Cancer Prevention An Introduction to Toxicology · the discipline of toxicology 7 Illustrations...

Biomedicine springer.com/NEWSonline

26

S. Baltan, Cleveland Clinic Foundation, Cleveland, OH, USA; S. T. Carmichael, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; C. Matute, University of Pais Vasco (UPV/EHU), Leioa, Spain; G. Xi, University of Michigan Dept. Neurosurgery, Ann Arbor, MI, USA; J. H. Zhang, Loma Linda University Dept. Physiology, Loma Linda, CA, USA (Eds)

White Matter Injury in Stroke and CNS DiseaseContents White matter: Basic principles of axonal organiza-tion and function.- Electrophysiology evaluation of white matter injury.- CADASIL and animal models.- Neuroimaging of White Matter Injury: A Multimodal Approach to Vascular Disease.- Diffu-sion MRI Biomarkers of White Matter Damage in Traumatic Brain Injury.- Mechanisms underlying the selective vulnerability of developing white matter.- Neonatal experimental white matter injury.- Focal ischemic white matter injury in ex-perimental models.- Global ischemic white matter injury in patients.- Experimental global ischemia and white matter injury.- White Matter Injury after Experimental Intracerebral Hemorrhage.- White Matter Repair after Ischemic Injury.- White Matter Injury in Subarachnoid Hemorrhage in Humans.- Neurodegenerative diseases and white matter injury in patients.- Unmyelinated and myelinated axons exhibit differential injury and treatment response following traumatic brain injury.- Age-Dependent Mechanisms Of White Matter Injury After Stroke.- White matter damage in multiple sclerosis.- Calcium dyshomeostasis in white matter injury.- Inflammation and white mat-ter injury in animal models of ischemic stroke.- Oxidative stress in white matter injury.- Acute Axonal Injury in White Matter Stroke.- Mito-chondria disorder and white matter injury.- Heave metal and white matter injury. [...]

Fields of interestNeurosciences; Neurology; Neurobiology

Target groupsResearch

Product categoryContributed volume

Due November 2013

2014. XII, 696 p. 126 illus., 81 in color. (Springer Series in Translational Stroke Research, Volume 4) Hardcover7 * € (D) 181,89 | € (A) 186,99 | sFr 226,507 € 169,99 | £153.00ISBN 978-1-4614-9122-4

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A. M. Bode, Z. Dong, The Hormel Institute, Austin, MN, USA (Eds)

Cancer PreventionDietary Factors and Pharmacology

Contents Combining Computational and Experimental Methods for Identifying Molecular Targets of Phytochemicals.- Common Methods Used for the Discovery of Natural Anticancer Compounds.- Nrf2-Target Approaches in Cancer Chemopre-vention Mediated by Dietary Phytochemicals.- Methods to Analyze Chemopreventive Effect of Silibinin on Prostate Cancer Biomarkers Protein Expression.- An Approach to the Evaluation of Berries for Cancer Prevention with Emphasis on Esophageal Cancer.- The Use of Mouse Models for Lung Cancer Chemoprevention Studies.- The Azoxymethane Plus Dextran Sulfate Sodium-Induced Mouse Colon Cancer Model for the Study of Dietary Chemoprevention of Inflammation-Associated Carcinogenesis.- The Use of Seahorse Extracellular Flux Analyzer in Mechanistic Studies of Naturally-Occurring Cancer Chemo-preventive Agents.- Utilizing RNA-Seq to Define Phytochemical-Induced Alterations in Insulin and IGF Regulated Transcriptomes.- The Ex Vivo Use of Keratinocytes from Adult Mice to Define Stem Cell Activities in Cancer Research.- Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Al-cohol Consumption.- Imaging Tools in Discovery and Development of Phytochemical Chemopre-ventive Agents.- Designing the Chemoprevention Trials of Tomorrow: Applying Lessons Learned from Past Definitive Trials.

Fields of interestPharmacology/Toxicology; Oncology

Target groupsProfessional/practitioner


Due November 2013

2014. XV, 495 p. 46 illus., 32 in color. (Methods in Pharmacology and Toxicology) Hardcover7 * € (D) 101,64 | € (A) 104,49 | sFr 126,507 € 94,99 | £85.50ISBN 978-1-4614-9226-9

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P. C. Burcham, The University of Western Australia, Perth, WA, Australia

An Introduction to ToxicologyThis book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxic-ity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as di-verse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as sci-entists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents.

Features 7 A readable yet up-to-date volume to introduce the discipline of toxicology 7 Illustrations that “unpack” the concepts being discussed in the text 7 The author is an academic researcher with extensive teaching experience at undergraduate and graduate level

Contents The Emergence of Modern Toxicology.- Core Concepts in Toxicology.- Toxicokinetics - The Fate of Chemicals within the Body.- Toxicodynam-ics - How Chemicals Induce Toxicity.- Fightback - Adaptive Responses to Toxicant Exposure.- Tar-get Organ Toxicity: Liver and Kidney.- Chemical Toxicity to the Unborn.- Chemicals and Can-cer.- Everyday Toxicology I - Alcohol.- Everyday Toxicology II - Tobacco.

Fields of interestPharmacology/Toxicology; Molecular Medicine; Biomedicine general

Target groupsGraduate

Product categoryGraduate/Advanced undergraduate textbook

Due November 2013

2014. XII, 339 p. 94 illus., 1 in color. Hardcover7 * € (D) 74,89 | € (A) 76,99 | sFr 93,507 € 69,99 | £62.99ISBN 978-1-4471-5552-2

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www.springer.com/978-1-4614-9122-4



News 10/2013 Biomedicine

27

G. W. Caldwell, Z. Yan, Janssen Research & Development, LLC, Spring House, PA, USA (Eds)

Optimization in Drug DiscoveryIn Vitro Methods

Contents Small Molecule Formulation Screening Strategies in Drug Discovery.- Assessment of Drug Plasma Protein Binding in Drug Discovery.- Drug Parti-tion in Red Blood Cells.- Permeability Assessment Using 5-Day Cultured Caco-2 Cell Monolay-ers.- In Situ Single Pass Perfused Rat Intestinal Model.- Metabolic Stability Assessed by Liver Microsomes and Hepatocytes.- Metabolic Assess-ment in Alamethicin-Activated Liver Microsomes: Co-Activating CYPs and UGTs.- Phenotyping UDP-Glucuronosyltransferases (UGTs) Involved in Human Drug Metabolism: An Update.- In Vitro CYP/FMO Reaction Phenotyping.- Human Pregnane X Receptor (hPXR) Activation Assay in Stable Cell Lines.- Characterization of Constitu-tive Androstane Receptor (CAR) Activation.- DNA Binding (Gel Retardation Assay) Analysis for Identification of Aryl Hydrocarbon (Ah) Receptor Agonists and Antagonists.- Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators.- In Vitro CYP Induc-tion Using Human Hepatocytes.- Assessment of CYP3A4 Time-Dependent Inhibition in Plated and Suspended Human Hepatocytes.- Evaluation of Time-Dependent CYP3A4 Inhibition Using Human Hepatocytes.- Rapidly Distinguishing Re-versible and Time-Dependent CYP450 Inhibition Using Human Liver Microsomes, Co-Incubation, and Continuous Fluorometric Kinetic Analyses.- Identification of Time-Dependent CYP Inhibitors Using Human Liver Microsomes (HLM).- CYP Time-Dependent Inhibition (TDI) Using an IC50 Shift Assay with Stable Isotopic Labeled Substrate Probes to Facilitate Liquid Chromatography/Mass Spectrometry Analyses. [...]

Field of interestPharmacology/Toxicology



Due November 2013

2nd ed. 2014. X, 990 p. 105 illus., 46 in color. (Methods in Pharmacology and Toxicology) Hardcover7 * € (D) 133,74 | € (A) 137,49 | sFr 166,507 € 124,99 | £112.50ISBN 978-1-62703-741-9

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N. Daw, Branford, CT, USA

Visual DevelopmentThe only book on the market to cover the psycho-physics, anatomy, physiology, and clinical deficits of the developing visual system in an accessible format and length. The visual system is the most commonly studied aspect of the nervous system and is the primary model for the study of both normal development and the effects of environ-ment and sensory deprivation on development. This third edition highlights new research and features a large number of illustrations, many in color. It can be used as a supplementary text in neuroscience and ophthalmology courses. This book is a great resource for both novice and ad-vanced researchers in the field of vision.

Features 7 Wide, comprehensive coverage of an important area 7 Concise descriptions, without giving up the rigor of the scientific discussion 7 Handy reference for researchers experienced in one perspective of the visual system but not in all the perspectives presented

Contents Introduction.- Functional Organization of the Visual System.- Part I: Development of the Visual System.- Development of Visual Capabilities.- Anatomical Development of the Visual System.- Development of Receptive Field Properties.- Part II: Amblyopia and the Effects of Visual Depriva-tion.- Modifications to the Visual Input that lead to Nervous System changes.- Known Physiological and Anatomical changes from optical and motor deficits.- What is Amblyopia?.- Critical Periods.- Treatment of Amblyopia.- Part III: Mechanisms of Plasticity.- Concepts of Plasticity.- Mechanisms of Plasticity in the Visual Cortex.- Deprivation Myopia and Emmetropization.- Index.

Fields of interestNeurosciences; Ophthalmology; Biomedical Engineering


Product categoryMonograph

Due October 2013

3rd ed. 2013. XV, 325 p. 165 illus., 43 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-1-4614-9058-6

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N. Durán, Universidade Estadual de Campinas, Campinas, Brazil; S. S. Guterres, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; O. L. Alves, Universidade Estadual de Campinas, Campinas, Brazil (Eds)

NanotoxicologyMaterials, Methodologies, and Assessments

Foreword by: V. Zucolotto, University of Sao Paulo, Sao Carlos, Brazil

Contents Foreword.- Preface.- Chapter 1: Nanomateri-als.- Chapter 2: Concepts and Methodology of Interaction of Carbon Nanostructures with Cel-lular Systems.- Chapter 3: Nanostability.- Chapter 4: Pharmacokinetics and Phamacodynamics of Nanomaterials.- Chapter 5: In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines.- Chapter 6: Carbon Nanotubes: From Synthesis to Genotoxicity.- Chapter 7: From Combinato-rial Display Techniques to Microarray Technol-ogy: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedi-cines.- Chapter 8: Genetic Studies on the Effects of Nanomaterials.- Chapter 9: Cellular Mechanisms in Nanomaterial Internalization, Intracellular Traf-ficking and Toxicity.- Chapter 10: Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles.- Chap-ter 11: Cytotoxicity and Genotoxicity of Biogeni-cally Synthesized Silver Nanoparticles.- Chapter 12: Cytotoxicity and Genotoxicity of Iron Oxides Nanoparticles.- Chapter 13: Poloxamers as Drug-Delivery Systems: Physico-Chemical, Pharma-ceutical And Toxicological Aspects.- Chapter 14: Polymeric Nanoparticles: In Vivo Toxicological Evaluation, Cardiotoxicity and Hepatotoxicity.- Chapter 15: Cyto,Geno and Ecotoxicity of Copper Nanoparticles. [...]

Fields of interestPharmacology/Toxicology; Nanochemistry; Ecotoxicology



Due November 2013

2014. XV, 366 p. 41 illus., 17 in color. (Nanomedicine and Nanotoxicology) Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-8992-4

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J. Gómez Ramirez, Universidad Politécnica de Madrid, Madrid, Spain

A New Foundation for Representation in Cognitive and Brain ScienceCategory Theory and the Hippocampus

The purpose of the book is to advance in the understanding of brain function by defining a general framework for representation based on category theory. The idea is to bring this math-ematical formalism into the domain of neural representation of physical spaces, setting the basis for a theory of mental representation, able to relate empirical findings, uniting them into a sound theoretical corpus.

Features 7 It is a truly multidisciplinary book that provides interesting insights into mathematics, philosophy and neurobiology 7 The book estab-lishes a common working theoretical framework for mathematicians, philosophers and cognitive scientists 7 It is a unique opportunity for cogni-tive scientists to understand how the mathematical theory of category works

Contents Preface.- Research tools and paradigms.- State of the Art: Mathematical approaches in brain science.- The Categorical Imperative: Category theory in Cognitive and Brain Science.- Elemen-tary principles in cognitive systems modeling.- The shift towards structure.- A general framework for representation.- Towards a Theory of Brain Structure and Function.- A theory of hippocam-pus structure and function based on Category Theory.- From Cells to Memories. A Categorical Approach.- Epilogue.

Fields of interestNeurosciences; Category Theory, Homological Algebra; Philosophy (general)



Due November 2013

2014. X, 246 p. 73 illus., 40 in color. (Springer Series in Cognitive and Neural Systems, Volume 7) Hardcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-94-007-7737-8

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V. V. Gurevich, Vanderbilt University Medical Center, Nashville, TN, USA (Ed)

Arrestins - Pharmacology and Therapeutic PotentialFeatures 7 Discusses therapeutic potential of biased ligands of G protein-coupled receptors 7 De-scribes the molecular mechanisms and therapeu-tic implications of arrestin-mediated signal-ing 7 Discusses the potential of reengineered signaling proteins for gene therapy

Contents Therapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-inde-pendent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localiza-tion.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regula-tion of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.

Fields of interestPharmacology/Toxicology; Biochemistry, general; Protein Structure


Product categoryHandbook

Due November 2013

2014. X, 462 p. 53 illus., 42 in color. (Handbook of Experimental Pharmacology, Volume 219) Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-3-642-41198-4

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M. Hammarlund-Udenaes, Uppsala University Pharmacokinetics and Drug Therapy, Uppsala, Sweden; E. de Lange, Leiden University, Leiden, The Netherlands; R. Thorne, University of Wisconson, Madison, WI, USA (Eds)

Drug Delivery to the BrainPhysiological Concepts, Methodologies and Approaches

Contents Anatomy and physiology of the blood-brain bar-riers.- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharma-ceutical Relevance for Drug Delivery to the Brain.- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP).- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers.- Pharmacokinetic Concepts in Brain Drug Delivery.- In vitro models of blood-brain barriers.- In situ and in vivo animal models.- Principles of PET and its Role in Understanding Drug Delivery to the Brain.- PKPD Aspects of Brain Drug Delivery in a Translational Perspec-tive.- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution.- Prediction of Drug Exposure in the Brain from the Chemical Structure.- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions.- Pharmacoeconomic Considerations in CNS Drug Development.- In-tranasal Drug Delivery to the Brain.- Blood-To-Brain Drug Delivery using Nanocarriers.- Devel-opment of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors. [...]

Fields of interestPharmaceutical Sciences/Technology; Biomedi-cine general



Due November 2013

2014. XII, 852 p. 137 illus., 112 in color. (AAPS Advances in the Pharmaceutical Sciences Series, Volume 10) Hardcover7 * € (D) 181,89 | € (A) 186,99 | sFr 226,507 € 169,99 | £153.00ISBN 978-1-4614-9104-0

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Current Topics in Microbiology and ImmunologyM. D. Cooper, P. K. Vogt, Series editor: M. B. Oldstone, Y. Kawaoka, F. Melchers, K. Aktories, T. Honjo, R. W. Compans, B. Malissen, R. Rappuoli, J. E. Galan, Y. Y. Gleba

Volume 376H. Hilbi, Ludwig-Maximilians University München, Munich, Germany (Ed)

Molecular Mechanisms in Legionella PathogenesisContents From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts.- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors.- Facets of small RNA-mediated regulation in Legionella pneumophila.- Type II secretion and Legionella virulence.- Effector translocation by the Legionella Icm/Dot type IV secretion system.- Modulation of small GTPases by Legionella.- Host lipidation: A mechanism for spatial regulation of Legionella effectors.- Phosphoinositides and the Legionella pathogen vacuole.- Legionella phospholipases implicated in virulence.- Cytotoxic glucosyltrans-ferases of Legionella pneumophila.- Modulation of the ubiquitination machinery by Legionella.- Host signal transduction and protein kinases implicated in Legionella infection.- Mouse models of Legion-naires´ disease.

Fields of interestMedical Microbiology; Infectious Diseases; Mo-lecular Medicine



Due October 2013

2013. X, 295 p. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-40590-7

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P. Keohavong, University of Pittsburgh Dept. Environmental &, Pittsburgh, PA, USA; S. G. Grant, Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL, USA (Eds)

Molecular Toxicology ProtocolsContents Array-Based Immunoassays with Rolling-Circle Amplification Detection.- Analysis of Protein Changes Using Two Dimensional Difference Gel Electrophoresis.- Assessment of Pathological and Physiological Changes in Mouse Lung Through Bronchoalveolar Lavage.- Analysis of Clinical and Biological Samples Using Microsphere-Based Multiplexing Luminex System.- Detection of DNA Methylation by MeDIP and MBDCap Assays: An Overview of Techniques.- Screening of DNA Methylation Changes by Methylation-Sensitive Random Amplified Polymorphic DNA-Poly-merase Chain Reaction (MS-RAPD-PCR).- Strat-egies for Measurement of Biotransformation Enzyme Gene Expression.- Genotyping Technolo-gies: Application to Biotransformation Enzyme Genetic Polymorphism Screening.- TaqMan Fluorogenic Detection System to Analyze Gene Transcription in Autopsy Material.- 32P-Postla-belling Analysis of DNA Adducts.- Modification of the 32P-Postlabeling Method to Detect a Single Adduct Species as a Single Spot.- DNA Isolation and Sample Preparation for Quantitation of Ad-duct Levels by Accelerator Mass Spectrometry.- Analysis of DNA Strand Cleavage at Abasic Sites.- Premature Chromosome Condensation in Human Resting Peripheral Blood Lymphocytes without Mitogen Stimulation for Chromosome Aberra-tion Analysis Using Specific Whole Chromosome DNA Hybridization Probes.- Mutagen Sensitivity as Measured by Induced Chromatid Breakage as a Marker of Cancer Risk.- Pulsed-Field Gel Electro-phoresis Analysis of Multicellular DNA Double-Strand Break Damage and Repair. [...]

Fields of interestPharmacology/Toxicology; Human Genetics



Due February 2014

2nd ed. 2014. 620 p. 105 illus., 25 in color. (Methods in Molecular Biology, Volume 1105) Hardcover7 * € (D) 133,74 | € (A) 137,49 | sFr 166,507 € 124,99 | £112.50ISBN 978-1-62703-738-9

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F. Kiefer, Max Planck Institute for Molecular Biome, Münster, Germany; S. Stefan, Hubrecht Institute Development Biology, Utrecht, The Netherlands (Eds)

Developmental Aspects of the Lymphatic Vascular SystemContents Introduction by Friedemann Kiefer.- Transcrip-tional control of lymphatic endothelial cell type specification by Ying Yang and Guliermo Oliver.- Mechanosensing in developing lymphatic vessels by Lara Planas-Paz and Eckard Lammert.- Plas-ticity of airway lymphatics in development and disease by Li-Chin Yao and Donald M. McDon-ald.- Regulation of lymphatic vasculature by extra-cellular matrix by Sophie Lutter and Taija Makki-nen.- Interplay of mechanotransduction, FOXC2, connexins and calcineurin signaling in lymphatic valve formation by Amélie Sabine and Tatiana V. Petrova.- Development of secondary lymphoid or-gans in relation to lymphatic vasculature by Serge A. van de Pavert and Reina Mebius.- Platelets in lymph vessel development and integrity by Steve P. Watson, Kate Lowe and Brenda A. Finney.- In-teractions of immune cells and lymphatic vessels by Raghu P. Kataru, Yulia G. Lee and Gou-Young Koh.- Lymphatic vessels in the development of tissue and organ rejection by Denis Hos and Claus Cursiefen.- The role of neuropilin-1 / semaphorin 3A signaling in lymphatic vessel development and maturation by Alexandra M. Ochsenbein, Sinem Karaman, Giorgia Jurisic and Michael Detmar.- A fisheye view on lymphangiogenesis by Andreas van Impel and Stefan Schulte-Merker.- Visualiza-tion of lymphatic vessel development, growth and function by Cathrin Pollmann, René Hägerling, and Friedemann Kiefer.- Clinical disorders of primary malfunctioning of the lymphatic system by Carlo Bellini and Raoul C.M. Hennekam.- Sub-ject index.

Fields of interestHuman Physiology; Cell Biology; Immunology



Due December 2013

2014. X, 201 p. 27 illus. in color. (Advances in Anatomy, Embryology and Cell Biology, Volume 214) Softcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-7091-1645-6

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30

C. Köppl, G. A. Manley, Carl von Ossietzky University, Oldenburg, Germany; A. N. Popper, University of Maryland, College Park, MD, USA; R. R. Fay, Falmouth, MA, USA (Eds)

Insights from Comparative Hearing ResearchFeatures 7 Highlights significant recent developments in auditory research achieved through the use of non-standard animal species 7 Showcases a diversity of experimental approaches in auditory research 7 The first broad compilation of such models in decades

Contents Unique Contributions from Comparative Audi-tory Research.- Transduction and Amplification in the Ear: Insights from Insects.- Roles for Prestin in Harnessing the Basilar Membrane to the Organ of Corti.- Origin and development of hair-cell orientation in the inner ear.- The Remarkable Ear of Geckos and Pygopods.- Ultrasound Detection in Fishes and Frogs: Discovery and Mechanisms.- The Malleable Middle Ear: an Underappreciated Player in the Evolution of Hearing in Vertebrates.- Auditory Brainstem Processing in Reptiles and Amphibians: Roles of Coupled Ears.- Modern Imaging Techniques as a Window to Prehistoric Auditory Worlds.- Emu and Kiwi: The Ear and Hearing in Paleognathous Birds.- Diversity in Hearing in Fishes: Ecoacoustical, Communicative, and Developmental Constraints.- Reptile Auditory Neuroethology: What do Reptiles do with Their Hearing?.- Advances in Understanding the Audi-tory Brain of Songbirds.

Fields of interestNeurosciences; Neurobiology; Otorhinolaryngol-ogy



Due January 2014

2014. Approx. 300 p. 175 illus., 75 in color. (Springer Handbook of Auditory Research, Volume 49) Hardcover7 approx. * € (D) 112,34 | € (A) 115,49 | sFr 137,507 approx. € 104,99 | £93.00ISBN 978-1-4614-9076-0

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Y. L. Lian, I. Vythilingam, University of Malaya Faculty of Medicine, Kuala Lumpur, Malaysia (Eds)

Parasites and their vectorsA special focus on Southeast Asia

Although countries in the Southeast Asian region are relatively similar in their climate, culture, politics and economics, there are many gaps of knowledge in terms of disease patterns, transmis-sion dynamics and vectors. This book highlights parasitic diseases that are peculiar to Southeast Asia and new emerging problems in relation to parasitic diseases. It provides an up-to-date over-view to the current knowledge about parasites and their respective vectors in this specific geographic region. The authors of the individual chapters have years of experience working in their respective areas and an excellent overview of what is hap-pening in the ground and ways to improve public health measures which is clearly reflected in the respective contributions.

Features 7 Includes specific regional information about parasites and their vectors in Southeast Asia 7 Comprehensive information on the topic 7 Up-to-date knowledge with regional recommendations

Contents Background information on Southeast Asia region.- Entamoeba.- Giardia and Cryptospo-ridium.- Blastocystis.- Soil transmitted helmin-thes.- Free living amoeba .- Toxoplasma and Sarcocystis.- Plasmodium.- Filarial worm.- Vec-tors for malaria and filariasis.- Future prospect of the application of advanced tools.

Fields of interestParasitology; Infectious Diseases



Due January 2014

2014. Approx. 150 p. 20 illus. in color. Hardcover7 * € (D) 106,99 | € (A) 109,99 | sFr 133,507 € 99,99 | £90.00ISBN 978-3-7091-1552-7

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S. F. Martin, University Medical Center Freiburg, Freiburg, Germany (Ed)

T Lymphocytes as Tools in Diagnostics and ImmunotoxicologyThis book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and re-place animal testing in research and immunotoxi-cology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respi-ratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.

Features 7 Alternative assays for the detection of contact allergens and drug metabolites 7 Summarizes the state-of-the art 7 Written by experts in the field

Fields of interestMolecular Medicine; Immunology; Laboratory Medicine



Due November 2013

2014. X, 190 p. 27 illus., 21 in color. (Experientia Supplementum, Volume 104) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-0348-0725-8

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31

G. Melillo, Bristol-Myers Squibb, Princeton, NJ, USA (Ed)

Hypoxia and CancerBiological Implications and Therapeutic Opportunities

The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype.

Features 7 Features comprehensive and systematic analysis of biological and therapeutic targets as-sociated with intra-tumor hypoxia 7 Focuses on translational aspects associated with intra-tumor hypoxia 7 Explores the opportunities for drug development offered by this unique feature of the tumor microenvironments

Contents Preface.- Hypoxia and breast cancer metastasis.- Hypoxia and the DNA damage response.- Hypoxia and non-coding RNAs.- Hypoxia and ROS.- Hy-poxia and gene expression.- Carbonic anhy-drase IX: from biology to therapy.- Imaging the hypoxic tumor microenvironment in preclinical models.- Clinical imaging of hypoxia.- Hypoxia, antiangiogenic therapy and metastasis.- UPR and therapeutic opportunities.- Targeting the hypoxic phenotype.- Marianne Nordsmark: Hypoxia and Radiation therapy.- Pharmacological strategies targeting hypoxia.- Targeting the hypoxic tumor microenvironment.- Clinical exploitation of hypoxia.- Index.

Fields of interestCancer Research; Molecular Medicine; Pharma-cology/Toxicology



Due November 2013

2014. I, 541 p. 53 illus., 36 in color. (Cancer Drug Discovery and Development) Hardcover7 * € (D) 160,49 | € (A) 164,99 | sFr 200,007 € 149,99 | £135.00ISBN 978-1-4614-9166-8

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D. Mochly-Rosen, K. Grimes, Stanford University School of Medicine, , CA, USA (Eds)

A Practical Guide to Drug Development in AcademiaThe SPARK Approach

Contents Advancing New Treatments to the Clinic within Academia.- Overview of Drug Discovery and Development.- Assessing Clinical Need.- Target Product Profile (TPP).- Project Management and Project Planning.- Robustness of Preclinical Studies.- Repurposing Drugs.- Developing Assays for High Throughput Screening (HTS).- Medici-nal Chemistry and Lead Optimization.- Vaccine Development.- When to Begin Animal Stud-ies.- In vivo pharmacology: Multiple Roles in Drug Discovery.- Pharmacokinetics and ADME Properties.- Route of Administration and Drug Formulation.- Preclinical Safety Studies.- Regula-tory Considerations in Product Development.- Manufacturing and Quality Control.- Technical Development and Manufacturing of Biological Products.- Clinical Trial Design.- Overview of Clinical Trials.- Intellectual Property.- Working with the University Technology Transfer Office.- Avoiding Conflicts of Interest.- Working with the University Compliance Office.- Selecting the Mar-ket for Your Drug.- Commercial Assessments.- Making a Compelling Pitch to Potential Inves-tors.- Venture Capital Funding.- Not-For-Profit Drug Development.- Legal Aspects of a Start-up Biotechnology Company.- Founder Preferred Stock.- Plan, Organize, Motivate and Control.- A Call to Action: Changing How We Pursue Drug Discovery and Development.

Field of interestPharmaceutical Sciences/Technology


Product categoryBrief

Due October 2013

2014. X, 158 p. 9 illus., 3 in color. (SpringerBriefs in Pharmaceutical Science & Drug Development) Softcover7 * € (D) 53,49 | € (A) 54,99 | sFr 67,007 € 49,99 | £44.99ISBN 978-3-319-02200-0

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Y. Nagai, CRNID, RIKEN, Tokyo, Japan (Ed)

Sendai Virus VectorAdvantages and Applications

Features 7 Comprehensively reviews the development of SeV vector, a multipurpose cytoplasmic (non-integrating) RNA vector with extremely high performance 7 Describes advanced devices such as transmissibilty-deficient or replication-incom-petent safer versions and a “footprint (transgene) free” expression system 7 Illustrates diverse applications with high medical impact

Contents 1. Reverse genetics of Mononegavirales: the rabies virus paradigm Karl-Klaus Conzelmann.- 2. Sendai virus biology and engineering leading up to the development of a novel class of expression vector Yoshiyuki Nagai and Atsushi Kato.- 3. Concept and technology underlying Sendai virus (SeV) vector development Akihiro Iida and Makoto Inoue.- 4. Roadmap for development of a replication-deficient Sendai virus vaccine vector (provisional) Marian Wiegand and Wolfgang Neubert.- 5. Development of vaccines using SeV vectors against AIDS and other infectious diseases Sayuri Seki and Tetsuro Matano.- 6. BioKnife, a modified Sendai virus, to resect malignant tomorsYoshikazu Yonemitsu, Yasuji Ueda and Mamoru Hasegawa.- 7. Induction of human pluripotent stem cells by the Sendai virus vector:Establishment of a highly efficient and foot-print free system Noemi Fusaki and Hiroshi Ban.- 8. Gene therapy for peripheral arterial disease using Sendai virus vector: From preclinical Studies to the phase I/IIa clinical trial Yoshikazu Yonemitsu, Takuya Matsumoto and Yoshihiko Maehara.

Fields of interestVirology; Gene Therapy; Gene Expression



Due November 2013

2014. XII, 248 p. 33 illus., 17 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-4-431-54555-2

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V. Nägerl, University of Bordeaux, Bordeaux, France; A. Triller, Ecole Normale Supérieure, Paris, France (Eds)

Nanoscale Imaging of SynapsesNew Opportunities and Concepts

Synapses underlie rapid and flexible neural com-munication in the brain and they hold the key to understanding higher brain functions in health and disease.

Features 7 Timeliness – Superresolution methods are beginning to transform neurobiological re-search 7 Relevance – Progress in synapse research hinges on advances in superresolution imaging 7 Competence – Chapters are written by leading innovators and practitioners in the field of bioimaging

Contents Preface.- Nanoscale imaging of protein molecules at the postsynaptic densit.- Electron tomography for the study of synaptic ultrastructure in fixed brain sections.- Time-resolved electron micros-copy: coupling optogenetics with high-pressure freezing.- Investigating AMPA receptors diffusion and nanoscale organization at synapses with high density single molecule tracking methods.- Vi-sualising the ultra-structures and dynamics of synapses by single molecule nanoscopy.- Live-cell PALM of intracellular proteins in neurons.- Mon-itoring nanoscale mobility of small molecules with time-resolved fluorescence anisotropy imaging.- Imaging signalling transduction in single dendritic spines.- Imaging-based measures of synaptic tenacity.- Zooming in on the (peri)synaptic extracellular matrix.- Two-photon STED microscopy for imaging synapses and glia in acute brain slices.- Index.

Fields of interestNeurosciences; Neurobiology; Imaging / Radiol-ogy



Due December 2013

2014. Approx. 250 p. (Neuromethods, Volume 84) Hardcover7 approx. * € (D) 149,79 | € (A) 153,99 | sFr 186,507 approx. € 139,99 | £126.00ISBN 978-1-4614-9178-1

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L. Nguyen, University of Liège, Liège, Belgium; S. Hippenmeyer, Institute of Science and Technology Austria, Klosterneuburg, Austria (Eds)

Cellular and Molecular Control of Neuronal MigrationCellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain.

Features 7 Contains numerous illustrations that help the reader to understand concepts 7 Contains supplementary material including movies as well as all figures in PowerPoint format useful for teaching 7 Is the most comprehensive publica-tion in the field of neuron migration and neurobi-ology in general

Contents Preface.- Molecular Pathways Controlling the Se-quential Steps of Cortical Neuron Migration.- The Dynamics of Neuronal Migration.- The Impact of JNK on Neuronal Migration.- Novel Functions of Core Cell Cycle Regulators in Neuronal Migra-tion.- Microtubules and Neurodevelopmental Disease: The Movers and the Makers.- Mark/Par-1 Marking the Polarity of Migrating Neu-rons.- The PAR Polarity Complex and Cerebellar Granule Neuron Migration.- Spinal Motor Neuron Migration and the Significance of Topographic Organization in the Nervous System.- Extracel-lular Signals Controlling Neuroblast Migration in the Postnatal Brain.

Fields of interestNeurosciences; Neurobiology; Anatomy



Due November 2013

2014. VI, 173 p. 43 illus., 42 in color. (Advances in Experimental Medicine and Biology, Volume 800) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-007-7686-9

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M. F. Ochs, The College of New Jersey, Ewing, NJ, USA (Ed)

Gene Function AnalysisContents The Present State and Future Direction of Integrated Gene Function Analysis.- Perform-ing Integrative Functional Genomics Analysis in GeneWeaver.org.- Functional Annotation of Dif-ferentially Regulated Geneset Using WebGestalt: A Geneset Predictive of Response to Ipilimumab in Tumor Biopsies.- Integrative Data-Mining Tools to Link Fene and Function.- Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large Scale Transcriptome-Interactome Integra-tion.- Pattern Identification in Time Course Gene Expression Data with the CoGAPS Matrix Factorization.- Statistical Tools and R Software for Cancer Driver Probabilities.- Predicting the Func-tional Consequences of Somatic Missense Muta-tions Found in Tumors.- Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells.- Reverse Engineering Transcriptional Gene Network.- Integrating In Silico Resources to Map a Signaling Network.- A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using Pogostick.- Con-struction and Application of Site-specific Artificial Nucleases for Targeted Gene Editing.- Selection of Recombinant Antibodies from Antibody Gene Libraries.- Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Se-quences from Mammalian Genes.- Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination.- In Ovo Electroporation of miRNA-Based Plasmids to Investigate Gene Function in the Developing Neural Tube.- Proteomic Strategies: SILAC and 2D-DIGE - Powerful Tool to Investigate Cellular Alterations. [...]

Fields of interestHuman Genetics; Gene Function



Due November 2013

2nd ed. 2014. X, 458 p. 109 illus., 85 in color. (Methods in Molecular Biology, Volume 1101) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-720-4

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Current Topics in Microbiology and ImmunologyM. D. Cooper, P. K. Vogt, Series editor: M. B. Oldstone, Y. Kawaoka, F. Melchers, K. Aktories, T. Honjo, R. W. Compans, B. Malissen, R. Rappuoli, J. E. Galan, Y. Y. Gleba

Volume 375K. E. Palmer, University of Louisville, Owensboro, KY, USA; Y. Gleba, Icon Genetics GmbH, Halle, Germany (Eds)

Plant Viral VectorsContents Preface.- A personal history of virus-based vector construction by William O. Dawson.- Virus-de-rived ssDNA vectors for the expression of foreign proteins in plants by Edward P. Rybicki and Darrin P. Martin.- Plant Viral Epitope Display Systems for Vaccine Development by Denis Leclerc.- Ap-plications of plant viruses in bionanotechnology by George P. Lomonossoff and David J. Evans.- Milestones in the development and applications of plant virus vector as gene silencing platforms.- by Christophe Lacomme.- Emerging Antibody-based Products by Kevin J. Whaley, Josh Morton, Steve Hume, Ernie Hiatt, Barry Bratcher, Victor Klimyuk, Andrew Hiatt, Michael Pauly, and Larry Zeitlin.- Production of Recombinant Antigens and Antibodies in Nicotiana benthamiana Using ‘mag-nifection’ Technology: GMP-Compliant Facilities for Small-and Large-Scale Manufacturing by Victor Klimyuk, Gregory Pogue, Stefan Herz, John Butler, and Hugh Haydon.- Plant viral vectors for delivery by Agrobacterium by Yuri Y. Gleba, Dan-iel Tusé and Anatoli Giritch.- Subject index.

Fields of interestVirology; Vaccine


Product categoryHandbook

Due October 2013

2013. X, 194 p. 33 illus., 19 in color. Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-40828-1

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A. N. Popper, University of Maryland, College Park, MD, USA; R. R. Fay, Falmouth, MA, USA (Eds)

Perspectives on Auditory ResearchContents A Brief History of SHAR.- Structures, Mecha-nisms, and Energetics in Temporal Processing.- The Human Auditory Cortex: In Search of the Flying Dutchman.- From Cajal to the Connec-tome: Building a Neuroanatomical Framework for Understanding the Auditory System.- Record-ing from Hair Cells.- Three Decades of Tinnitus Related Research.- The Sense of Hearing in Fishes.- A Quarter-Century’s Perspective on a Psy-choacoustical Approach to Loudness.- Nonsyn-dromic Deafness: It Ain’t Necessarily So.- Evolving Mechanosensory Hair Cells to Hearing Organs by Altering Genes and Their Expression.- The Impli-cations of Discharge Regularity - My Forty-Year Peek into the Vestibular System.- Aging, Hearing Loss and Speech Recognition: Stop Shouting, I Can’t Understand You.- Cochlear Mechanics, Otoacoustic Emissions and Medial Olivocochlear Efferents: 20 Years of Advances and Controversies Along with Areas Ripe for New Work.- Examin-ing Fish in the Sea: A European Perspective on Fish Hearing Experiments.- The Behavioral Study of Mammalian Hearing.- Hearing in Insects: The Why, When, and How.- The Cognitive Auditory System.- Fundamentals of Hearing in Amniote Vertebrate.- Directional Hearing in Insects and Other Small Animals: The Physics of Pressure-Dif-ference Receiving Ears.- Cortical Representation of Sound Locations: Distributed Representation by Magnitude and Timing of Neural Spike Pat-terns.- Mechanisms Underlying the Pitch of Pure and Complex Tones.- Unavoidably Delayed: A Personal Perspective of Twenty Years of Research on a Sound Localization Cue. [...]

Fields of interestNeurosciences; Otorhinolaryngology; Neurobiol-ogy



Due January 2014

2014. Approx. 300 p. 175 illus., 75 in color. (Springer Handbook of Auditory Research, Volume 50) Hardcover7 approx. * € (D) 112,30 | € (A) 115,45 | sFr 148,007 approx. € 104,95 | £93.00ISBN 978-1-4614-9101-9

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W. E. Müller, Universität Mainz Inst. Physiologische Chemie, Mainz, Germany; H. Schröder, NanotecMARIN GmbH, Mainz, Germany (Eds)

Biomedical Inorganic PolymersBioactivity and Applications of Natural and Synthetic Polymeric Inorganic Molecules

In recent years, inorganic polymers have attracted much attention in nano-biomedicine, in particular in the area of regenerative medicine and drug de-livery. This growing interest in inorganic polymers has been further accelerated by the development of new synthetic and analytical methods in the field of nanotechnology and nanochemistry.

Features 7 Summarizes the state-of-the art in this rapidly growing field 7 Comprehensively reviews the potential biomedical applications of inorganic polymers 7 Written by eminent experts

Contents Chemical, biochemical and biological behaviors of vanadate and its oligomers.- Structural Charac-terization of Inorganic Biomaterials.- Enzymes of Inorganic Polyphosphate Metabolism.- Poly-oxometalates Active against Tumors, Viruses, and Bacteria.- Modeling Biosilicification at Subcellular Scales.- Cell reactivity to different silica.- Bioactive Poly(arsenic) Compounds.- Biogenic inorganic polysilicates (bio-silica): formation and biomedi-cal applications.- Inorganic polymers: Morpho-genic inorganic biopolymers for rapid prototyping chain.- Inorganic polyphosphates: biologically active biopolymers for biomedical applications.

Fields of interestMolecular Medicine; Medical Biochemistry; Bio-chemistry, general



Due November 2013

2014. IV, 269 p. 90 illus., 50 in color. (Progress in Molecular and Subcellular Biology, Volume 54) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-3-642-41003-1

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U. Storz, Michalski Huettermann & Partner Patent Attorneys, Duesseldorf, Germany; M. Quodbach, Cornelius Bartenbach Haesemann and Partners (CBH), Cologne, Germany; S. D. Marty, Ballard Spahr LLP, Atlanta, GA, USA

Biopatent Law: European vs. US Patent LawSpringerBriefs in Biotech Patents presents timely reports on intellectual properties (IP) issues and patent aspects in the field of biotechnology. This volume focus on particular aspects of the US pat-ent law, which can have tremendous differences compared to the European law. This includes ques-tions of biopatent prosecution, novelty, inventive step, written disclosure and sufficiency of enable-ment as well as questions of law enforcement of biotech patents.

Features 7 Addresses currently debated issues concern-ing biotechnological inventions 7 Written by internationally active experts 7 Provides a basis for understanding biotech patentability

Contents Preface.- Ulrich Storz: Patentability Require-ments of Biotech Patents.- Martin Quodbach: Law Enforcement of Biotech Patents.- Scott Marty: Particular: Aspects of US Patent Law in Biotech-nologies.- About the Authors.

Fields of interestMolecular Medicine; International IT and Media Law, Intellectual Property Law; Biochemistry, general


Product categoryBrief

Due November 2013

2014. VI, 86 p. 7 illus., 5 in color. (SpringerBriefs in Biotech Patents) Softcover7 * € (D) 53,45 | € (A) 54,95 | sFr 66,507 € 49,95 | £44.99ISBN 978-3-642-41292-9

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J. G. Taylor, University of London, London, UK

Solving the Mind-Body Problem by the CODAM Neural Model of Consciousness?Contents Preface.- The Story of Consciousness.- The Search for Consciousness in the Brain.- Attention and Consciousness: Fused or Independent?.- Past & Current Neural Models of Consciousness.- The Control Nature of Attention.- The Full CODAM Model.- The Owner and CODAM.- Does I Really Exist?.- Does the Corollary Discharge of Attention Exist?.- Understanding Mental Diseases.- The Escape from Life through Meditation.- The Evolution of Human Consciousness.- Animal Consciousness.- Understanding Consciousness and Emotions.- Solving the Mind-Body Problem through CODAM.- Is there Free Will in CO-DAM?.- Beyond Consciousness?

Fields of interestNeurosciences; Evolutionary Biology; Simulation and Modeling



Due November 2013

2014. X, 240 p. 28 illus., 16 in color. (Springer Series in Cognitive and Neural Systems, Volume 9) Hardcover7 * € (D) 149,79 | € (A) 153,99 | sFr 186,507 € 139,99 | £126.00ISBN 978-94-007-7644-9

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I. F. Uchegbu, University of London School of Pharmacy, , UK; A. Schätzlein, University College London School of Pharmacy, , UK; W. P. Cheng, Bexleyheath, UK; A. Lalatsa, Edgware, UK (Eds)

Fundamentals of Pharmaceutical NanoscienceNanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery.

Features 7 Provides sections on problem sets, case studies, and reading assignments 7 Includes Q&A and Test Your Knowledge sections 7 Contains a multiple choice section

Contents Nanoscience and nanotechnology overview.- Li-posome preparation and characterization.- Solid polymeric nanoparticles.- Lipid nanoparticles.- Polymeric vesicles.- Low molecular weight amphiphile micelles.- Polymeric micelles.- Nio-somes.- Quantum dots.- Magnetic particles.- Drug nanoparticles.- Polymeric pro-drugs.- Therapeutic Applications of pharmaceutical nanosystems.- Drug solubilisation.- Gene therapy.- Chemo-therapy.- Tissue engineering.- Anti-infectives.- Vaccination.- Anti-arthritic drugs.- Imaging agents.- Commercial exploitation of pharmaceuti-cal nanosystems.- Future perspectives.- Multiple Choice.- Problem Sets.- Case Studies.- Suggested Reading.

Fields of interestPharmacology/Toxicology; Pharmacy; Nanotech-nology

Target groupsGraduate

Product categoryGraduate/Advanced undergraduate textbook

Due November 2013

2014. XXI, 666 p. 154 illus., 98 in color. Hardcover7 * € (D) 96,29 | € (A) 98,99 | sFr 120,007 € 89,99 | £81.00ISBN 978-1-4614-9163-7

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M. Yousef, Dabburiya Village, , Israel; J. Allmer, Ismir Institute of Technology, Izmir, Turkey (Eds)

miRNomics: MicroRNA Biology and Computational AnalysisFeatures 7 Presents clear methods, accessible to the entire biology community 7 Examines methods to predict small non-coding RNA based on se-quence 7 Includes tips from the experts on how best to implement the techniques

Contents Introduction to MicroRNAs in Biological Systems.- The Role of MicroRNA‘s in Biological Processes.- The Role of MicroRNAs in Human Diseases.- Introduction to Bioinformatics.- Mi-croRNA and Non-Coding RNA Related Date Sources.- High Throughput Approaches for MicroRNA Expression Analysis.- Introduction to Machine Learning.- Introduction to Statistical Methods for MicroRNA Analysis.- Computational Bioinformatics Methods for MicroRNA Gene Prediction.- Machine Learning Methods for Mi-croRNA Gene Prediction.- Functional, Structural, and Sequence Studies of MicroRNA.- Computa-tional Methods for MicroRNA Target Prediction.- MicroRNA Target and Gene Validation in Viruses and Bacteria.- Gene Reporter Assay to Validate MicroRNA Targets in Drosophila S2 Cells.- Com-putational Prediction of MicroRNA Function and Activity.- Analysis of MicroRNA Expression using Machine Learning.- MicroRNA Expression Land-scapes in Stem Cells, Tissues, and Cancer.- Master Regulators of Post-Transcriptional Gene Expres-sion are Subject to Regulation.- Use of MicroRNAs in Personalized Medicine.

Fields of interestHuman Genetics; Gene Function



Due December 2013

2014. 320 p. 80 illus., 1 in color. (Methods in Molecular Biology, Volume 1107) Hardcover7 * € (D) 117,69 | € (A) 120,99 | sFr 146,507 € 109,99 | £99.00ISBN 978-1-62703-747-1

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Cancer Prevention An Introduction to Toxicology · the discipline of toxicology 7 Illustrations...

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