Brazilian Society for Biochemistry and Molecular Biology...

Brazilian Society for Biochemistry and Molecular Biology - SBBq

XXXVI Annual Meeting of the SBBq

The International Union ofBiochemistry and Molecular Biology10th IUBMB Conference

“Infectious Diseases: Biochemistry of Parasites, Vectors and Hosts”

Program

Convention Center of SalvadorSalvador, Bahia, Brazil

May 21-25, 2007

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Scientific Program OverviewTu

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�h to 1�h Registration Desk (Fourth Floor)

�h to 1�h�0 Technical and Books Exhibits (Second Floor, Hall B)

10h to 12h�0 and 14h to 17h�0 Technical Conferences - Chega Nego and Omolu Room

17h�0 to 1�h�0 Poster Session (Second Floor Halls A and C)

Courses (Portuguese) - � to 10h

Oxalá 2 Room Biomarcadores de Processos Oxidativos

Oxalá � Room Bioquímica dos Venenos Animais

Oxum Room Aspectos Bioquímicos e Nutricionais dos Alimentos Funcionais

Conferences – � to 10h

Iemanjá Platéia Room CF-2. How Bacteria Talk to Each Other

Iemanjá Balcão Room CF-�. Mechanisms of Protein Assembly and Folding: Lessons from Minimalist Models

Xango Room CF-4. Trypanosoma cruzi Proline Racemases: Potential Targets for the Development of a Therapy against Chagas’Infection Disease

Oxalá 1 Room CF-5. Looking into Mosquito’s Nose with an Eye on West Nile Virus Surveillance

Break – 10h to 10h�0

Symposia – 10h�0 to 12h�0

Iemanjá Platéia Room SP-1. Arthropod Immunity and Pathogen Transmission

Iemanjá Balcão Room SP-2. Ion Transport in Microorganisms

Xangô Room SP-�. Cell Cycle Control, Cell Proliferation and Cell Death

Oxalá 1 Room SP-4. Cone Sur Symposium-on Infectious Diseases

Oxalá 2 Room SP-5. Bio-Interactions using Surface Plasmon Resonance (SPR)

Oxalá � Room SP-�. Antimicrobial Peptides: Novel Strategies in the Control of Hu-man and Phytopathogens

Lunch – 12h�0 to 14h

Symposia – 14h to 1�h

Iemanjá Platéia Room SP-7. Gene Expression in Trypanosomatids

Iemanjá Balcão Room SP-�. Poxvirus-Host Interaction: An Old and Yet Re-Emergent Story Revisited

Xangô Room SP-�. Antioxidant Therapy: From Past Lessons to New Horizons

Oxalá 1 Room SP-10. Structure and Function of Cysteine Peptidase and Inhibitors

Oxalá 2 Room SP-11. Evolutionary Aspects on Intracellular Protein Trafficking

Oxalá � Room SP-12. Biosafety

Break – 1�h to 1�h�0

Conferences – 1�h�0 to 17h�0

Iemanjá Platéia Room CF-�. Phosphosignalling in Malaria Parasites: Opportunities for Anti-malarial Drug Discovery

Iemanjá Balcão Room CF-7. Surprises in How Microbes Cope with Uncertainty

Xangô Room CF-�. Interdependence of Oxidative Phosphorylation Components for Assembly and Stability

Oxalá 1 Room CF-�. Mast Cell Proteases and their Inhibitors - Biochemistry and Medi-cal Significance

Oxalá 2 Room Midia Exhibitions in Biochemistry (Portuguese and English)

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14h to 17h�0 Registration Desk (Fourth Floor)

14h to 17h00 Technical and Books Exhibits (Second Floor, Hall B)

17h�0 Opening Ceremony (Iemanjá Platéia Room)

1�h�0 Opening Conference (Iemanjá Platéia Room)

1�h�0 Show: Balé Folclórico da Bahia (Iemanjá Platéia Room)

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7�h to 1�h�0 Technical and Books Exhibits (Second Floor, Hall B)

10h to 12h�0 and 14h to 17h�0 Technical Conferences (Chega Nego and Omolu Rooms)

17h�0 to 1�h�0 Poster Session (Second Floor Halls A and C)

Courses (Portuguese) – �h to 10h




Conferences – �h to 10h

Iemanjá Platéia Room CF-10. Protein - Protein Interaction Network of the Quorum Sensing Response in Xanthomonas axonopodis pv. citri

Iemanjá Balcão Room CF-11. The Role of Polyamines in Hypusine Formation, Cell Prolifera-tion and Cancer

Xangô Room

Oxalá 1 Room CF-1�. GMP/Large Scale Production of Liposomal Therapeutics and Vaccines


Symposia - 10h�0 to 12h�0

Iemanjá Platéia Room SP-1�. Hemoglobin Digestion and Heme Detoxification in Vectors and Parasites

Iemanjá Balcão Room SP-14. New Insights into the Pathophysiology, Diagnosis and Treat-ment of Neurodegenerative Disorders

Xangô SP-15. A Protein View in Mechanism of Disease

Oxalá 1 Room SP-1�. Divulgação Científica (Portuguese)

Oxalá 2 Room SP-17. Structural Biology

Oxalá � Room SP-1�. Molecular Motors, Cystoskeleton and Disease


Symposia - 14h to 1�h

Iemanjá Platéia Room SP-1�. Viruses and Vaccines

Iemanjá Balcão Room SP-20. Glial Cells: Old Functions, New Insights

Xangô Room SP-21. Bioinformatics: Genomics and Transcriptomics

Oxalá 1 Room SP-22. Biopolimers and Nanotechnology

Oxalá 2 Room SP-2�. XI Young Life Sciences Talent Award

Oxalá � Room SP-24. Pós Graduação (portuguese)


Conferences - 1�h�0 to 17h�0

Iemanjá Platéia Room CF-14. Interaction of Prion Protein with RNA and DNA: A Crossroad between the Protein and Nucleic Acid World

Iemanjá Balcão Room CF-15. In Vitro Neuronal Differentiation of Embryonic and Progenitor Cells Depends on Kinin-B2 Receptor Activity

Xangô Room CF-1�. Novel Regulation of Posttranslational Modifications In the Golgi Apparatus: From Basic Science to Diseases

Oxalá 1 Room CF-17. Protozoan Associate Molecular Patterns and Toll-Like Receptors (TLRs): New Microbial Adjuvants for Immunological Interventions?

Oxalá 2 Room Midia Exhibitions in Biochemistry (Portuguese and English)

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Thu

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�h to 1�h�0 Technical and Books Exhibits (Second Floor, Hall B)

10h to 12h and 14h to 17h�0 Technical Conferences (Chega Nego and Omolu Rooms)

17h�0 to 1�h�0 Poster Session (Second Floor Hall A and C)

Courses (Portuguese) � – 10 h




Conferences - �h to 10h

Iemanjá Platéia Room CF-1�. Molecular Determinants of Sand Fly Vector Competency for Leishmania

Iemanjá Balcão Room CF-1�. Role of Autophagy in Ischemia/Reperfusion

Xangô Room CF-20. Peptide Concepts with Emphasis on the Blood-Brain Barrier

Oxalá 1 Room CF-21. Mass Spectrometry in Proteomics: Studies of Protein Interac-tion



Iemanjá Platéia Room SP-25. Plasmodium Molecular and Cellular Interactions - from Mos-quito Vector to Infected-Erythrocytes

Iemanjá Balcão Room SP-2�. Molecular Aspects of Ion Transport in Health and Disease

Xangô Room SP-27. INPS Symposium Neuropeptides: Perspectives and Applications

Oxalá 1 Room SP-2�. V Symposium-on Proteomics: “Back to the Future”

Oxalá 2 Room Workshop on Education: SBBQ-IUBMB Workshop: Development of a Concept Inventory for the Molecular Life Sciences: A New IUBMB Initiative

Oxalá � Room CL-1. Oral Presentation (Student Plataform Session)

General Assembly - 12h�0 to 14h (Oxalá 1 Room)


Symposia - 14 to 1� h

Oxalá 1 Room YSF-1. Young Scientist Forum

Iemanjá Balcão Room YSF-2. Young Scientist Forum

Xangô Room YSF-�. Young Scientist Forum

Iemanjá Platéia Room YSF-4. Young Scientist Forum

Oxalá 2 Room CL-2. Oral Presentations (Student Plataform Session)

Oxalá � Room CL-�. Oral Presentations (Student Plataform Session)


Conferences - 1�h�0 to 17h�0

Iemanjá Platéia Room CF-22. Unconventional Control of Gene Expression: mRNA Degrada-tion in Trypanosomes

Iemanjá Balcão Room CF-2�. Protein Homo-Oligomerization: The Biological Significance and Mechanism For Its Occurrance

Xangô Room CF-24. Gliomal Stem Cells as Targets and Normal Stem Cells as Origins and Vectors in a New Approach of Cerebral Tumors

Oxalá 1 Room CF-25. Protein Communication between Plant Pathogenic Bacteria and the Host

Second Floor Hall A and C – Poster Session – 17h�0 to 1�h�0

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�h to 14h Technical and Book Exhibits (Second Floor, Hall B)

10h to 12h Technical Conferences (Omolu Room)

Conferences – � to 10h

Iemanjá Platéia Room CF-2�. Sophisticated Science as Background for Simple Solutions: A Model to Witches’ Broom, a Devastating Cacao Disease Caused by the Fungus Moniliophtora Perniciosa

Iemanjá Balcão Room CF-27. Modulation of Mitochondrial Membrane Permeability in Pathogenesis and Control of Metabolism

Xangô Room CF-2�. Proteomics for Elucidating Protein Function, Regulatory Net-works and Improving Human Health



Iemanjá Balcão Room SP-2�. Chemotherapy and Drug Resistance

Xangô Room SP-�0. Education in Structural Biology and Biotechnology

Oxalá 1 Room SP-�1. Molecular Bases for Patogenic Fungi Studies

Oxalá 2 Room SP-�2. Molecular Mechanisms Involved in Sepsis Progression

Oxalá � Room CL-4. Oral Presentations (Student Plataform Session)

Oxum Room CL-5. Oral Presentations (Student Plataform Session)

Closing Ceremony – 12h45

Iemanjá Balcão Room Closing Ceremony

SBBq Award for Poster Presentation and XI Young Life Sciences Talent Award

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17h30

Opening CeremonyRoom: Iemanjá Platéia

Paulo S. L. Beirão, President of SBBqGlaucius Oliva, Chairman of X IUBMB Conference

18h

Conference 01Room : Iemanjá PlatéiaIntroducer: Bianca Zingales, Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Research, Development and Innovation on Neglected Diseases: Challenges and Opportunities?Carlos Medicis MorelCasa de Oswaldo Cruz (FIOCRUZ), Centro de Desenvolvimento Tecnológico em Saúde, Rio de Janeiro, Brazil

19h30

Show: Balé Folclórico da Bahia

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Conference 4Room : XangoIntroducer: Marcelo Alves Ferreira, Fundação Oswaldo Cruz, Departmento de Bioquímica Biologia Molecular, Brazil

Trypanosoma cruzi Proline Racemases: Potential Targets for the Development of a Therapy Against Chagas’ Infection DiseasePaola MinoprioInstitut Pasteur, Department of Immunology, Paris, France

Conference 5Room : Oxalá 1Introducer: Walter R. Terra, Universidade de São Paulom, Instituto de Química, Departamento de Bioquímica, Brazil.

Looking into Mosquito’s Nose with an Eye on West Nile Virus SurveillanceWalter S. LealUniversity of California, Department of Entomology, USA

Conference 2Room : Iemanjá PlatéiaIntroducer: Jacques-Henry Weil, Institut de Botanique, France

How Bacteria Talk to Each OtherBonnie L. BasslerPrinceton University, Department of Molecular Biology, USA

Conference 3 – PABMB LectureRoom : Iemanjá BalcãoIntroducer: Hernan Chaimovich, Universidade de São Paulo, Instituto de Química, Departmento de Bioquímica and Sergio Teixeira Ferreira, Charmain of the Pan-American Association for Biochemistry and Molecular Biology (PABMB)

Mechanisms of Protein Assembly and Folding: Lessons from Minimalist ModelsJose Nelson OnuchicUniversity of California, San Diego, Center for Theoretical Biological Physics, USA

10h30 to 12h30Symposium 1Room: Iemanjá PlatéiaChair: Marcos Henrique Ferreira Sorgine, Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica Médica

Arthropod Immunity and Pathogen Transmission

Carolina Barillas-MuryNational Institute of Allergy and Infectious Diseases, NIH, Laboratory of Malaria and Vector Research, USAEpithelial Responses of the A. gambiae Midgut to Plasmodium Invasion

Elena A. LevashinaInstitut de Biologie Moléculaire et Cellulaire – IBMC, FranceSurvival of Malaria Parasites in the Mosquito Vector: Role of the Insect Immune System

Alexander RaikhelUniversity of California, Riverside, Department of Entomology, USAToll Immune Pathway in the Mosquito Aedes aegypti

Sirlei DaffreUniversidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Parasitologia, BrazilAntimicrobial Peptides as Part of the Tick Defensive Armamentarium

Symposium 2Room: Iemanjá BalcãoChair: Hector Barrabin, Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica

Ion Transport in Microorganisms

Roberto DocampoUniversity of Georgia, Center for Tropical and Emerging Global Diseases, USAPolyphosphate Accumulated in the Acidocalcisomes is Involved in Osmoregulation in Trypanosomatids

Kildare Rocha MirandaUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, BrazilStructure and Microchemical Anatomy of Acidocalcisomes in Protozoan Parasites

Sergio Akira UyemuraUniversidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, BrazilRNA Interference of Ca2+-ATPase Gene in Aspergillus fumigatus

Hector BarrabinUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica, BrazilProton Transport in Acidocalcisomes in Herpetomonas and Leptomonas

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Room: XangoChair: Nadia Monesi, Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Brazil

Cell Cycle Control, Cell Proliferation and Cell Death

Michelle DebatisseInstitut Curie, FranceRegulation of S-Phase Length in Mammalian Cells

Gustavo Henrique GoldmanUniversidade de São Paulo,Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departamento de Ciências Farmacêuticas, BrazilRegulation of Hyphal Morphogenesis and the DNA Damage Response by the Aspergillus nidulans ATM Homolog ATMA

Gustavo Pessini Amarante MendesUniversidade de São Paulo,Instituto de Ciências Biomédicas, Departamento de Imunologia, BrazilFASL Upregulation and T Cell Death by Aicd are Prevented by Macrophage- and DC-Derived PGE2

Hugo Aguirre ArmelinUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilFGF2 Triggers RHO-A-Mediated-Senescence in RAS-Transformed Mouse Tumor Cell Lines

Symposium 4Room: Oxalá 1Chair: Paulo Sérgio Lacerda Beirão, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Bioquímica e Imunologia, Brazil

Cone Sur Symposium on Infectious Diseases

Juan Jose CazzuloUniversidad Nacional de General San Martin, Instituto de Investigaciones Biotecnológicas INTECH, ArgentinaCysteine Proteinases of Trypanosoma cruzi: Digestive Enzymes, Virulence Factors, and Mediators of Autophagy and Programmed Cell Death

Lucia PiacenzaFaculdade de Medicina Udelar, UruguayEnhanced Expression of Antioxidant Enzymes as a Virulence Factor in Trypanosoma cruzi Infection

Maria Julia Manso AlvesUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilMany Routes that Trypanosoma cruzi Employs to Invade Cells

Symposium 5Room: Oxalá 2Chair: Mauricio Da Silva Baptista, Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Bio-Interactions using Surface Plasmon Resonance (SPR)

Mauricio Da Silva BaptistaUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilSPR in Brazil

Thierry LivacheUniversité Joseph Fourier, FranceSurface Plasmon Resonance Imaging for Clinical Applications

Carlos Bloch JrCentro Nacional de Pesquisa em Recursos Genéticos e Biotecnologia, Departamento de Química, BrazilThermodynamics and Kinetics of Enzyme/Inhibitors Systems and Interaction Studies of Peptides and DMPC Vesicles

Jan Adrianus VerschoorUniversity of Pretoria, Department of Biochemistry, South AfricaCell Wall Mycolic Acids and Cholesterol in the Diagnosis and Pathogenesis of Tuberculosis

Symposium 6Room: Oxalá �Chair: Octávio Luiz Franco, Universidade Católica de Brasília, Departamento de Biologia

Antimicrobial Peptides: Novel Strategies in the Control of Human and Phytopathogens

Marylin AndersonLa Trobe University, Department of Biochemistry, Melbourn, AustráliaDefining the Molecular Interaction of Plant Defensin with Fungal Pathogen

Luciano Paulino da SilvaCentro Nacional de Pesquisa em Recursos Genéticos e Biotecnologia, Laboratório de Espectrometria de Massa, BrazilHigh-Through Put Identification and Co-Localization of Antimicrobial Peptides in Tissue Samples by Imaging Mass Spectrometry

Margherita Anna Antonia Maria BarraccoUniversidade Federal de Santa Catarina, Departamento de Biologia Celular, Embriologia e Genética, BrazilAntimicrobial Peptides from Crustaceans and their Role as Immune-Effectors in the Control of Infections

Octávio Luiz FrancoUniversidade Católica de Brasília, Departamento de Biologia, BrazilStorage Seeds Peptides: The Plants Secrete Guard with Effectiveness against Phyto and Human Pathogens

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Symposium 9Room: XangoChair: Francisco Rafael Martins LaurindoUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração do Hospital das Clínicas, Laboratório de Biologia Vascular, Brazil

Antioxidant Therapy: From Past Lessons to New Horizons

Francisco Rafael Martins LaurindoUniversidade de São Paulo, Faculdade de Medicina, Instituto do Coração do Hospital das Clínicas, Laboratório de Biologia Vascular, BrazilCritical Review of Clinical Studies of Antioxidant Compounds as a Therapeutic Strategy

Ohara AugustoUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilMechanistic and Structural Aspects of Nitroxides as a Model Family of Antioxidants

Marcelo Ganzarolli de OliveiraUniversidade Estadual de Campinas, Instituto de Química, Departameto de Físico Química, BrazilS-Nitrosothiols: From Design to Applications

Homero RubboUniversidad de La República, Facultad de Medicina, Departmento de Bioquímica, UruguayNitrolipids and Tocopherol-Nitric Oxide Donors: Effects on Inflammation and Atherosclerosis

Symposium 10Room: Oxalá 1Chair: Guacyara Da Motta, Universidade Federal de São Paulo, Departamento de Bioquímica, Brazil

Structure and Function of Cysteine Peptidase and Inhibitors

Christiane NeuhofUniversity of Giessen, Faculty of Medicine, Department of Internal Medicine, GermanyEffect of Calpain Inhibition on Myocardial Infarction Following Local Ischemia and Reperfusion

Rogerio MargisUniversidade Federal do Rio Grande do Sul, Centro de Biotecnologia, BrazilPhytocystatins: New Insights after the Arabidopsis, Rice and Poplar Genomes.

Rodrigo Luiz Oliveira Rodrigues CunhaUniversidade Federal de São Paulo, Departamento de Biofísica, BrazilDeveloping Tools for Biology: Study of New Classes of Synthetic Cysteine-Protease Inhibitors and Some Preliminary Applications

Guacyara Da MottaUniversidade Federal de São Paulo, Departamento de Bioquímica, BrazilKininogen Activity is Controlled by Interaction with Cells

Symposium 7Room: Iemanjá PlatéiaChair: Bianca Zingales, Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Gene Expression in Trypanosomatids

Elisabetta UlluYale University, USARNAi Machineries in Ancient Eukaryotes

Alberto Carlos C. FraschUniversidad Nacional de General San Martin, Instituto de Investigaciones Biotecnologicas, ArgentinaPost-Transcriptional Regulation of Gene Expression in Trypanosomes

Santuza Maria Ribeiro TeixeiraUniversidade Federal de Minas Gerais, Departamento de Bioquimica e Imunologia, BrazilMechanisms Controlling Gene Expression in Trypanosoma cruzi

Keith GullUniversity of Oxford, UKThe Biochemistry of Motility and Morphogenesis in Trypanosome Parasites

Symposium 8Room: Iemanjá BalcãoChair: Claudio Antonio Bonjardim, Universidade Federal de Minas Gerais, Brazil

Poxvirus-Host Interaction: An Old and Yet Re-Emergent Story Revisited

Paula TraktmanMedical College of Wisconsin, Department of Microbiology and Molecular Genetics, USAVaccinia Virus DNA Replication and Virion Morphogenesis: Complex Interplay of Virus and Host

Erna Geessien KroonUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, BrazilVaccinia Virus Strains Isolated from Outbreaks in Brazil: Genetic Polymorphism and Variations of Pathogenicity in Mice Model

Hermann Gonçalves SchatzmayrFundaçao Oswaldo Cruz, Laboratório de Virologia, Rio de Janeiro, BrazilMolecular and Epidemiological Aspects on Orthopoxvirus in Humans and Cattle in the State of Rio de Janeiro

Claudio Antonio BonjardimUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, BrazilSignal Transduction Pathways (MAPKs) Associated with Orthopoxviruses Replication

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Room: Oxalá 2Chair: Marcio De Castro Silva Filho, Universidade de São Paulo, Escola Superior de Agricultura “Luiz de Queiroz”, Departamento de Genética, Brazil

Evolutionary Aspects on Intracellular Protein Trafficking

Trevor James LithgowUniversity of Melbourne, Dep of Biochemistry & Molecular Biology, AustraliaEvolution of the Protein Import Machinery in Mitochondria

Gilberto Sachetto MartinsUniversidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de Genética, BrazilArabidopsis Trytophan-Rich Sensory Proteins: Different Subcellular Localization and Alternative Translation Start Codons?

Marcia Maria Margis-PinheiroUniversidade Federal do Rio Grande do Sul, Departamento de Genética, BrazilRice Ascorbate Peroxidase Gene Family Encodes Functionally Diverse Isoforms Localized in Different Subcellular Compartiments

Marcio de Castro Silva FilhoUniversidade de São Paulo, Escola Superior de Agricultura “Luiz de Queiroz”, Departamento de Genética, BrazilDual Targeting as a Conserved Evolutionary Constraint on Gene Duplication

Symposium 12Room: Oxalá �Chair: Walter Colli, Presidente da Comissão Técncia Nacional de Biossegurança (CNTBio), e Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Biosafety

Patricia Machado Bueno FernandesUniversidade Federal do Espírito Santo, Departamento de Ciências Fisiológicas e CTNBio – Área Meio Ambiente, BrazilBiotechnology, Biosafety and Environmental Protection

Edilson PaivaCentro Nacional de Pesquisa de Milho e Sorgo (EMBRAPA) e CTNBio - Área Vegetal, BrazilProspects of Biotech Crops in Brazil

Marco Antonio ZagoUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Clínica Médica e CTNBio – Área de Saúde Humana e Animal, BrazilGenetic Modified Organisms for Human and Veterinary Use

James BroachPrinceton University, Department of Molecular Biology, USARegulation of Genetically Modified Organisms in the United States

16h30 to 17h30Conference 6Room : Iemanjá PlatéiaIntroducer: Knut-Jan Andersen, University of Bergen, Norway

Phosphosignalling in Malaria Parasites: Opportunities for Antimalarial Drug DiscoveryChristian DoerigUniversity of Glasgow Biomedical Research Centre, Centre for Molecular Parasitology, Scotland, UK

Conference 7Room : Iemanjá BalcãoIntroducer: Frederico José Gueiros Filho, Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Surprises in How Microbes Cope with UncertaintyRichard M. LosickHarvard University, USA

Conference 8Room : XangoIntroducer: Anibal Eugenio Vercesi, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Departmento Patologia Clínica, Brazil

Interdependence of Oxidative Phosphorylation Components for Assembly and Stability.Carlos Torres MoraesUniversity of Miami School of Medicine, Department of Neurology, USA

Conference 9Room : Oxala 1Introducer: Maria Luiza Vilela Oliva, Universidade Federal de São Paulo, Department de Bioquímica, Brazil

Mast Cell Proteases and their Inhibitors - Biochemistry and Medical SignificanceChristian SommerhoffLudwig-Maximilians University of Munich, Germany

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Room: Oxalá 2

MEB.01 - BioQuix: A Live-CD system for Biochemistry learning Rodrigues, R.S.; Castro, M.S.; Fontes, W.Universidade de Brasília, Brasília-DF, Brasil20 min

MEB.02 - Science and Art: Muscle Contraction (Ciência com Arte: Contraction of the Muscle)Diucênio Rangel, Luiz A. Dourado, Alexandro Machado, Alessandro Cerqueira, Marcelo N. do Vale, Leopoldo de MeisInstituto de Bioquímica Médica, Universidade Federal do rio de Janeiro-RJ-Brasil�0 min

MEB.03 - NUTRITIONAL AND HORMONAL ASPECTS OF DIABETES: computer tutorialsGraham Parslow¶, Bruce Livett¶, Jonathan Gould†, Janet Macaulay†, Ron Maxwell†

and Marie-Paule Van Damme† ¶

Depart. Bioche. and Mol. Biol., †Monash University, and ¶Melbourne Univ., Victoria-Au.20 minuts

MEB.04 - Biblioteca Digital de Ciências (BDC)Eduardo Galembek**, Bayardo Torres** Depto. de Bioquímica, Instituto de Química, Universidade de São Paulo** Depto. Bioquímica, Instituto de Biologia 20 min.

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Conference 10Room : Iemanjá PlatéiaIntroducer: Sandro Roberto Marana, Universidade de São Paulo, Instituto de Química, Department ode Bioquímica, Brazil.

Protein - Protein Interaction Network of the Quorum Sensing Response in Xanthomonas axonopodis pv. citriShaker Chuck FarahUniversidade de São Paulo, Instituto de Química, Departmento de Bioquímica, Brazil

Conference 11Room : Iemanjá BalcãoIntroducer: Sandro Roberto Valentini, Faculdade de Ciências Farmacêuticas de Araraquara (UNESP), Departmento Ciencias Biologicas

The Role of Polyamines in Hypusine Formation, Cell Proliferation and CancerMyung Hee ParkNational Institute of Dental and Craniofacial Research (NIH-NIDCR), USA

Conference 13Room : Oxalá 1Introducer: Maria Helena Bueno Da Costa, Instituto Butantan, Centro de Biotecnologia, Brazil

GMP/Large Scale Production of Liposomal Therapeutics and VaccinesAndreas WagnerLiposome Technology, Polymun Scientific GmbH, Wien, Austria

10h30 to 12h30Symposium 13Room: Iemanjá PlatéiaChair: Marcus Fernandes de Oliveira, Universidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica, Departamento de Bioquímica Médica, Brazil

Hemoglobin Digestion and Heme Detoxification in Vectors and Parasites

Timothy J. EganUniversity of Cape Town Medical School, Dep Chemistry, South AfricaHaem Detoxification by Spontaneous Self-Assembly of Haemozoin at the Lipid/Water Interface

Paul BrindleyTulane University School, Tropical Medicine, USAAspartic Protease Activities of Blooding Feeding Helminth Parasites Cleave Mammalian Haemoglobins in a Host-Specific Manner

Marcus Fernandes de OliveiraUniversidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica, Departamento de Bioquímica Médica, Brazil Heme Biocrystallization as a Preventive Antioxidant Defense in Blood Feeding Organisms.

Amitabha MukhopadhyayNational Institute of Immunology, New Delhi, IndiaHemoglobin Endocytosis and Trafficking to the Lysosomes: A Novel Process to Generate Intracellular Heme by Leishmania for their Survival

Symposium 14Room: Iemanjá BalcãoChair: Iscia Lopes-Cendes, Universidade Estadual de Campinas, Depto de Genética Médica, Brazil

New Insights into the Pathophysiology, Diagnosis and Treatment of Neurodegenerative Disorders

Maria Luiza Saraiva PereiraUniversidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Serviço de Genética Médica, BrazilDiagnostic Approach in PoliQ Disorders

Henry L. PaulsonUniversity of Iowa, Dep Neurology, USARNA Interference in PoliQ Disordes

Iscia Lopes-CendesUniversidade Estadual de Campinas, Departamento de Genética Médica, BrazilProtein Structural Studies in PoliQ Disorders

Naihe JINGShanghai Institute of Biochemistry and Cell Biology, ChinaThe N-Terminal Region of Amyloid Precursor Protein Determines its Subcellular Localization and Regulates its Processing

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Room: XangoChair: Maria Luiza Vilela Oliva, Universidade Federal de São Paulo (UNIFESP-EPM), Departamento de Bioquímica, Brazil

A Protein View in Mechanism of Disease

Hans FritzUniversity of Munich, Institute for Physical Biochemistry, GermanyKallikreins as Target for Medical Application.

Russolina Benedeta ZingaliUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica Médica, BrazilWhat Snake Venoms Components Can Do for the Treatment of Thrombotic Diseases

Roger ChammasUniversidade de São Paulo, Faculdade de Medicina, Laboratório de Oncologia Experimental, BrazilA Proteomics View of Melanoma Progression and Development of Chemoresistance.

Maria Luiza Vilela OlivaUniversidade Federal de São Paulo, Departamento de Bioquímica, BrazilMolecular Diversity and Biological Implications of Plant Proteinase Inhibitors

Symposium 16Room: Oxalá 1Chair: Débora Foguel, Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica Médica, Brazil

Divulgação Científica (Portuguese)

Débora FoguelEditora de Ciências Biológicas da Revista Ciência Hoje e Professora da Universidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica Médica, Brazil

Ciência Hoje: Uma Revista Brasileira de Divulgação Científica Escrita por Cientistas

Ana Maria Correia MoutinhoUniversidade de Lisboa, Gabinete de Apoio à Investigação, PortugalI&Deiafix - Entre a Ciência e o Jornalismo

Mariluce MouraFundação de Amparo à Pesquisa do Estado de São Paulo, Diretora de Redação da Revista FAPESP, Brazil

Claudio Angelo MonteiroEditor de Ciências do Jornal Folha de São Paulo, BrazilEntre duas Culturas: Cobrindo Ciência em um Jornal Diário

Symposium 17Room: Oxalá 2Chair: Richard Charles Garratt, Universidade de São Paulo, Instituto de Física de São Carlos, Departamento de Física e Informática, Brazil

Structural Biology

Pedro Maria AlzariInstitut Pasteur, Unité de Biochimie Structurale, FranceGlobal Regulation of Fatty Acid Biosynthesis in Gram-Positive Bacteria

Jorge IulekUniversidade Estadual de Ponta Grossa, Departamento de Química, BrazilSearch for New Inhibitors of the Pteridine Reductase (PTR1) from Trypanosoma brucei: Structures of Complexes with Folate Analogues

Ana Carolina de Mattos ZeriLaboratório Nacional de Luz Síncrotron, BrazilNuclear Magnetic Resonance in Structural Biology

Richard Charles GarrattUniversidade de São Paulo, Instituto de Física de São Carlos, Departamento de Física e Informática, BrazilA Structural Approach to the Study of Sept4 and the Human “Septinome”

Symposium 18Room: Oxalá �Chair: Luiz Claudio CameronUniversidade do Rio de Janeiro, Laboratório de Bioquímica de Proteínas, Brazil

Molecular Motors, Cystoskeleton and Disease

John A. MercerMontana State University, McLaughlin Research Institute and Department of Microbiology, USAMyosin-VB Continues to Bind Actin During Microtubule-Based Transport

George S. BloomUniversity of Virginia - Health System, Department of Biology, USATAU-Dependent Microtubule Disassembly Induced by Pre-Fibrillar β-Amyloid: A Seminal Cell Biological Event in Alzheimer’s Disease

Margaret TitusUniversity of Minnesota Medical School, Dep of Genetics, Cell Biology and Development, USAA Link Between Myosin VII and Talin, Conserved Proteins with Critical Roles in Adhesion

Luiz Claudio CameronUniversidade do Rio de Janeiro, Laboratório de Bioquímica de Proteínas, BrazilMyosin V: A Link Between Ischemic Injury and Nervous System Regeneration.

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Symposium 19Room: Iemanjá PlatéiaChair: Ricardo Galler, Instituto Oswaldo Cruz, Departamento de Bioquímica e Biologia Molecular, Brazil

Viruses and Vaccines

Peter W. MasonUniversity of Texas, Department of Pathology and Sealy Center for Vaccine Develop, USADevelopment of Replication-Defective Viruses as Vaccines for Flavivirus Diseases

Arash GrakouiEmory University School of Medicine, Division of Infectious Diseases Core Scientist, Yekes Vaccine Research Center, USAHepatitis C Virus: From Replication to Infection Outcome

Ricardo GallerInstituto Oswaldo Cruz, Departamento de Bioquímica e Biologia Molecular, BrazilExpression of Foreing Protein Epitopes at the Surface of Recombinant Yellow Fever 17D Viruses Based on Three Dimensional Modeling of Its Envelope Protein

Noel TordoInstitut Pasteur, Unit Viral Strategies, FranceFuture Challenges in Rabies Vaccinology

Symposium 20Room: Iemanjá BalcãoChair: Maria de Fatima Dias Costa, Universidade Federal da Bahia, Instituto de Ciências da Saúde, Brazil

Glial Cells: Old Functions, New Insights

Marcienny Bloch TardyUniversité PARIS XII, Faculte de Medecine, FranceRadial Glia in the Adult Brain

Vivaldo Moura NetoUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Anatomia, BrazilNeuron-Glia Interactions: Properties of Human Glioblastoma Cells

Leny Alves CavalcanteUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, BrazilSchwann and Schwannoma Cells Express a Prospectively Functional Mannose Receptor-Like Protein

Alexandre Moraes PinheiroUniversidade Federal da Bahia, Instituto de Ciências da Saúde, Departamento de BiofunçãoGlial Cells Response to N. caninum Infection

Symposium 21Room: XangoChair: Sergio Verjovski-Almeida, Universidade de São Paulo, Instituto de Química, Departamento de Bioquímica, Brazil

Bioinformatics: Genomics and Transcriptomics

Michael GalperinNational Institutes of Health (NIH), National Center for Biotechnology Information, USAConserved Hypothetical Genes and Unassigned Enzymes: How Much Do We Not Understand?

Alasdair IvensWellcome Trust Sanger Institute, UKThe Schistosoma mansoni Genome Sequence Draft: Prospects for Biology and Post-Genomics.

Sergio Verjovski-AlmeidaUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilHypothetical ‘No Match’ Genes in Schistosoma mansoni are Expressed in Adult Worms

Eduardo Moraes Rego ReisUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilNoncoding Intronic RNAs and the Complexity of Gene Expression in Eukaryotes

Symposium 22Room: Oxalá 1Chair: Joana Lea Meira Silveira, Setor de Ciências Biológicas, Universidade Federal do Paraná (UFPR), Departamento de Bioquímica/Setor Ciencias Biologicas

Biopolimers and Nanotechnology

Joana Lea Meira SilveiraSetor de Ciências Biológicas, Universidade Federal do Paraná, Departamento de Bioquímica/Setor Ciencias Biologicas, BrazilCarbohydrate Hydrogel Nanoparticles as a Drug Delivery System

Denise Freitas Siqueira PetriUniversidade de São Paulo, Instituto de Química, Departamento Química Fundamental, , BrazilThin Films of Polysaccharides: Functional and Versatile Surfaces

Regina Célia Monteiro de PaulaUniversidade Federal do Ceará, Departamento de Química Orgânica e Inorgânica, BrazilPolysaccharide as Drug Delivery Matrix: I- Cashew Gum/Chitosan Gels

Robert C. EberhartUniversity of Texas, Southwestern Medical Center at Dallas, USAProgress in Drug-Eluting Bioresorbable Stent Technology

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Room: Oxalá 2Chair: Leda Quercia Vieira, Vice President of SBBq and Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Departamento de Bioquímica e Imunologia, Brazil

XI Young Life Sciences Talent Award

Andrés TrostchanskyUniversidad de La República, Facultad de Medicina, Departamento de Bioquímica-Center for Free Radical and Biomedical Research, UruguayNitroarachidonic Acid Modulates Inflammation Through the Nrf2/are Pathway

Ariane ZamonerInstituto de Ciências Básicas da Saúde (ICBS-UFRGS), Departamento de Bioquímica, BrazilNongenomic Actions of Thyroxine on Cytoskeleton Phosphorylation in Cerebral Cortex of Young Rats are Mediated by Intracellular Calcium Levels and Kinase Pathways

Heberty di Tarso Fernandes FacundoUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilMechanisms in Which Preconditioning and Mitochondrial ATP-Sensitive K+ Channels Protect against Damage Promoted by Ischemia/Reperfusion

Katia da ConceiçãoInstituto Butantan, BrazilBiological Effect-Driven Biochemical Assessment of the Skin Secretion of the Tree-Frog Phyllomedus hypochondrialis

Symposium 24Room: Oxalá �Chair: Anibal Eugenio Vercesi, Coordenador de Política Nacional da SBBq, Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Patologia Clínica

Pós Graduação (portuguese)

Leopoldo de MéisUniversidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica, Brazil

Aline Maria da SilvaUniversidade de São Paulo, Instituto de Química, Brazil

Adalberto R. VieyraUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Fiho, Brazil.

Jorge Almeida GuimarãesPresidente da Coordenação de Aperfeiçoamento e Pessoal de Nível Superior (CAPES), Brazil

Carlos Alberto de Bragança PereiraDepartamento de Estatística, Universidade de São Paulo, Instituto de Matemática e Estatística, Brazil.

16h30 to 17h30Conference 14Room : Iemanjá PlatéiaIntroducer: Iolanda Midea CuccoviaUniversidade de São Paulo, Instituto de Química, Department de Bioquímica, Brazil

Interaction of Prion Protein with RNA and DNA: A Crossroad Between the Protein and Nucleic Acid WorldJerson Lima Da SilvaUniversidade Federal do Rio de Janeiro, Instituto de Ciências Biomédicas, Departamento de Bioquímica Medica, Brazil

Conference 15Room : Iemanjá BalcãoIntroducer: Walter ColliUniversidade de São Paulo, Instituto de Química, Departmento de Bioquímica, Brazil

In Vitro Neuronal Differentiation of Embryonic and Progenitor Cells Depends on Kinin-B2 Receptor ActivityAlexander Henning UlrichUniversidade de São Paulo, Instituto de Química, Departmento de Bioquímica, Brazil.

Conference 16Room :XangoIntroducer: Helena Bonciani NaderUniversidade Federal de São Paulo (UNIFESP-EPM), Department de Bioquímica, São Paulo, Brazil

Novel Regulation of Posttranslational Modifications In the Golgi apparatus: From Basic Science to DiseasesCarlos B. HirschbergBoston University, Department of Molecular and Cell Biology, Boston, USA

Conference 17Room : Oxalá 1Introducer: Paulo Sérgio Lacerda BeirãoUniversidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departmento de Bioquímica e Imunologia, Brazil

Protozoan Associate Molecular Patterns and Toll-Like Receptors (TLRs): New Microbial Adjuvants for Immunological Interventions?Ricardo Tostes GazzinelliFundação Instituto Oswaldo Cruz, Centro de Pesquisa René Rachou, Minas Gerais, Brazil

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Room: Oxalá 2

MEB.05 - Insulin and Leptin relations in obesity(Obesidade: Nova fronteira metabólica)Bayardo Torres*, Eduardo Galembek*** Depto. de Bioquímica, Instituto de Química, Universidade de São Paulo** Depto. Bioquímica, Instituto de Biologia 20 min.

MEB.06 - SISFISIO: um software de apoio ao ensino de fisiologiaSilva, T.V.1, Alves, R.S.P.1, Avelar, J.L.V.2, Guiné, A.A.A.1, Pêgo, P.N.1, Carvalho C.V.A.2, De Mesquita J.F.1,�

Universidade Severino Sombra - Curso de 1Biomedicina e 2 de Sistemas de Informação, Vassouras; �UNIRIO/ UNIGEN, Rio de Janeiro, RJ, Brazil.e-mail: [email protected] minuts

MEB.07 -The impact of the website Biochemical View on biochemistry learningRodrigues, R.S.; Castro, M.S.; Fontes, W.Universidade de Brasília, Brasília-DF, Brasil20min

MEB.08 - Virtual Cells, (HTML and Windows)(Células Virtuais) Leila M. Beltramini, Luciano D.S.Abel, Oscar H. Ramos , Ana Paula U. de AraujoCentro de Biotecnologia Molecular Estrutural, Instituto de Física de São Carlos, Universidade de São Paulo, SP-Brasil10 min

MEB.09 - Ciência com Arte: O Método CientíficoDiucênio Rangel, Luiz A. Dourado, Alexandro Machado, Alessandro Cerqueira, Marcelo N. do Vale, Leopoldo de MeisInstituto de Bioquímica Médica, Universidade Federal do rio de Janeiro-RJ-Brasil�0 min

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Conference 18Room : Iemanjá PlatéiaIntroducer: Angelo Azzi, Tufts University, USA

Molecular Determinants of Sand Fly Vector Competency for LeishmaniaDavid L. SacksNational Institute of Allergy and Infectious Diseases, NIH, Laboratory of Parasitic Diseases, USA

Conference 19Room : Iemanjá BalcãoIntroducer: Alicia Juliana KowaltowskiUniversidade de São Paulo, Instituto de Química, Department ode Bioquímica, Brazil.

Role of Autophagy in Ischemia/ReperfusionRoberta A. GottliebScripps Research Institute, La Jolla, Department of Molecular & Experimental Medicine, USA

Conference 20Room : XangoIntroducer: Mario Sergio PalmaInstituto de Biociências de Rio Claro (UNESP), Centro de Estudos de Insetos Sociais, Brazil

Peptide Concepts with Emphasis on the Blood-Brain BarrierAbba J. KastingPennington Biomedical Research Center, Lousiana State University Systems, USA

Conference 21Room : Oxalá 1Introducer: Gilberto Barbosa DomontUniversidade Federal do Rio de Janeiro, Instituto de Química, Departmento de Bioquímica, Brazil

Mass Spectrometry in Proteomics: Studies of Protein InteractionPeter RoepstorffUniversity of Southern Denmark, Department of Biochemistry

and Molecular Biology, Denmark

10h30 to 12h30Symposium 25Room: Iemanjá PlatéiaChair: Célia Regina da Silva Garcia, Universidade de São Paulo, Instituto de Biociências, Departamento de Fisiologia, Brazil

Plasmodium Molecular and Cellular Interactions - from Mosquito Vector to Infected-Erythrocytes

Artur ScherfInstitut Pasteur – Paris, Biology of Host-Parasite Interactions Unit, FranceAn Essential Role for the 5’ Non-Coding Var Region in Chromatin-Mediated Imprinting of Mono-Allelic Expression of Antigenic Variation Genes in Malaria Parasites

Rogério AminoUniversidade Federal de São Paulo, Departamento de Microbiologia, Imunologia e Parasitologia, BrazilIn Vivo Imaging of Plasmodium Pre-Erytrocytic Phase. Vessel Invasion and the Trojan Hepatocyte

Marcelo Jacobs-LorenaJohns Hopkins School of Public Health, USAMolecular Interaction between Plasmodium and Its Mosquito Vector

Célia Regina da Silva GarciaUniversidade de São Paulo, Instituto de Biociências, Departamento de Fisiologia, BrazilDoes Plasmodium Signal with G Protein-Coupled Receptors? Searching Molecular Mechanisms to Sense the Environment

Symposium 26Room: Iemanjá BalcãoChair: Adalberto Ramon Vieyra, Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Brazil

Molecular Aspects of Ion Transport in Health and Disease

Adalberto Ramon VieyraUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, BrazilRole of the N-Terminal Region of Ccc2, the Yeast Cu(I)-ATPase, in Copper Handling at Alkaline pH in Extreme Copper and Iron Conditions

Gustavo Benaim-AttiasInstituto de Estudios Avanzados, VenezuelaThe Antiproliferative Effect of the Anti-arrhythmic Amiodarone on Trypanosoma cruzi and Leishmania mexicana is Driven by Disruption of the Mitochondrial Calcium Regulation without Affecting the Host Cell

Miguel Arredondo OlguinUniversidad de Chile, Instituto de Nutricíon y Tecnologia de los Alimentos, ChileIntracellular Copper Regulation: Interactions with Iron

Leopoldo de MeisUniversidade Federal do Rio de Janeiro, Instituto de Bioquímica Médica, BrazilATP Synthesis and Heat Production by Brown Adipose Tissue Mitochondria

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Room: XangoChair: Mario Sergio Palma, Instituto de Biociências de Rio Claro (UNESP), Centro de Estudos de Insetos Sociais, Brazil

INPS Symposium: Neuropeptides: Perspectives and Applications

Illana GozesTel Aviv University, Clinical Biochemistry, IsraelNAP: Recent Research and Development of a Neuroprotective Drug Candidate

Weihong PanPennington Biomedical Research Center, Division of Nutrition and the Brain, USATransport of Urocortin and Leptin in Cerebral Microvessels and Implications in Obesity

Michael Joseph KuharEmory University School of Medicine, Division of Neuroscience, Yerks Natural Primate Research Center, USACART Peptides: Regulators of Appetite and Addiction

Jackson Cioni BittencourtUniversidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Anatomia, BrazilThe Twelve Labors of MCH: The Tale of a Neuropeptide Through Phylogeny

Symposium 28Room: Oxalá 1Chair: Gilberto Barbosa Domont, Universidade do Rio de Janeiro, Instituto de Química, Departamento de Bioquímica, Brazil

V Symposium on Proteomics: “Back to the Future”

Concha GilUniversidad Complutense de Madrid, Departamento de Microbiologia II, SpainIntegrated Proteomic and Genomic Strategies Bring New Insight into Candida albicans Response Upon Macrophage Interaction

Carlos Andre Ornelas RicartUniversidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, BrazilProteomics Applied to Chagas Disease

Gilberto Barbosa DomontUniversidade do Rio de Janeiro, Instituto de Química, Departamento de Bioquímica, BrazilSystems Biology of Sepsis and Parasites

Peter NilssonRoyal Institute of Technology - KTH Biotechnology, SwedenA Human Protein Atlas for Normal and Cancer Tissues

Workshop on EducationRoom: Oxalá 2Chair: Susan Hamilton, University of Queensland, Faculty of Biological and Chemical Sciences, Australia and Member for Education of IUBMB

SBBQ-IUBMB Workshop: Development of a Concept Inventory for the Molecular Life Sciences: A New IUBMB Initiative

Susan HamiltonUniversity of Queensland, Faculty of Biological and Chemical Sciences, AustraliaDevelopment of a Concept Inventory for the Molecular Life Sciences: An Overview

Manuel João Tavares Mendes da CostaUniversidade do Minho, Escola de Ciências da Saúde, PortugalA Review of Concept Inventories as Teaching and Learning Tools

Trevor Ryan AndersonUniversity of KwaZulu-Natal, Biochemistry, South AfricaDiscussion of Research that Can Be Associated with the Concept Inventory Project

Judith G. VoetSwarthmore College, Department of Chemistry, USARethinking One Biochemical Concept: Signaling - A Vital Topic in Molecular Life Science Education

Oral Presentation 1Room: Oxalá �Maria Isabel Cano NogueiraInstituto de Biociências de Botucatu (UNESP)

Alan Brito CarneiroInstituto de Bioquímica Médica (IBqM-UFRJ)Lysophosphatidylcholine is a Modulator of Trypanosoma cruzi Infection (C-16)

Camila Pinto ArantesInstituto Ludwig de Pesquisa sobre o Câncer (ILUDWIG)Exosome Dependent Trafficking of Stress-Inducible Protein 1 in Association with Cellular Prion Protein (Q-25)

Fernando Lucas Palhano SoaresInstituto de Bioquímica Médica (IBqM-UFRJ)Production of Heterotetramers as a Strategy to Prevent Familial Amyloidotic Polyneuropathy, a Fatal Amyloidogenic Disease (N-51)

Luana Salgado QuiliciUniversidade de Brasilia (UnB)Characterization of Elements that Modulate Gene Expression in Chinese Ovary Hamster Cells (CHO) (H-72)

Marcelo Santos da SilvaInstituto de Biociências de Botucatu (UNESP) Characterization of the Leishmania amanozensis Telomere Repeat-Binding Factor 2 (LATRF2) (G-50)

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Forum 1Room: Oxalá 1Chair: Knut-Jan Andersen, University of Bergen, Norway

Young Scientist Forum 1

Chris WoodUniversidad Nacional Autonoma de Mexico, Institute de Biotechnologia, MexicoCa2+ Fluctuations Light the Path to the Egg - Imaging Dynamic Ca2+ Changes in the Flagella of Swimming Sea Urchin Sperm with a Novel LED-based Epifluorescence Imaging System.

Cecilia CasaravillaDepartamento de Imunologia, Faculdade de Química, Instituto de Higiene, UruguayAdvances on the Structural Mucins of the Echinococcus granulosus Laminated Layer

Andrea Medeiros PereyraFacultad de Medicina, Montevideo, Departamento de Bioquimica, UruguayImmunobiology Study between Parasites Antigens and Cancer Development

Anastasia KhandazhinskayaEngelhardt Institute of Molecular Biology, RussiaAryl-Containing Esters of Triphosphoric Acid as Substrates of DNA Polymerases of X-Family

Xing-Jie Richard LiangNational Institute of Neurological Diseases and Strokes – NIH, USASIRT1 Is Involved in Cisplatin Resistance by Maintaining Glucose Homeostasis and Mitochondrial Stability in Cancer Cells

Forum 2Room: Iemanjá BalcãoChair: Alicia Juliana Kowaltowski, Universidade de São Paulo, Instituto de Química, Departamento de Bioquimica, Brazil


Fanis MissirlisNational Institute of Child Health and Human Development – NIH, USADrosophila as a Model System to Study Iron Metabolism

Janice OnukiInstituto Butantan, Laboratório de Bioquímica e Biofísica, BrazilAnalysis of Target Genes on Chromosome 8 In Fe-NTA-Induced Rat Renal Cell Carcinoma

Lukasz PulaskiUniversity of Lodz, Molecular Biophysics, PolandThe Role of Thioredoxin System Enzymes and their Transcriptional Regulation in Oxidative Stress Resistance of Human Cancer Cells

Krisztian StadlerNational Istitute of Environmental Health Sciences, NIH, USAUnraveling the Causative Role of iNOS-Mediated Free Radical Production in the Pathogenesis of Diabetes

Marcelo Gialluisi BoniniNational Istitute of Environmental Health Sciences, NIH, USAImmunospin-Trapping Based Protein Free Radical Imaging in Sub-Cellular Structures

Forum 3Room: XangoChair: Arnaldo Zaha, Universidade Federal do Rio Grande do Sul, Brazil

Young Scientist Forum

Antonio José da Costa FilhoUniversidade de São Paulo, Instituto de Física de São Carlos, Departamento de Física e Informática, BrazilDefects in Micelle Core Induced by Escherichia coli DHODH

Mário Tyago MurakamiInstituto de Biociências, Letras e Ciências Exatas (UNESP), Departamento de Física, BrazilStrategies for the Control of Blood Coagulation: Possible New Platforms for Drug Design

Janet G. YangUniversity of California, San Francisco, USAA Mechanism for ATP-Dependent Nucleosome Spacing by the Chromatin Remodeling Complex ACF

Attila AmbrusSemmelweis University, Medical Biochemistry, HungaryStructure of the Human Telomeric DNA

Arun Kumar ShuklaDuke University Medical Center, USATowards Understandin G Protein Coupled Receptor: A Multidisciplinary Approach

Forum 4Room: Iemanjá PlatéiaChair: Leda Quercia Vieira, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Departamento de Bioquímica e Imunologia, Brazil


Alexander Vladimirovich IvanovEngelhardt Institute of Molecular Biology, Russian Academy of Science, RussiaInteraction between Hepatitic C Virus RNA-Dependent RNA Polymerase and NS5A Protein: Mechanism and Regulation

Justin R. AndersonSouthwest Foundation for Biomedical Research, Virology & Immunology, USAViral Factors in Dengue Virus Transmission

Matloob HusainNational Institute of Allergy and Infectious Diseases, NIH, Viral Diseases, USAExistence of an Operative Pathway from the Endoplasmic Reticulum to the Poxvirus Membrane

Patricia Silvia RomanoUniversidad Nacional de Cuyo, Inst. de Histologia y Embriologia (IHEM-Conicet), ArgentinaTrypanosoma cruzi Subvert the Autophagic Pathway to Increase the Infection in the Host Cell

Michail KotsyfakisNational Institute of Allergy and Infectious Diseases, NIH, Lab. of Malaria and Vector Research, USACysteine Protease Inhibitors in the Saliva of the Tick Ixodes scapularis Contribute to Feeding Success Through their Immunomodulatory Action to the Vertebrate Host

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Room: Oxalá 2Marisa Helena Gennari de MedeirosInstituto de Química (IQ-USP), Brazil

Lívea Fujita BarbosaInstituto de Química (IQ-USP), BrazilDNA Damage, P53 Activation and Apoptosis in a Cellular Model of Amyotrophic Lateral Sclerosis (T-25)

Luize Gonçalves LimaInstituto Nacional do Câncer (INCA), BrazilMalignant Transformation in Melanocytes Increases the Production of Procoagulant Microvesicles (C-11)

Douglas Vendas FagetInstituto Nacional do Câncer (INCA), BrazilWNT4 Expression Profiling and Evaluation of its Putative Role as a Prostate Cancer Tumor Antigen (Q-22)

Sandra Mara Naressi ScapinLaboratório Nacional de Luz Síncrotron (LNLS), BrazilHuman Tip41 is a Novel Regulator of the Transcription Factor MafB (B-39)

Vivian Matsukura dos SantosUniversidade de Mogi das Cruzes (UMC), BrazilPhenothiazines-Induced Cell Death in Leukemic K562 Cells (P-26)

Oral Presentation 3Room: Oxalá �Enilza Maria EspreaficoFaculdade de Medicina de Ribeirão Preto (FMRP-USP), Brazil

Alexandre Rossi PaschoalLaboratório Nacional de Computação Científica (LNCC), BrazilHomodimeric Structure of B. japonicum D-Ncaase (V-12)

Mariângela de Sousa Santos DizCentro de Biociências e Biotecnologia (UENF-CBB), BrazilIsolation, Characterization and Immunolocalization of a Lipid Transfer Protein (LTP) from Chili Pepper Seeds (E-52)

Milene Mantovani LopesFaculdade de Medicina de Ribeirão Preto (FMRP-USP), BrazilSearching for Cellular Functions and Localization of Kiaa0090, a Novel Conserved Human Protein (J-4)

Paulo Costa CarvalhoUniversidade Federal do Rio de Janeiro (UFRJ), BrazilA Novel Strategy for Differential Proteomics by Spectral Counting and Statistical Learning (W-1)

Philipe Edwin Westerlund FaçanhaUniversidade Federal de Uberlandia, BrazilPurification and Partial Characterization of a Hemorrhagic Enzyme from Bothrops alternatus Snake Venom (L-38)

16h30 to 17h30Conference 22Room : Iemanja PlateiaIntroducer: Glaucius OlivaUniversidade de São Paulo, Instituto de Física de São Carlos, Departmento de Física e Informática, Brazil

Unconventional Control of Gene Expression: mRNA Degradation in TrypanosomesChristine E. ClaytonUniversity of Heidelberg, Germany

Conference 23Room : Iemanjá BalcãoIntroducer: Hernan ChaimovichUniversidade de São Paulo, Instituto de Química, Departmento de Bioquímica, São Paulo, Brazil

Protein Homo-Oligomerization: The Biological Significance and Mechanism For Its OccurranceZengyi ChangThe Center for Protein Science, College of Life Sciences, Peking University, China

Conference 24Room : XangoIntroducer: Silvia Lima CostaUniversidade Federal da Bahia, Instituto de Ciências da Saúde, Departamento de Biofunção, Brazil

Gliomal Stem Cells as Targets and Normal Stem Cells as Origins and Vectors in a New Approach of Cerebral TumorsHervé ChneiweissInstitut National de La Santé et de La Recherche Médicale, College de France, Paris, France

Conference 25Room : Oxala 1Introducer: Shaker Chuck FarahUniversidade de São Paulo, Instituto de Química, Departmento de Bioquímica, Brazil.

Protein Communication between Plant Pathogenic Bacteria and the HostUlla BonasMartin-Luther University Halle-Wittengerg, Institute of

Genetics, Halle, Germany

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Conference 26Room : XangoIntroducer: Julio Cezar De Mattos CascardoUniversidade Estadual de Santa Cruz, Departamento de Biologia e Genética Molecular, Bahia, Brazil

Sophisticated Science as Background for Simple Solutions: A Model to Witches’ Broom, a Devastating Cacao Disease Caused by the Fungus Moniliophtora perniciosa Gonçalo Amarante Guimarães PereiraUniversidade Estadual de Campinas , Instituto de Biologia, Departmento de Genética e Evolução, Brazil

Conference 27Room : Oxalá 2Introducer: Anibal Eugenio VercesiUniversidade Estadual de Campinas, Faculdade de Ciências Médicas, Departmento de Patologia Clínica, Brazil

Modulation of Mitochondrial Membrane Permeability in Pathogenesis and Control of MetabolismJohn J. LemastersMedical University of South Carolina, USA

Conference 28Room : Oxalá 1Introducer: Paulo Sergio Rodrigues CoelhoUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular, Brazil

Proteomics for Elucidating Protein Function, Regulatory Networks and Improving Human HealthMichael SnyderYale University, Department of Molecular, Cellular and Developmental Biology, USA

10h30 to 12h30Symposium 29Room: Iemanjá BalcãoChair: Alexander Henning Ulrich, Universidade de São Paulo, Instituto de Química, Departamento de Bioquimica, Brazil

Chemotherapy and Drug Resistance

Leopoldo FloheMOLISA GmbH, GermanyDesign of Trypanocidal Drugs Interfering with the Trypanothione System

Kiyoshi KitaUniversity of Tokyo, Dep Biomedical Chemistry, JapanParasite Mitochondria as a Target for Chemotherapy

Valerie MizrahiUniversity of the Witwatersrand, Molecular Mycobacteriology Research Unit, South AfricaMutational Mechanisms in Mycobacterium tuberculosis

Carsten Wrenger Bernhard Nocht Institute for Tropical Medicine, GermanyValidation of the Vitamin B1 and B6 Biosyntheses as Potential Drug Targets in Malaria

Symposium 30Room: XangoChair: Leila Maria Beltramini, Universidade de São Paulo, Instituto de Física de São Carlos, Departamento de Física e Informática, Brazil

Education in Structural Biology and Biotechnology

Bayardo Baptista TorresUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, BrazilAn Intradisciplinary PBL-Like Strategy to Teach Biochemistry

Edward J. WoodLeeds University, UKEducation in Structural Biology - What are the Aims?

Graham Royston ParslowUniversity of Melbourne, Dep of Biochemistry, AustraliaEducational Approaches to Teaching Structure and Function in Biology

Leila Maria BeltraminiUniversidade de São Paulo, Instituto de Física de São Carlos, Departamento de Física e Informática, BrazilMolecules within the Reach of the Hands: Development and Evolution Process

Manuel João Tavares Mendes da CostaUniversidade do Minho, Escola de Ciências da Saúde, PortugalIUBMB Education Policy for 2007-2009

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Room: Oxala 1Chair: Cezar Mendes de Assis, Instituto Adolfo Lutz, Seção de Bioquímica, Brazil

Molecular Bases for Patogenic Fungi Studies

Márcia Eliana da Silva FerreiraUniversidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Departmento de Ciências Farmacêuticas, BrazilFunctional Characterization of the Aspergillus fumigatus Calcineurin.

Luiz Rodolpho Raja Gabaglia TravassosUniversidade Federal de São Paulo, Unidade de Oncologia Experimental, BrazilPeptide Vaccines against Fungi Causing Systemic Disease. The Paracoccidioides brasiliensis Quest.

Rosana PucciaUniversidade Federal de São Paulo, Departamento de Biologia Celular, BrazilProteomic Analysis of the Cell Wall from Genetically Distinct Paracoccidioides brasiliensis Isolates that Differ in Pathogenicity

Leonardo NimrichterUniversidade Federal do Rio de Janeiro, Instituto de Microbiologia Prof. Paulo de Góes, Departamento de Microbiologia, BrazilGlucuronoxylomannan, the Major Capsular Polysaccharide of Cryptococcus neoformans, is Released Extracellularly in Secretory Vesicles and Assembled at the Cell Surface by Ion-Dependent Self Aggregation

Symposium 32Room: Oxalá 2Chair: Felipe Dal Pizzol, Universidade do Extremo Sul Catarinense, Laboratório de Fisiopatologia Experimental, Brazil

Molecular Mechanisms Involved in Sepsis Progression

Francisco Garcia SorianoUniversidade de São Paulo, Faculdade de Medicina, Departamento de Clínica Médica, BrazilPoly(ADP-ribose) Polymerase-1 and Sepsis Progression

Fernando de Queiroz CunhaUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Farmacologia, BrazilFailure of Neutrophil Migration to Infection Focus in Severe Polymicrobial Sepsis is Mediated by TLR2 and TLR4 Signaling

Felipe Dal PizzolUniversidade do Extremo Sul Catarinense, Laboratório de Fisiopatologia Experimental, BrazilOxidative Stress and Mitochondrial Dysfunction during Sepsis Development

Jamil Assreuy FilhoUniversidade Federal de Santa Catarina, Centro de Ciências Biológicas, BrazilVascular Hyporeactivity in Sepsis: Involvement of Nitric Oxide, Guanylate Cyclase and Potassium Channels

Oral Presentation 4Room: Oxalá �Katia Flavia Fernandes SilvaInstituto de Ciências Biológicas – UFG, Brazil

Antônio Carlos Burlamaque NetoHospital de Clínicas de Porto Alegre (HCPA-UFRGS)Cartoons that Portrait Scientific Procedures (K-3)

Felipe Roberto Freitas RegoUniversidade Federal da Bahia (UFBa), BrazilBiochemistry: From Supermarket to Laboratory (K-21)

Liza Figueiredo Felicori VilelaInstituto de Ciências Biológicas (ICB-UFMG), BrazilCombining Bioinformatic and Experimental Approaches to Map a Neutralizing Epitope on the Loxosceles intermedia Protein 1 (LiD1)

Patrícia Caetano de Medeiros BorgesInstituto de Ciências Biológicas – UFG, BrazilCovalent immobilization of lípase from Baccillus sp. onto Poly(vinyl alcohol)-Glutaraldehyde-Poly(aniline)-Glutaraldehyde Discs (H55)

Sandra Regina Costa MaruyamaFaculdade de Medicina de Ribeirão Preto (FMRP-USP), BrazilAnalysis of Transcriptomes of Larvae from Female Ticks Fed on Genetically Resistant and Susceptible Cattle Reveals Genes Affected by Host Immune Responses (D-2)

Oral Presentation 5Room: OxumRoger ChammasFaculdade de Medicina (FM-USP)

Flávia Gama Gomes LeiteInstituto de Ciências Biológicas (ICB-UFMG)Distinct Roles Played by C-Jun in the Orthopoxviruses Vaccinia and Cowpox Biology (F-7)

Patrícia Fernanda SchuckInstituto de Ciências Básicas da Saúde (ICBS-UFRGS)CIS-4-Decenoic Acid Alters Respiratory Parameters In Rat Brain (R-3)

Patrícia Luiza Nunes da CostaFaculdade de Medicina (FM-USP)Combined Use of the Bradykinin B1r Antagonist R954 and the Chemotherapeutic Agent Dacarbazine Increased Global Survival of Melanoma Bearing Mice (S-32)

Raquel de Sousa CarreiraUniversidade de Coimbra - PortugalIschemic Preconditioning Enhances Fatty Acid-Dependent Mitochondrial Uncoupling (A-11)

Renata Lopes AraujoUniversidade do Rio de Janeiro (UniRio)Normalization of Serum T4 During Caloric Restriction Induces Significant Loss of Body Protein Content (I-6)

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Closing CeremonyRoom: Iemanjá Balcão

Includes Results for the SBBQ Award for Poster Presentation and XI Young Life Sciences Talent Award

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Biomarcadores de Processos Oxidativos

Coordenadores: Profs. Drs. Pio Colepicolo Neto e Paolo Di Mascio (IQ-USP)

Ementa: Processos Redox capazes de intermediar circuitos de sinalização fisiológicas ou patológicas e lesões em constituintes celulares.

22 de maio de 2007 – Room Oxalá 2�h00 to �h55 Prof Dr. Etelvino J.H. Bechara Fontes biológicas, reatividade e alvos celulares de radicais livres�h05 to 10h00 Profa. Dra. Ohara Augusto Produtos biológicos do NO: Da sinalização aos circuitos patofisiológicos

23 de maio de 2007�h00 to �h55 Profa. Dra. Dulcineia Saes Parra Abdalla Formação de produtos derivados da interação entre NO e produtos da

lipoperoxidação.�h05 to 10h00 Prof Dr. Luis Eduardo Soares Netto Estados de oxidação de tiois em macromoléculas e papéis biológicos

24 de maio de 2007�h00 to �h�5 Profa. Dra. Glaucia Regina Martinez Detecção de espécies reativas e de modificações em biomoléculas por

espectrometria de massas�h�5 to �h10 Profa. Dra. Lia Sumie Nakao Marcadores de estresse oxidativo durante progressão de doenças crônicas e

detecção de radicais por EPR.�h10 to 10h00 Prof. Dr. Francisco Rafael Martins Laurindo Indicadores moleculares fluorescentes para a “detecção” de espécies reativas de

oxigênio e nitrogênio.

Bioquímica dos Venenos Animais

Coordenador: Bayardo B. Torres (IQ-USP)

Professores: André Kisil Miskalo, Erik Montagna e Silvia Lopes de MenezesUniversidade de São Paulo, Instituto de Química, Departamento de Bioquímica, SP, Brazil

Ementa: Os venenos de animais peçonhentos são estudados há bastante tempo, tanto pelo interesse médico como por sua aplicabilidade em modelos experimentais em diversos campos das ciências biomédicas. Apesar de muitos mecanismos de ação ainda não estarem completamente elucidados, o que se conhece dá suporte para o estudo de alguns temas relevantes de fisiopatologia que não são abordados em cursos regulares de graduação. A abordagem do curso será multidisciplinar, enfocando a ação dos venenos quanto à sua ação em neurotransmissão, coagulação sanguínea, mediação inflamatória e dor. Foram escolhidos como modelo de estudo os animais de maior importância epidemiológica no Brasil e com maior número de informações disponíveis sobre a ação tóxica dos seus venenos: Crotalus sp (cascavel), Bothrops sp (jararaca), Loxosceles sp (aranha marron), Tityus sp (escorpião amarelo) e Phoneutria sp (aranha armadeira).

22 de maio de 2007 – Room Oxalá 3�h00 to �h50 Introdução ao Curso; Crotalus sp.�h00 to 10h00 Bothrops sp.

23 de maio de 2007�h00 to �h50 Lonomia sp.�h00 to 10h00 Loxosceles sp.

24 de maio de 2007�h00 to �h50 Tityus sp.�h00 to 10h00 Phoneutria sp. Co

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Aspectos Bioquímicos e Nutricionais dos Alimentos Funcionais

Coordenadora: Eliane Fialho de OliveiraInstituto de Nutrição Josué de Castro/ UFRJ

Ementa: Evidências epidemiológicas têm confirmado que, dietas ricas em frutas e vegetais, estão associadas com a prevenção de diversas doenças crônicas não transmissíveis, tais como: câncer, diabetes, doenças cardiovasculares, dentre outras. Nesse contexto, os nutracêuticos, substâncias presentes nos alimentos funcionais apresentam propriedades químicas, bioquímicas, fisiológicas e nutricionais envolvidas na prevenção dessas doenças.

22 de maio de 2007 – Room Oxum�h00 to �h00 Eliane Fialho de Oliveira Instituto de Nutrição Josué de Castro, UFRJ Alimentos Funcionais: Definição, Legislação e sua Relação com Saúde e Doença�h00 to 10h00 Patrícia Souza dos Santos IBqM-UFRJ Antioxidantes em Alimentos (Carotenóides, Vitamina C, Tocoferol)

23 de maio de 2007�h00 to �h00 Ana Luísa Kremer Faller Instituto de Nutrição Josué de Castro, UFRJ Polifenóis, Atividade Antioxidante e Doenças�h00 to 10h00 Vagner Rocha Simonin Instituto de Nutrição Josué de Castro, UFRJ Probióticos, Prebióticos e Função Intestinal

24 de maio de 2007�h00 to �h00 Raquel Senna Telhado Instituto de Bioquímica Médica, UFRJ Fitosteróis e Hipercolesterolemia�h00 to 10h00 Fabiana Alves Casanova Instituto de Nutrição Josué de Castro, UFRJ Compostos Organosulfurados e Câncer

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Wednesday – 23/05/07 – 13:00 to 18:00h

Room: Chega NegoFlávio Marques PeraltaAssessor Cientifico; LGC Biotecnologia, Brasil

Quimioluminescência 2007

O uso da quimioluminescência é hoje empregada em diferentes áreas da pesquisa, desde departamentos de bioquimica à proteômica, sendo utilizada para diversos propósitos A LGC Biotecnologia destaca o que há de mais novo em detecção quimioluminescente desde a detecção In Vivo ao uso de amplificadores de sinal quimioluminescentes.

Thursday – 24/05/07 – período da manhã

Room:Sandra Valéria de Sá, Ph.D.Especialista de Aplicação da Roche Applied Science, São Paulo-SP, Brasil

GENOME SEQUENCER FLX: Flexibilidade em Diversas Aplicações

O Genome Sequencer FLX é um sistema que oferece a solução completa para sequenciamento em alta escala, desde a construção da biblioteca até a análise dos dados. Plataforma que permite análise simultânea de vários genomas, gerando dezenas de milhares de bases em uma única corrida. Uma única pessoa pode sequenciar um genoma bacteriano em poucos dias, de forma economicamente eficaz. O Genome Sequencer FLX suporta inúmeras aplicações, desde a caracterização de DNA genômico até a identificação de transcritos e em estudos de regulação gênica.

Room: Omolu – para todas as palestras a seguir

Tuesday – 22/05/07 – 10:30 to 11:30h

Robert Marchmont2D Label & Detection - Marketing DirectorGE Healthcare Life Sciences, England

Advance Techniques in Proteomics

Advanced techniques in proteomics analysis are essential for detecting proteins, studying differencial expression and identify target proteins. At the same time, it has to be considered minimizing experimental errors, increasing reproductibility and sensitivity, optimizing results. Some of these techniques will be presented in this workshop.

Tuesday – 22/05/07 – 14:30 to 15:30h

Maurício Marques, PhD.Field Applications ScientistGE Healthcare Life Sciences, Brazil

Workshop Proteomics - DIGE

DIGE technology is a proven method that combines the most statistically accurate protein abundance data with the greatest resolving power available in 2-D electrophoresis.The presentation will include an overview, new products and applications of this technology.

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Wednesday – 23/05/07 – 10:30 to 11:30h

Dan Schoeffner, Ph.D., Field Applications Scientist, Stratagene Inc.. USA

Quantitative PCR (Real Time PCR) Assay Design and Validation

A brief introduction to Quantitative PCR (QPCR) technology followed by a description of the benefits, methods and selection criteria for the design, validation and optimization of a new assay. Assay validation is necessary to determine the specificity of your primers and probes, the sensitivity, dynamic range, linearity and reproducibility of your assay. Additionally, this discussion will include methods of quantification and the appropriate use of normalizer/housekeeping genes.

Wednesday – 23/05/07 – 14:30 to 15:30

Hans Müller-Kahle, MBA Industrial Business Development - DirectorBiacore (part of GE)

Efficient Biotherapeutic Development Using Label-Free Protein Interaction Analysis

Presenting case studies, demonstrating the use of protein interaction analysis at key stages during development of biotherapeutics. Will focus on: * Antibody characterization for early selection of the most suitable candidates; * Detection and characterization of immune responses; The presentation will include examples of real, industry-based applications showing how protein interaction analysis using the latest Biacore systems can be used at every stage - from initial screening of crude hybridomas for lead selection through QC during manufacturing.

Wednesday – 23/05/07 – 16:30 to 18:00

Marcelo AnéasProduct SpecialistGE Healthcare Life Sciences, Brazil

Viviane Abreu Nunes Cerqueira DantasInstituto de Biociências – USP – Centro de Estudos do Genoma Humano, Brazil

Assessing the Regulation of T Cell Function by Distinct Cytokine Combinations on the Guava EasyCyte™ Plus Platform

Precise regulation of effector function is critical for mounting a potent, yet specific immune response to a given antigenic challenge. It has been hypothesized that the cytokine content of secondary lymphoid organs and at the actual site(s) of inflammation exert localized control over immune cell populations. Distinct cytokine combinations present within a given microenvironment can induce changes in the phenotype and effector functions of immune cells that differ dramatically from the effects exerted by each cytokine alone.

Thursday – 24/05/07 – 10:30 to 11:30

David Willmot, Ph.D.Applications ScientistAgilent Technologies, USA

Gene Expression, Comparative Genome Hybridization and other Applications of Agilent Microarrays in Genomic Research

Several high profile papers will be summarized in which Agilent in situ synthesized oligonucleotide microarrays surpass previous technologies. The Greenechip panmicrobial array custom designed for Columbia University is the first tool to provide comprehensive differential diagnosis of infectious diseases including viruses, bacteria, protozoa, etc. Agendia’s MammaPrint breast cancer test is the first multi-gene

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expression test to receive regulatory clearance. The array identified a gene expression signature that reflects biological behavior of a tumor and out-performed all clinical variables for predicting patient survival. It provides classifiers to direct customized therapy. Agilent has developed a highly sensitive miRNA profiling assay, based on a highly efficient labeling method and novel microarray probe design.

Thursday – 24/05/07 – 15:30 to 16:30

Anna HeijbelSenior Product ManagerGE Healthcare Life Sciences, Sweden

Maximize your purity and yield of histidine- or GST-tagged proteins

For simplification of protein purification and detection of your target protein histidine- and GST-tags are today the most widely used tags world wide. Let us show you our new product portfolio, get some hints and tips for solving your purifications problems with histidine- or GST-tagged proteins.How can you save time? How to minimize your sample preparation time?How to optimize your purification to increase purity?How and when to use the new tools for tagged protein purification With application examples and knowledge from our R&D labs we want to give you our perspective on how to purify histidine- or GST-tagged proteins in an optimized way.

Wednesday – 23/05/2007 – 10h30 to 12:00

Room: OgumAna Paula de Andrade AukarDoutora em Genética e Melhoramento de PlantasAssessora Científica da Eppendorf do Brasil

Estratégias para otimizar os resultados de PCR em Tempo Real e economizar reagentes.

A técnica de PCR em Tempo Real, ou PCR quantitativo está sendo muito utilizada atualmente na pesquisa científica e no diagnóstico para a quantificação de ácidos nucléicos, monitoramento da expressão gênica, detecção de patógenos, identificação gênica, taxa de SNP, genotipagem, ensaios +/- (Multiplexing), detecção End point, dentre outras aplicações. Vários fatores influenciam os resultados de um ensaio de PCR em Tempo Real como, por exemplo, a concentração inicial de ácido nucléico, concentração do primer usado, pipetagem, e outros fatores. Desta maneira, o preparo da reação de forma otimizada irá gerar dados confiáveis e ainda, trabalhando-se com sistemas eficientes de pipetagens é possível reduzir os volumes das reações e o número de replicatas, refletindo em economia para o laboratório.

Tuesday 22/05/2007 and Wednesday 23/05/2007 – 13:00 to 16:00

Room: OgumLuis Marcelo BravoChileGerente de Negócios América Latina – Divisão Acadêmica / Invitrogen Corporation

Mini-curso Proteomics – Tornando mais fácil a análise de proteínas

Propomos, em formato de mini-curso, fazer um overview das etapas para estudo de proteínas com fornecimento de certificação. Abordaremos alternativas para preparação da amostra, separação e caracterização de proteínas e sua validação funcional.

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