BRUCE CHRISTOPHER WHEELER Phone: 352-273-9313 Dept: … · January 2012 Bruce C. Wheeler p. 1/25...

January 2012 Bruce C. Wheeler p. 1/25

BRUCE CHRISTOPHER WHEELER University of Florida

J. Crayton Pruitt Family Department of Biomedical Engineering JG-56 BioMedical Sciences Building, 1275 Center Drive, P.O. Box 116131, Gainesville FL 32611-6131

Phone: 352-273-9313 Dept: 352-273-9222 Fax: 352-273-9221 [email protected]

RESEARCH AREAS

Technologies for the Study of Small Neuronal Networks: Micropatterning the Growth of Individual Neurons; Microelectrode Array Fabrication; Neural Signal Processing

Biomedical Engineering & Signal Processing EDUCATION Ph.D., M.S., Cornell University, Electrical Engineering, 1981, 1977.

S.B., S.B., MIT, Physical Science / History, 1971 (courses XIIB and XXI) POSITIONS 2008 - Professor of Biomedical Engineering, University of Florida

2009- Acting Chair, Department of Biomedical Engineering, University of Florida 2008- Professor Emeritus, University of Illinois 2004-2008 Professor of Bioengineering, University of Illinois 2004-2008 Interim and Founding Head, Department of Bioengineering, U. Illinois 2002-2003 Director, Bioengineering Program, University of Illinois 2000-2008 Professor of Electrical and Computer Engineering 1995-2001 ECE Dept. Assoc. Head for Undergraduate Affairs / Chief Advisor 1988-2000 Associate Professor of Electrical and Computer Engineering, U. Illinois 1990-1993 Chair, Neuroscience Graduate Program, University of Illinois 1989-1990 Acting Chair, Bioengineering Faculty, University of Illinois 1982-1988 Assistant Professor of Electrical and Computer Engineering, U. Illinois 1980-1982 Visiting Assistant Professor of Electrical Engineering, University of Illinois 1974-1980 Research and Teaching Assistant, Cornell University, Ithaca NY 1972-1974 Programmer, Virginia Polytechnic Institute, Blacksburg VA 1971-1972 Teacher, Niskayuna Public Schools, Schenectady NY

PROFESSIONAL ACTIVITIES

President Elect, President, Past President, IEEE EMBS (’12-’15). Editor in Chief, IEEE Trans Biomed Eng (‘07-12). Adv.Brd. Bernstein Center Freiburg (neuroscience technology research center;‘12-); Adv.Brd. U. Fla BME Dept. (‘03-08). Adv.Brd. Cornell U. Dept. Biol.&Environ Eng. (‘04-08); Adv.Brd. KAIST (Daejon Korea) Dept Brain&Bio Engrg. KAIST ( ’07). IEEE Trans Biomed Eng Assoc. Ed. (‘01-06); Editorial Boards -- J. Neurosci. Meth. (since ’96); J Neuroeng (since ’03); Nanomed, since ’05; Front. Neurosci. Rev. Ed. ‘09-. Member: IEEE (Senior), BMES, ASEE, AAAS, Soc. Neurosci. Offices: IEEE local offices, IEEE EMBS Student AdCom. MIT Ed Council (interview HS seniors) 78-08. Extensive reviewing (NIH, NSF, TBME, et al.).

HONORS Fellow, IEEE, 2008. Fellow, American Institute for Medical and Biological Engineering, 2004. UIUC Outstanding MD/PhD Advisor 2003; UIUC Campus Wide Award Excellence in Undergrad. Advising, 2000; Illinois Dad’s Assoc. Outstanding Professor, 1999; Honorary Knight of St. Pat (student leader chosen award), 1999; Pierce Award (student/faculty relations, Engineering College), 1987; Outstanding Advisor, ‘89,93,97,01. “Incomplete List” Outstanding Instructors, UIUC, 84,87,96. PBK, HKN. Cornell: McMullen Fellow (79-80). MIT: NCAA Postgrad Fellow, Outstanding Freshman. MVP Greater Boston Baseball League. Player of week, Greater Boston Basketball. Sr. Athlete of Year, MIT (’71). Mohonasen High School Athletic Hall of Fame 2010.

ADMINISTRATIVE HIGHLIGHTS

Acting Chair, U Fla. Co-author Undergrad Proposal. Interim Head, Illinois Dept. Bioen. Start dept. from zero to 8 faculty, 110 undergrads, 30 grad students. Director, Bioen. Pgm. Wrote proposal for Dept., BS, MS, PhD degrees. Assoc. Head ECE (6 years). Proactive advising policies reduced ECE undergraduate drop and probation rates. Earned campus wide award for this effort. (Enrollment: 1600) Chaired both the Neuroscience (3 years) and Bioengineering (1 year) Programs.

TEACHING ACTIVITY SUMMARY

Ph.D. / M.S. Students Supervised: 9 / 31 graduated, 2 in progress. Postdocs 6. Courses Taught: Neural Eng., Electronic Ckts, Analog Filter Design, Digital Signals & Systems, Medical Image Processing, Intro. Medical Imaging, Biomed. Instrumentation & Lab, Modeling of BioSystems, Theory & Fab. Solid State Devices Lab, Integrated Ckt. Fab. Lab, Basic EE Lab., Intro. Ckt Analysis, Intro to Bioeng., Coordinate ECE Undergrad Honors Seminar & Neuroscience Seminar. ECE Explorations (undergrad seminar)


PUBLICATIONS Invited / Reviewed 1. Nam, Y. and Wheeler, B.C. (2011) In vitro microelectrode array technology and neural recordings. Critical

Reviews in Biomedical Engineering, 39(1): 45-62. 2. Wheeler, B.C. and Brewer, G.J. (2010) Designing Neural Networks in Culture, Proceedings of the IEEE,

98(3) (March), 398-406, DOI: 10.1109/JPROC.2009.2039029. Peer Reviewed 3. Leondopulos, SS, Boehler, MD, Wheeler, BC, Brewer, GJ. Chronic stimulation of cultured neural networks

boosts oscillatory activity in the beta and theta frequencies, accepted, J. Neural Engineering. 4. Boehler, MD, Leondopulos, SS, Wheeler, BC, Brewer, GJ. (2012) Hippocampal networks on reliable

patterned substrates. J. Neurosci. Meth. 203:344-353. doi: 10.1016/j.jneumeth.2011.09.020 5. Pan, L., Alagapan, S., Franca, E., Brewer, GJ, Wheeler, BC, (2011) Propagation of action potential activity in

a predefined microtunnel neural network, J. Neural Eng. 8, 046031. doi:10.1088/1741-2560/8/4/046031. 6. Ide, AN, Andruska, A, Boehler, MD, Wheeler, BC, and Brewer, GJ. (2010) Chronic Network Stimulation

Enhances Evoked Action Potentials. J. Neural Eng. 7, 016008 (15 pp) doi: 10.1088/1741-2560/71/1/016008. 7. Brewer, GJ, Boehler, MD, Ide, AN, and Wheeler, BC. (2009) Chronic electrical stimulation of hippocampal

networks during development increases spontaneous spike rates, J. Nsci. Meth., 184, 104-109. NIHMSID#137731. Publ.ID NSM5380. PubMed#19666055.

8. Musick, K., Khatami, D., and Wheeler, B.C. (2009) Three-dimensional microelectrode array for recording dissociated neuronal cultures, Lab on Chip, 9, 2036-2042. DOI: 10.1039/b820596e.

9. Nam, Y., Brown, E.A., Ross, J.D., Blum, R.A., Wheeler, B.C., DeWeerth, S.P., (2009) A retrofitted neural recording system with a novel stimulation IC to monitor early neural responses from a stimulating electrode. J. Neurosci. Meth. 178, 99–102.

10. Dworak, B.J., and Wheeler, B.C., (2009) Novel MEA platform with PDMS microtunnels enables detection of action potential propagation from isolated axons in culture, Lab on Chip, 9, 404-410.

11. Brewer, G.J., Boehler, M.D., Pearson, R.A., DeMaris, A.A., Ide, A.N., Wheeler, B.C. (2009), Neuron network activity scales exponentially with synapse density, J. Neural Eng. 6., 014001, doi:10.1088/1741-2560/6/1/014001.

12. Brown, E.A., Ross, J.D., Blum, R.A., Nam, Y., Wheeler, B.C., DeWeerth, S.P. (2008) Stimulus-artifact elimination in a multi-electrode system. IEEE Trans. Biomed. Circuits and Systems, 2 (1), March., 10-21.

13. Brewer, G. J.; Boehler, M. D.; Jones, T. T.; Wheeler, B. C., (2008) NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. Journal of Neuroscience Methods, 170, (2), 181-187.

14. Boehler, MD, Wheeler, BC, and Brewer, GJ. (2008) Added astroglia promote greater synapse density and higher activity in neuronal networks, Neuron Glia Biology, 3(2):127-140.

15. Vieira, M.; Christensen, B. L.; Wheeler, B. C.; Feng, A. S.; Kollmar, R., (2007) Survival and stimulation of neurite outgrowth in a serum-free culture of spiral ganglion neurons from adult mice. Hearing Research, 230, (1-2), 17-23.

16. Nam, Y, Brewer, GJ, Wheeler, BC. (2007) Development of astroglial cells in patterned neuronal cultures, J. Biomaterials Science, Polymer Edition, 18(8), 1091-1100.

17. Rowe, L., Almasri, M., Lee, K., Fogleman, N., Brewer, G.J Nam, Y., Wheeler, B.C., Vukasinovic, J., Glezer, A., Frazier, A.B. (2007) Active 3-D Microscaffold System with Fluid Perfusion for Culturing in Vitro Neuronal Networks, Lab on a Chip (4),475-482.

18. Chang, J.C., Brewer, G.J, Wheeler, B.C. (2006) Neuronal network structuring induces greater neuronal activity through enhanced astroglial development, J. Neuroeng. 3, 217-226.

19. Nam, Y., Musick, K., and Wheeler, B.C. (2006) Application of a PDMS microstencil as a replaceable insulator toward a single-use planar microelectrode array, Biomedical Microdevices, 8(4), 375-381.

20. Phatak, SA, Ratnam, R, Wheeler, BC, O'Brien, WD, Jr., Feng, AS (2006). Effect of reflectors on sound source localization with two microphones, J. Audio Eng. Soc., 54 (6), 512-524. ]

21. Nam, Y., Branch, D.W., and Wheeler, B.C. (2006) Epoxy-silane linking of biomolecules is simple and effective for patterning neuronal cultures, Biosensors and Bioelectronics, 22(5), 589-597.

22. Nam, Y, Wheeler, B.C., and Heuskel, M.O. (2006) Neural recording and stimulation of dissociated hippocampal cultures in vitro using microfabricated three dimensional tip electrode array, J. Nsci. Meth., 155 (2), 296-299.

23. Nam, Y., Chang, J.C., Khatami, D., Brewer, G.J., and Wheeler, B.C., (2004) “Patterning to enhance activity of cultured neuronal networks”, IEE Proc. Nanobiotechnology, 151(3), 109-115.


24. Larsen, J., Lansing, C., Bilger, R., Wheeler, B., Phatak, S., Lockwood, M., O’Brien, W., Jr., and Feng, A.S, (2004) “Speech perception in noise with a two-sensor FMV beamforming algorithm”, Acoustics Research Letters Online, 5(3), 100-105.

25. Lockwood, M.E., Jones, A.L., Bilger, R.C., Lansing, C.R., O'Brien, W.D., Wheeler, B.C. and Feng, A.S., (2004) “Performance of time-and frequency-domain binaural beamformers based on recorded signals from real rooms,” J. Acoust. Soc. Am., 115, 379-391.

26. Nam, Y., Chang, J.C., Wheeler, B.C., Brewer, G.J., (2004) “Gold coated microelectrode array with thiol linked self-assembled monolayers to engineer neuronal cultures”, IEEE Trans Biomed. Eng., 51(1), 158-165, January.

27. Ratnam, R., Jones, D.L., Wheeler, B.C., O’Brien, W.D., Jr., Lansing, C., Bilger, R.C., and Feng, A.S., (2003) “The blind estimation of reverberation time,” J. Acoust. Soc. Am., 114, 2877-2892.

28. Chang, J.C., Brewer, G.J., Wheeler, B.C. (2003) “A Modified Microstamping Technique Enhances Polylysine Transfer and Neuronal Cell Patterning”, J. Biomaterials, 24(17) (August): 2863-2870.

29. Cornish T, Branch DW, Wheeler BC, Campanelli JT (2002) “Microcontact printing: a versatile technique for the study of synaptogenic molecules,” Mol. Cell. Neurosci. 20(1):140-53.

30. Liu, C., Wheeler, B.C., O'Brien, W.D. Jr., Bilger, R.C., Lansing, C.R., Feng, A.S. (2001) “A two microphone dual delay-line approach for extraction of a speech sound in the presence of multiple interferers,” J. Acoust. Soc. Amer., 110(6), 3218-3231.

31. Chang, J.C., Brewer, G.J., and Wheeler, B.C., (2001) "Modulation of neural network activity by patterning", Biosensors and Bioelectronics, 16 (7-8) (Sept): 527-533.

32. Branch, DW, Wheeler, BC Brewer, GJ & D.E. Leckband, DE (2001) “Long-term stability of microstamped sub-strates of polylysine and grafted polyethylene glycol in cell culture conditions,” J. Biomaterials, 22, 1035-1047.

33. Chang, J.C., Wheeler, B. C., and Brewer, G. J. (2000) "Microelectrode array recordings of patterned hippocampal neural networks for four weeks," Biomedical Microdevices, 2:4, 245-253.

34. Venkateswar, R.A., Wheeler, B.C., and Branch, D.W. (2000) "An electrophoretic method for producing patterned biomolecule gradients," Biomedical Microdevices, 2:4, 255-264.

35. Branch, D.W., Wheeler, B.C., Brewer, G.J., and Leckband, D. (2000) “Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine,” IEEE Trans. Biomed. Eng., 47, 290-300.

36. Liu, C., Wheeler, B.C., O’Brien, W.D., Jr., Bilger, R.C., Lansing, C.R., and Feng, A.S. (2000) “Localization of multiple sound sources with two microphones in complex acoustic environments,” J. Acoust. Soc. Amer., 108(4), 1888-1905.

37. Wheeler, B.C., Corey, J.M., Brewer, G.J., & Branch, D.W (1999), “Microcontact printing for precise control of nerve cell growth in culture,” J. Biomech. Eng., 121, 73-78.

38. Gordon, S.H, Wheeler, B.C., Schudy, R.B., Wicklow, D.T., and Greene, R.V. (1998). “Neural network pattern recognition of photoacoustic FTIR spectra and knowledge-based techniques for detection of mycotoxigenic fungi in food grains,” J. of Food Protection, 61(2), 221-230.

39. Branch, D.W., Corey, J.M., Weyhenmeyer, J. A., Brewer, G. J., & Wheeler, B.C. (1998) “Micro-stamp patterns of biomolecules for high-resolution neuronal networks,” Med. & Biol. Comp. & Eng., 36, 135-141.

40. Corey, J.M., Brunette, A.L., Chen, M.S., Weyhenmeyer, J.A., Brewer, G.J., and Wheeler, B.C.(1997), “Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates,” J. Neurosci. Methods, 75, 91-97.

41. Gordon, S.H., Schudy, R.B., Wheeler, B.C., Wicklow, D.T., & Greene, R.V. (1997) “Identification of Fourier transform infrared photoacoustic spectral features for detection of aspergillis flavus infection in corn,” Int. J. Food Microbiol., 35, 179-185.

42. Corey, J.M., Wheeler, B.C., & Brewer, G.J. (1996) "Micrometer resolution silane-based micropatterning of hippocampal neurons: a comparison of photoresist and laser ablation methods for fabricating substrates," IEEE Trans. Biomed. Eng., 43, 944-955.

43. Gordon, S.H., Greene, R.V., Wheeler, B.C., and James, C. (1993) “Multivariate FTIR analysis of substrates for protein, polysaccharide, lipid and microbe content: Potential for solid-state fermentations,” Advances in Biotechnology, 11, 665-675.

44. Boppart, S., Wheeler, B.C., and Wallace, C. (1992) "A flexible, perforated microelectrode array for extended neural recordings," IEEE Trans. Biomed. Eng., BME-39, 37-42.

45. Corey, J.L, Wheeler, B.C., and Brewer, G.J. (1991) "Compliance of hippocampal neurons to patterned substrate networks," J. Neurosci. Res., 30, 300-307.


46. Willming, D.A. and Wheeler, B.C. (1990) "Real-time multichannel neural spike recognition with DSPs," IEEE EMBS Magazine, 9, 37-40.

47. Novak, J.L. and Wheeler, B.C. (1989) "Two-dimensional current source density analysis of propagation delays for components of epileptiform bursts in rat hippocampal slices," Brain Res., 497, 223-230.

48. Novak, J.L. and Wheeler, B.C. (1989) "A high-speed multichannel neural data acquisition system for IBM PC compatibles," J. Neurosci. Meth., 26, 239-247.

49. Wheeler, B.C. and Smith, S.R. (1988) "High-resolution alignment of action potential waveforms using cubic spline interpolation," J. Biomed. Eng., 10, 47-53, 1988.

50. Novak, J.L. and Wheeler, B.C. (1988) "Multisite hippocampal slice recording and stimulation using a 32 element microelectrode array," J. Neurosci. Meth., 23, 149-159.

51. Smith, S.R. and Wheeler, B.C. (1988) "A real-time multiprocessor system for acquisition of multichannel neural data," IEEE Trans. Biomed. Eng., BME-25, 875-877.

52. Wheeler, B.C. and Novak, J.L. (1986) "Current source density estimation using microelectrode array data from the hippocampal slice preparation," IEEE Trans. Biomed. Eng., BME-33, 1204-1212, 1986.

53. Novak, J.L. and Wheeler, B.C. (1986) "Recording from the Aplysia abdominal ganglion with a planar microelectrode array," IEEE Trans. Biomed. Eng., BME-33, 196-202.

54. Wheeler, B.C. (1985) "Exercises for an introductory image processing class," IEEE Trans.Educ., E-28,31-35. 55. Wheeler, B.C. and Valesano, W.R. (1985) "A real-time digital filter based data acquisition system for the

detection of neural signals," Med. & Biol. Eng. & Comput., 23, 243-248. 56. Wheeler, B.C. and Heetderks, W.J. (1982) "A comparison of techniques for classification of multiple neural

signals," IEEE Trans. Biomed. Eng., BME-29, 752-759. 57. Kim, M., Wheeler, B.C., Shin, K.B., and Perry, S. (1979) "Design of optimal chemotherapy schedules using

kinetic models for cancerous and normal tissues, " J. Cybernetics & Info.Science, 2, 92-108. 58. Kim, M., Wheeler, B.C., and Perry, S. (1978) "Quantitative description of cell cycle kinetics under

chemotherapy utilizing flow cytometry, " Cell Tissue Kinetics, 11, 497-512. Submitted and in Preparation: 1. Dworak, B.J., Varghese, K., Pan, L., Brewer, G.J., and Wheeler, B.C., Formation and Assembly of On-Chip

Unidirectional Neuronal Network Topologies, under revision 2. Chang, J.C., Nam, Y., Wheeler, B.C., Brewer, G.J. Silane modified platinum and titanium nitride electrodes

are biocompatible for patterning hippocampal cultures, in preparation. 3. Khatami, D.B., Nam, Y., and Wheeler, B.C., A new approach for semi-automated stimulation and

connectivity analysis of neuronal networks grown on multielectrode arrays, in preparation. 4. Scharnweber, R.F., Brewer, G.J., and Wheeler, B.C. Polarized axon growth of hippocampal neurons cultured

on tapered lines of laminin – approximate title. In preparation. 5. Scharnweber, R.F., Nam, Y., and Wheeler, B.C. Improved microchamber design for selectively harvesting

CNS axons for molecular signaling studies – approximate title. In preparation. Book Chapters 1. Chang, J.C., and Wheeler, B.C., (2006) “Pattern technologies for structured neuronal networks on MEAs,”

book chapter in Advances in Network Electrophysiology using Multi Electrode Arrays, M. Taketani and M. Baudry (eds), Kluwer Academic/Plenum.

2. Wheeler, B. C. (1998) “Automatic discrimination of single units,” in M. Nicolelis, Ed., Methods for Neural Ensemble Recordings, CRC Press, Ch. 4, 61-77.

3. Wheeler, B. C., & Brewer, G. J. (1994). “Multineuron patterning and recording”, in McKenna & Stenger (Eds.), Enabling Technologies for Cultured Neural Networks, 167-185, Academic Press.

4. Novak, J. L. & Wheeler, B. C. (1987) “Epileptiform activity recorded simultaneously at multiple sites on the surface of a hippocampal slice with a planar microelectrode array,” in Brain Slices: Fundamentals, Applications and Implications, A.Schurr, TJ Teyler, & M.Tseng, Eds, S.Karger, Basel, Switzerland, 177-183.

Patents Granted 1. Feng, A.S., Lansing, C.R., Liu, C., O'Brien, W.D. and Wheeler, B.C. "Binaural Signal Processing System

and Method" Patent issued on April 24, 2001. (US Patent #6,222,927). 2. Feng, A.S., Liu, C., Jones, D.L., Bilger, R.C., Lansing, C.R., O’Brien, W.D, Wheeler, B.C., “Binaural Signal

Processing Using Multiple Acoustic Sensors and Digital Filtering,” US Patent 6,978,159 B2, Dec. 20, 2005.


3. Feng, A.S., Liu, C., Bilger, R.C., Jones, D.L., Lansing, C.R., O’Brien, W.D, Wheeler, B.C., “Binaural Signal Processing Techniques,” US Patent 6,987,856 B1, Jan. 17, 2006.Canadian Patent #2,348,894 issued on 09/25/2007; European Patent #1133899 issued on August 6, 2008.

4. Feng, A.S., Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., O'Brien, W.O., Wheeler, B.C. - System and Methods for Interference-Suppression with Directional Sensing Patterns. US Patent # 7,076,072 issued on July 11, 2006.

5. Feng AS, Jones DL, Wheeler BC, Bilger RC, Lansing CR, O'Brien WD - "Intrabody communication for a hearing aid" - US patent #7,206,423 B1, issued on 4/17/2007; DE 195 41 648 C2; WO 01/87014 A2.

6. Jones, D.L., Lockwood, M.E., Bilger, R.C., Feng, A.S., Lansing, C.R., O'Brien, W.D., Wheeler, B.C., Elledge, M. and Liu, C. Interference suppression techniques. - US Patent # 7,613,309 B2 (issued on Nov 3, 2009);. European patent #1 312 239 (issued on 12/27/2006). Canadian Patent #2407855 (issued on Feb 2, 2010)

7. Feng, A.S., Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., O'Brien, W.O., Wheeler, B.C. - System and Methods for Interference-Suppression with Directional Sensing Patterns. US Patent # 7,577,266 (issued Aug 18, 2009).

8. O'Brien, W.D., Feng, A.S., Wheeler, B.C., Lansing, C.R., Bachler, H, and Bilger, R.C. Intrabody Communication with Ultrasound. US Patent 7,945,064 B2, issued May 17, 2011.

Patents Applied For 1. Jones, D.L., Lockwood, M.E., Bilger, R.C., Feng, A.S., Lansing, C.R., O'Brien, W.D., Wheeler, B.C.. -

Refinements of dual-channel extraction algorithm/system for high fidelity interference suppression from non-distinct sources. PCT patent application filed on May 10, 2001 (Original US Serial number 09/568,430); WO 01/87011 A2.

2. Feng, A.S., Jones, D.L., Wheeler, B.C., Bilger, R.C., Lansing, C.R. and O'Brien, W.D. Wireless Intrabody Interconnect Technology for Hearing Aids and Acoustic Processing. (UIUC Tech ID- TF00048) - Patent application filed in May 10, 2000 (US Serial number 09/568,435).

3. Ratnam, R., Jones, D., Feng, A.S., Lansing, C., O’Brien, W.D., Jr., Wheeler, B.C. "System for Blind Determination of Reverberation Time in Unknown Acoustic Environments Using Passively Perceived Sounds,” File date: March 24, 2004, Application No. 10/807,885.

Conference And Other Papers/Abstracts 1. Pan, L., Alagapan, S., Franca, E., DeMarse, TB, Brewer GJ, Wheeler, BC. Unidirectional burst propagation

is controlled by strength of connectivity in a predefined neural network, submitted, Soc. for Neurosci. 2011. 2. Alagapan, S., Pan, L., Wheeler, B.C., and DeMarse, T. Validation of Granger Causality within In Vitro

Engineered Feed-Forward Cortical Networks, Front. Neuroinform. Conference Abstract: 4th INCF Congress of Neuroinformatics. (Sept 2011), Boston, MA doi: 10.3389/conf.fninf.2011.08.00163

3. Franca, E., Alagapan, S., Pan, L., Varghese, K., Brewer, G.J. and Wheeler, B.C. Methodology and Characteristics of Micropatterned Neural Networks, BMES Meeting 2010, (October 9, 2010), Austin, TX

4. Alagapan, S., Pan, L., Wheeler, B.C. and DeMarse, T., Validation of Granger Causality using Unidirectional Neuronal Networks, BMES Meeting 2010, (October 2010), Austin, TX

5. Alagapan, S., Wheeler, B.C., DeMarse, T. Exploring Granger Causality As A Tool For Understanding Connectivity In Patterned Networks, MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

6. Pan, L., Brewer, G.J., Wheeler, B.C. PDMS Microtunnels for MEA Recordings: Improvements in Mold Fabrication and Compatibility with Conventional MEAs,MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

7. Brewer, GJ, Boehler, M, Wheeler, BC. NbActiv4 medium improvement to Neurobasal/B27 increases network activity which scales exponentially with synapse density MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

8. Joag, C., Wheeler, B.C., DeMarse, T. Stimulation of MEA‘s inside Incubator MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

9. Brewer, G.J., Boehler, M., Wheeler, B.C. MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

10. Dworak, B, Varghese, K., Pan, L., Brewer, G.J., Wheeler, B.C. Creating Unidirectional Neural Networks on a Chip MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.


11. Ide, AN, Andruska, A, Boehler, M, Wheeler, BC, Brewer, GJ. Chronic network stimulation enhances evoked action potentials MEA 2010 (7th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, June 2010.

12. Ide, AN, Andruska, A, Boehler, M, Wheeler, BC, Brewer, GJ. Chronic Network Stimulation Enhances Evoked Action Potentials, Soc. Neurosci. 2009.

13. Musick, K and Wheeler, BC. Three-Dimensional Microelectrode Array for Recording Dissociated Neuronal Cultures. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.

14. Dworak BJ and Wheeler BC. Enhanced Extracellular Recordings from Axons Patterned through PDMS Microtunnels in a Neuronal Culture. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.

15. Brewer G, Boehler M, Jones T, Wheeler B. NbActiv4TM, a Novel Improvement to Neurobasal/B27TM Medium, Increases Activity in Neuronal Networks by Promoting Synaptogenesis. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.

16. Brewer G, Boehler, Pearson, R, DeMaris A, Wheeler, B. Neuron Network Activity Scales Exponentially with Synapse Density. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.

17. Brewer G, Boehler M, Wheeler B, Embryonic Hippocampal Cultures in NbActiv4TM Surpass Spiking Activity of Embryonic Cortical Cultures in either Serum Medium or NbActiv4TM. MEA 2008 (6th Int. Mtg., Substrate-Integrated Microelectrode Arrays), Reutlingen Germany, July 2008.

18. Khatami DB, Brewer GJ, Wheeler BC, Effect of Short- and Long-term Electrical Stimulation on Network Behavior. MEA 2008 (6th Int. Mtg.,Substrate-Integrated Microelectrode Arrays),Reutlingen Germany, 2008.

19. Jones, D.L., Lockwood, M.E., Feng , A.S., and Wheeler, B.C., Biologically Inspired Beamforming with small Acoustic Arrays, BIOSIGNALS 2008, Funchal/Madeira, Portugal, Jan 28-31, 2008.

20. Khatami, D.B., Dworak B.J., Brewer, G.J., and Wheeler, B.C. Functional Connectivity Analysis and Tracking in Biological Neuronal Networks Patterned on Microelectrode Arrays. BMES Annual Fall Meeting, Los Angeles, CA., September 26-29, 2007.

21. Dworak, B.J. Scharnweber, R.F., Musick, K.M., Khatami, D.B., Brewer, G.J., and Wheeler, B.C. Multi-compartment neural soma aggregates linked by electrically accessible 3-D axonal microchannels. BMES Annual Fall Meeting, Los Angeles, CA., September 26-29, 2007.

22. Musick, K.M., and Wheeler, B.C. Three-dimensional microelectrode array for recording dissociated neuronal cultures, BMES Ann. Conf. Los Angeles, September 26-29, 2007.

23. Wheeler, B.C., Engineering Form and Function in Cultured Neuronal Circuits, Medicon 2007, Ljubljana, Slovenia, June 2007.

24. Kollmar, R, Vieira, M, Christensen, BL, Shah, SM, Kang, Y-J, Wheeler, BC and Feng, AS Promoting Neurite Outgrowth from Adult Spiral Ganglion Neuron, Age Related Hearing Impairment Conference, Antwerp, May 2007.

25. Shah, SM, Christensen, BL, Kang, Y-J, Vieira, M, Wheeler, BC, Feng, AS, Kollmar, R. Expression of Frizzled Genes in the Inner Ear of Adult Mice. Abstract. Ann. Mtg. Assoc. Res. Otolaryng., Feb 2007.

26. Cullen, DK, Vukasinovic, J, Irons, HR, Gleser, A, Wheeler, BC, and Laplaca, MC. Engineered high cell density three-dimensional constructs, Soc. Neurosci. Ann. Conf., Atlanta, Oct 2006.

27. Wheeler, BC, Khatami, DB, Nam, Y, Boehler, MD, Brewer, GJ, Designed In Vitro Neuronal Networks: Dependency of Activity on Geometric Pattern, Biomedical Engineering Society Annual Meeting, Chicago, Oct 2006, featured presentation.

28. Khatami, DB, Nam, Y, Wheeler, BC, Mapping Functional Connectivity in Geometrically Confined Neuronal Networks, Biomedical Engineering Society Annual Meeting, Chicago, Oct 2006.

29. Brewer, GJ, Boehler, MD, Wheeler, BC, Higher activity with increased connections in patterned hippocampal neurons, Biomedical Engineering Society Annual Meeting, Chicago, Oct 2006.

30. Brewer, GJ, Fogleman, CN, Boehler, MD, Wheeler, BC. (2006) Neural plasticity in hippocampal neurons by paired-pulse stimulation on MEA, International MEA Conference, Reutlingen Germany, July 2006.

31. Brewer, G.J., Boehler, M.D., Wheeler, B.C. (2006) Higher activity with increased connections in patterned hippocampal neurons, International MEA Conference, Reutlingen Germany, July 2006.

32. Brewer, G.J., Boehler, M.D., Wheeler, B.C., (2006) Added astroglia promote greater synapse density and higher activity in neuronal networks, International MEA Conference, Reutlingen Germany, July 2006.


33. Musick, K., Nam, Y., Wheeler, B.C. (2006) Microstamped electrodes with PDMS insulator: A design towards inexpensive, single-use microelectrode arrays, International MEA Conference, Reutlingen Germany, July 2006.

34. Khatami, D.B., Nam, Y., Wheeler, B.C. (2006) Tools for Automated Stimulation and Connectivity Analysis of Neuronal Networks Grown on Multielectrode Arrays, International MEA Conference, Reutlingen Germany, July 2006.

35. Brown, E.A., Blum, R.A., Ross, J.D., Nam, Y., Wheeler, B.C., DeWeerth, S.P., (2006) An Integrated System for Simultaneous Multichannel Stimulation and Recording, International MEA Conference, Reutlingen Germany, July 2006.

36. Kollmar, R., Vieira, R., Christensen, B., Wheeler, B., Feng, A., (2006) Survival and Stimulation of Neurite Outgrowth in a Serum-Free Culture of Adult Spiral-Ganglion Neurons. Ann. Mtg. Assoc. Res. Otolaryng., Feb, 2006, Baltimore MD.

37. Scharnweber, R.F., Brewer, G.J., and Wheeler, B.C. (2005) Polarized Axon Growth of Hippocampal Neurons Cultured on Tapered Lines of Laminin, Soc. Neurosci. Ann. Conf., Wash. DC.

38. Nam, Y., Brewer, G.J., Wheeler, B.C. (2005) Glial guidance by neurons in patterned hippocampal cultures in vitro. Soc. Neurosci. Ann. Conf., Wash DC.

39. Vieira, M, Christensen; BL Wheeler, BC, Kollmar, R, Feng, AS. (2005). Survival and stimulation of neurite outgrowth in a serum-free culture of adult spiral-ganglion neurons, Soc Neurosci. Conf., Wash DC, Oct.

40. Wheeler, BC (2005) Cultured neuronal networks: past, present, and future. BMES Ann Conf Baltimore. 41. Wheeler, B.C. (2005) Enhancing neuron / electrode interfaces in culture. BMES Ann.Conf. Baltimore, Sept. 42. Khatami,D.B., Brewer,G.J., Ujhelyi, E.,Wheeler, B.C. (2005) Bicuculline application enhances long-term

activity in low density cultured hippocampal neurons, BMES Ann. Conf., Baltimore, Sept. 43. Musick, K., Nam, Y., and Wheeler, B.C. (2005) Microstamp Patterned Electrodes with PDMS Insulator:

Design for Inexpensive Microelectrode Arrays. BMES Ann. Conf. Baltimore, Sept. 44. Wheeler, B.C. (2005) Starting a Bioengineering Department at the University of Illinois. Vietnam Bioeng.

Conf. Ho Chi Minh City. July. 45. Nam, Y., Wheeler, B.C., and Nam, M. H., Technological developments in studying neural information

processing in patterned neuronal 46. Nam, Y. and Wheeler, B.C. Imaging locations of neurons vs. glia in low density culture, 2nd International

IEEE EMBS Special Topic Conference on Neural Engineering, Washington DC, March 2005. 47. Scharnweber, R.F., Brewer, G.J. and Wheeler, B.C., 2004, Cytochalasin treatment disrupts growth cone

guidance on thin laminin lines in culture, Abstract, Society for Neuroscience Annual Meeting, San Diego CA Oct 2004.

48. Khatami, D.B., Chang, J.C., Brewer, G.J., Wheeler, B.C, 2004, Effects of spatial confinement on the spontaneous and evoked activity of linearly patterned biological neural networks, Abstract, Society for Neuroscience Annual Meeting, San Diego CA Oct 2004.

49. Brewer, G.J., Boehler, M.P., Nam, Y., Wheeler, B.C., 2004, Added astroglia increase spontaneous spiking, sensitivity to a GABA antagonist and to glutamate on multielectrode arrays in serum-free medium, Abstract, Society for Neuroscience Annual Meeting, San Diego CA Oct 2004.

50. Nam, Y., and Wheeler, B.C., 2004, Micro-stencil based microelectrode array for neuronal cultures, Abstract, Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.

51. Chen, H.C., and Wheeler, B.C., Evaluation of algorithms for displaying apparent connectivity in neuronal networks, Abstract, Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.

52. Krishnan, B., and Wheeler, B.C., Evaluation of wavelet-based methods for spike sorting, Abstract, Biomedical Engineering Society Meeting, Oct. 2004, Philadelphia.

53. Khatami, D.B., Nam, Y., Brewer, G.J., and Wheeler, B.C. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. EMBS Annual Conference, San Francisco, Sept 2004.

54. Nam, Y., and B.C. Wheeler, Multichannel recording and stimulation of neuronal cultures grown on microstamped poly-D-lysine,EMBS Annual Conference, San Francisco, Sept 2004.

55. Bruce C. Wheeler, Yoonkey Nam, and Gregory J. Brewer, Patterning to Influence in vitro Neuronal Interfaces, invited talk, EMBS Annual Conference, San Francisco, Sept 2004.

56. Wheeler, B.C., Nam, Y., Khatami, Y., Scharnweber, R.F., Brewer, G.J., 2004, Patterned Neuronal Networks to Study Information Processing in vitro on Microelectrode Arrays,abstract, SIMEA 2004, Reutlingen Germany, July 6, 2004.


57. Nam, Y., Wheeler, B.C. Neural recordings of dissociated hippocampal cultures using a 3D tip shaped microelectrode array, abstract, SIMEA 2004, Reutlingen Germany, July 6, 2004.

58. Choi, Y., Seungkeun Choi, S., Powers, R., Nam, Y., Marr, A., Brewer, G.J., Wheeler, B.C., Allen, M.G., 2004, Three-Dimensional Tower Structures with Integrated Cross-Connects for 3-D Culturing of Neurons, poster, 2004 Solid-State Sensor and Actuator Workshop.

59. Ratnam, R., Jones, D.L., Wheeler, B.C., and Feng, A.S., 2003, "Online estimation of room reverberation time," Journal of the Acoustical Society of America, vol. 113, p. 2269, 2003.

60. Nam, Y., Khatami, D., Brewer, G.J., Wheeler, B.C., Spontaneous and Evoked Electrical Activity in Patterned, Cultured Neuronal Networks, Ann. Conf., Soc. Neurosci, New Orleans, Nov. 2003.

61. Scharnweber, R.F., Nam, Y., Chang, J.C., Brewer, G.J., Wheeler, B.C., Technique for presenting multiple guidance cues to cultured embryonic rat hippocampal neurons, Ann Conf., Soc. Neurosci, New Orleans, Nov. 2003.

62. Larsen, E., Lansing, C.R., O’Brien, W.D., Jr., Wheeler, B.C., Feng, A.S. Acoustic scene analysis using estimated impulse responses, 37th Asilomar Conf on Signals, Systems and Computers, Nov 6-9, Pacific Grove CA, 2003.

63. Nam, Y., Khatami, D., Wheeler, B.C., and Brewer, G.J., Electrical stimulation of patterned neuronal networks in vitro, IEEE EMBS Annual Conference, Cancun, Mexico, October, 2003

64. Mohan, S., Kramer, M.L., Wheeler, B.C., and Jones, D.L., Localization of nonstationary sources using a coherence test. IEEE Workshop on Statistical Signal Processing. September 2003.

65. Nam, Y., Scharnweber, R., Chang, J.C. Wheeler, B.C., Brewer, G.J., A new MEA design approach for patterned neuronal circuits, poster presentation at SIMEA, Denton TX, May 2003.

66. Khatami, D., Nam, Y., Wheeler, B.C., Neural characterization of spontaneous activity of spatially confined neuronal networks, poster presentation at SIMEA, Denton TX, May 2003.

67. Nam, Y., Scharnweber, R., Khatami, D., Wheeler, B.C., Brewer, G.J. Neural networks in vitro – does function follow the form?, poster presentation at SIMEA, Denton TX, May 2003.

68. Brewer, G.J., Wheeler, B.C., Enhanced synaptogenesis from nutrient support and neuron patterning on microelectrode arrays, presentation at SIMEA, Denton TX, March 2003.

69. Nam, Y., Wheeler, B.C., Brewer, G.J., Electrical recordings with gold coated microelectrode arrays that permit alkanethiol control of neuronal attachment, IEEE EMBS Mtg, Houston TX, Oct 2002, on CD ROM

70. Chang JC, Brewer GJ, Wheeler BC. An enhanced microstamping technique for controlled deposition of proteins. 2nd Annual International IEEE-EMBS Spec. Top. Conf. Microtechnologies in Medicine and Biology. Proceedings (Cat. No.02EX578). IEEE. 2002, pp.126-31. Piscataway, NJ, USA.

71. B.C. Wheeler, "Designing In Vitro Patterned Neuronal Networks," invited presentation, 49th International Vacuum Society Meeting, Denver, CO, November 7, 2002.

72. Nam, Y., Wheeler, B. C., and Brewer, G. J., "Electrical recordings with gold coated microelectrode arrays that permit alkanethiol control of neuronal attachment," IEEE EMBS Mtg, Houston, Oct 2002. On CD.

73. Chang, J. C., Brewer, G. J., and Wheeler, B. C., "An enhanced microstamping technique for controlled deposition of proteins," [Conference Paper], 2nd Annual Int.l IEEE-EMBS Special Topic Conf. Microtechnologies in Medicine & Biology. Proc. Cat. No.02EX578, IEEE, Piscataway, NJ, 126-131, 2002.

74. Nam, Y., Wheeler, B.C., Brewer, G.J. Gold surface microelectrode arrays permit geometrical control of neuronal networks via thiol linking chemistry, IEEE EMBS Spec. Top. Conf. On Microtechnologies in Medicine and Biology, Madison, WI, May 2-4, 2002.

75. Nam, Y., Chang, J. C., Wheeler, B. C., Brewer, G. J., "Building Biological Neuronal Networks," presented at Cambridge Healthtech Conference BioMEMS & Biomedical Nanotechnology World 2001, Columbus Ohio, and at the NIH Neural Prosthesis Program Annual Meeting, Bethesda, MD, October, 2001.

76. J. Larsen; Lockwood, M. E.; Lansing, C. R.; Bilger, R. C.; O'Brien, Jr., W. D.; Jones, D. L.; Wheeler, B. C.; and Feng, A.S., "Performance of a frequency-based minimum variance beamforming algorithm for normal and hearing impaired listeners," ASA Meeting, Chicago, IL 2001. Journal of the Acoustical Society of America, vol. 109, June, 2001.

77. Berry, M. Lockwood, M.E., Jones, D.L., Bilger, R.C., Lansing, C.R., Liu, C., O'Brien, W.D., Wheeler, B.C. and Feng, A.S. (2001) Beamformer improvement with increasing number of sensors. J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.

78. Lockwood, M.E., Lansing, C.R., Bilger, R.C., O'Brien, W.D., Jones, D.L., Wheeler, B.C. and Feng, A.S. (2001). Performance of a frequency-based minimum variance beamforming algorithm for normal and hearing impaired listeners. J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.


79. Zheng, Y., Lockwood, M.E., Wheeler, B.C., Jones, D.L., Feng, A.S., O'Brien, W.D., Bilger, R.C., Lansing, C.R. (2001) Comparison of binaural beamformers for speech extraction in complex auditory scenes. J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.

80. Lockwood, M.E., Yang, K.L., Jones, D.L., Bilger, R.C., Lansing, C.R., Liu, C., O'Brien, W.D., Wheeler, B.C. and Feng, A.S. (2001) Robustness of the beamforming algorithms with head-related transfer functions. J. Acoust. Soc. Am. 109, June, ASA Mtg., Chicago.

81. Lockwood, M.E., Elledge, M.E., Yang, K.L., Jones, D.L., Lansing, C.R., Bilger, R.C., Wheeler, B.C., O'Brien, W.D. and Feng, A.S. (2000) Simulation and real-time implementation of a new optimum beamforming technique. Intern. Hearing Aid Research Conference in Lake Tahoe (CA): 32-33.

82. Yang, K.L., Lockwood, M.E., Elledge, M.E. & Jones, D.L. (2000) A comparison of beamforming algorithms for binaural acoustic processing. Proc. 9th IEEE Digital Signal Processing Workshop. Hunt (TX), Oct. 2000.

83. Larsen, J., Lockwood, M.E., Lansing, C.R., Bilger, R.C., O'Brien, W.D., Jones, D.L., Wheeler, B.C. and Feng, A.S. (2001) Performance of a frequency-based minimum variance beamforming algorithm for normal and hearing impaired listeners. Abstr. 24th Annual Midwinter Meeting of the Assoc. Res. Otolaryngol., 174.

84. Elledge, M.E., Lockwood, M.E., Bilger, R.C., Feng, A.S., Jones, D.L., Lansing, C.R. O'Brien, W.D. and Wheeler, B.C. (2000) Real-time implementation of a frequency-domain beamformer on the TI C62X EVM. Presented at 10th Ann. DSP Technol. Educ. & Res. Conf., Houston (TX), August 2-4.

85. I. C. Henry, A. B. Kirillov, B. C. Wheeler, and H. W. Wiggins, Jr., "Spike Sorting Performance Metrics," conference paper, IEEE EMBS Meeting, Chicago, IL, July 2000. On CD ROM.

86. D. W. Branch, B. C. Wheeler, G. J. Brewer, and D. E. Leckband, "Long-term Stability of Microstamped Substrates of Polylysine and Grafted Polyethylene Glycol in Cell Culture Conditions," conference paper, IEEE EMBS Meeting, Chicago, IL, July 2000. On CD ROM.

87. M. E. Elledge; Lockwood, M. E.; Bilger, R. C.; Feng, A. S.; Goueygou; Jones, D. L.; Lansing, C. R.; Liu, C.; O'Brien, Jr., W. D.; and Wheeler, B. C., "A real-time dual-microphone signal-processing system for hearing aids," Journal of the Acoustical Society of America, vol. 106, Part 2, no. 2279A, 1999.

88. Lockwood, M. E., Jones, D. L., Elledge, M. E., Bilger, R. C., Feng, A. S., Goueygou, M., Lansing, C. R., Liu, C. O'Brien, Jr., W. D., Wheeler, B. C., "A minimum variance frequency-domain algorithm for binaural hearing aid processing," ASA Meeting, Columbus OH, October 1999. Journal of the Acoustical Society of America, vol. 106, p. 2278, 1999.

89. M. E. Lockwood, D. L. Jones, M. E. Elledge, R. C. Bilger, A. S. Feng, M. Goueygou, C. R. Lansing, C. Liu, W. D. O'Brien, Jr., and B. C. Wheeler, "A minimum-variance frequency domain algorithm for binaural hearing aid processing," ASA Meeting, Columbus OH, October 1999. Journal of the Acoustical Society of America, vol. 106, p. 2278, 1999.

90. M. E. Elledge, M. E. Lockwood, R. C. Bilger, A. S. Feng, M. Goueygou, D. L. Jones, C. R. Lansing, W. D. O'Brien, Jr., and B. C. Wheeler, "A real-time dual-microphone signal processing system for hearing aids," ASA Meeting, Columbus OH, October 1999. JASA, vol. 106, p. 2279, 1999.

91. Wheeler, B.C. (1999) “Micropattern neural networks in a dish,” invited talk, Cambridge Healthtech Institute Fourth Annual Conference on Microsystems Technology in Medicine and Biology, Boston MA.

92. Venkateswar, R. A., Branch, D. W., and Wheeler, B. C. (1999) “A novel method for producing patterned biomolecule gradients,” Proc. IEEE EMBS 21st Annual Int. Conf., Atlanta, GA, October.

93. Chang, J. C., Wheeler, B. C., and Brewer, G. J. (1999) “Substrate recording of patterned hippocampal neurons on multielectrode arrays,” Proc. IEEE EMBS 21st Annual Int. Conf., Atlanta, GA, October.

94. Branch, D. W., Wheeler, B. C., Brewer, G. J. (1999) “Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine,” Proc. IEEE EMBS 21st Annual Int. Conf., Atlanta, GA, October.

95. B. C. Wheeler, G. J. Brewer, D. W. Branch, J. Chang, and K. Venkateswar, "Rational Design Of In Vitro Neural Networks Using Patterned Self-Assembled Monolayers," American Chemical Society Abstracts, Los Angeles CA, March 1999.

96. Lockwood, M.E., Jones, D.L., Elledge, M.E., Bilger, R.C., Feng, A.S., Goueygou, M., Lansing, C.R., Liu, C. O'Brien, W.D. Jr., Wheeler, B.C. (1999) A minimum variance frequency-domain algorithm for binaural hearing aid processing. J. Acous. Soc. Am. 106 (Pt. 2): 2278A.

97. Elledge, M.E., Lockwood, M.E., Bilger, R.C., Feng, A.S., Goueygou, Jones, D.L., M., Lansing, C.R., Liu, C. O'Brien, W.D. Jr., Wheeler, B.C. (1999) A real-time dual-microphone signal-processing system for hearing aids. J. Acous. Soc. Am. 106 (Pt. 2): 2279A.


98. Wheeler, B.C. (1998) “Multineuron Assemblies: Multidimensional Scaling For Visualization”, Symposium on Developments in Multichannel Extracellular Recording, U. Mich. Center for Neural Communication Technology, in conjunction with the 28th Soc. Neurosci. Conf., Los Angeles.

99. Branch, D.W. Chang, J., Brewer, G.J., and Wheeler, B.C. (1998) “Micropatterned Neural Networks,” Abstr. 29th NIH Neural Prosthesis Conference Abstracts, 29, Bethesda MD.

100. Wheeler, B.C., Brewer, G.J., and Branch, D.W. (1998) “Micropatterned Neural Networks,”Abstr. Biomed. Eng. Soc. Conf., Annals of Biomedical Engineering, 26, sup. 1, p. 93, Cleveland OH.

101. Wheeler, B.C. (1998) “Multineuron Assemblies: Multidimensional Scaling For Visualization,” (invited presentation), Abstracts from the Int. Conf. on Substrate-integrated Microelectrode Arrays: Technology and Applications, p. 7, Natural and Medical Sciences Instititue at Tubingen in Reutlingen, Germany.

102. Wheeler, B.C. (1998) “Microstamping Proteins For Precise Control Of Nerve Cell Growth In Culture,” (invited presentation), Abstracts from the Int. Conf. on Substrate-integrated Microelectrode Arrays: Technology and Applications, p. 45, Natural and Medical Sciences Instititue at Tubingen in Reutlingen, Germany.

103. Wheeler B.C., & Brewer, G.J. (1998) “Microstamping proteins for precise control of nerve cell growth in culture,” Cambridge Healthtech Inst. Third Ann. Conf. Microsystems Techn. in Med. & Biol., Boston MA.

104. Liu,C., Feng, A.S., O’Brien, W.D.,Jr., Wheeler,B.C., Bilger, R.C., & Lansing, C.R. (1997) “Improving the acuity and robustness of localization of multiple sources using ‘stencil’ filters,” JASA, 102(5), 3140.

105. Liu, C., Feng, A.S., Wheeler, B.C., O'Brien, W.D., Bilger, R.C. & Lansing, C.R. (1997) “A binaurally-based auditory processor effectively extracts speech in the presence of multiple competing sounds,” Hearing Aid Research and Development Conference, NIH, Bethesda, MD.

106. Corey, J.M., Branch, D.W., Wheeler, B.C., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Influencing polarity of hippocampal neurons using micro-stamp patterns of biomolecules,” Abstr. 27th Soc. Neurosci. Conf., 23, p. 32, New Orleans, LA.

107. Branch, D.W., Corey, J.M., Wheeler, B.C., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Micro-stamp patterns of biomolecules for control of neuronal growth,” Abstr. 27th Soc. Neurosci. Conf., 23, p. 32, New Orleans, LA.

108. Wheeler, B.C., Branch, D.W., Corey, J.M., Weyhenmeyer, J.A. and Brewer, G.J. (1997) “Engineering neural networks in vitro: microstamping biomolecules to control cell position,” Proc. IEEE EMBS 19th Annual Int. Conf., Chicago, IL.

109. B. C. Wheeler and G. J. Brewer, "Microstamping Proteins for Precise Control of Nerve Cell Growth in Culture," Cambridge Healthtech Institute Third Annual Conference on Microfabrication Technology for Biomedical Applications, San Jose CA, October 1997.

110. B. C. Wheeler, D. W. Branch, J. M. Corey, J. A. Weyhenmeyer, and G. J. Brewer, "Microstamping Proteins for Precise Control of Nerve Cell Growth in Culture," Abstract, 28th NIH Neural Prosthesis Conference Abstracts, Bethesda MD, p. 22, October 1997.

111. Liu, C., Feng, A.S., Wheeler, B.C., O'Brien, Jr., W. D., Bilger, R.C., and Lansing, C., "Speech enhancement via directional hearing based on the 'place' theory," Second Biennial Hearing Aid Research & Development Conference, Washington DC, vol. 58A, no. II-P-29, September 1997.

112. C. Liu, A. S. Feng, B.C. Wheeler, W. D. O'Brien, Jr., R. C. Bilger, and C. R. Lansing, "A binaurally-based auditory processor effectively extracts speech in the presence of multiple competing sounds," Hearing Aid Research and Development Conference, NIH, Bethesda, MD, September 1997.

113. J. M. Corey, M. S. Chen, A. L. Brunette, D. W. Branch, J. A. Weyhenmeyer, B. C. Wheeler, and G. J. Brewer, "Influencing neuronal growth with multibiomolecule patterned substrates," 26th Society of Neuroscience Annual Conference, Washington, D.C., vol. 22, p. 1717, November 1996.

114. Wheeler, B. C. (1996) "Universal access to ECE undergraduate information via the Web," IEEE Frontiers in Education Conference, Salt Lake City, UT, on CD ROM, November.

115. Wheeler, B. C., Corey, J.M., Brunette, A.L., Chen, M.S., and Weyhenmeyer, J.A. (1996) "Micropatterning B104 neuroblastoma cells in culture: an assay for neuronal pattern synthesis", IEEE EMBS Annual Conference, Amsterdam, The Netherlands, on CD ROM.

116. Wheeler, B. C., Chang, J. C., Berke, B. A., Corey, J. M. and Branch, D. W. (1996) "Technology for neuronal pattern synthesis and recording," Annals of Biomedical Engineering, p. S-68, v. 24, supplement 1, Fall 1996 Meeting, Biomed. Eng. Soc., University Park, PA.

117. Wheeler, B. C., R. L. Magin, M. Osborne, and B. Bruce (1996) "A freshman general education bioengineering course on the world wide web," ASEE Annual Meeting, on CD ROM, Wash., D.C.


118. Wheeler, B. C., R. L. Magin, M. Osborne, and B. Bruce (1996) "Asynchronous learning in the small engineering classroom," ASEE Annual Meeting, on CD ROM, Washington D.C., on CD ROM.

119. Wheeler, B.C., Corey, J.M. and Brewer, G.J. (1995), “Micropatterning of neural growth in culture: A comparison of laser and photoresist based techniques,” 18th Mtg. Electrochem. Soc., Chicago, 1-8.

120. J. M. Corey, B. C. Wheeler, and G. J. Brewer, "Confinement of hippocampal neurons to grid patterns using three silane-based photolithographic processes," Abstract, 26th NIH Neural Prosthesis Conference Abstracts, Bethesda, MD, p. 24, 1995.

121. Corey, J.M., Wheeler, B.C. and Brewer, G.J., (1995) “Selective silane removal: A technique for micropatterning of neurons in culture,” 17th IEEE EMBS Conference, Montreal, 1995, 1731-1732.

122. Bendre, A., Swain, R., Wheeler, B.C., & Greenough, W. (1995). Augmentation of cerebellar responses to parallel fiber activation following skilled motor acquistion in rats," Soc. Neurosci. Abstr. 21, San Diego, CA.

123. Wheeler, B.C. (1995) “Multineuron assemblies: A generalized clustering approach,” International Workshop on Measures of Spatio-Temporal Dynamics, Bryn Mawr College.

124. Corey, J. M., Wheeler, B.C., & Brewer, G. J. (1995). “Confinement of hippocampal neurons to grid patterns using three silane-based photolithographic processes,” NIH Neural Prosthesis Workshop, Bethesda MD.

125. Wheeler, B.C. and Brewer, G.J., (1994), "Selective hippocampal neuritogenesis: axon growth on laminin or pleiotrophin, dendrite growth on poly-D-lysine", Soc. Neurosci. Abs., 20, p.1292, Miami Beach FL.

126. Stavrakos, N. J., Wheeler, B. C., Gordon, S. H., Wicklow, D. T., Greene, R. V., & Schudy, R. B. (1994) “Identification of contaminated corn from FTIR spectra: A MATLAB tool for pattern recognition and neural network studies,” in C. H. Dagli,F. R. Fernandez,J. Ghosh, & R. T. S. Kumara (Ed.), Artificial Neural Networks in Engineering, 4 (779-784). St. Louis, MO.

127. Wheeler, B. C. (1994). Visualizing multineuron assemblies a generalized clustering approach. In International Symposium on the Dynamics of Neural Processing, June (79-83). Washington D.C.

128. Wheeler, B.C., Corey, J.M., and Brewer, G.J., (1993), "Patterned microcircuits of hippocampal neurons: comparisons of photoresist versus laser ablation processes," Soc. Neurosci Abstr. 19, p1292, Wash. DC.

129. B. C. Wheeler, S. H. Gordon, D. R. DeWispeleare, M. A. Jackson, and R. V. Greene, "Neural network identification of contaminated corn from FTIR spectra," Proceedings of the IEEE EMBS 15th Annual International Conference, San Diego, CA, pp. 301-302, October 1993.

130. Wheeler, B.C., Fang, L., Zardoshti, M., and Wiggins, H. (1993), "Multiple unit action potential sorting: investigation of features, algorithms, and parameters for a fully automated system," Proc. IEEE EMBS 15th Annual Int. Conf., 261-262.

131. Peck, T.L., LaValle, L., Magin, R.L., Adesida, I., and Wheeler, B.C. (1993), "RF Microcoils with Micron-Scale Feature Sizes for NMR Microscopy," Proc. IEEE EMBS 15th Annual Int. Conf., 174-175.

132. Zardoshti, M., Wheeler B.C., Badie, K. and Hashemi R., (1993) "Evaluation of EMG features for movement control of prostheses," Proc. IEEE EMBS 15th Annual Int. Conf., 1141-1142.

133. Wiggins, H., Hetzel, G., Wheeler, B.C., and Lupescu, M., (1993) "Real-time sorting of neural action potentials one hundred channels at a time," NIH Neural Prosthesis Workshop, Bethesda MD, October.

134. Wheeler, B.C., (1993), "Matlab exercises to demonstrate principles of biological modeling and signal processing," Proc. 100th Annual Conference ASEE, 1789-1790, Champaign IL.

135. Wheeler, B.C. (1993), "Micropatterned neuronal cultures," Proc. 5th Iranian Biomed. Eng. Conf., Teheran. 136. Wheeler, B.C. and Zardoshti, M., (1993), "Advances in neural spike sorting," Proc. 5th Iranian Biomedical

Engineering Conference, Teheran. 137. O. Ozdamar and B. C. Wheeler, "Real-time processing of neurological signals: neuronal and EEG spike

detection using digital signal processors," IEEE 14th Ann Int. Conf. IEEE EMBS, Paris, France, Nov. 1992. 138. Wheeler, B.C. (1992), "Sorting action potentials one hundred channels at at a time," Proc. IEEE 14th Annual

Int. Conf. IEEE EMBS, 1256-7 (invited paper). 139. Fang, L., and Wheeler, B.C. (1992), "Sorting neural action potentials in extracellular recordings: a

comparison of the effectiveness of popular sorting features," Proc. Comp. Nsci. Symp., Indianapolis. 140. Zardoshti, M., and Wheeler, B.C. (1992), "Finding the number of neurons in extracellular recordings: a

comparison of the effectiveness of popular clustering indices," Proc. Comp. Nsci. Symp., Indianapolis. 141. Smith, S.R., Wheeler, B.C., Dowd, J.P., and Comer, C.M., (1991), "Investigation of multi-cellular neural

code for directed movement," IEEE EMBS Conf., Orlando. 142. Corey, J.M., Wheeler, B.C., and Brewer, G.J., (1991), "Localization of hippocampal neurons to chemically

modified silicon nitride surfaces," Soc. Neurosci. Abstr., 17, p. 210, New Orleans. 143. B. C. Wheeler, S. Boppart, and C. Wallace, "A flexible, perforated microelectrode array for extended neural

recordings," 21st Society of Neuroscience Conference, New Orleans, LA, vol. 17, p. 175, November 1991.


144. Wheeler, B.C. (1991), "Multi-unit neural recording," Abstr. Biomed. Eng. Soc. Conf., Annals of Biomedical Engineering, 19, 622, Charlottesville.

145. Boppart, S., Wheeler, B.C., and Wallace, C. (1991), "A flexible, porous electrode array improves longevity in hippocampal slice recordings," 14th Midwest Neuroscientists Conf., Urbana IL.

146. Corey, J.M., Wheeler, B.C., and Brewer, G.J. (1990), "Compliancy of hippocampal neurons grown on patterned microcircuits," Soc. Neurosci. Abstr., 16, p. 1008, St. Louis.

147. Wheeler, B.C., Eden, G.J., and Brewer, G.J. (1989), "Patterned growth of hippocampal neurons on microcircuits," Soc. Neurosci. Abstr., 15, p. 1036, Phoenix AZ.

148. Brusnighan, D.A., Strauss, M.G., Floyd, J.M., and Wheeler, B.C., (1989) "Orientation aid implementing the global positioning system," Proc. NE Bioeng. Conf., Boston.

149. Dowd, J.P., Smith, S.R., Comer, C.M., and Wheeler, B.C. (1988), "Multi-unit analysis of a neural ensemble controlling directed movement," Soc. Neurosci. Abstr., 14, p. 689, Toronto.

150. Smith, S.R., Dowd, J.P, Wheeler, B.C., and Comer, C.M. (1988), "Analysis of multiunit data from a neural ensemble controlling directed movement," Proc. 10th IEEE EMBS Conf., 1171-1172, New Orleans, LA.

151. Willming, D.A. and Wheeler, B.C. (1988), "A real-time multichannel DSP-based neural signal analysis system," Proc. 10th IEEE EMBS Conf., 1169-1170, New Orleans, LA.

152. Wheeler, B.C. and Tang, B. (1988), "A flexible electrode array for brain slice recording," Proc. 10th IEEE EMBS Conf., 816-817, New Orleans, LA.

153. Wheeler, B.C. and Smith, S.R. (1988), "Neural network models of an escape response," Neural Networks, 1 (Suppl. 1), 281.

154. B. C. Wheeler, "Personal computer based multiunit and multichannel neural data acquisition," 3rd Symposium on Networks in Brain and Computer Architecture, Denton, TX, 1987.

155. Novak, J.L., Wheeler, B.C., and Chang, F.-L. (1987), "Variations in the delays between peaks within population bursts in CA1 recorded with a 32 element array," Soc. Neurosci. Abstr., 13, 942, New Orleans.

156. Wheeler, B.C. and Smith, S.R. (1987), "Action potential waveform alignment with cubic splines," Proc. 9th IEEE EMBS Conf. 1852-3, Boston, MA.

157. Novak, J.L. and Wheeler, B.C. (1986), "Epileptiform activity recorded from the rat hippocampal slice with a planar microelectrode array," Soc. Neurosci. Abstr., 12, p. 1528, Washington, DC.

158. Smith, S.R. & Wheeler, B.C. (1986), "A digital, real-time action potential detection system," Proc. 8th IEEE EMBS Conf., 259-262, Fort Worth, TX.

159. Wheeler, B.C. and Novak, J.L. (1986), "Current Source Analysis of Brain Slice Electrode Array Data", Proc. 8th IEEE EMBS Conf., 458-460, Fort Worth, TX.

160. Wheeler, B.C., Novak, J.L., and Smith, S.R. (1986), "32 channel microelectrode array recordings from brain slices," Proc. 19th ACEMB, 327, Baltimore, MD.

161. Smith, S.R. & Wheeler, B.C. (1985), "Neural signal detection techniques: performance for real-time applications", Proc. 7th IEEE EMBS Conf., 1274, Chicago, IL.

162. Novak, J.L. and Wheeler, B.C. (1985), "Multi-site stimulation and recording from rat hippocampal slices using a microelectrode array," Proc. 7th IEEE EMBS Conf., 1275, Chicago, IL.

163. Picus, M.M. and Wheeler, B.C. (1983), "A nine channel probe for multiple neuron recording," Proc. 36th ACEMB, 224, Columbus OH.

164. Wheeler, B.C. and Heetderks, W.J. (1980), "Performance of algorithms for the detection and classification of waveforms from individual neurons," Workshop Dig. Sign. & Waveform Anal., 5th Int. Conf. Patt. Recog., Miami Beach.

165. Wheeler, B.C. and Heetderks, W.J. (1980), "The effects of sampling rate on the signal-to-noise ratio of biological signals," Proc. 8th New Eng. Bioeng. Conf., 446-450, Cambridge MA.

166. Wheeler, B.C. and Heetderks, W.J. (1979), "Separation of cockroach giant axon action potentials using multiunit analysis techniques," Proc. 7th New Eng. Bioeng. Conf., 310-313, Troy NY.

167. Kim, M., Shin, K.G., and Wheeler, B.C. (1978), "A systems model of cell kinetics and its application to cancer chemotherapy," Proc. Joint Automatic Control Conf.

Other Conference and Workshop Presentations (unpublished) 1. Microstamping Proteins for Precise Control of Nerve Cell Growth in Culture, Bruce C. Wheeler, Darren W.

Branch, Joseph M. Corey, James A. Weyhenmeyer and Gregory J. Brewer, Conference on Microfabrication for Biotechnology, San Jose CA, October 27, 1997.

2. Artificial Patterning of the Growth of Neurons: a Beginning Technology, Lecture to Spinal Cord Injury Center, Amirkabir University, Tehran, Iran, Jan. 6, 1993.


3. Technology for Recording from Many Individual Neurons, Tutorial, 5th Annual Iranian Biomedical Engineering Conference, Tehran, Iran, Jan. 5-7, 1993.

4. H. Wiggins, G. Hetzel, B. C. Wheeler, and M. Lupescu, "Real-time sorting of neural action potentials one hundred channels at time," 24th Annual Neural Prosthesis Workshop, Bethesda, MD, October 13-15, 1993.

5. NCSA Workshop on Real-Time Applications of High Performance Computing for Biological Imaging, Urbana, IL. , September 1993. (Poster authors: B. C. Wheeler, M. Lupescu, G. Hetzel, and H. Wiggins)

6. Ozdamar, O., and Wheeler, B.C., (1992), "Real-time processing of neurological signals: neuronal and EEG spike detection using digital signal processors", invited tutorial, IEEE EMBS Ann. Conf. (Paris, France)

7. Multineuron Patterning and Recording, ONR Conference on Controlled Growth and Communication in Cultured Mammalian Neurons, Elkridge, MD, April 27, 1992.

8. Techniques for Patterning Hippocampal Neurons in Culture, Midwest Hippocampal Mtg. Urbana, July10, 1992.

Invited Lectures and Presentations – Science and Engineering 1. Can We Forward Engineer a Living Brain? Advances Neural Culture Technology Invited Keynote Lecture.

World Congress on Medical Physics and Biomedical Engineering, Beijing, China, March 25, 2012. 2. Designing Neural Circuits In Vitro. Invited Keynote Speaker. Neuroprothetics 2012. Worcester Polytechnic

Institute, Worcester MA. Feb 23, 2012. 3. Grand Challenge in Neural Engineering: Can We Forward Engineer a Living Brain? BME Department

Seminar, Tsinghua University, Beijing, China, Jan 10, 2012. 4. Grand Challenge in Neural Engineering: Can We Forward Engineer a Living Brain? Invited Keynote

Lecture. Int. Conf. Biomed. & Health Informatics, Shenzhen, China, Jan 4, 2012. 5. Brain on a Chip: Can We Build One? Seminar, School of Health Engineering. Arizona State University, Dec

16, 2011. 6. Enhanced Neural Culture Recording from MEAs Using Microtunnels, Liangbin Pan, Bruce Wheeler.

Satellite Event, 41st Annual Meeting, Soc. For Neuroscience, Nov. 14, 2011. Presentation delivered by Liangbin Pan.

7. Brain on a Chip: Can We Build One? Presentation to the US Turkey Advanced Study Institute on Global Health Care Challenges. Antalya, Turkey. July 19, 2011.

8. Brain on a Chip: Can We Build One? Seminar. Biomedical Engineering Dept. Illinois Institute of Technology, Feb 4, 2011.

9. Brain on a Chip: Can We Build One? IEEE International Conference on Information Technology and Applications in Biomedicine (ITAB 2010), Corfu Greece, November 3-5, 2010.

10. Brain on a Chip: Can We Build One? Packaging Center, Binghamton University, May 19, 2010. 11. Brain on a Chip: Can We Build One? Electrical Engineering Dept., Seoul National University, May 16,

2010. 12. Brain on a Chip: Designing Neural Networks in Culture. Keynote Speaker. Korean Biomedical Engineering

Society Meeting on Future Neurotechnologies for Neuron, Network and Brain, Seoul, May 13, 2010. 13. Can We Forward Engineer a Living Brain? Featured Speaker. IEEE EMBS Forum on Grand Challenges in

Neuroengineering, Bethesda MD May 7-8, 2010. 14. Brain on a Chip: Can We Build One? Center for Exercise Science, University of Florida, Jan 14, 2010. 15. Brain on a Chip: Can We Build One? ISABEL 2009 (bioengineering conference), Bratislava, Slovakia,

November 24, 2009. 16. Brain on a Chip: Can We Build One? Los Alamos National Laboratory, February 27, 2009. 17. Faculty for “Neuro-Electronic Hybrid School, Institute for Advanced Studies, the Hebrew University of

Jerusalem, Israel, March 15-20, 2009. Invited but withdrew for health reasons. 18. Brain on a Chip: Progress in its Design and Construction", Workshop on Nanotechnology as an Enabler for

Neuroscience, Neuroengineering and Neural Prostheses, Stanford University, Dec 11, 2008. 19. Brain on a Chip: If We Build One, What Will It Say? Distinguished Lecture Series, invited talk, Institute for

Computing, Information and Cognitive Systems, University of British Columbia, October 23/24, 2008. 20. Brain on a Chip. U Florida Biomedical Engineering Dept Seminar, Sept 2009. 21. Brain on a Chip: Can We Build One? IEEE EMBS Annual Conference, Neural Engineering Symposium,

Vancouver, British Columbia, Aug 2008. 22. Brain on a Chip: Can We Build One? ECE Dept., Southern Methodist University, April 30, 2008. 23. Brain on a Chip: Can We Build One? Brain and Bio Engineering Department, KAIST, November 14, 2007.


24. Biologically inspired binaural hearing aid algorithms: Design principles and effectiveness, Seoul National University, November 13, 2007

25. Brain on a Chip: Can We Build One? Seoul National University, November 12, 2007. 26. Brain on a Chip: Can We Build One? Biomedical Engineering Department, Yale University, Oct. 18, 2007. 27. From Engineered Neural Networks to Biologically Inspired Hearing Aids, Samples of Bioengineering and

Neural Engineering Research, University of New Mexico, Sept. 13, 2007. 28. Brain on a Chip: Can We Build One? Tutorial, Workshop on Advances in Cognitive and Neural

Engineering, IEEE EMBS Conf, Lyon, August 2007. 29. Brain on a Chip: An Engineer's Challenge, ECE Department seminar, Univ. New Mexico, June 19, 2007. 30. Brain on a Chip: Can We Build One? Plenary Address, IEEE Neural Engineering Conf., Hawaii, May 2007. 31. Brain on a Chip: An Engineer's Challenge, Department seminar, Michigan State University, April 5 2007. 32. Engineering Form & Function in Cultured Neuronal Networks, Univ. Central Florida, March 22, 2007.

Department of Biomedical Engineering Department, University of Florida, March 20, 2007. 33. Engineering Form and Function in Cultured Neuronal Networks, Department seminar, Department of

Molecular Pharmacology, Physiology, and Biotechnology, Brown University, March 16, 2007. 34. Brain on a Chip: An Engineer's Challenge. Colloquium Speaker, Electrical and Computer Engineering

Department, Montana State University, Jan 26, 2007. 35. Engineering Form and Function in Cultured Neuronal Circuits, Bioengineering Department Seminar, UC

Irvine, January 25, 2007 36. Engineering Form and Function in Cultured Neuronal Circuits, Workshop on the Frontiers in Quantum and

Biological Information Processing, U. Central Florida, Orlando, Nov 17, 2006. 37. Progress and Challenges for Engineering Form and Function in Cultured Neuronal Networks,

Bioengineering Department Seminar, Penn State University, Nov 3, 2006. 38. An Introduction to the Use of Microelectrode Arrays, invited talk, International MEA Conference,

Reutlingen Germany, July 2006. (not delivered due to emergency) 39. Engineering Form and Function in Cultured Neuronal Circuits, University of Texas at Dallas, June 26, 2006.

(not delivered due to emergency) 40. Progress and Challenges for the Engineering Design of In Vitro Neuronal Networks, Duke University,

Biomedical Engineering Dept., June 20, 2006. 41. Engineering Form and Function in Cultured Neuronal Networks, Bioeng. Dept., U. Utah, Apr 28, 2006. 42. Engineering Cultured Neuronal Networks. University of Louisville School of Medicine, Neuroscience

Department Seminar, Jan 26, 2006. 43. Engineering Cultured Neuronal Networks. Center for Nano Science and Technology, U Illinois, Nov 2,

2005. 44. Engineering Cultured Neuronal Networks. Biocomplexity Institute, University of Indiana, Oct. 4, 2005. 45. Advances in Neural Interfaces From In Vitro Models, Neural Interfaces Workshop, Bethesda, Sept 9, 2005. 46. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Presentation to the Bioengineering and

Bioinformatics Summer Institute, Clemson University, June 30, 2005. 47. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Presentation to Bioelectrode Interfaces

Short Course, University of Illinois at Chicago, June 3, 2005. 48. Micropatterned Neuronal Networks in Culture: Simplicity or Complexity? Invited talk, 5th Understanding

Complexity Symposium, Department of Physics, University of Illinois at Urbana-Champaign, May 17, 2005 49. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Invited talk, Bioengineering

Department, University of Minnesota, Feb 28, 2005. 50. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Indiana University Purdue

University at Indianapolis, November, 2004. 51. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Bioengineering Department,

University of California at San Diego, October 22, 2004. 52. Patterning to Influence in vitro Neuronal Interfaces, Bruce C. Wheeler, Yoonkey Nam, and Gregory J.

Brewer, invited talk, EMBS Annual Conference, San Francisco, Sept 2004. 53. Cultured Neuronal Networks: Design, Function, Interfaces, Analyses. Invited talk, Bioengineering

Department, Arizona State University, April 2, 2004. 54. Patterning to Enhance Activity of Cultured Neuronal Networks. Invited Talk. Biomedical Engineering

Department, Northwestern University, Mar. 11, 2004. 55. Multineuron Assemblies: Multidimensional Scaling For Visualization, invited talk, Center for

Computational biology, Montana State University, Bozeman MT, January 16, 2004.


56. Patterning to Enhance Cultured Neuronal Networks. Invited talk, Center for Computatonal Biology, Montana State University, Bozeman MT, January 16, 2004.

57. Cultured Neuronal Networks: Design, Function and Interfaces. Invited talk, Fifth International Workshop on Future Information Processing Technologies, Miyazaki, Japan, November 11, 2003.

58. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, Cornell University Nanofabrication Center, October 28, 2003.

59. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, Annual Provost’s Neuroscience Symposium, University of Southern California, October 9, 2003.

60. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk, School of Engineering, University of California at Santa Cruz, August 21, 2003.

61. Taking Neurons to the Electrode, invited talk to the Asilomar Conference on Implanted Auditory Prostheses, Pacific Grove CA, August 20, 2003.

62. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk at Session on Neural Engineering at Gordon Conference on Biomaterials: Biocompatibility & Tissue Engineering, July 20-25, 2003.

63. Patterning to Enhance Activity of Cultured Neuronal Networks, invited presentation at workshop on Nonlinear Dynamics, Control and Guidance of Unmanned Autonomous Vehicles (UAV), ONR and University of Florida, Gainesville, May 29, 2003.

64. Neurons on Chips as Signaling and Control Devices, tutorial presentation at workshop on Nonlinear Dynamics, Control and Guidance of Unmanned Autonomous Vehicles (UAV), ONR and University of Florida, Gainesville, May 29, 2003.

65. Designing In Vitro Patterned Neuronal Networks, seminar, Biomedical Engineering Department, University of Twente, Netherlands, May 20, 2003.

66. Patterning to Enhance Activity of Cultured Neuronal Networks, invited talk at Workshop on Biology and Physics at Interfaces: From Single Molecules to Cells, Research Center at Julich, Germany, May 21, 2003.

67. Designing In Vitro Patterned Neuronal Networks, invited seminar, BioEngineering Department, RPI, Troy NY, March 24, 2003.

68. Designing In Vitro Patterned Neuronal Networks, invited seminar, Chemical Engineering Department, University of California at Santa Barbara, Feb 20, 2003.

69. Biologically inspired binaural hearing aid algorithms: Design principles and effectiveness. Invited talk, McMaster-Gennum Workshop on Intelligent Hearing Instruments, Kimberley, Ontario, Canada, Oct 1, 2002.

70. Designing In Vitro Patterned Neuronal Networks, invited seminar, Bioengineering Department, Case Western Reserve University, Cleveland OH Sept 20, 2002.

71. Designing In Vitro Patterned Neuronal Networks, invited talk, 60th Device Research Conference, Emerging Technologies Session, June 24, 2002.

72. Designing In Vitro Patterned Neuronal Networks, invited talk, Bioeng Dept, U. Southern Cal., June 25, 2002.

73. Designing In Vitro Patterned Neuronal Networks, invited talk, Rutgers University Bioengineering Department, April 1, 2002.

74. Designing In Vitro Patterned Neuronal Networks, invited talk, Complex Systems Symposium, University of Illinois, Urbana, May 14, 2002.

75. Designing In Vitro Patterned Neuronal Networks, invited talk, Materials Research Society Annual Conference, Boston, November 26, 2001.

76. Rational Design of Neural Networks with Real Neurons, graduate seminar, Bioengineering Department, Penn State University, State College PA, Nov 8, 2001.

77. Novel Algorithms for Binaural, Directionally Selective Microphones for Hearing Aid Applications, graduate seminar, Bioengineering Department, Penn State University, State College PA, Nov 8, 2001.

78. Designable Neuronal Networks in Vitro, invited dinner symposium technical talk, Conference on Artificial Neural Networks In Engineering (ANNIE 2001), St. Louis, MO, Nov 6, 2001.

79. Surface Micro-Nanotech Symposium Chair, BioMEMS and Biomedical Nanotechnology Conference, Columbus Ohio, September 22-25, 2001.

80. Progress toward the Design of In Vitro Neural Networks, invited talk, Conference on Assembly and Self-Assembly at the Interface of Biology, Chemistry and Physics, Il Ciocco, Italy, Aug. 20-25, 2001.

81. Progress and Challenges for the Design of In Vitro Neural Networks, International Workshop on Cell-Substrate Coupling, Munich, Germany, June 2001.


82. Rational Design of Neural Networks, seminar to the Max Planck Institute for Polymer Research, Mainz, Germany, March 20, 2001.

83. Microcontact Printing of Biomolecules on Glassy Substrates, lecture to Samsung Central Research Laboratory, Seoul Korea, Feb 9, 2001.

84. Neural Signal Processing Techniques, II. Tutorial to the Nano-Bio Engineering Research Center Workshop, Seoul National University, Korea, Feb 9, 2001.

85. Bioengineering Opportunities for Electrical Engineers, graduate seminar to Konkuk University, Seoul, Korea, Feb 8, 2001.

86. Neural Signal Processing Techniques, I. Tutorial to the Nano-Bio Engineering Research Center Workshop, Seoul National University, Korea, Feb 8, 2001.

87. Rational Design of Neural Networks with Real Neurons, lecture to the Nano-Bio Engineering Research Center Workshop, Seoul National University, Korea, Feb 5, 2001.

88. Micropatterned Neural Networks in a Dish, graduate seminar, Dept. of Bioengineering, Clemson University, Dec. 8, 2000, Clemson SC

89. Rational Design of Neural Networks in Vitro by Micropatterning, IEEE Solid State Circuits and Technology Workshop on Biomedical Electronics, October 12, 2000, Arlington VA

90. Micropatterned Neural Networks in a Dish, seminar to Johns Hopkins University Department of Bioengineeirng, Sept 22, 2000, Baltimore MD.

91. Hybrid Systems, talk to NSF Workshop on Biocomputation, Sept 21, 2000, Arlington VA 92. Biological/Electronic Interface Panel Presenter, NIH BECON Symposium on Nanoscience and

Nanotechnology: Shaping Biomedical Research, Bethesda MD, June 25-26, 2000. 93. Patterned Neural Networks in a Dish. Seminar at University of Illinois at Chicago. February 2, 2000. 94. Neural Networks in a Dish, Southern Illinois University, Springfield, Jan 19, 1999. 95. Micropatterned Neural Networks in a Dish. invited talk, Cambridge Healthtech Institute Fourth Annual

Conference on Microsystems Technology in Medicine and Biology, Boston MA, December 3, 1999. 96. Cochlear Prostheses. Seminar at University of Illinois at Chicago. November 29, 1999. 97. Multiple Neuron Signal Processing: Spike Sorting and Multidimensional Scaling For Visualization,Seminar

to the Inter-University Semiconductor Research Center, Seoul National University, Seoul Korea, Sept, 1999. 98. Undergraduate Electrical and Computer Engineering Education: Trends at the University of Illinois at

Urbana-Champaign. ECE Department Seminar Seoul National University, Seoul, Korea, Sept, 1999. 99. Applications of Cellular Microlithography: The Creation of a Neural Network in a Culture Dish. Seminar to

the Korea Advanced Institute for Science and Technology (KAIST), Taejon, Korea, Sept., 1999. 100. Applications of Cellular Microlithography: The Creation of a Neural Network in a Culture Dish. Seminar to

the Inter-University Semiconductor Research Center, Seoul National University, Seoul Korea, Sept., 1999. 101. Microstamping Deposition for Patterned Nerve Cell Culture. Cambridge HealthCare Institute Conference on

Microsystems Technology in Medicine and Biology, Boston MA, April 16, 1998. 102. Micropatterned Neuronal Networks, Workshop on Novel Applications of VLSI Methodology, Defense

Sciences Research Council, LaJolla CA, July 23, 1997. 103. Can We Use Neural Networks to Understand Neural Networks? Neural Spike Waveform Separation and the

Understanding of Multiple Spike Trains, Physiology Department, Northwestern University, Chicago, IL June 18, 1993.

104. Signals, Sensors, and Structures for Neural Pattern Analysis, Sangamon County Chapter of the Society for Neuroscience, Southern Illinois University, Springfield, IL, December 15, 1992.

105. Microelectrode Arrays for Neuroscience, Delaware State College, Minority Access to Research Careers Seminar, March 20, 1992

Invited Lectures and Presentations – Seientific Writing; Journal Editorship 106. Tips for Scientific Writing and What Editors and Reviewers Are Looking For? BME Dept Graduate

Seminar, Worcester Polytechnic Institute, Worcester MA. Feb 22, 2012. 107. Meet the Editors – IEEE TBME. Int. Conf. Biomed. & Health Informatics. Shenzhen, China, Jan 5, 2012. 108. Writing Scientific Papers: Preparing your manuscript – what are the editors and reviewers looking for? Int.

Conf. Biomed. & Health Informatics. Shenzhen, China, Jan 5, 2012. 109. Writing Scientific Papers: Preparing your manuscript – what are the editors and reviewers looking for? Int.

Conf. Biomed. & Health Informatics. Pre-Conference Workshop. Hong Kong, China, Jan 3, 2012. 110. Writing Scientific Papers: Preparing your manuscript – what are the editors and reviewers looking for? IEEE

Eng. Med. Biol. Conf, Buenos Aires, Argentina, Sept 2, 2010.


111. Writing Scientific Papers, Korean Biomedical Engineering Society Meeting on Future Neurotechnologies for Neuron, Network and Brain, Seoul, May 14, 2010.

112. Writing Scientific Papers, ISABEL 2009 (bioengineering conference), Bratislava, Slovakia, November 25, 2009.

113. Meet the Editors. ISABEL 2009 (bioengineering conference), Bratislava, Slovakia, November 24, 2009. 114. Meet the Editors. IEEE Eng. Med. Biol. Conf, Minneapolis MN Sept 3, 2009. 115. Writing Scientific Papers: Preparing your manuscript – what are the editors and reviewers looking for? IEEE

Eng. Med. Biol. Conf, Minneapolis MN Sept 3, 2009. 116. Meet the Editors. IEEE Eng. Med. Biol. Conf, Vancouver, British Columbia, Aug 2008.. 117. Meet the Editors. IEEE Eng. Med. Biol. Conf, Lyon France, August 2007. Invited Lectures and Presentations – Biomedical Engineering Overviews and Other 118. Balancing BS, MS, PhD programs amidst new funding realities: Issues for BME programs, International

BME Leaders and Department Heads Forum, IEEE Eng. Med. Biol. Conf, Buenos Aires, Argentina, Aug 30, 2010.

119. Developments in Biomedical Engineering. Talk to Gainesville Chapter of the IEEE EMBS. March 25, 2009. 120. Starting a Bioengineering Department at the University of Illinois, invited talk, First International

Conference on the Development of Biomedical Engineering in Vietnam, Ho Chi Minh City, July 27, 2005 121. Future of Bioengineering at UIUC, informal presentation to the Dean of Engineering and key staff at the

University of Texas at Dallas, Feb 20, 2004. 122. Interdisciplinary Bioengineering Research and Programs at the University of Illinois. Invited talk, McMaster

University, Workshop, Adapative Systems Laboratory, Dec. 2, 2002. 123. Bioengineering Opportunities for Electrical Engineers, graduate seminar to Konkuk University, Seoul,

Korea, Feb 8, 2001. 124. Undergraduate Electrical and Computer Engineering Education: Trends at the University of Illinois at

Urbana-Champaign. ECE Department Seminar Seoul National University, Seoul, Korea, Sept, 1999.

DEPARTMENT PROPOSALS University of Florida Biomedical Engineering Department Proposal for an undergraduate degree program in Biomedical Engineering. PI. Submitted Fall 2010. Approved by Board of Trustees, Spring 2011; Board of Governors, November 2011. University of Illinois Bioengineering Department Bioengineering Department proposal; BS Bioengineering proposal; MS, PhD Proposal. Approved by the Urbana-

Champaign Campus, the University of Illinois, and the Illinois Board of Higher Education, 2003. PI: B. Wheeler. (Campus proposal for funding written by Dean David Daniel.)

NCI Siteman Center of Cancer Nanotechnology Excellence (Wickline, Wash. U., overall PI; Adesida, UIUC subcontract PI; Wheeler, co-PI for nanofabrication module). 1/6 summer month for the Bioengineering Department. Funded. 2006-2011. Acted as PI from 2006-2008.

GRANTS Active Support as PI NIH. PI: Wheeler. Engineering Form and Function in Neuronal Networks. R01. 2006-2011. Direct/Indirect

$931k, $380k; subcontract to SIUSM Direct/Indirect $670/270k.] IEEE Transactions on Biomedical Engineering. Editor in Chief Support. $63k/year, 2007-2012 (6 years). Submitted, Likely to be Funded NIH. PI: Wheeler. Engineering Form and Function in Neuronal Networks. R01. 2012-2017. Requested

Direct/Indirect $956k/432k; subcontract to SIUSM Direct/Indirect $744k/288k. 17.5% cut expected. Previous External Funding as PI or with Substantial Involvement as Co-PI


NIH: R01 EB 000786 BRP program, 2002-2007, Development and Information Processing in 3-D Patterned Neural Circuits, subcontract from Georgia Tech, DeWeerth PI; UIUC component: Wheeler, PI approx $500k direct over 5 years.

Information Processing in Designed Neuronal Circuits, PI: Wheeler, Co-PI: Brewer. 2002-2006, NSF. $1,156,000 total direct+indirect.

Project FROG (for hearing aid algorithm development). Phonak. PI: Feng. Co-PIs: Wheeler, Jones, 10% effort. $330,000 annual, 11/00-6/01; $550,00 annual, 6/01-6/03.

NIH: PHS 1 F30 MH12397-02 PI: Wheeler, 2000-2005. Studies of living, sparse, patterned neural network. Support for pre/post doctoral student John Chang.

Real Time Implementation of Intelligent Hearing Aids. NIH. $150,000 total direct, two years plus extension. PI: Wheeler. 7/00-6/03.

DARPA Subcontract from SUNY Binghamton. Development of a Biomimetic Acoustic Microsensor. 9/29/00-9/28/03. $179,525 annual. (PI: Jones; coinvestigator: Feng, Wheeler, O’Brien, 5% effort).

Micropatterned Neural Networks. NIH. $150,000. 10/99-4/02. PI: BC Wheeler (10% time) Microstamping Proteins and Micropatterning Neurons. NIH. $100,000. 10/98-10/00. PI BC Wheeler (10% time) U.S.-Korea Cooperative Research: Micropatterned Neural Networks and Microelectrode Arrays. NSF: PI: BC

Wheeler. $16, 504 direct costs, 1999-2001 (travel support). Optimizing Data Processing Systems for Grain Evaluation. US Dept. Agriculture, Northern Regional Research

Center, Peoria IL. 07/95-07/99. PI: BC Wheeler. $18,000. Bioengineering Curriculum Development at UIUC: Engaging Non-Science Majors and Future Teachers.

Whitaker Foundation. 8/93-8/96. PIs: RL Magin, B Bruce. Duration: 3 years. Total: $452,568. Role: coinvestigator.

Novel Sensors to Monitor Solid-Substrate Fermentations, Biotechnology Research and Development Corporation, PI: BC Wheeler. 6/89-7/94. Total: $169,656.

Investigation Of Neuronal Spike Recognition Algorithms, PI BC Wheeler. (Subcontract to NIH SBIR Phase II Program, Spike Detector for Multichannel Neuronal Data Acquisition, PI: Harvey Wiggins, Spectrum Scientific, Dallas.) 4/91-3/93. $77,593 total.

Investigation Of Neuronal Spike Recognition Algorithms, $4270, UIUC Research Board, 1 year, 1992. Patterned Neuronal Networks, NIH. PI: Bruce C. Wheeler. 10% effort. 4/91-3/93. Direct Cost: $70,000. Spike Detector For Multichannel Neuronal Acquisition, consultant, (PI H. Wiggins, Spectrum Scientific, Dallas,

$45,600, 1 year.) Spatial Description Of Epileptiform Activity In The Hippocampal Slice With A Microelectrode Array, $25,000, 1

year, Epilepsy Foundation of America, 1987-8. 3M Faculty Award, $20,000, 1984-6. Research Gift For Electrode Array And Microsensor Studies. Fabrication Of Buried Membrane Ion-Selective Field Effect Transistors,$39,000,NSF ECS83-07399,1983-6. Fabrication And Use Of Microelectrode Arrays For Neural Recording, $114,882, Whitaker Found., 1982-4. Other Previous Funding Experience Dependent Changes in Brain. NIH. $782.964. 3/99-2/04. PI: D. Clayton. Co-PIs: Volman, Wheeler

(2% time – primarily consultative) Physical exercise, mental activity, and brain plasticity. NIH 2 R01 AG10154-10A2. PI WT Greenough. Co-PI

BC Wheeler. 7/1/00-6/30/03. (consultative) Physical Exercise, Mental Activity, And Brain Plasticity. NIH. PI WT Greenough. Co-PI BC Wheeler. 7/1/95-

6/30/98. $304,073 (consultative). A Database System for Neuronal Pattern Analysis. NSF. 9/98-8/03. PI M. Gabriel. CoPIs: M Nelson, BC

Wheeler and 5 others. Total: $480,836. (2% – primarily consultative) A Database System for Neuronal Pattern Analysis. NSF. 6/92-5/98. PI M. Gabriel. CoPIs: M Nelson, BC

Wheeler and 5 others. (consultative) Total: $103,402. Development of Microdomain RF Coils for NMR Microscopy, NSF:. PI: R.L. Magin. Co-PIs: BC Wheeler, P

Lauterbur. 9/1/91-8/31/94. Total cost: $295,000 Center for the Neurobiology of Learning and Memory, NSF BNS 88-21219, PI: W.T. Greenough. Co-PIs: Feng,

Gabriel, Wheeler. Entire period of support: 5/89-5/94. Total: $593,566 Chemical Communication Between Cells and Engineered Bioscaffold Materials. University of Illinois Critical

Research Initiative. $200,000. 6/98-6/00. PI: D. Leckband. Co-PIs: Wheeler, Gross, Eurell. (10% time) Fabrication of Micro-Miniature Devices and Micro-Electrical-Mechanical Systems. PI: MA Shannon. One of

seven co-PIs. University of Illinois, Critical Research Initiative Program. 6/95-5/97. $200,000.


Surface Modification to Enhance Selective Neuronal Growth. 7/95-8/96. UIUC Research Board. $19,600. PI: BC Wheeler.

Precise Control of Neuronal Growth: An Enabling Technology for Neural Prosthetics; University of Illinois, Mary Jane Neer Fund; $15,000; 1997-1998. PI: BC Wheeler.

Micropatterned substrates as an aid to spinal cord regrowth, $13,000, 1 year, with T. Khan, co-PI, UIUC-Hines VA Satellite Research Program, 1990-1.

A proposal to develop a global navigation system for the visually impaired, co-investigator with M.G. Strauss, $6,394, UIUC Research Board, 1988.

Neurobiological and ultrasonic applications of neural networks, with C.M.W. Daft, $7872, 1 year, UIUC Research Board, 1988.

Initial microsensor investigations of fundamental properties of biological films, with B.E. Rittmann. Data acquisition system for brain slice studies with microelectrode arrays, $4332, NIH Biomedical Research

Support Grant, UIUC, and Bioengineering Faculty Grant, UIUC, 1984. Fabrication and use of a planar microelectrode array in brain slice recording, NIH Biomedical Research Support

Grant, UIUC, and Bioengineering Faculty Grant, UIUC, 1984. A Prototype Biomedical Ion-Specific Sensor For Incorporation Into A Miniature Array, $3000, NIH Biomedical

Research Support Grant, UIUC, 1982. A multiple miniature electrode array for insertion into neural tissue, $3500, NIH Biomedical Research Support

Grant, UIUC, 1981. Neural systems laboratory development, with Burks Oakley; $37,500; UIUC Research Board, 1981. Request for Test and Measurement Equipment. PI: BC Wheeler, RB Uribe, PT Krein. Hewlett Packard University

Grants Program. $130,000. (As department representative) Learning Technology Infrastructure Development for the ECE Department. $24,500. 11/95-12/96. University of

Illinois, Learning Technology Initiative. PI: BC Wheeler. Virtual Computer Laboratory and Guided Engineering Design in Modeling of Biological Systems. 6/95-6/96.

SCALE (Sloan Center for Asynchronous Learning Environments.) $19,500. PI: BC Wheeler Enhancement of Freshman Discovery Course: Bioengineering in Biology and Medicine -- Focus on Medical

Imaging. 6/95-6/96. SCALE (Sloan Center for Asynchronous Learning Environments.) $12,000. PI: BC Wheeler

THESES SUPERVISED

Ph.D. Novak, J.L. "Two-dimensional electrode array studies of propagating epileptiform neural activity in the rat

hippocampal slice," Ph.D., 1988, Electrical Engineering. Dr. Novak is a senior project manager at Sandia. He almost succeeded with his own startup for integrated sensors. He began as a research scientist at Sandia.

Smith, S.A. "Extraction, processing, and analysis of multineuron data, analysis, and network simulation," Ph.D., 1991, Electrical Engineering. Dr. Smith is an EE faculty member at Southern Illinois University at Edwardsville.

Corey, J.L. " Cell Patterning: Building Living Neural Networks," Ph.D. 1997, Neuroscience, MD UIUC, 1999. Dr. Corey is an Assistant Professor at the University of Michigan School of Medicine.

Branch, D. “Elastomeric stamping : design considerations for long-term maintenance of neuronal networks”, PhD 1999, Biophysics. Dr. Branch is a Senior Research Scientist at Sandia.

Chang, J. “Technologies for and electrophysiological studies of structured, living, neuronal networks on microelectrode arrays,” Ph.D., Electrical and Computer Engineering, 2002, MD UIUC 2004. He began a residency at Stanford in 2005.

Nam, Y. “Engineering principles to design and analyze patterned neuronal cultures using multielectrode array,” PhD Electrical Engineering, September 2005. Dr. Nam is an Asst Prof. Korean Advanced Institute for Science and Technology.

Musick, K. PhD Electrical Engineering, “Three-dimensional microelectrode array for recording dissociated neuronal cultures,” June 2008.

Scharnweber, R., Neuronal polarization and axonal mRNA localization on microfabricated substrates, PhD, Neuroscience, 2009, MD expected 2009.

Khatami, D. Design, Considerations For Electrical Stimulation And Functional Connectivity Analysis Of Neuronal Networks Patterned On Microelectrode Arrays, PhD, Elect. Eng. 2008. MD expected 2010.

Alagapan, Sankar. Granger Causality and Cultured Neural Networks, PhD expected, 2012 Franca, Eric. How do carbon nanotubes affect in vitro neural recording, PhD expected, 2013.


M.S. Picus, M.M. "Fabrication of a nine-channel probe-type microelectrode array," M.S. 1983, EE. Harvath, A.R. "Fabrication of a covered chamber in silicon," M.S. 1984, EE.. Valesano,W.R. "Multichannel neural data acquisition system with real-time digital filtering," M.S. 1984, EE.. Baillargeon, J.B. "Fabrication of a field effect transistor for use in aqueous environments," M.S. 1984, EE. Novak, J.L. "Simultaneous neural recording with a durable, easily reproducible multimicroelectrode array," M.S.

1985, EE. Boggs, B.A. "Fabrication of a potassium sensor based on an insulated gate FET," M.S. 1985, EE. Smith,S.A. "Performance of neural signal detection techniques for real-time data acquisition," MS. 1985, EE. Stevenson, P.E. "Fabrication of a silicon based microelectrode," M.S. 1985, EE. Hula, D.L. "A PMOS process for the Illinois Fab II lab", M.S. 1986, EE. Ficht, D.A.,"Electrode array development for advanced brain slice recordings," M.S. 1987, EE. Valenti, A."An automated learning phase system for multiunit neural classification," M.S. 1987, EE. Bhyrabvhotla, U. "Hybrid circuit impedance monitoring device for estrus detection," M.S. 1988, EE. Willming, D., "Performance of a real-time neural signal analysis system based upon the TMS320C25 digital

signal processor," M.S. 1988, EE. Tang, B. "Fabrication of a perforated multichannel microelectrode array," M.S. 1989, EE. Chapman, D. "A competitive neural network model of the cockroach escape response," M.S. 1989, EE. Brown, S. "Multichannel spike simulation package," M.S. 1989. Boppart, S. "An approach toward a flexible microelectrode array net for extended neural recordings," M.S. 1991,

EE. Katz, J., "Neural network analysis of FTIR-PAS spectral data from infected corn," M.S. 1991, EE. Fang, L. "Multiple unit action potential sorting: investigation of features, algorithms, and parameters for a fully

automated system," M.S., 1994, EE. Chang, J. “A novel, thin silicon oxide coating for multielectrode array surface modification,” MS., 1997, EE. Venkateswar, R. “A method for microstamping gradients of biomolecules,”M.S., 1998, EE. Shah, M. “Using optical tweezers to position cells on patterned substrates,” M.S. 1999, EE. Henry, I., “Spike detection metrics: error estimation for an automated spike sorting system,” MS, 2000, EE. Zheng, Yang, “Real-time realization issues of the localization and the extraction algorithm,” MS, 2002, EE. Nam, Y., “Implementation of alkanethiol based linking chemistry on microelectrode arrays for neural

engineering,” MS, 2003, ECE. Phatak, Sandeep, “Analysis of acoustics of environment and effect of a reflector on localization,” M.S., 2003,

ECE. Lam, L. 2003. “Evaluation of feature extraction techniques for classification of tetrode recordings of action

potentials”, MS, 2003, ECE. Krishnan, B., “Evaluation of wavelet-based methods for spike sorting, M.S. 2004, ECE. Khatami, D., “Effects of spatial confinement on the spontaneous and evoked activity of linearly patterned

biological neural networks,” MS, 2004, ECE. Chen, H., “Evaluation of algorithms for displaying apparent connectivity in neuronal networks”, MS, 2004, ECE. Musick, Katherine, “Microstamped electrodes with pdms insulator: a design towards disposable and inexpensive

microelectrode arrays,” MS ECE, 2005. Subramaniam, S. Patterned neural culture leads to enhanced learning. MS, 2010 Joag, C. Standalone stimulator for neural cultures for long term use in incubators. MS, 2010. Undergraduate Research and Special Topics Projects: approximately 120 students in 28 years of teaching. Other Training Activities Pan, Liangbin. Postdoctoral Research Scientist, May 2009 – present. Varghese, Kucku. Postdoctoral Research Scientist. April 2009 – Jan 2011. Next position: research engineer at

Sanofi Pasteur, Orlando FL. Dworak, Bradley, Postdoctoral Research Scientist, December 2006-August 2009. Next position: Electrical

Engineer, FAA, Oklahoma City. Nam, Yoonkey, Postdoctoral Research Scientist, Fall 2005-Fall 2006. Next position: Asst Prof. Korean

Advanced Institute for Science and Technology. Vieira, Mauricio, Postdoctoral Research Student, 2005-2007. Next Position: U. Illinois.


Liu, Chang, Postdoctoral Scientist (cosupervised with A. Feng) 1996-2000. Next Position: Research Engineering, Motorola.

Brandt, Robert L. Visiting Research Scientist, Beckman Insitute, 1994-6. Berke, Bret. Non-Degree Graduate Neuroscience Student, 1995-6. Young, Wendy. Research Engineer, 1991-2. Zardoshti-Kermani, Mayhar. Visiting Research Scholar. 1992-1993. Doctoral Committee Service: ~ 60 students.

TEACHING ACTIVITIES

At Florida BME1008 Introduction to Biomedical Engineering. 1 hour freshman introductory course. Created course, guest

lecturers. 2 semesters, 52/100 students. BME 6360 Neural Engineering. 3 hour graduate course. 2 semesters. 26/20 students. At Illinois: Courses BIOEN199--Introduction to Bioengineering: Focus on Medical Imaging. UIUC Freshman Discovery Course. 5

semesters -- 8 to 20 students. Course creator. Integrate computer exercises, electronic conferencing, World Wide Web based course.

BIOEN 298BW- Circuits for Bioengineering Majors. 20/30 students, 2 semesters. Created course to become required for BioE majors.

BIOEN 398 – Fundamentals of Bioengineering. Pilot of required course for BioE majors. 5 students, 1 semester. ECE200--Honors Undergraduate Seminar--20 semesters, 10 to 100 students. Coordinate student/faculty

presentations EE244--Introductory Laboratory; 9 semesters; typically 300 students, >10 TAs; introduced lab practical exams,

computer lecture demonstrations. EE260--Introduction to Circuit Analysis; 1 semester; 250 students. EE270--Introduction to Circuit Analysis; 2 semesters; 80 students. Course Director: 1 semester. EE310--Digital Signals and Systems; 1 semester; 90 students. ECE314/BIOEN314--Biomedical Instrumentation; 2 semesters; 60 students. EE315--Biomedical Instrumentation Laboratory; 1 semester, 45 students. EE324--Analog Filter Design; 1 semester; 150 students. ECE342-- Electronic Circuits; 1 semester, 80 students EE344--Theory and Fabrication of Solid State Devices; lab instructor; 2 semesters; UIUC "Incomplete List of

Excellent Instructors." EE371WA/BIOEN370D--Medical Image Processing; created new curriculum, computer exercises; 2 semesters;

20 students; UIUC "Incomplete List of Excellent Instructors"; paper in IEEE Transactions on Education. EE371WH--Integrated Circuit Fabrication Laboratory; course creator; 1 semester; 8 students; designed exercises,

fabrication processes, devices. ECE375/BIOEN375--Modeling of Biological Systems; 13 semesters; 15--40 students. Rewrote entire course,

introduced computer exercises, team building exercises, conferencing, WWW materials. BIOEN120--Introduction to Bioengineering; 5 semesters; 60 students. EE272/BIOEN270--Special Projects; 2 students per semester average. Currently: 1 student working on laboratory

fabrication, neuronal culture, and on computer pattern recognition and neural network projects. Bioengineering Faculty Advisor--supervised student Open House projects, presentations for eight years;

supervised student editing of international IEEE EMBS student magazine; received Pierce Award for student/faculty interactions. Faculty advisor to UIUC edited, internationally distributed student newsletter.

BIOL 420--Neurobiology Seminar. Coordinator. 6 semesters. 20 students. Awards Related to Instruction and Advising UIUC Medical Scholars Outstanding MD/PhD Advisor 2003 UIUC Campus Wide Award for Excellence in Undergraduate Advising, 2000 Illinois Dad’s Association Outstanding Professor, 1999 Honorary Knight of St. Pat (student leader chosen award), 1999 Pierce Award (student/faculty relations, Engineering College), 1987 Outstanding Advisor, ‘89,93,97,01


“Incomplete List” of Outstanding Instructors, 1984, 1987, 1996. Teaching Prior to UIUC: 1971-1980 1971, Volunteer, Rindge Tech, Cambridge MA. Assisted classroom teacher; both of us were overwhelmed by

inner city students. Estimate: 2 hours/week for 4 weeks. 1971-72. High School Mathematics Teacher, Niskayuna School District, Schenectady NY. Certified by the State of New York as a High School Teacher in mathematics, social studies, physics, and general

science (permanent certification 9/1/77) 1972-73. Teacher, Blacksburg New School 1972-3. Worked with children K-5, mostly in mathematics. Part-time

and unpaid. This was a tiny alternative elementary school serving mostly children of faculty of Virginia Tech. 1973-74. School Board Member, Blacksburg New School. Assisted with policy in the school. 1974-1980. Teaching Assistant, Cornell University Department of Electrical Engineering. I taught every semester

of my graduate career as I did not have research support until my last semester and even then I helped with a digital signal processing laboratory course. Subjects: basic electronics laboratory, freshman computer discovery class, signal processing lab, biomedical instrumentation lab.

ADMINISTRATIVE DUTIES -- SUMMARY Acting Chair, Department of Biomedical Engineering, University of Florida, Jan 2009-present. Budgeting,

advising assistant professors, initiate faculty search. Unexpected development with abrupt departure of previous Chair. Co-author of UG proposal.

Interim Head, Department of Bioengineering, University of Illinois, Jan 2004-Jan 2008 Establishing department, hiring faculty, implementing undergraduate curriculum, overseeing grad admissions,

external affairs, admitting undergraduates. Director, Bioengineering Program, Mar 2002 – Jan 2004. Appointed Director to establish a Bioengineering Department Proposals written: Undergraduate Curriculum, Graduate Program Guide and Curriculum, Departmental Creation;

approved by College of Engineering Executive Committee, Graduate College and UIUC Faculty Senate. Approved by the Illinois Board of Higher Education December 9, 2003. Steady state budget: approximately $20M startup and $3M recurring.

Associate Department Head for Undergraduate Affairs and Chief Academic Advisor, Electrical and

Computer Engineering Department, 1995 - 2001 Major Initiatives: Aggressive intervention with students on probation and poor grades in key technical courses is

correlated with 50% decline (from 4% to 2%) in number students dropped each semester from the ECE Department and a decrease in probation levels from 10% to 8% of ECE students; initiated undergraduate seminar series; rewrote the entire undergrad advising manual for print and the web.

Coordinate Advising Activities of 90 faculty and 1600 Undergraduate Students ECE Schedule advising activities. Interface with Engineering College advisors. Advisor of last resort for students on academic probation, drop status, readmits, and transfers. Arbiter of transfer credit and curriculum substitutions. Development of new honors program activities. Oversight of undergraduate ECE organizations. Initiated Freshman Scholarship Program (1996-present) Initiated ECE Explorations -- department wide undergraduate seminar Rewrote Undergraduate Advising Manual

Development of ECE Department World Wide Web activities Revision and WWW publication of all advising documents relevant to undergraduate advising Developed financial support to ECE faculty for course WWW pages (1995-6) Development of WWW support for student activities, job postings, etc. Development of targeted email capabilities for ECE Department communication with students Development of WWW assisted scheduling of advising appointments

Advise Department Head on policies related to undergraduate programs.


Coordination of campus presentation of proposals for revision of undergraduate curricula Public Representation of the ECE Department

Advising and outreach to prospective students, transfer students, and parents. Develop ECE activities for on-campus WYSE (Worldwide Youth in Science and Engineering) students

(junior/seniors in high school). Develop WWW pages for outreach to high schools.

Chair, Neuroscience Graduate Program, 1990-1993 Oversight of All Program Activities

Reported to the Director of the School of Life Sciences 65 affiliated faculty from 5 colleges and 10 departments, 35 (on average) graduate students. Managed support for continuing graduate students and supervised recruitment of new students $70,000 / year direct budget (no faculty lines) Member, Neuroscience Faculty Search Committees for Computational and Molecular Neuroscience Wrote proposals for training grants.

Acting Chair, Bioengineering Program, 1989-1990

Substituted for RL Magin, who was on sabbatical leave. Managed $100,000 / year budget (no direct faculty lines) Developed seminar series. Developed first draft mission statement and proposal for PhD program.

PROFESSIONAL, SERVICE, AND REVIEWING ACTIVITIES

University of Texas at Dallas Review of Graduate Degree Proposal for the Texas Higher Education Coordinating Board. April 2009.

Departmental Review Panel, Biomedical Engineering Department, University of Miami, Sept. 2008. External Advisory Board, UC Davis / Lawrence Livermore Point of Care Technologies Center. 2008-. External Advisory Board, U Cincinnati Point of Care Technologies Center, 2009-. External Advisory Board, BME Dept, U. Florida, 2003-2008. External Advisory Board, Brain and Bio Engineering Dept., KAIST, Daejon Korea 2007-8. External Advisory Board, Cornell U. Dept. Biol. & Environ Eng., 2004-8, MIT Educational Counselor, since 1978 (Interview approx. 6 MIT applicants each year.) Member, Bioengineering Faculty, 1981-2008; Neuroscience Program, 1984-2008. Bioengineering Student Society Advisor - 1983 to1995; 2001-2008. AAAS Advisory Panel for Louisiana EPSCOR Grant on Bio/Nano Technologies, 2001-3 (four visits) IEEE Fellow, 2008. IEEE Senior Member, 2003. IEEE EMBS Student Advisory (International) Committee - 1992-Present IEEE Central Illinois Section: Member-at-Large, 1982-3; Vice-Chair, 1983-4; Chair, 1984-5. IEEE Engineering in Medicine and Biology Society, Editorial Advisor for internationally distributed student

newsletter, 1992-5. IEEE EMBS Technical Program Committee, 1997 Annual Conference NIH Site Visit Team, Program Project, 1990, 1991, 1995, 1999. NIH Ad Hoc Reviewer, since 1993. NIH Neural Prostheses Program Proposal Concept Reviewer, 1993, 1994, 2000, 2004. NIH Neural Prosthesis Program Progress Report Evaluator, 2006. NIH:Special Study Sections: 1991-4 SBIR Applications in Rehabilitation Engineering; 1992-3 Neuroscience &

Engineering proposals; 2001 Molecular, Cellular and Developmental Neurosciences 7 Study Section, 2001; 1999 (twice), 2002, Bioengineering. 2003, 2004, 2005 Neural/Bioengineering.

NIH Study Sections: Apr 03 MDCN1; Aug 03 ZRG1 MDCN-4; Jan 04 MDCN-A(06); Feb 04 NDPR; Mar 04 ZRG1 MDCN-C(55); May 04 MDCN-A(55); Jul 04 MDCN-G(56), MDCN-A (55), July 04 NINDS TMR RFP-NIH-NINDS-04-04; Aug 04 ZRG1 MDCN-C(55); Feb 05 MDCN-K(55); Dec 04 2005/01 ZRG1 BST-A(50); Jun 05 2005/10 ZRG1 BDCN-G(02); Aug 05 ZRG1-MDCN-C(41); Sep 05 ZDC1 SRB-W(49); Feb 05 BDCN K10, BDCN K50; Jul 06 ZRG1 BDCN-K (50); Jul 06 Nanomedicine Development Centers. Jan08 NIHOD2007035 (Electrode Fab).

NSF: Ad Hoc Reviewer, since 1990 (34 proposals). Panel reviewer 1994. NSF Panel on Biosystems at the Nanoscale. 1999.


NSF Panel Review on Information Technology (preproposals), 2000. NSF Panel Review on Information Technology, 2001. NSF Engineering Research Center Reviewer, 2000, 2002, 2003, 2003. NSF EPSCOR Advisory Committee, 2001, 2002, 2003. NSF Biological Computation Workshop Presenter, 2001. IEEE Trans. Biomed. Eng. Associate Editor – 2001- IEEE Press book series Emerging Technologies in Biomedical Engineering, Member Ed. Board, 1995- J. Neuroscience Methods. Member of Editorial Board, 1996-present. Memberships: AAAS, IEEE, ASEE, Society for Neuroscience Journal Reviewer (# reviews 1990-2011 in parentheses): Advanced Materials (5), Analyt. Chemi (1), Annals

Biomed. Eng. (10), Appl. Phys. Lett. (1), Audiology-Neurology (1), Biomaterials (5), Biomed. Micro Devices (3), Biophysical J. (1), Biosensors and Bioelectronics (1), Biotech. & Bioeng. (3), Biotech. Progress (2), Euro. Biomicrofluidics (1), Biophysics J. (2), Euro. J. Neurosci. (3); Exp. Cell Res. (2), Frontiers Neuroscience (1), IEE Proc. (1), IEEE EMBS Magazine (1), IEEE Sensors J. (4), IEEE Trans. Biomed. Eng. (~100), IEEE Trans. Education (2), IEEE Trans. Nanotech (1), IEEE Trans. Neural Sys. & Rehab Eng. (1), IEEE Trans. Rehab. Eng. (8), J. Applied Bionics & Biomech. (1), J. Biomaterials (1), J. Biomat. Sci, Polymer (1), J. Biomed Mat. Res. Part A (2), J. Nanosci. & Nanotech. (1), J. Neuroeng. (5), J. Neurobiol. (1), J. Neurophysiol. (2), J. Neurosci. (3), J. Neurosci. Methods (34), J. Neurotox. (1), J. Smart Engrg. (1), Lab on Chip (4), Langmuir (12), Med. & Biol. Eng. & Comp. (5), Med. Sci. Monitor (2), NanoLetters (2), NASA (1), Nature Methods (1), Nature Physics (1), Nature Protocols (1), Neural & Behav. Biol. (1), Neurosci. (2), Neurosci. Letters (3), Physiol. Measure. (1), Physica A (1), PLOS 1 (1)Science (1), Sensors & Actuators (1), Tissue Engrg (1)

Proposal Reviewer: NSF (many), NIH (many), Army Research Office (1), Canadian Research Council (1), DOE (2), Engineering Foundation (1), Human Frontier Science Program (2), Indiana 21st Cent. R&D Fund (1), Keck Fdn (1), Louisiana Board of Regents (1), South Carolina DoD EPSCOR (1), Spinal Cord Foundation (2), US-Israel Binational Science Found (2), UIUC (14), US Army Med RsrchCommand (panel), Swiss National Science Foundation (June 2010), European High Frontiers Scientific Program (Dec 2010)

German Federal Ministry Of Education and Research. Review of Centers for Comp. Neurosci. And Neuroechnology. Fall 07, Jan 08. May 2011.

Professorial Reviews for Senior (W3) faculty at Berlin (2011) and Freiburg (2010) Book Proposals: Academic Press (1),Elsevier (1), Prentice Hall (2), West Educational Publishing (1). Promotion Reference Letter Writer: Boston U., Bucknell, UC Irvine (2), Case Western, Drexel, U. Wash, Rutgers

(2), UCSD (2), USC, Georgia Tech (3), Brown, Yale, Purdue( 2), RPI, UCLA, U. Missouri, Stanford, Tel Aviv U., New Jersey Inst. Tech., Michigan State, University of Macao, U. Wisconsin, Minnesota, Pennsylvania (2), U. British Columbia, Arizona State University (2), U. Cincinnati, U. Florida. U. Albany (2).

Award Reference Letters: IEEE Fellow (20), U Minn (3), Drexel (1), UI Chicago (2).

FLORIDA SERVICE AND COMMITTEE ASSIGNMENTS

Acting Chair, Biomedical Engineering, 2009- Search Committee -- Director of the Nanoscience Institute for Medical and Engineering Technology. Search Committee -- Director of the Veterans Administration Brain Research and Rehabilitation Center, 2010-11. Co-Chair, College of Engineering Strategic Planning Committee on Health Care and Biotechnology, 2009-10. Reviewer, UF Planning Grants for Collaborative Research Projects, 2009.

ILLINOIS SERVICE AND COMMITTEE ASSIGNMENTS

Interim Head, Bioengineering, 2004-2008. Campus Health and Wellness Research Initiatives Committee, 2006-7 Campus Translational Research Advisory Committee, 2004-7. Faculty Search Committee, College of Applied Life Studies, 2004-5. Faculty Search Committee, Department of Agricultural and Biological Engineering, 2004-5. Director, Bioengineering Program, 2002-3 Bioinformatics Committee, 2002-2005 ECE Department Advisory Committee (elected), 2001-2003. ECE Department Curriculum Committee, 1994-2005.


Assoc. Head, ECE Department, 1995-01 Dean’s Committee to Propose a Bioengineering Department, 2000-01 Chairman, Neuroscience Graduate Program, 1990-93 Chairman, Bioengineering Faculty, 1989-90 Committee Assignments: Chair, Bioeng. Curr & Courses, 1982-4; Eng. Coll. Teach. & Eval., 1988-90, Chair,

1989-90; Grad. College Eng. & Phys. Sci., 1983-5; Bioproc. Tech., 1984-5; Neurosci. Exec. Comm., 1988-01; ECE Curric., 1984-01; ECE Grad. Comm. 1989-1990; Chair ECE Teach. Eval. & Awards, 1989-90; ECE Honors Comm. Chair, 1992-96, 1997-9.

UIUC Biotechnology Council, 1999. UIUC International Programs Committee, 1997-0. Graduate Dean Search Committee, 1999-2000. Severns Chair Search Committee, 1999. Medical Scholars Program Steering Committee, 1997-2003; Subcommittee on Educational Policy, 1992-93, 97-

98; Admissions Committee, 1997-00. Beckman Program Subcommittee on Office Space Utilization, 1992-93 Beckman Library Committee, 1992-93 Engineering College Honors Committee, 1992-96, 97-99; EOH and SITE Committee, 1992-96 Engineering College Knights of St. Pat Selection Committee, 2000 ECE Department Open House Advisor, 1989-95 Bioengineering Student Society (IEEE EMBS) Advisor, 1982-95, 01-; Open House Advisor, 1982-95 School of Life Sciences Fellowships Committee, 1990-93 Markey Foundation Grant Steering Committee, 1991-93 Computational Neuroscience Faculty Search Committee, 1989-92 UIUC Admissions - Wrote Recruiting Letters to High School Seniors, 1991-98 UIUC Admissions Honors Symposium Presentation to High School Seniors at UIUC, 1991-93 Council on Undergraduate Education 1994-95. Educational Technology Board 1995-98 UIUC Study Abroad Advisory Committee, 1997-8. Women in Engineering: Camp 21st presentation, August 1998; Bioengineering Presenter, 2001 Summer Orientation Faculty Group Leader, 1997-00. Campus Translational Research Activities Committee. 2004-2006.

BRUCE CHRISTOPHER WHEELER Phone: 352-273-9313 Dept: … · January 2012 Bruce C. Wheeler p. 1/25...

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