“bringing the best of nature to mankind”

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““bringing the best of nature to mankind”bringing the best of nature to mankind”

• Our Facilities

• Product Development

• Making ACTIValoe®

• Topical Indications

• Qmatrix Processing

• Certification

• Innovation

• Services

Modified Aloe barbadensis Polysaccharide with Immunoregulatory

Activity. Zhihua Qiu, Ken Jones: Planta Medica 66, 1-5, 2000

The Farm at Aloecorp de MexicoThe Farm at Aloecorp de Mexico

Aloecorp is a Vertically Integrated Aloecorp is a Vertically Integrated Aloe veraAloe vera supplier supplier

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Processing

• Processing capacity tripled since 2000• Progressive Research Investment• Patented processing methods• Product & Process Innovation

Gonzales, Mexico (120 km from Tampico)Gonzales, Mexico (120 km from Tampico)

Finishing & Packaging FacilityFinishing & Packaging FacilityLyford, TexasLyford, Texas

An ECONET Family Company

TTS Quality Control takes into account all aspects of growing, harvesting TTS Quality Control takes into account all aspects of growing, harvesting and processing and processing Aloe veraAloe vera raw materials to retain biological activity in the raw materials to retain biological activity in the finished product.finished product.

Time, Temperature & Sanitation

Time• Minimal time from Harvest to Stabilization• Minimal time of Processing• Minimal Heat exposure

Temperature• HTST pasteurization followed by cold storage

Sanitation• Quality Assurance and Control on production floor• In-process QC at every step

Our Patented Aloe vera Processing

• Activates macrophage

• Restores the UVB suppressed immune system

• Stimulates fibroblast proliferation

Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity. Zhihua Qiu, Ken Jones: Planta Medica 66, 1-5, 2000

Publication

Unigen Pharmaceuticals investigated the biological role of polysaccharide molecular weight in order to develop a processing method that would retain and enhance the biological activity of native aloe… resulting in the patented processing method now used exclusively by Aloecorp.

U.S. Patent 6,436,679

Bioactivity Guided Process DevelopmentBioactivity Guided Process Development

The Patented MAP Process The Patented MAP Process

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Identification of Optimal Molecular Size of Modified Aloe Polysaccharides with Maximum Immunomodulatory Activity. Sun-A Im et al.: International Immunopharmacology 5, 2005

Publication

Further studies on MAP bioactivityFurther studies on MAP bioactivity

The Patented MAP Process The Patented MAP Process

G2E1 – Aloe vera crude methanol extractG2E1D – Protein free MAP*G2E1DS1 – Polysaccharide fraction < 5 kDaG2E1DS2 – Polysaccharide fraction 5 kDa – 400 kDa (MAP**)G2E1DS3 – Polysaccharide fraction > 400 kDa

* MAP contains <5 kDa - > 2000 kDa PS with 3X increase in max active PS fraction

** 1999 MAP paper identified a specific PS MW max activity of 80 kDa. 2005 paper did not determine specific MW max.

Abstract conclusion

Aloe polysaccharides of 5 – 400 kDa exhibit

• Most potent macrophage activation

• Most phagocytic activity

• Most potent antitumor activity in vivo

The Patented MAP Process The Patented MAP Process

Bioactivity Guided Process DevelopmentBioactivity Guided Process Development

It has been noted that diverse results are reported in clinical studies using Aloe vera. This may be explained in part by the observation that researchers commonly do not determine the composition of aloe used in studies and, in particular, the content or molecular weight distribution of acetylated mannan polysaccharides.

Aloecorp is unique in this respect. Researchers using Aloecorp products are provided with extensive analytical characterization of the test material. As a result, consistent results have been published by these researchers.

Most importantly, all Aloecorp products are manufactured by our patented processing method based on the results of our bioactivity guided processing research. The polysaccharide content and molecular weight distribution of every batch of aloe produced by Aloecorp is determined by HPLC size exclusion chromatography

• Increases important MW fraction 3X

• Stabilized by HTST inactivation• Guaranteed PS content• Substantiated bioactivity

cellulase

Modified Aloe Polysaccharide (MAP) 50 – 200kD

monosaccharide

Timed inactivation of cellulase

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Aloecorp’s patented processing methodAloecorp’s patented processing method

The Patented MAP Process The Patented MAP Process

In vivo topical application

Global ResearchGlobal Research

Original research of Aloecorp’s Original research of Aloecorp’s Aloe veraAloe vera products products

The Patented MAP Process The Patented MAP Process

• Antigenotoxic ActivityCarcinogenesis 1997

• Anticarcinogenic ActivityCarcinogenesis 1999

• Stimulates Antioxidant Production

Journal of Nutritional Science & Vitaminology. 2003 Aug

• Lowers CholesterolJournal of Nutritional Science & Vitaminology. 2003 Aug

• Stimulates Immune SystemPlanta Medica 1999

• Accelerates Wound HealingPlanta Medica 1999

• Aloecorp MAP Enhances Native Biological Activity of AloeInternational Immunopharmacology 2005

Topical Indications Topical Indications

Topical Indications Topical Indications

Biologically Active Vehicle in Topical ApplicationsJournal of the American Podiatric Medical Association June 1989

Accelerating Wound HealingBritish Journal of Dermatology 2001Journal of the Medical Association of Thailand 2000Journal of Ethnopharmacology 1998Journal of the American Podiatric Medical Association 1994Journal of Dermatologic Surgery and Oncology* Too many to list

Wound Healing/Dermal Integument (Anti-aging)

Life Sciences 2003Journal of Ethnopharmacology 1998Molecular & Cellular Biochemistry 1998Indian Journal of Experimental Biology 1998Journal of the American Podiatric Medical Association 1994Journal of the American Podiatric Medical Association 1989

Topical Indications Topical Indications

Moisturizing EffectSkin Research and Technology 2006Association for Professionals in Infection Control and Epidemiology 2003

Topical Immunomodulatory ActivityInternational Immunopharmacology 2005Planta Medica 1999The Journal for Investigative Dermatology 1998Planta Medica 1989* Too many to list

Topical Anti-Inflammatory

Korean Journal of Dermatology 2004Journal of Ethnopharmacology 1996Journal of the American Podiatric Medical Association 1989Journal of the American Podiatric Medical Association 1994*Too many to list

Topical Indications Topical Indications

Calcium and the Skin

Calcium plays a critical roll in epidermal cell differentiation, turnover and wound healing. There is some evidence that cell turnover can be up-regulated by increasing calcium availability topically. Calcium has also been shown effective in treating dry skin due to its role in regulating lipid barrier processes. The National Cancer Research Institute has reported that people with low skin calcium experience greater premature aging of the skin and incidence of skin cancer.

Aloe contains approximately 7% calcium by dry weight and this content is thought to play a role in the accelerated wound healing properties of aloe, moisturizing effect and anti-carcinogenic effects. For this reason aloe should be a critical component of cosmetic and cosmeceutical applications such as:

• Stimulation of post-dermabrasion wound healing J Dermatol Surg Oncol 1990

• OTC exfoliation products (wound healing and moisturizing)

• Anti-aging and skin cancer protection

Aloecorp’s new Qmatrix™ Processing is the latest step in our effort to Aloecorp’s new Qmatrix™ Processing is the latest step in our effort to ““bring the best of nature to mankind”. bring the best of nature to mankind”.

• Qmatrix™ is an patented aloe manufacturing process

• A combination of our patented Modified Aloe Polysaccharide (MAP) process and patent pending Low Temperature/Short Time (LTST) drying process.

• Qmatrix™ Processing… Designed to produce the highest quality Aloe vera powder available

• Only from Aloecorp

Qmatrix ProcessingProcessingTM

Another Innovation… Only from AloecorpAnother Innovation… Only from Aloecorp

Qmatrix ProcessingProcessingTM

Another Innovation… Only from AloecorpAnother Innovation… Only from Aloecorp

• Gentle low temperature/short time drying

• Superior sensory attributes retained (Academic study)• Superior retention of nutrients and bioactivity (Academic study)• Atmospheric pressure (no vacuum)• Energy efficient (Green)• Environmentally friendly (Green)• Superior solubility characteristics• New proprietary products due to versatility

Published studies show that LTST dehydration technology provides Published studies show that LTST dehydration technology provides superior retention of heat labile components, color & flavor characteristicssuperior retention of heat labile components, color & flavor characteristics

Dispersion & dissolution Dispersion & dissolution improvedimproved

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Solubility, bulk density and moisture Solubility, bulk density and moisture absorbance are positively affectedabsorbance are positively affected

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Qmatrix™ Processing Product Advances (8010XQ)Qmatrix™ Processing Product Advances (8010XQ)

Superior Quality Characteristics

Sensory attributes (better taste and color)

Color stability (after reconstitution)

Shelf life (testing in process)

Reduced thermal degradation

Reduced microbial degradation

Superior Physical Characteristics

Improved solubility

Targeted bulk density

Improved flow ability

Less hydroscopic

Homogeneous dry matrix

Patent submitted November 2004

Attorney Docket: ALOE.01/PRExpress Mail No.:

DEHYDRATION OF FOOD COMBINATIONS

FIELD of the inventionThe invention relates to the drying of blends of

aloe, foods or food extracts, herbs or herb extracts, supplements, and the like.

Proprietary blends and Turn-key products possibleProprietary blends and Turn-key products possible

New From AloecorpNew From Aloecorp

New From AloecorpNew From AloecorpQmatrix™ - O2P™ Qmatrix™ - O2P™ Aloe veraAloe vera oil powders oil powders

Qmatrix – O2P Processing enables aloe & oil mixtures to be dried as Qmatrix – O2P Processing enables aloe & oil mixtures to be dried as stable, unique powdersstable, unique powders

• Combinations of nutritional, functional and therapeutic foods, herbs and excipients are combined with aloe to produce proprietary products

• Liquid combinations dried by this process are stabilized in a homogeneous dry matrix

• Patented oil to powder conversion process

• Turn-key proprietary products can be developed

• Offers an alternative tablet or capsule delivery form

• Transforms most edible oils, pastes, gels, liquids into a free-flowing powder

Concept

New From AloecorpNew From AloecorpQmatrix™ - O2P™ Qmatrix™ - O2P™ Aloe veraAloe vera oil powders oil powders

Multiple ApplicationsMultiple Applications

• Nutraceuticals

• Food fortification

• Cosmetics, personal care

• Animal feed, pet food fortification

Certified ProductsCertified Products

Aloecorp products are Certified for the Quality and Purity you needAloecorp products are Certified for the Quality and Purity you need

IASC

• Aloecorp products first Certified in 1989

• Currently have 26 IASC Certified products

ISO 9001

• ISO Certified since 2003

Organic

• Powder products certified Organic in Texas and Europe

Kosher

• Certified Kosher since 1999

Halal (2005)

Aloecorp expects to be cGMP by 2007

SAQA&C Scientific AffairsScientific Affairs

Scientific Affairs

• Original research

• Technical consultation• Indications library• Quality Assurance• Quality Control• Analytical labs• International support structure

• Europe, Asia, Mexico, USA

Innovative & service oriented… we are always working to provide our Innovative & service oriented… we are always working to provide our customers with the best product and supportcustomers with the best product and support

Vertically IntegratedVertically IntegratedThe World’s Leading Supplier of Quality The World’s Leading Supplier of Quality Aloe veraAloe vera

Summary

• Leading the Industry in Quality & Scientific advances

• Bioactivity guided process development• Original research on the product we supply• Investment and innovation• Certified products• Commitment to product development• Scientific support and services

““bringing the best of nature to mankind”bringing the best of nature to mankind”ALOECORP

Thank YouThank You

CEO

Peter Hafermann

Chief Science Officer

Ken JonesDirector of Business DevelopmentBarb Apps

VP Sales and Marketing

Wayne McCune

VP International SalesMick Anderson

SalesJeff BarrieBob Smith