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Carbapenem resistance

PRESENTER : Dr. AISHIYA

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Carbapenems are a classof beta-lactam antibioticswith very broad activity

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Lactam Antibiotics

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4

Most widel !rescribed

dr"#s

Penicillin Monobactams

$arbe!enems

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Penicillins

betalactamases

Ist generation cepalosporins

2ndgeneration cephalosporins

3rdgeneration cephalosporins

Extended spectrmbetalactamases

!- "actam Inhibitors # C$%&EPE'E()

%esistance

*

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BACTERIAL RESISTANCE

Even in presence of antimicrobials+ ifpathogenic microorganisms is mltiplying

treatment otcome is compromised,

his phenomenon is referred to as antimicrobial

resistance .$(%/,

0

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SURVIVAL OF THE FITTEST

%esistant bacteria srvive+ ssceptible ones die

(tant emergesslowly

)ensitive cellsilled by antibiotic

(tants progenyoverrn

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&ENETI$ 'I($HEMI$AL

E))L*+P*MPS

M(DI)I$ATI(N() TAR&ETSITES

$HR(M(S(MA

L

E+TRA

$HR(M(S(MAL

INA$TI,ATIN&EN-YMES

E#: /Lactamases

BACTERIAL RESISTANCE

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BACTERIAL RESISTANCE

0.&ENETI$

Chromosomal 5

Extrachromosomal5

Plasmids

C6'789$I6'

%$'):8CI6'

%$');6%($I6'

idime 2-(CP cefta>idim

e2-(CP

Enhancement of inhibition >one towards 2-(CP disc

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3

I(IPE'E(

Imipenem N&6%6'IC $CI:

&6%6'IC$CI: :I)C

E)

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(6"EC8"$% EC'IO8E)

)eGencing 3<

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NE9ER Dr"#sTi#eccline)os7omcinPolmin$olistin

4=

P%EBE'I6'

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P%EBE'I6'

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Hand was%in# still t%e best

o!tion to !re6ent s!read o7 $REand hygiene is aprimary part ofpreventing mltidrg-

resistant organism.(:%6/ transmission,

;acilities sholdensre thathealthcare personnel

are familiar with 42

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9e ma not be able to sto! t%eemer#ence o7 S"!er b"#s

b"t we $AN

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