CARBONIC ANHYDRASE INHIBITOR: DIURETICS ACT ON PCT(PROXIMAL

CONVOLUTED TUBULE)

PRESENTED BY GOURAB BANDYOPADHYAY

B.Pharm 3rd year BENGAL SCHOOL OF TECHNOLOGY

DiureticesA diuretic is any substance that promotes the

production of urine. Use:-In medicine diuretics are used to treat Heart failure,

Liver cirrhosis, Hyper tension , water poisoning and certain Kidney diseases .

Example:-Some diuretics such as Acetazolamide help to make

the urine more alkaline and helpful in increasing excretion of substance such as aspirin in case of overdose or poisoning.

INTRODUCTION

Site of Na+ Ion Re-absorptioN

Carbonic anhydrase inhibition, results in:

Decreased H+ formation inside PCT cell

Decreased Na+/H+ antiport

Increased Na+ and HC03

- in lumen Increased diuresis

MECHANISM OF CA INHIBITOR

Carbonic anhydrous inhibitors Acetazolamide Methazolamide

Drugs:-

Systemic acidosis Kidney stone Drowsiness

Adverse Effect:-

Essentials of MEDICAL PHARMACOLOGY

By, JAYPEE & KD TRIPATHI Edition- 6th (2008) www.wikipedia.com

BIBLIOGRAPHY

Rudranil Bhowmik

GUIDED BY:-