Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling.
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Transcript of Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling.
![Page 1: Calcium Cycling in Cardiac Cells Lin Guo-hua. Cardiac E-C coupling.](https://reader036.fdocuments.in/reader036/viewer/2022062500/5697bfee1a28abf838cb98ee/html5/thumbnails/1.jpg)
Calcium Cycling in Cardiac Cells
Lin Guo-hua
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Cardiac E-C coupling
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Slow or L-type Ca2+ Channels (DHPRs)
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L-type Ca2+ Channels
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Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor)
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cardiac ryanodin receptor
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Physiological and pathophysiological regulation
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Ca2+ Pump of the Sarcoplasmic Reticulum
(SERCA)
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SERCA
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SERCA-PLN complex
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Phospholamban (PLN)
&Sarcolipin
(SLN)
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The Ca2+ Pump of the PlasmaMembrane (PMCA)
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Sodium/Calcium Exchanger (NCX)
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Troponin C (TnC)
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Calmodulin (CaM)
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Calmodulin (CaM) &
Calmodulin Kinase II (CaMKII)
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Calmodulin Kinase II (CaMKII)
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Regulation of Ca Transporters by CaM and CaMKII
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frequency-dependent acceleration of relaxation (FDAR)
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Calsequestrin (CSQ)
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Organization of EC coupling elements
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Integrative Analysis of Calcium Cycling in Cardiac Muscle
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[Ca2+]i Transient in Heart Cell
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[Ca2+]I Transient
[Ca2+]i sparks
&
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Ca2+ Requirements for Activation of Myofilaments
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Autoregulation of SR Ca2+ Content
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Changes of sarcolemmal fluxes and SR CaCa2+ release during potentiation of CICR by caffeine (500 mmol/L)
Modulation of the RyR
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relationships between the various Ca2+ fluxes
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Ca2+ Influx During the Cardiac AP
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Ca2+ Removal From the Cytosol During
Cardiac Relaxation
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Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR
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Measurement of SR Ca2+ content and forcefrequency relationship.
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force frequency relation
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Frequency-dependence of isometric twitch force (twitch) and rapid cooling contractures (RCC) in nonfailing and failing human myocardium
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Relationship between NCX and SERCA protein levels and in non-failing and failing human myocardium
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Caffeine contractures in isolated rabbit myocytes following adenoviral gene transfer of LacZ and NCX
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Frequency-dependent changes in twitch force, aequorin light signals RCCs in huma atrial muscles (A) and ventricular muscles (B).
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Steady-state twitches, postrest twitches, and RCCs in isolated human atrial myocardium.
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Rapid Cooling Contracture
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Paired RCCs and Ca2+ Reuptake Into the SR
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Rest-dependent changes in the amplitudes of twitch force and RCCs) in human atrial myocardium (A) and ventricular muscles (B)
postrest potentiation & postrest decay
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restitution
postextrasystolic potentiation
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Ca2+ Restitution of the Ca transient
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