Stem Cells Expertiseby Dior

260 LVMH Researchers

35 Years of research

For more than 35 years, Dior Skincare has made it its mission to enhance women’s beauty, by incorporating the latest scientific breakthroughs into exceptionally efficient and sensorial skincare products.

This cosmetic feat stems from the unique expertise and know-how of Dior Science –ever a pioneering force and at the forefront of innovation- in clo-se collaboration with more than 260 LVMH Researchers and renowned scientific partners. This merging of specialist knowledge allows Dior Skincare to reveal –as a preview in the cosmetic anti-ageing universe- the extraordi-nary power of stem cells*, the veritable creators of youthful skin.

Today, an original and innovative approach to beauty and time is opening the way to an entirely new era of cosmetic skin care.

Dior Anti-ageing Excellence

CONSTANTLY PUSHING BACK THE FRONTIERS OF PROGRESS

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Stem Cells*: Guardians of Life

CREATING FABULOUS HOPES IN REGENERATIVE MEDECINE

Constantly honing their expertise in the domain of skin and the preservation of its youth, Dior is the 1st cosmetics brand to investigate the territory of adult stem cells*.

If stem cells* create such hope and fascination, it is because these rare and precious natural gems contain a considerable power of renewal.The guardians of life, they are independently capable, from the initial em-bryonic stage of the stem cell*, of giving life to various, differentiated tissues of the organism (blood vessels, epidermis and neurons, etc.).

Today, stem cell* related technologies have emerged from the domain of science fiction thanks to lightning acceleration in scientific progress. They are now the vital force of cellular regeneration.Stem cells* could, therefore, be used to replace missing cells, or even to re-pair deficient organs, for example restoring sight to the blind, or even repai-ring burns without recourse to skin grafts. Such are the medical applications currently undergoing evaluation in research laboratories.

From thereon, the fascinating perspective of a new type of regenerative me-dicine unfolds, based on the implementation of long-awaited cellular thera-pies, whose initial advances were the building blocks of a major turning point in the current cosmetic anti-ageing universe. It is a turning point synonymous with new youthfulness.

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A Further Commitment to Stem Cells*

DIOR & STANFORD UNIVERSITY SCHOOL OF MEDECINE

Convinced from the start of the fabulous potential of stem cells*, and following the research carried out over the past 7 years by Professor Pincelli of the University of Modena in Italy, Dior Science is now going further in its commitment to adult stem cell* research, to constantly push back the limits of cosmetic progress and anti-ageing knowledge.

In 2007, Dior Science therefore decided to support research programs at Stanford University for Stem Cell Biology and Regenerative Medicine, one of the most prestigious American institutes, dedicated to the latest research in adult stem cells* and their applications in reparative medicine. With this exceptional partnership, Dior provides the most in-depth understanding of skin ageing, and Stanford offers its extraordinary breakthroughs in the field of regenerative medicine.

This unique commitment has allowed Dior to reveal a new power of within stem cells* and to further push back the frontiers of anti-ageing.

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A major discovery by Dior Science

S T E M C E L L S * , T H E F U T U R E O F A N T I - AG E I N G

Whereas an epidermal cell divides 2 or 3 times, each stem cell* is capable of giving birth to a dozen or so “daughter” cells, which themselves produce about a hundred cells at the origin of the construction of a young and healthy epidermis. It is this capacity to produce large “cells colonies” that has made their precise identification possible.Stem cells* are the guardians to the secrets of life and beauty, for they help the skin remain visibly young and beautiful longer.

2008 Dior Sc ience revea l s the fundamenta l ro le o f s tem ce l l s* in ep iderma l ce l l renewa l .

This discovery makes stem cells* Dior’s most complete breakthrough against aging. They are the real heart of youthfulness and beauty of the skin.

2011 Dior Science goes one step further in revolutionising the cosmetics world with a new discovery: the stem cell’s* sphere of influence is felt on surrounding cells.

Stem cells*, the Source of Global Youth

In addition to regenerating the epidermis, or upper layer of the skin, the ef-fect of stem cells* is also felt at a deeper level of the dermis, where the most difficult to repair signs of ageing form.Stem cells* are important producers of cellular messengers and growth fac-tors, destined to ensure their own growth, but which also act on all other surrounding cells in possession of adequate receptors. Among the growth factors, NGF (Nerve Growth Factor), is a messenger with a crucial role, as it has a 360° influence around the epidermal stem cells. Studies carried out by Dior have shown that one stem cell* produces 5,5 times more NGF than a simple keratinocyte.

Stem cells* are therefore much more than simple, new cell ‘factories’ within the epidermis. They behave as an active interface between the epidermis and the dermis, and therefore act as the ‘heart’ of the skin, for that is precisely where youthfulness originates.

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DERMIS*E

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Constantly pushing back the boundaries of anti-ageing

knowledge and moving resolutely into the field of future

cosmetic regeneration, this fundamental discovery has

made stem cells* the supreme weapon for Dior in

defying time and crossing the frontiers of a new anti-

ageing efficiency.

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A total revolution by Dior that will continue to dramatically change the world of cosmetic anti-ageing.