Canine Respiratory disease - Amazon...
Transcript of Canine Respiratory disease - Amazon...
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Chumkee Aziz, DVMResident, UC-Davis
Canine Infectious Respiratory Disease Complex: Diagnosis & Treatment
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INTRODUCTION
Canine infectious respiratory disease complex (CIRDC) remains a persistent challengefor many shelters
Goals:• Identification & Recognition• Treatment & Management
• PREVENTION
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PATHOGEN ROLES
Primary Pathogens:
Bordetella bronchisepticaDistemper
Influenza (H3N8 & H3N2)Strep equi subsp zoo
Parainfluenza Adenovirus type-2
Unclear Role:
Respiratory CoronavirusMycoplasma spp.
PneumovirusHerpesvirus-1
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PATHOGENS:VIRUSESBACTERIA
HUSBANDRY FACTORS:CROWDING
STRESS SANITATION
VENITILATION/AIR QUAILTYHOUSING
HOST FACTORS:AGE
IMMUNE STATEDEBILITATION
STRESS
MULTIFACTORIAL ETIOLOGY
CIRDC
•Experimental infection with single pathogen* typically causes mild clinical signs
•Severe clinical disease, seen in natural outbreaks, cannot be reproduced
*CDV is exception
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DETECTION OF RESPIRATORY VIRUSES & BORDETELLA BRONCHISEPTICA IN DOGS WITH ACUTE RESPIRATORY TRACT INFECTIONS, 2014
Sampled 61 CIRDC & 90 healthy dogs Paraflu, Distemper, Resp corona, Adeno-2, H3N8, Herpes, & Bordetella Both owned & shelter dogs
Paraflu, Resp corona, & BordetellaMore frequently isolated in CIRDC dogs compared to healthy dogs
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TAKE HOME POINTS:
• Co-infections in• 48% of Brodetella positive dogs• 83% of paraflu positive dogs• 100% of resp corona positive dogs
•Healthy animals can be carriers• 1% positive for adeno-2• 8% positive for paraflu• 46% positive for Bordetella
• No pathogens found in 9 CIRDC dogs•False negatives? •Pathogen not included in panel
79% of CIRDC dogs had Bordetella - highest prevalence
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*H3N2 - NOVEL VIRUS MOST EXPOSED DOGS BECOME CLINICAL
Clinical Signs 80%
Non-Clinical20%
Exposed Dogs
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CIRDC CHARACTERISTICS
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TRANSMISSION
Respiratory secretions Fomites – STAFF! Direct contactAerosolization > 20 ft Environmental contamination
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TYPICAL DISEASE COURSE
•Typical incubation period: 2-3 d, up to 14 d•Exception: distemper •Flu: short incubation period at 2-5 d
•Variable duration of illness
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TYPICAL DISEASE COURSE
•Early shedding occurs for all pathogens monitoring is critical
•Shed for 7-10 days in respiratory secretions- H3N8 = sheds for 7 d post onset of clinical signs
*H3N2 = some shelter dogs shedding up to 18 d post onset of clinical signs
•Pre-clinical & post-recovery shedding occurs but is greatly reduced once clinical signs resolve
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DISEASE COURSE - DISTEMPER
Implications for: •Controlling spread
•When to test•What to advise adopters on
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RECOGNITION & IDENTIFICATION
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CLINICAL SIGNSTypical: coughing, sneezing, nasal discharge, mild fever
GOALS:- Prompt disease recognition
- When to do additional diagnostics & what to do with the results - Identify the outliers as quickly as possible
- Know when to get extra help
Distemper:Multi-systemic disease
Puppies & unvax adultsNot responding to tx
Influenza:Any age
Any health statusAny vaccine status
Can affect lower resp tract
Strep zoo:Can affect lower resp tractSevere signs w/rapid onset
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* H3N2 – READILY TRANSMITTED
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CLINICAL SIGNS
All CIRDC pathogens cause similar clinical signs cannot diagnose based on signs cannot always gage if an outlier is present
Clinical signs vary based on strain, host age/immune status, & co-infections mildly clinical dog could be shedding a severe pathogen
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WHY & WHEN TO DO DIAGNOSTIC TESTING
Purpose: to target treatment & control measures
Unusual clinical signs Increased morbidity/mortality During an outbreak Non-resolving signs in an individual animalMore concerns/complaints from new owners/community vets
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COMMON DIAGNOSTIC OPTIONS
PCR
Bacterial culture & sensitivity
Histopathology
Serology
-Indicates exposure not necessarily current infection
-Good for novel pathogen
Confirm that pathogen is on requested panel
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WHO TO TEST
Acutely affected (< 4 days of signs) & exposed dogs Prior to treatment Enough to reflect larger population10–30% of the population, at least 10
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HOW TO PCR TEST
•Change PPE between dogs
•Individually wrapped swabs
•Swab 2 different sites & place into one red top tube
•Takes at least 3 people
http://sheltermedicine.vetmed.ufl.edu/shelter-services/tools-tips-fact-sheets/
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REAL-TIME PCR PANEL
Best for acute infections
False negatives – transient/intermittent shedding
False positives – recent MLV vx, contamination
Must interpret in context of all infoDifficult to pinpoint single pathogen Positive does not imply disease causation Many pathogens found in healthy dogs
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*H3N2 – INTERMITTENT SHEDDING
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DISTEMPER PCR
•High sensitivity •False positives from recent MLV vax• IDEXX will differentiate between vax & wild type strains •Recombinant vx should NOT produce false positives
•Point-of-Care PCR available outside of U.S.
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NECROPSYCan directly identify presence & role of pathogens
Fresh, unfixed tissue submitted for PCR & culture/isolation
Obtain first before contamination Refrigerate for bacteria, freeze for virusesURT & lung samples
Histopathology samples
Formalin (10:1, formalin:tissue) Nasal sinus, trachea, lung, heart, hilar or thoracic inlet LNsGI, liver, kidney, spleen if systemic disease
Chapter 7, Infectious Disease Management in Animal Shelters, Miller and Hurley
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TREATMENT
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PROMPT RECOGNITION & ISOLATION
•Move into isolation as soon as clinical signs seen Importance of staff training
•Intensity of shedding does NOT correlate with severity or duration of signs
•Who should be moved?• Any animal with clinical signs • Deadly pathogens can cause mild signs in some animals
•Isolation period = pathogen shedding period
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*H3N2- PROLONGED SHEDDING REQUIRED PROLONGED ISOLATION
- Initial rec was 7 d isolation, then 14 d, but continued to see other dogs getting sick- Shedding can continue for at least 18 d post onset of clinical signs (avg 12-13 d)
- Viral load significantly decreases over time- Viability confirmed in long term shedder
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ISOLATION SPACE
• Separate building > same building, separate air flow > same building, restricted access (at least 25 ft distance)
• Easily disinfected with dedicated equipment
• Sufficient staffing for monitoring & care
• Ideally, separate staff w/ PPE • Full length gowns, booties, gloves
• Change clothes after handling affected animals
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TREATMENT RECOMMENDATIONS
Isolate
Antibiotic use is shelter, animal, & severity dependent
Most important
part!
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TREATMENT - PHARMACEUTICALS
Doxycycline 10m/kg PO SID x 7-10 dBest first choice antibiotic for run-of-the-mill CIRDC
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SUPPORTIVE CARE
Generally not recommended in shelter:GlucocorticoidsAntitussives Anti-viralsConvenia*
however in an adopted or foster home, consider specific supportive treatment
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TREATMENT –PRIMARY VS. SECONDARY BACTERIAL INFECTIONS
• Consider risk of bacterial bronchopneumonia• Ie. young puppies more at risk of progressive disease• If others have progressed to pneumonia
• Best choice for Bordetella is often different than best choice for secondary invaders• Antibiotic resistance is a reality culture & sensitivity
• Non-responsive to treatment (signs persist > 7-10d)• Outbreak
• Okay to combine -static w/ -cidal drug• Partially suppressed distemper?
• Severe pneumonia parenteral combination of a fluoroquinoloneand a penicillin or clindamycin
• Nebulization (+/- aminoglycoside)• Supplemental oxygen
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• Use effective drugs at appropriate doses• Choose realistic dosing schedules
• Start & stop treatment promptly• Re-evaluate treatment consistently• When switching, consider antibiotic spectrum • Monitor daily• Use shelter software to track
TREATMENT COURSE
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TREATMENT –MONITORING
• Record daily signs• Better or worse
• Importance of initializing
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TREATMENT – PREVENT COUGHING
•Maximize outdoor exposure
•Minimize irritants
•Minimize barking/excitement
•Minimize leash pulling
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TREATMENT – FOSTERING FOR MILD DISEASE
Requires disease transmission training
Designated area Separated from other pets Pets with rock-solid vaccination hxGood ventilationCalm, low traffic Easily disinfectedDedicated supplies
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OUTBREAK RESPONSE
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OUTBREAK RESPONSE
•Prompt isolation of sick dogs
reduces infectious dose in environment
•Clean break for un-exposed animals
•Consider points of common contact
•Communication
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Municipal shelter Annual intake ~11,000 (5,700 dogs) Live release ~ 67% (74% for dogs)
CIRDC OUTBREAK RESPONSE - CASE STUDY
• Clinical signs breaking at 2 weeks after intake• 3 cases progressed to pneumonia – 2 adults, 1 puppy
• 36 dogs currently being treated• Isolation ward is full, others being treated in gen. pop.
• Affected dogs in 50% of shelter wards• Not vaccinating for Bordetella bronchiseptica
• Tries to do DHPP vx on intake • Trying to increase LRR for harder adoption candidates
• How many dogs to PCR test?• When to test?
• Test nonclinical dogs?• Implement Bordetella vaccine? If so, which one?
• How to make a clean break?
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CASE STUDY – RISK FACTORS
Increased length of stay Over capacity; not using housing appropriately Not isolating clinical dogs Not using mucosal Bordetella or paraflu vaccine Not DHPP vaccinating unhandleable dogs on intake
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CASE STUDY – ISOLATION & BIOSECURITY
Designated multiple iso wards to separate affected dogs Doggy tetris = started moving all clinical dogs into “iso” wards
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CASE STUDY – DIAGNOSTICS:
IDEXX Canine Respiratory PCR Panel
10 samples Positive results:
2 – CRCoVAll 10 – Mycoplasma
5 - Pneumovirus
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CASE STUDY – TREATMENT
Started intranasal Bordetella, CPIV, CAV-2 vaccine Started doxycycline as soon as first signs are seen Switched to enrofloxacin after PCR results returned
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CASE STUDY - COMMUNICATION
Staff compliance - challengeStaff, volunteers, local practitioners, adopters
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CASE STUDY-CHANGES MADECont. to use Accel; new focus on drying surfaces
Sent home CIRDC info sheets
Allowed mild CIRDC cases to be adopted with surgical waiver; must make sx appt before leaving with new pet
Started a CIRDC foster program
Realization that response must be multifactorial
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RESOURCES:
www.sheltermedicine.comwww.sheltermedicine.vetmed.ufl.eduwww.animalsheltering.orgwww.maddiesinstitute.orgwww.sheltervet.orgwww.aspcapro.org
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REFERENCES
Buonavoglia C, Martella V. Canine respiratory viruses.Vet Res. 2007;38:355–373.
Chalker VJ1, Owen WM, Paterson C, Barker E, Brooks H, Rycroft AN, Brownlie J. Microbiology. Mycoplasmas associated with canine infectious respiratory disease. 2004 Oct;150(Pt 10):3491-7.
Davis R1, Jayappa H, Abdelmagid OY, Armstrong R, Sweeney D, Lehr C. Vet Ther. Comparison of the mucosal immune response in dogs vaccinated with either an intranasal avirulent live culture or a subcutaneous antigen extract vaccine of Bordetella bronchiseptica. 2007 Spring;8(1):32-40.
Erles K, Dubovi EJ, Brooks HW, Brownlie J. Longitudinal study of viruses associated with canine infectious respiratory disease. J Clin Microbiol. 2004;42:4524–4529.
Erles K., Brownlie J., Investigation into the causes of canine infectious respiratory disease: antibody responses to canine respiratory coronavirus and canine herpesvirus in two kennelled dog populations, Arch. Virol. (2005) 150:1493-1504
Crawford C. “Canine Respiratory Infections in Animal Shelters” http://sheltermedicine.vetmed.ufl.edu/files/2011/11/canine-respiratory-infections-in-
animal-shelters.pdf
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REFERENCES
Kawakami K, Ogawa H, Maeda K, et al. Nosocomial outbreak of serious canine infectious tracheobronchitis (kennel cough) caused by canine herpesvirus infection. J Clin Microbiol.2010;48:1176–1181.
Larson LJ, Henningson J, Sharp P,et al. Efficacy of the canine influenza virus H3N8 vaccine to decrease severity of clinical disease after co-challenge with canine influenza virus and Streptococcus equi subsp. zooepidemicus. Clin Vaccine Immunol. 2011;18(4):559–564.
Pesavento PA & BG Murphy. Common and Emerging Infectious Disease in the Animal Shelter. Vet Path. 2014:51:478-491.
Priestnall SL1, Mitchell JA, Walker CA, Erles K, Brownlie J. New and emerging pathogens in canine infectious respiratory disease. Vet Pathol. 2014 Mar;51(2):492-504. doi: 10.1177/0300985813511130. Epub 2013 Nov 14.
Schulz BS, S. Kurz, K. Weber, H.-J. Balzer, K. Hartmann, Detection of respiratory viruses and Bordetella bronchiseptica in dogs with acute respiratory tract infections, The Veterinary Journal (2014), doi: 10.1016/j.tvjl.2014.04.019
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REFERENCES
Schultz RD, P. Sharp, BE Thiel, LJ Larson. A Comparative Study of Protective Immunity Provided by Oral, Intranasal and Parenteral Canine Bordetella bronchiseptica Vaccines. Intern J Appl Res Vet Med. 2013; 11: 153-160. Sykes JE. “Canine and Feline Infectious Diseases” 2013 Weese JS, Stull J. Respiratory disease outbreak in a veterinary hospital
associated with canine parainfluenza virus infection. Can Vet J. 2013;54:79–82. Lila Miller, DVM and Kate Hurley, DVM, MPVM. Infectious Disease
Management In Animal Shelters. Wiley-Blackwell,2009. Birchard and Sherding. Saunders Manual of Small Animal Practice,2nd
Edition.Saunders,2000. http://www.sheltermedicine.com/shelter-health-portal/information-sheets
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CANINE INFLUENZA (H3N2)
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H3N2 - EPIDEMIOLOGY
2006-2007 emergence in Korea, China, Thailand Direct transfer from avian influenza likely
Korean reports of clinical signs and mortality in cats
No zoonosis reported
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H3N2 - CHICAGO OUTBREAKFirst cases identified in homes
Risk factors• Doggie daycare• Boarding
Initial respiratory panels = false negatives
UW & Cornell used broader primers to discover H3N2
IDEXX retrospective study on 884 submissions from March 2015 • 63 (7.1%) positive for H3N2 • 59 cases from Chicago area & 1 from each: IN, MI, WI, CA
Origin? • Although rumors have circulated that the virus was introduced to the U.S. through dogs
rescued and imported from Asia, there is no evidence to confirm these rumors. - AVMA
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H3N2 – SHELTER OUTBREAK CHARACTERISTICS
Novel virus most exposed dogs become clinical
Clinical signs Honking cough Mostly mild to moderate respiratory signs Some progression to pneumonia Handful of deaths
No cats clinically affected so far Clinical Signs80%
Non-Clinical20%
Exposed Dogs
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H3N2 – SHELTER OUTBREAK CHARACTERISTICS
Risk Factors: Early on: sharing adoption/training center with public animals Later on: brining in community dogs
Identification Higher rate of CIRDC Slightly more severe signs Spread of CIRDC very quickly ( 2-4 days) tidal wave
Incubation period: typically 2-4
Shedding period: up to 18 days?Weak positives early and late in disease course (diff from H3N8)
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H3N2 – READILY TRANSMITTED
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H3N2 - SHEDDING
- Initial rec was 7 day isolation, then 14 days, but continued to see other dogs getting sick- Shedding can continue for at least 18 days post clinical signs’ onset
- Viral load significantly decreases over time- Intermittent shedding
- Currently testing for viability
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H3N2 - TESTING
Acutely affected (<5 days)Cornell, UW, or IDEXX WVDL = same day turn around, $33/test for shelters Cornell + UW = place swabs into red top tube w/ 1mL saline
H3N2 positives average of 12-13 days
Not yet recommended to test in non-endemic areas even if dogs have CIRDC signsIn endemic area, yet unaffected still periodic surveillance
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H3N2 - PREVENTION
Prompt recognition
Isolation
Divert intake when possible Reduce exposure
Responsible movement of animals
Sanitation• Most disinfectants kill flu virus on
surfaces
• Shorted lived, reportedly: • 48 hours on surfaces• 24 hours on fabric • 12 hours on hands
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H3N2 – VACCINATION?
Commercially available: H3N8 killed vaccine
Anecdotal: handful of dogs that had been vaccinated against H3N8 have become ill with H3N2
Disadvantages: Unclear of cross immunity Killed vaccine longer time to onset of immunity Cost
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H3N2 – IMPACT ON SHELTERS
Very difficult to prevent - readily transmitted in shelter despite good biosecurity
Huge scale (200 dogs affected at one time in CACC)
Stopped live releases
Canceled fundraisers
Canceled community outreach
PetSmart Charities rerouted transfer ins
Exposure to staff pets
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H3N2 - ADOPTION/RESCUE RECS
Clinically healthy/exposed from affected facilityOkay to release from shelterQuarantine/separate for 7 days at least
Clinically ill from affected area/shelterOkay to release from shelter Isolate away from other dogs for 21 days from onset of clinical signs Or two negative PCR tests since
Do not travel to unaffected areas for 21 days (do not cross state line without a vet cert)
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H3N2 – ALTERNATIVES FOR BREAKING THE CYCLE
1. Divert intake completely No new intakes that can be exposed or can expose existent population
2. Establish a clean break PAWS: Newly intaken dogs are on a completely separate pathway Sick dogs upstairs New dogs on 1st floor
3. House new intakes with fully dogs that have fully recovered (21 days since onset of signs)