Cannabis Paper 12

8/16/2019 Cannabis Paper 12

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May 21 2014 20:15

_______________________________________________________________ VICERRECTORÍA ACADÉMICA. SISTEMA DE INFORMACIÓN Y BIBLIOTECAS

21 May 2014 ProQuest


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abla de contenido

1. Depression; Research reports on depression from University of British Columbia, Department of

Psychology provide new insights..................................................................................................................... 1

Bibliografía........................................................................................................................................................ 3

21 May 2014 ii ProQuest


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Documento 1 de 1

Depression; Research reports on depression from University of British Columbia, Department of

Psychology provide new insights

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Resumen Abstract): DEC 22 - (NewsRx.com) -- New investigation results, "Involvement of the

endocannabinoid system in the ability of long- term tricyclic antidepressant treatment to suppress stress-

induced activation of the hypothalamic-pituitary-adrenal axis," are detailed in a study published in

Neuropsychopharmacology.

Texto completo: 2006 DEC 22 - (NewsRx.com) -- New investigation results, "Involvement of the

endocannabinoid system in the ability of long- term tricyclic antidepressant treatment to suppress stress-

induced activation of the hypothalamic-pituitary-adrenal axis," are detailed in a study published in

Neuropsychopharmacology. According to recent research from Vancouver, Canada, "The efficacy of

antidepressants has been linked in part to their ability to reduce activity of the hypothalamic-pituitary-adrenal

(HPA) axis; however, the mechanism by which antidepressants regulate the HPA axis is largely unknown.

Given that recent research has demonstrated that endocannabinoids can regulate the HPA axis and exhibit

antidepressant potential, we examined the hypothesis that the endocannabinoid system is regulated by long-

term antidepressant treatment."

"Three-week administration of the tricyclic antidepressant desipramine (10 mg/kg/day) resulted in a significant

increase in the density of the cannabinoid CB(1) receptor in the hippocampus and hypothalamus, without

significantly altering endocannabinoid content in any brain structure examined. Furthermore, chronic

desipramine treatment resulted in a reduction in both secretion of corticosterone and the induction of the

immediate early gene c-fos in the medial dorsal parvocellular region of the paraventricular nucleus of the

hypothalamus (PVN) following a 5 min exposure to swim stress. Acute treatment with the CB(1) receptor antagonist, AM251 (1 mg/kg), before exposure to swim stress, completely occluded the ability of desipramine to

reduce both corticosterone secretion and induction of c-fos expression in the PVN," wrote M.N. Hill and

colleagues, University of British Columbia, Department of Psychology.

The researchers concluded: "Collectively, these data demonstrate that CB(1) receptor density in the

hippocampus and hypothalamus is increased by chronic tricyclic antidepressant treatment, and suggest that this

upregulation could contribute to the ability of tricyclic antidepressants to suppress stress-induced activation of

the HPA axis."

Hill and colleagues published their study in Neuropsychopharmacology (Involvement of the endocannabinoid

system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of thehypothalamic-pituitary- adrenal axis. Neuropsychopharmacology, 2006;31(12):2591-9).

For additional information, contact M.N. Hill, University of British Columbia, Dept. of Psychology, Vancouver,

BC, Canada.

Publisher contact information for the journal Neuropsychopharmacology is: Nature Publishing Group, Macmillan

Building, 4 Crinan St., London N1 9XW, England.

Keywords: Canada, Vancouver, Depression, Antidepressant, Neuropsychopharmacology, Therapy, Treatment.

This article was prepared by Drug Week editors from staff and other reports. Copyright 2006, Drug Week via

NewsRx.com.

Empresa/organización: Nombre: University of British Columbia; NAICS: 611310;

Título: Depression; Research reports on depression from University of British Columbia, Department of

Psychology provide new insights

21 May 2014 Page 1 of 3 ProQuest

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Título de publicación: Drug Week

Páginas: 55

Número de páginas: 0

Año de publicación: 2006

Fecha de publicación: Dec 22, 2006

Año: 2006

Editorial: NewsRx

Lugar de publicación: Atlanta

País de publicación: United States

Materia de publicación: Medical Sciences

ISSN: 15316440

Tipo de fuente: Trade Journals

Idioma de la publicación: English

Tipo de documento: Expanded Reporting

ID del documento de ProQuest: 206466592

URL del documento: http://search.proquest.com/docview/206466592?accountid=39719

Copyright: (c)Copyright 2006, Drug Week via NewsRx.com

Última actualización: 2010-06-07

Base de datos: ProQuest Health & Medical Complete


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Bibliografía

Citation style: APA 6th - American Psychological Association, 6th Edition

Depression; research reports on depression from university of british columbia, department of psychology

provide new insights. (2006). Drug Week, , 55. Retrieved from

http://search.proquest.com/docview/206466592?accountid=39719

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