BSRBR-RA UK CRN ID: 7302
description
Transcript of BSRBR-RA UK CRN ID: 7302
BSRBR-RAUK CRN ID: 7302
August 2013 update
Recruitment Certolizumab
Must have diagnosis of
RA
Must be registered within 6 months of first dose of certolizumab
Can be re-registered if already on the
study
TocilizumabMust have
diagnosis of RA
Must be registered within 6 months of first
dose of tocilizumab
Can be re-registered if already on the
study
Anti-TNF Comparison CohortMust have
diagnosis of RA
Must be registered within 6 months of first dose of etanercept, adalimumab or infliximab
Numbers recruited up to 25/07/2013
605As of 25/07/2013
561As of 25/07//2013
492As of 25/07//2013
Recruitment
July 2011 July 2013
Certolizumab recruitment by month
Tocilizumab recruitment by month
Anti-TNF cohort recruitment by month
Dec2011 July 20130
60
30
July 2011 July 20130
40
20
0
40
20
Recruitment 01/01/2013 – 19/07/2013
BSR Region Number recruited since 1st January 2013
North West 90East Midlands 89
Yorkshire and the Humber 85West Midlands 64
South West 61Mersey 49
London (South) 22South Central 21
North East 18South East 18
East of England 17London Central and North East 17
Scotland 14London (North West) 13
Wales 8Northern Ireland 3
BSR Region Awards January - July 2013
North West East
Midlands Yorkshire and the Humber
90 89 85
Help is available with the BSRBR-RAIf you do not have enough staff support currently, then in England the National Institute for Health Research Comprehensive
Clinical Research Network (CCRN) may be able to provide assistance
What is the CCRN?The CCRN is made up of 25 Comprehensive Local Research Networks (CLRNs) which cover the whole of England. Each local Network facilitates research within their region, with the aim of widening participation in research. A study is eligible for CLRN assistance if it has been adopted on to the Network portfolio of studies; the BSRBR-RA was adopted on to this portfolio in 2008 (ID: 7302).
How can my CLRN help me?The CLRN may be able to help by assisting in R&D set up or by providing funding for the people/facilities you require in order to carry out research in which you are involved in. For example, you may be allocated research nurse time or a data clerk to assist with the recruitment and follow up of participants on the BSRBR-RA.
How can I apply for CLRN help?You should contact the team within your regional network (details found via the link below) to discuss your requirements. You will then have to complete an application form, with which we can help.
www.crncc.nihr.ac.uk/about_us/ccrn/ccrn_about_us/clrns_list.htm
The BSRBR-RA Study reference number within the Network is 7302 – please remember to quote this when asking for help with the study. If you need any help with completing the paperwork, please contact [email protected]
Is there help outside of England?Regional Support
Northern Ireland
The Northern Ireland Clinical Research Network (NICRN) may be able to provide assistance in Northern Ireland in the same way as the NIHR CCRN in England, please contact the team to discuss requirements:
Wales
The National Institute for Social Care and Health Research Clinical Research Centre (NISCHR CRC) may be able to provide assistance in Wales in the same way as the NIHR CCRN in England , please contact the team to discuss requirements:
Scotland
NHS Scotland may be able to provide assistance in Scotland in the same way as the NIHR CCRN in England, please contact the team to discuss if support is possible for you:
http://nrs.mtcserver8.com/297_ClinicalResearchNetworks.html
Recent BSRBR-RA publications– Risk of cancer in patients receiving non-biologic disease-modifying therapy for
rheumatoid arthritis compared with the UK general population.Mercer, L., Davies, R., Galloway, J., Low, A., Lunt, M., Dixon, W., Watson, K., Symmons, D., Hyrich, K. & BSRBR_Control_Centre Consortium, B (2013). Rheumatology (Oxford), 52(1), 91-98.
– Anti-TNF therapy in women with rheumatoid arthritis with a history of carcinoma in situ of the cervix. Mercer, L., Low, A., Galloway, J., Watson, K., Lunt, M., Symmons, D., Hyrich, K. & BSRBR_Control_Centre_Consortium, B (2013). Ann Rheum Dis, 72(1), 143-144.
– The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA. Závada, J., Lunt, M., Davies, R., Low, A., Mercer, L., Galloway, J., Watson, K., Symmons, D., Hyrich, K. & , B (2013). Ann Rheum Dis, [Epub ahead of print]
Accessing BSRBR-RA data
http://www.rheumatology.org.uk/resources/bsr_biologics_registers/requesting_data_from_bsrbr.aspx
Recent/ongoing research projects via the BSRBR-RA data access scheme
Non-inflammatory pain mechanisms as confounders in the clinical assessment of synovitis in RA
Study of fatigue in inflammatory arthritis
Effectiveness of TNF response define by season of initiation of therapy, with particular focus on vitamin D
To explore the influence of gender and gender-related variables on severity of prognosis for RA
Obesity and clinical response to anti-TNF medication
2) ACR conference 2013 – San Diego
1. Non-differential Reporting of Myocardial Infarction to a National Observational Drug Safety Study Using Linked Data: Linkage of the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis and the Myocardial Ischaemia National Audit Project.
2. Comparison of the Occurrence and Severity of Myocardial Infarction in Subjects with Rheumatoid Arthritis Receiving Tumour Necrosis Factor Inhibitors or Standard Non-biologic Disease Modifying Anti-rheumatic Drugs: Results from a Linkage between the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis and the Myocardial Ischaemia National Audit Project.
3. The risk of serious infections in patients receiving rituximab for rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register-Rheumatoid Arthritis.
BSRBR-RA abstracts submitted:
What to look out for soon1) Web portal development
The Robertson Centre at the University of Glasgow are developing a new web portal for online data capture.
The portal will include the facility to register new patients as well as enter follow-up data for patients already on the study
Acknowledgements
• UK Consultant Rheumatologists and Specialist Nurses
• Comprehensive Local Research Networks
• BSRBR Control Centre Consortium
• British Society for Rheumatology
• Arthritis Research UK Epidemiology Unit, Manchester