Calculations &Dilutions (2)
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Transcript of Calculations &Dilutions (2)
7/23/2019 Calculations &Dilutions (2)
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DR.DHAVAL.S.PATEL
CALCULATION OF DRUG DOSES AND
DILUTIONS
7/23/2019 Calculations &Dilutions (2)
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■ Factor infuencing the dose o a drug:
• Patient Factors: 1. Age
2. Weight 3. !"# $%&'()e (&e( *. Se+ ,. Se-e&it# !' the "i$e($e %"e& t&e(t/et 0. St(t%$ !' &e( !& he(ti) '%)ti! . Se)ie$ (" &()e
4. He&e"it(&# i5%e)e 6geeti)$7 8. F!!" 19. P$#)h!!gi)( '()t!&$
•Drugs actors: 1. Che/i)( (t%&e !' the "&%g
2. O &ee(te" %$e !' "&%g$ 6i7 T!e&()e6ii7 Re$i$t()e
3. C!)%&&et ("/ii$t&(ti! !' the !the& "&%g$. *. Ti/ig R(te ;R!%te !' ("/ii$t&(ti! !' "&%g$
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■ Expression o Doses :
< For adults: • S!i" "&%g$ i /g !& g/=>g="(# i "(i# "i-i"e" "!$e$
• Li?%i" i /iiite& 6/7 !& ite& • i!!gi)( &e(&(ti!$6e.g. i$%i7 i I.U.=>g=h&$ • Ae&!$! i %@="(#
■ D!$e )()%(ti!$ '!& pediatrics patients:
6(7 ! the ($i$ !' Age: 6i7 Young’s ormula: Chi"B$ "!$eA"%t "!$e
6ii7 Dilling ‘s ormula:
Chi" $ "!$eA"%t "!$e 67 O ($i$ !' Weight: 6i !lar"’s ormula: Chi"B$ "!$eA"%t "!$e Chi"B$ "!$eA"%t "!$e
)!ti.
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637O the ($i$ !' SA: • Chi"B$ "!$e: A"%t $ "!$e SA i$ )()%(te" # %$ig :
Du#ois ormula:
Re("# /("e )h(&t$= $i"e &%e !/!g&(/$ '!& SA:
Age $deal
%eight&"g
'(A& ) o adult
dose
Ne !& 3 0.22 12
3 /!th$ 6 0.33 18
1 #&$ 10 0.45 28
, #&$ 20 0.8 48
8 #&$ 30 1.0 60
12 #&$ 40 1.3 78
1* #&$ 50 1.5 90
Age $deal
%eight&"g
) o adult
dose
Ne !& 3 0.22 12
3 /!th$ 6 0.33 18
1 #&$ 10 0.45 28
, #&$ 20 0.8 48
8 #&$ 30 1.0 60
12 #&$ 40 1.3 78
1* #&$ 50 1.5 90
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* For elderl+ patients &, -. +rs/ : • N! J+e" &%e$ !& '!&/%(e '!& "ete&/iig the "!$e ie"e&#
(tiet$.
• D!$e /(# e &e"%)e" t! 2=3 !' the ("%t "!$e . ▪ Sh!%" ($e" ! -(&i!%$ '()t!&$:
617 T#e$ !' "&%g eig("/ii$te&e". 627 Age &e(te" "e)ie i &e(!& >i"e#
'%)ti!.
For patients o renal ailure:
• D!$e A"%t "!$e
☻6N!&/( )&e(tiie )e(&()e '!& ( 9 >g he(th# /( i$ 0..102. ml3min7
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►(trength o ormulations and drug dilutions:
&0 Percentage: 1K $!%ti! /e($ 1g !' $!%te i 199 / 619/g=/7
&2 W34: '!& $!i"$ i i?%i" t#e !' '!&/%(ti!$ /e($ %/e& !' g&(/$ !' ()ti-e $%$t()e i 199 / !'i?%i" &!"%)t. e.g. ,K "e+t&!$e )!t(i$ , g/ "e+t&!$e i 199 / !'i'%$i!.
&5 W3W: '!& $!i"$ i $!i" t#e !' &e(&(ti!$ /e($ %/e& !' g&(/$ !' th(t )!$tit%et i 199 g !''!&/%(ti!$ e.g. 3K '&(/#)eti !it/et )!t(i 3g !' '&(/#)eti i199g !'
!it/et.
&6 434: '!& i?%i"$ i i?%i" t#e !' &e(&(ti!$/e($ the -!%/e !' )!$tit%et 6i /7 i 199 / !' t!t(
'!&/%(ti!. e.g. 9K eth# ()!h! )!t(i$ 9 / eth# ()!h! i (
t!t( !' 199 /( %e!%$ $!%ti!
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☻Assignment: 1. A 19 #e(& !" !# i$ &e$)&ie" $#&% i$!i(i" '!& t%e&)%!$i$.i' the "%&(ti!
!' t&e(t/et i$ 09 "(#$ h! /(# !tte$ !' i$!i(i" i e
&e?%i&e" Weight 2* >g D!$e i )hi"&e , /g=>g="(#. E()h !tte )!t(i$ 199 /g=, / "&%g. !tte )(()it# 199 /
2. A "i(eti) (tiet &e?%i&e$ i$%i (t the &(te !' 9.1 U=>g=h&.Set % i$%i "&i (" )()%(te the &(te !' i'%$i!.
Weight 49>g I$%i i$ (-(i(e ($ *9 U=/ i , / -i(.
3. eti! the $te$ t! &e(&e :
19 / !' 1,K N(C $!%ti!. 19 / !' i$!t!i) $(ie $!%ti!.
*.C()%(te the "(i# "!$e !' (/i>()i '!& , #e(&$ !" 'e/(e !e$e(tiet 89 >g h(-ig S.)&e(tiie 2., /g=" $%@e&ig '&!/ &e( (&e)h#/("i$e($e.