electrolytes management in IntensiveCare UnitsS. Accardo (Rome)

12.45 CRRT and available anticoagulation strategies: which is thebest one?L. Tellini (Rome)

13.00 Clinical relationship between CRRTs and pressure - relatedlesions in cardiac surgery intensive care unitM. Palombi (Rome)

13.15 Discussion

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EXHIBIT HALL

10.45 Poster SessionDiscussant: F.R. Festuccia (Rome), V. Pistolesi (Rome)

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INVITED SPEAKERS AND CHAIRMEN4Stanislao Accardo, Rome

Roberto Addesse, Tivoli

Simeone Andrulli, Lecco

Andrea Angioi, Cagliari

Sabrina Anticoli, Rome

Alice Atzeni, Cagliari

Filippo Aucella, San Giovanni Rotondo

Camillo Autore, Rome

Alessandro Balducci, Rome

Vincenzo Barbera, Colleferro

Joan Bargman, Toronto - Canada

Jose Antonio Barrabes, Barcelona - SpainAntonio Bellasi, Bergamo

Vincenzo Bellizzi, Salerno

Stefano Bianchi, Livorno

Irma Bisceglia, Rome

Giuliano Brunori, Trento

Raffaele Bugiardini, Bologna

Raffaella Buzzetti, Rome

Paolo Calabrò, Caserta

Vincenzo Cantaluppi, Novara

Stella Caramiello, Rome

Franco Caravati, Varese

Giuseppe Castellano, Bari

Santina Castellino, Taormina

Christine Castellitto, Bologna

Michele Ciaburri, Rome

Giuseppe Cianciolo, Bologna

Massimo Ciavolella, Frascati

Gennaro Cice, Naples

Maria Paola Cicini, Rome

Paolo Conti, Grosseto

Mario Cozzolino, Milan

Carlo Crepaldi, Padua

Giuseppe Crispino, Vibo Valentia

Adamasco Cupisti, Pisa

Achiropita Curti, Cosenza

Claudia D’Alessandro, Pisa

Alessandro D’Amelio, Lecce

Leonardo De Luca, Tivoli

Ariella De Monte, Trieste

Luca De Nicola, Naples

Antonio De Pascalis, Galatina

An De Vriese, Bruges - Belgium

Marco Mario Del Prete, Milan

Goffredo Del Rosso, Teramo

Natale Di Belardino, Anzio

Nicola Di Daniele, Rome

Biagio Raffaele Di Iorio, Naples

Marina Di Luca, Pesaro

Luca Di Lullo, Colleferro

Giuseppe Di Pasquale, Bologna

Salvatore Di Simone, Colleferro

Olga Disoteo, Milan

Gabriele Donati, Bologna

Alberto Falorni, Perugia

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Giuseppe Fatati, Terni

Sandro Feriozzi, Viterbo

Giuseppe Ferraiuolo, Rome

Emiliana Ferramosca, Lecce

Francescaromana Festuccia, Rome

Enrico Fiaccadori, Parma

Marco Fiorentino, Bari

Fulvio Fiorini, Rovigo

Mattia Fleres, Palermo

Fulvio Floccari, Civitavecchia

Alberto Foletti, Lugano - SwitzerlandAlessandro Fontana, Tivoli

Alessandro Fucili, Ferrara

Maria Fusaro, Padua

Emilio Galli, Treviglio

Marco Galliani, Rome

Maurizio Gallieni, Milan

Loreto Gesualdo, Bari

Luca Gianotti, Monza

Ester Giaquinto, Cesena

Domenico Girelli, Verona

Antonio Gorini, Rome

Antonio Granata, Agrigento

Antonino Granatelli, Tivoli

Giuseppe Grandaliano, Foggia

Francesca Graziani, Rome

Domenico Grieco, Rome

Olaf Heimburger, Stockholm - Sweden

Gian Maria Iadarola, Turin

Gaetano Iapichino, Milan

Amir Kazory, Gainsville - Usa

John Kellum, Pittsburg - Usa

Reinhard Klingel, Cologne - Germany

Gaetano La Manna, Bologna

Vincenzo La Milia, Milan

Carlo Lavalle, Rome

Francesco Locatelli, Lecco

Carlo Lomonte, Aquaviva Delle Fonti

Bruno Macciocchi, Cassino

Riccardo Magistroni, Modena

Ciro Maiello, Naples

Jan Malik, Prague - Czech Republic

Francesca Mallamaci, Reggio Calabria

Raffaele Mancini, Catanzaro

Nicola Marchitto, Terracina

Rossella Marcucci, Florence

Raffaella Mari, Colleferro

Anna Maria Martino, Rome

Paolo Martucci, Rome

Sandro Mazzaferro, Rome

Giovanni Mazzitello, Catanzaro

Peter Mc Cullough, Dallas - Usa

Paolo Menè, Rome

Silvia Mennuni, Colleferro

Mauro Mennuni, Colleferro

Maria Cristina Mereu, Cagliari

Renzo Mignani, Rimini

Roberto Minutolo, Naples

Paolo Antonio Miserendino, Catania

Adele Mitrotti, Bari

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Vincenzo Monda, Ferrara

Vincenzo Montinaro, Tricase

Santo Morabito, Rome

Massimo Morosetti, Rome

Claudia Morozzi, Rome

Antonio Mugnolo, Legnano

Fabrizio Muratori, Como

Marcello Napoli, Lecce

Nicola Napoli, Terracina

Krzysztof Narkievicz, Gdansk - Poland

Giovanni Occhionero, Perugia

Giovanni Otranto, Colleferro

Giuseppe Pajes, Albano Laziale

Marina Palombi Rome

Antonello Pani, Cagliari

Vincenzo Panichi, Versilia

Ernesto Paoletti, Genoa

Cristian Parisi, Rome

Vincenzo Pasceri, Rome

Marzia Pasquali, Rome

Gianluca Paternoster, Potenza

Giuseppe Patti, Rome

Vittorio Pengo, Padua

Paola Peverini, Rieti

Federico Pieruzzi, Monza

Pasquale Pignatelli, Rome

Antonio Maria Pinna, Oristano

Nicola Pirozzi, Rome

Antonio Pisani, Naples

Giovanni Piscopo, Bari

Valentina Pistolesi, Rome

Roberto Pola, Rome

Alessandro Politano, Rome

Giacomo Polito, Frosinone

Roberto Pontremoli, Genoa

Luciano Potena, Bologna

Fabrizio Proietti, Rome

Vincenzo Provenzano, Palermo

Giuseppe Pugliese, Rome

Giovanni Pulignano, Rome

Pietro Quaretti, Pavia

Cristina Quarta, Bologna

Giuseppe Quintaliani, Perugia

Sonia Radenkovic, Nis - Serbia

Stefano Radicchia, Perugia

Danilo Radrizzani, Legnano

Paolo Raggi, Edmonton - Canada

Alfonso Ramunni, Bari

Maura Ravera, Genoa

Marco Rebecchi, Rome

Giampaolo Reboldi, Perugia

Zaccaria Ricci, Rome

Nunzio Rifici, Latina

Sergio Riso, Novara

Rodolfo Fernando Rivera, Monza

Anna Rachele Rocca, Rome

Claudio Ronco, Vicenza

Andrea Rubboli, Bologna

Maria Pia Ruggieri, Rome

Domenico Russo, Naples

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Assunta Sandonati, Rome

Alberto Santoboni, Colleferro

Francesca Santoboni, Colleferro

Antonio Santoro, Bologna

Domenico Santoro, Messina

Maria Teresa Sciarrone Alibrandi, Milan

Savino Sciascia, Turin

Francesco Scolari, Brescia

Antonio Selvi, Perugia

Michele Senni, Bergamo

Silvio Settembrini, Naples

Marianna Sgueglia, Rome

Gabriella Silvestri, Rome

Giovanni Stallone, Foggia

Francesco Summaria, Rome

Giovanni Paolo Talarico, Rome

Gloria Taliani, Rome

Laurent Tellini, Rome

Pierfranco Terrosu, Sassari

Danilo Toni, Rome

Claudia Turin, Reggio Calabria

Rosa Torra, Barcelona - Spain

Vincenzo Toscano, Rome

Matteo Tozzi, Varese

Paolo Trambaiolo, Rome

Francesco Trepiccione, Naples

Giovanni Luigi Tripepi, Reggio Calabria

Marco Tubaro, Rome

Filippo Tulli, Palestrina

Umberto Tulli, Tivoli

Massimo Uguccioni, Rome

Andrea Ungar, Florence

Walter Domenico Valentini, Rieti

Francesca Chiara Viazzi, Genoa

Grazia Maria Virzì, Vicenza

Roberto Volpe, Rome

Lars Wrammer, Lund - Sweden

Alberto Zambon, Padua

Marco Zanello, Bologna

Michela Zanetti, Trieste

Lorenzo Zuccaro, Rome

SCIENTIFIC INFORMATION

EDUCATIONAL COURSES Educational Courses will take place on Tuesday, March 12th from 9.00 to 13.00. Participation at the courses is free, but a pre-registration is required.

E-POSTERDuring the Congress, a Poster Session will take place on Thursday, March14th from 10.45 until 11.45Scientific works must be sent by January 15th, 2019 through the websitehttps://fenicia-events.eu/cardionefro/call-for-abstract/All the abstracts must be received exclusively in electronic and in English,completing the special form. The first Author will be considered as the onewho will make the presentation and must be regularly registrated at theCongress; Authors under 35 will be entitled to free admission to theCongress.

PUBLICATION OF ABSTRACTAll the abstracts received will be published on the websitewww.feniciaevents.eu/cardionefro, and three best abstracts will be publishedin the Cardionefro Magazine

CMEFor the Italian Participants: Cardionephrology 2019 will partecipate at theContinuing Medical Education

SCIENTIFIC TECHNICAL EXHIBITIONDuring the Congress an exhibition will be set up for biomedical,pharmaceutical and scientific publishing industry • Tuesday, March 12th 9.00-20.00 • Wednesday, March 13th 8.30-19.00 • Thursday, March 14th 8.30-14.30

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ORGANIZING SECRETARY ON SITE Organizing Secretariat in the Congress Venue will observe the followingtimetable: • Monday, March 11th (only for Delegations and Companies)9.00-19.00 • Tuesday March 12th 8.00-20.00 • Wednesday March 13th 8.00-19.30 • Thursday March 14th

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GENERAL INFORMATIONS

VENUEERGIFE PALACE HOTEL Largo Lorenzo Mossa For information and hotel reservations please contact the OrganizingSecretariat: FENICIA EVENTS & COMMUNICATIONPhone: +39 06 87671411 - Fax: +39 06 62278787Cardionefro2019@fenicia-events.eu;https://fenicia-events.eu/cardionefro

REGISTRATIONCongress website https://feniciaevents.eu/cardionefro/iscrizioni/

REGISTRATION FEES (rates include VAT 22%) By December 31th 2018 After that date

Doctors e 122,00 e 183,00Nurses/Dietitians e 61,00 e 91,50* Postgraduate e 61,00 e 91,50* Students free of charge free of charge* Each student and trainees must submit a copy of the certificate of registration at Specialities School.

Registration fee includes: participation in all scientific sessions, coffee breaksand light lunch, farewell party, certificate of attendance, badge and congressbag.

BADGE AND CERTIFICATE OF PARTICIPATION Badge and the certificate of attendance can be printed by all the participantsat the desks prepared using their QRCode received by e-mail whenregistering for the event.

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CANCELLATIONS AND REFUNDS Any refund will be recognized

OFFICIAL LANGUAGES OF THE CONGRESSEnglish and Italian. Translation tool will be available in the following rooms: Leptis Magna 2-4 Leptis Magna 1 Tarragona

HOW TO REACH THE VENUEHotel Ergife Palace is located about 200 meters from Via Aurelia, just 4 kmfrom Grande Raccordo Anulare and 26 km from Fiumicino airport. Themajor points of cultural and commercial importance of the city are easilyreachable with the bus lines and the underground that allow the connection. PUBLIC TRANSPORTATIONHotel is easily reachable by public transport,especially for those arriving from Termini station or from the center of Romeusing the underground line A and getting off at Cornelia, then about 1.200meters, about 15 minutes to walk or bus 246. 2 stops (get off at the Pio IXclinic) leaving from Piazza Irnerio. BY TRAIN From Termini Station take theunderground line A towards Battistini and get off at Cornelia. Then take theline 246 towards Malagrotta and get off after 3 stops. BY PLANE From Fiumicino airport: Leonardo Da Vinci airport is about 25km from the hotel. A direct train (Leonardo Express) leaves the airport every30 minutes and connects Fiumicino to Roma Termini. Once in Termini takethe metro line A direction Battistini, stop Cornelia. From Cornelia take bus246 for three stops. The hotel is just a few steps from the stop.From Ciampino airport: Ciampino airport is about 30 km from Ergife PalaceHotel. With Terravision bus you can easily reach the Termini station. FromTermini it is possible to 29 reach the hotel by taxi or by taking the metro lineA direction Battistini. From Ciampino to the hotel by taxi the ride lasts about40 minutes and costs about 50.00. You can also reach Termini by busCO.TRA.L. Once to Termini take the metro line A direction Battistini, get

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off Cornelia.Da Cornelia take the bus 246 for three stops. The hotel is a fewsteps from the bus stop. BY CAR At the exit of the motorway take the Grande Raccordo Anularetowards Fiumicino exit n.1.Direction Aurelia-Città del Vaticano.After about3 Km at the fourth traffic light turn right into Via Lombardi.. The hotel is atthe bottom of the Street.

PARKINGThe Hotel has a parking for 800 paid parking spaces (e 15,00 per day).

ORGANIZING SECRETARIAT

Fenicia Events & CommunicationVia Tor de’ Conti, 22 - 00184 Roma

Tel. +39 06.87671411 - Fax +39 06.62278787WhatsApp +39 342.8211587 - info@fenicia-events.eu

Fenicia Events&

Communication