Bulk Packing Material for Preparative Chromatography · Bulk Packing Material for Preparative...
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PRODUCT PHASE DESCRIPTION PORE SIZE* (nm) PARTICLE SIZE* (µm spherical) CARBON LOAD** (%C) pH TYPICAL APPLICATIONS Reversed Phase C18 YMC-Triart Prep C18-S pH-stable organic/inorganic hybrid particle, polymeric bonding 12; (20) 10; 15; 20 20 2.0–10.0 first choice for method development, most versatile phase YMC*Gel ODS-A-HG one of YMC's international bestsellers, traditional high performance C18 silica 8; 12; 20; 30 10; 15; 20; 50 20; 17; 12; 7 2.0–7.5 pharmaceuticals, vitamins, peptides, amino acids, general purpose phase YMC*Gel ODS-AQ-HG "hydrophilic" endcapping, for 100% aqueous eluent systems 8; 12; 20 10; 15; 20; 50 15; 14; 10 2.0–7.5 strong polar compounds, pharmaceuticals, peptides, nucleic and amino acids C8 YMC-Triart Prep C8-S pH-stable organic/inorganic hybrid particle, polymeric bonding 12; 20 10; 15; 20 13 2.0–10.0 proteins and peptides, general purpose phase YMC*Gel C8-HG (Octyl) traditional C8, high coverage monomeric bonding chemistry 12; 20; 30 10; 15; 20; 50 10; 7; 4 2.0–7.5 proteins and peptides, estrogens, general purpose phase YMCbasic specifically designed for the separation of basic compounds and peptides 20 10 7 2.0–7.5 basic molecules w/o modifiers, peptides YMC*Gel Ph-HG (Phenyl) monomeric bonded phenyl using π electron interactions 12; (20; 30) 10; 15; 20; 50 9 2.0–7.5 phenols, fullerenes, sweeteners, aromatics C4 YMC*Gel C4-HG (Butyl) traditional C4, less hydrophobic surface structure than C8 packing material 12; 20; 30 10; 15; 20; 50 7; 5; 3 2.0–7.5 biological separations, polar compounds, proteins C1 YMC*Gel TMS-HG trimethylsilane bonding, excellent hydrolytic stability 12; (20; 30) 10; 15; 20; 50 4 2.0–7.5 water-soluble vitamins YMC Omega specifically designed for the separation of polyunsaturated fatty acids proprietary 10; 20; 50 15 2.0–7.5 polyunsaturated fatty acids, EPA, DHA Normal Phase/HILIC YMC*Gel NH 2 -HG (Amino) primary amino derivative, high coverage monomeric bonding chemistry 12; (20; 30) 10; 15; 20; 50 3 2.0–7.5 saccharides, nucleotides, water-soluble vitamins YMC*Gel CN-HG (Cyano) for RP and NP applications, useful also for SFC and HILIC 12; (20; 30) 10; 15; 20; 50 7 2.0–7.5 proteins, steroids, catechols, for SFC applications YMC*Gel Diol-HG for NP applications, high recovery for biological material, suitable for HILIC and SFC 12; 20; 30 10; 15; 20; 50 – 2.0–7.5 polar natural products, pharmaceuticals, for HILIC and SFC applications YMC*Gel SIL-HG (Silica) ultra high purity, high mechanical stability, suitable for HILIC and SFC 6; 8; 12; 20; 30 10; 15; 20; 50 – – small organic molecules, fat-soluble vitamins, tocopherols, steroids YMC*Gel SIL (Silica) high purity, suitable for MPLC and column chromatography 6; 12 50; 75; 150 – – small organic molecules, fat-soluble vitamins, tocopherols, steroids IEX BioPro IEX Q75 high dynamic binding capacity, hydrophilic polymer anion exchange media porous 75 – 2.0–12.0 monoclonal antibodies, proteins and peptides, IgG BioPro IEX S75 high dynamic binding capacity, hydrophilic polymer cation exchange media porous 75 – 2.0–12.0 monoclonal antibodies, proteins and peptides, IgG BioPro IEX SmartSep Q10/20/30 high mechanical strength, hydrophilic polymer anion exchange media porous 10; 20; 30 – 2.0–12.0 oligonucleotides, antibody pharmaceuticals, proteins and peptides BioPro IEX SmartSep S10/20/30 high mechanical strength, hydrophilic polymer cation exchange media porous 10; 20; 30 – 2.0–12.0 antibody pharmaceuticals, proteins and peptides, insulin SEC YMC*Gel Diol-HG-120 versatile phase for gel filtration separations for MW 5,000 to 100,000 Da 12 10; 15; 20; 50 – 5.0–7.5 intermediate proteins, oligosaccharides YMC*Gel Diol-HG-200 versatile phase for gel filtration separations for MW 5,000 to 300,000 Da 20 10; 15; 20 – 5.0–7.5 large proteins, polysaccharides YMC*Gel Diol-HG-300 versatile phase for gel filtration separations for MW 20,000 to 1,000,000 Da 30 10; 15; 20 – 5.0–7.5 very large proteins, antibodies, polysaccharides Chiral Polysaccharides CHIRAL ART Amylose-C coated derivative [alternative to CHIRALPAK ® AD] proprietary 10; 20 – – wide application range, SFC/SMB CHIRAL ART Amylose-C Neo extended resolution and loadability, coated [alternative to CHIRALPAK ® AD] proprietary 10; 20 – – wide application range, SFC/SMB CHIRAL ART Cellulose-C coated derivative [alternative to CHIRALCEL ® OD] proprietary 10; 20 – – wide application range, SFC/SMB CHIRAL ART Amylose-SA immobilised derivative [alternative to CHIRALPAK ® IA] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB CHIRAL ART Cellulose-SB immobilised derivative [alternative to CHIRALPAK ® IB] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB CHIRAL ART Cellulose-SC immobilised derivative [alternative to CHIRALPAK ® IC] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB CHIRAL ART Cellulose-SJ immobilised derivative [alternative to coated CHIRALCEL ® OJ] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB Chiral Prep CD ST cyclodextrin based stationary phase for chiral RP separations 12 10; 20; 50 – 2.0–7.0 chiral separations, structural isomers Chiral Prep CD PM phenyl modified cyclodextrin based phase, for NP and RP applications 12 10; 20; 50 – 2.0–7.0 chiral separations, structural isomers Bulk Packing Material for Preparative Chromatography Analytical grades (3 and 5 µm) are routinely available in pre-packed columns. Particle sizes as indicated. If not listed, please ask for quotation. Multi ton capacity. Customized packing materials available on request. Pore sizes in parenthesis on request. | *Not all combinations available. | **With respect to pore size. Europe GmbH · Schöttmannshof 19 · D-46539 Dinslaken · Phone +49 (0) 2064 427-0 · Fax +49 (0) 2064 427-222 · Email: [email protected] · www.ymc.de
Transcript of Bulk Packing Material for Preparative Chromatography · Bulk Packing Material for Preparative...
PRODUCT PHASE DESCRIPTION PORESIZE*(nm)
PARTICLESIZE*(µm spherical)
CARBONLOAD**(%C)
pH TYPICAL APPLICATIONS
Reve
rsed
Pha
se
C18
YMC-Triart Prep C18-S pH-stable organic/inorganic hybrid particle, polymeric bonding 12; (20) 10; 15; 20 20 2.0–10.0 first choice for method development, most versatile phase
YMC*Gel ODS-A-HG one of YMC's international bestsellers, traditional high performance C18 silica 8; 12; 20; 30 10; 15; 20; 50 20; 17; 12; 7 2.0–7.5 pharmaceuticals, vitamins, peptides, amino acids, general purpose phase
YMC*Gel ODS-AQ-HG "hydrophilic" endcapping, for 100% aqueous eluent systems 8; 12; 20 10; 15; 20; 50 15; 14; 10 2.0–7.5 strong polar compounds, pharmaceuticals, peptides, nucleic and amino acids
C8
YMC-Triart Prep C8-S pH-stable organic/inorganic hybrid particle, polymeric bonding 12; 20 10; 15; 20 13 2.0–10.0 proteins and peptides, general purpose phase
YMC*Gel C8-HG (Octyl) traditional C8, high coverage monomeric bonding chemistry 12; 20; 30 10; 15; 20; 50 10; 7; 4 2.0–7.5 proteins and peptides, estrogens, general purpose phase
YMCbasic specifically designed for the separation of basic compounds and peptides 20 10 7 2.0–7.5 basic molecules w/o modifiers, peptides
YMC*Gel Ph-HG (Phenyl) monomeric bonded phenyl using π electron interactions 12; (20; 30) 10; 15; 20; 50 9 2.0–7.5 phenols, fullerenes, sweeteners, aromatics
C4 YMC*Gel C4-HG (Butyl) traditional C4, less hydrophobic surface structure than C8 packing material 12; 20; 30 10; 15; 20; 50 7; 5; 3 2.0–7.5 biological separations, polar compounds, proteins
C1 YMC*Gel TMS-HG trimethylsilane bonding, excellent hydrolytic stability 12; (20; 30) 10; 15; 20; 50 4 2.0–7.5 water-soluble vitamins
YMC Omega specifically designed for the separation of polyunsaturated fatty acids proprietary 10; 20; 50 15 2.0–7.5 polyunsaturated fatty acids, EPA, DHA
Nor
mal
Pha
se/H
ILIC YMC*Gel NH2-HG (Amino) primary amino derivative, high coverage monomeric bonding chemistry 12; (20; 30) 10; 15; 20; 50 3 2.0–7.5 saccharides, nucleotides, water-soluble vitamins
YMC*Gel CN-HG (Cyano) for RP and NP applications, useful also for SFC and HILIC 12; (20; 30) 10; 15; 20; 50 7 2.0–7.5 proteins, steroids, catechols, for SFC applications
YMC*Gel Diol-HG for NP applications, high recovery for biological material, suitable for HILIC and SFC 12; 20; 30 10; 15; 20; 50 – 2.0–7.5 polar natural products, pharmaceuticals, for HILIC and SFC applications
YMC*Gel SIL-HG (Silica) ultra high purity, high mechanical stability, suitable for HILIC and SFC 6; 8; 12; 20; 30 10; 15; 20; 50 – – small organic molecules, fat-soluble vitamins, tocopherols, steroids
YMC*Gel SIL (Silica) high purity, suitable for MPLC and column chromatography 6; 12 50; 75; 150 – – small organic molecules, fat-soluble vitamins, tocopherols, steroids
IEX
BioPro IEX Q75 high dynamic binding capacity, hydrophilic polymer anion exchange media porous 75 – 2.0–12.0 monoclonal antibodies, proteins and peptides, IgG
BioPro IEX S75 high dynamic binding capacity, hydrophilic polymer cation exchange media porous 75 – 2.0–12.0 monoclonal antibodies, proteins and peptides, IgG
BioPro IEX SmartSep Q10/20/30 high mechanical strength, hydrophilic polymer anion exchange media porous 10; 20; 30 – 2.0–12.0 oligonucleotides, antibody pharmaceuticals, proteins and peptides
BioPro IEX SmartSep S10/20/30 high mechanical strength, hydrophilic polymer cation exchange media porous 10; 20; 30 – 2.0–12.0 antibody pharmaceuticals, proteins and peptides, insulin
SEC
YMC*Gel Diol-HG-120 versatile phase for gel filtration separations for MW 5,000 to 100,000 Da 12 10; 15; 20; 50 – 5.0–7.5 intermediate proteins, oligosaccharides
YMC*Gel Diol-HG-200 versatile phase for gel filtration separations for MW 5,000 to 300,000 Da 20 10; 15; 20 – 5.0–7.5 large proteins, polysaccharides
YMC*Gel Diol-HG-300 versatile phase for gel filtration separations for MW 20,000 to 1,000,000 Da 30 10; 15; 20 – 5.0–7.5 very large proteins, antibodies, polysaccharides
Chir
al
Po
lysa
ccha
rid
es
CHIRAL ART Amylose-C coated derivative [alternative to CHIRALPAK® AD] proprietary 10; 20 – – wide application range, SFC/SMB
CHIRAL ART Amylose-C Neo extended resolution and loadability, coated [alternative to CHIRALPAK® AD] proprietary 10; 20 – – wide application range, SFC/SMB
CHIRAL ART Cellulose-C coated derivative [alternative to CHIRALCEL® OD] proprietary 10; 20 – – wide application range, SFC/SMB
CHIRAL ART Amylose-SA immobilised derivative [alternative to CHIRALPAK® IA] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB
CHIRAL ART Cellulose-SB immobilised derivative [alternative to CHIRALPAK® IB] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB
CHIRAL ART Cellulose-SC immobilised derivative [alternative to CHIRALPAK® IC] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB
CHIRAL ART Cellulose-SJ immobilised derivative [alternative to coated CHIRALCEL® OJ] proprietary 10; 20 – 2.0–9.0 wide application range for RP, NP, SFC and SMB
Chiral Prep CD ST cyclodextrin based stationary phase for chiral RP separations 12 10; 20; 50 – 2.0–7.0 chiral separations, structural isomers
Chiral Prep CD PM phenyl modified cyclodextrin based phase, for NP and RP applications 12 10; 20; 50 – 2.0–7.0 chiral separations, structural isomers
Bulk Packing Material for Preparative Chromatography
Anal
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and
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If n
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, ple
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Not
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Europe GmbH · Schöttmannshof 19 · D-46539 Dinslaken · Phone +49 (0) 2064 427-0 · Fax +49 (0) 2064 427-222 · Email: [email protected] · www.ymc.de
Bulk Packing Material for Preparative Chromatography
YMC*Gel Diol-HG 120
MW < 5,000
MW 5,000 ~ 100,000
MW 5,000 - 100,000 Da
MW 5,000 - 300,000 Da
MW 20,000 - 1,000,000 Da
YMC-Triart Prep series, YMC*Gel series
YMC*Gel series wide pore materials, YMCbasic
Reversed Phase
Size Exclusion (SEC)
Ion Exchange (IEX)
strong cation exchanger
strong anion exchanger
BioPro IEX S75 / BioPro IEX SmartSep S10/20/30
BioPro IEX Q75 / BioPro IEX SmartSep Q10/20/30
YMC*Gel Diol-HG 200
YMC*Gel Diol-HG 300
Proteins / Peptides
Ion Exchange (IEX)
strong cation exchanger
strong anion exchanger
BioPro IEX S75 / BioPro IEX SmartSep S10/20/30
BioPro IEX Q75 / BioPro IEX SmartSep Q10/20/30
MW 5,000 - 100,000 Da
MW 5,000 - 300,000 Da
MW 20,000 - 1,000,000 Da
Size Exclusion (SEC)
Reversed PhaseYMC*Gel Diol-HG 120
YMC*Gel Diol-HG 200
YMC*Gel Diol-HG 300
(Monoclonal) Antibodies
Reversed Phase
Ion Exchange (IEX)
strong cation exchanger
strong anion exchanger
BioPro IEX S75 / BioPro IEX SmartSep S10/20/30
BioPro IEX Q75 / BioPro IEX SmartSep Q10/20/30
YMC-Triart Prep series, YMC*Gel ODS-AQ-HG
YMC-Triart Prep series, YMC*Gel series
Oligonucleotides / Nucleic Acids
Nucleic acid bases, nucleosides, nucleotides
Oligonucleotides
Small Molecules
polar
hydrophobic
YMC-Triart Prep C18-S, YMC*Gel ODS-AQ-HG
YMC-Triart Prep series,YMC*Gel series
CH3
CH3
CH3
OH
O
Bul
k P
acki
ng M
ater
ial 3
/201
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