Spectrophotometric Determination of Bromhexine HCl in Pure and ...
Bromhexine from Wikipedia
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Transcript of Bromhexine from Wikipedia
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Bromhexine 1
Bromhexine
Bromhexine
Systematic (IUPAC) name
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline
Identifiers
CAS number 3572-43-8 [1]
ATC code R05 CB02 [2]
PubChem CID 2442 [3]
ChemSpider 2348 [4]
Chemical data
Formula C14H20Br2N2
Mol. mass 376.13
SMILES eMolecules [5] & PubChem[6]
Pharmacokinetic data
Bioavailability 75-80%
Half-life 12 hr
Therapeutic considerations
Pregnancy cat. A (Aus)
Legal status
Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessivemucus. In addition, bromhexine has antioxidant properties.[7]
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Bromhexine 2
FunctionBromhexine supports the body's own natural mechanisms for clearing mucus from the respiratory tract.It is secretolytic: that is, it increases the production of serous mucus in the respiratory tract and makes the phlegmthinner and less sticky. This contributes to a secretomotoric effect: it helps the cilia - tiny hairs that line therespiratory tract - to transport the phlegm out of the lungs. For this reason it is often added to some antitussive(cough) syrups.Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase theproportion of serous bronchial secretion, making it more easily to be expectorated. Bromhexine also enhances mucustransport by reducing mucus viscosity and by activating the ciliated epithelium. In clinical studies, Bromhexineshowed secretolytic and secretomotoric effects in the bronchial tract area which facilitates expectoration and easescough. It is indicated as “secretolytic therapy in bronchopulmonary diseases associated with abnormal mucussecretion and impaired mucus transport”. Bromhexine is contained in various formulations, high and low strengthsyrups 8mg/5ml, 4 mg/5ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml), adapted to the need of the patients. The posology varies with the age, but there are products for all age groupsfrom infant on. Bromhexine is a well established and well tolerated product in its indication.Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.
Brand names• Bisolvon Forte - link International website Bisolvon.com [8]
• Hoesttabletten Bromhexine HCl• Paxirasol• Barkacin• Vasican• Bisolex
References[1] http:/ / www. nlm. nih. gov/ cgi/ mesh/ 2009/ MB_cgi?term=3572-43-8& rn=1[2] http:/ / www. whocc. no/ atc_ddd_index/ ?code=R05CB02[3] http:/ / pubchem. ncbi. nlm. nih. gov/ summary/ summary. cgi?cid=2442[4] http:/ / www. chemspider. com/ Chemical-Structure. 2348[5] http:/ / www. emolecules. com/ cgi-bin/ search?t=ex& q=Brc1cc%28c%28N%29c%28Br%29c1%29CN%28C%29C2CCCCC2[6] http:/ / pubchem. ncbi. nlm. nih. gov/ search/ ?smarts=Brc1cc%28c%28N%29c%28Br%29c1%29CN%28C%29C2CCCCC2[7] Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents (http:/ / books. google. com/ books?id=mqaOMOtk61IC&
pg=PA55). Springer. p. 55. ISBN 0751404993. . Retrieved 2009-06-03.[8] http:/ / www. bisolvon. com
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Article Sources and Contributors 3
Article Sources and ContributorsBromhexine Source: http://en.wikipedia.org/w/index.php?oldid=367013013 Contributors: Almw113, Arcadian, Beetstra, Casforty, Collinf, Ean84, Edgar181, Hemlock Martinis, Iridescent,Jorgenumata, Kay.fluhr, Markhurd, Nirmos, Pen1234567, Persian splendour, QWen71n, Rifleman 82, Russell E, Selket, Stepa, Tavilis, Third and, Yo-sei Shoshi, 23 ,طبلا يلع نسح anonymousedits
Image Sources, Licenses and Contributorsfile:Bromhexine-PlainSVG.svg Source: http://en.wikipedia.org/w/index.php?title=File:Bromhexine-PlainSVG.svg License: Creative Commons Attribution-Sharealike 3.0 Contributors:User:Pen1234567
LicenseCreative Commons Attribution-Share Alike 3.0 Unportedhttp:/ / creativecommons. org/ licenses/ by-sa/ 3. 0/