Breast Ovarian Hereditary Breast & Ovarian Cancer Knowing one’s family medical history can be...
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Transcript of Breast Ovarian Hereditary Breast & Ovarian Cancer Knowing one’s family medical history can be...
Hereditary BreastBreast & OvarianOvarian Cancer
Knowing one’s family medical history can be life-saving.
Hereditary Breast Hereditary Breast and Ovarian Cancerand Ovarian Cancer
GENES: BRCA 1 & BRCA 2GENES: BRCA 1 & BRCA 2
BRCABRCA 1 1 52%52%
UNCERTAINUNCERTAIN16%16%
Hereditary
Looking deeper into the DNALooking deeper into the DNA
Hereditary = Born with the mutation
Sporadic = damage occurs after birth
MUTATION = increased MUTATION = increased risk for cancerrisk for cancer
Alcohol /poor Diet / TobaccoWeak immune systemObesity/ Lifestyle/HormonesEnvironment/Getting older
Consider…Consider…
How is a mutated gene passed on?How is a mutated gene passed on?
Cancer risks of BRCA 1 / 2 carriers Cancer risks of BRCA 1 / 2 carriers compared to General Populationcompared to General Population
Genetic Material SamplingGenetic Material Sampling
• Blood
• Saliva (Buccal cells)
Having the mutation does not necessarily
mean that you will
develop cancer.It means you are at a higher higher
riskrisk for developing cancer compared to someone who does
not have the mutation.
Possible Recommendations: If there is a mutation [+]
•Risk-reducing mastectomy
•Risk-reducing removal of ovaries and fallopian tubes
•Use of medications known to minimize risk: Tamoxifen or Raloxifene
Managing the riskManaging the risk