BRAIN/BEHAVIOUR DEVELOPMENT ALONG ADOLESCENCE … · BRAIN/BEHAVIOUR DEVELOPMENT ALONG ADOLESCENCE...
Transcript of BRAIN/BEHAVIOUR DEVELOPMENT ALONG ADOLESCENCE … · BRAIN/BEHAVIOUR DEVELOPMENT ALONG ADOLESCENCE...
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BRAIN/BEHAVIOUR DEVELOPMENT ALONG
ADOLESCENCE
Adolf Tobeña
Dept. of Psychiatry and Forensic Medicine. Institute of Neurosciences.
School of Medicine. 08193 Bellaterra Campus.
Autonomous University of Barcelona.
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Dahl RE (2004), in “Adolescent Brain Development: vulnerabilities and opportunities”,
Annals NYAS, Vol. 1021, pp. 1-22
Aristotle “Youth are heated by Nature as drunken men by wine”
Shakespeare “I would that there were no age between 10 and 23,
for there’s nothing in between but getting wrenches with child,
wronging the ancientry, stealing, fighting….”. The Winter’s Tale, Act. III.
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FACTORS MADURATIUS I ENTRADES AMBIENTALS
Hormones
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FACTORS MADURATIUS I ENTRADES AMBIENTALS
Hyman SE (2009), Nature Neuroscience, 12, 3, 241-242.
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Risky choices: blending of higher sensitivity/maturation of limbic structures with delayed prefrontal maturation
Impulsiveness: prefrontal protracted development alone
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Puberty/adolescence main regulators: Hypothalamic-
Hypophysis-Gonadal interactions
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Cameron JL (2004), in RE Dahl and LP Spear
(Eds.): Adolescent brain development, Annals
NYAS, Vol. 1021, 110-123.
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Dahl RE (2004), in Adolescent Brain Development: vulnerabilities and opportunities,
Annals NYAS, Vol. 1021, pp. 1-22
Gonadarche (Breasts and Phallus growth); Adrenarche (Acné and pubic/
axillary hair); Growth spurt: Size, Height and muscular/fat disposition.
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Mean youth values of steroid hormones in each sex
Females (N=81) Males (N=102)
Follicular Luteal
DHEAS (ng/ml) 1,32 (0,64) 1,3 (0,62) 2,07(0,93)
AD (ng/ml) 3,8 (2,56) 5,99 (2,78) 0,99 (0,6)
DHEA (ng/ml) 6,24 (6,5) 3,2 (3,4) 1,48 (1,03)
LH (miu/ml) 15,06 (6,17) 30,,57 (17,6) 10,75 (4,8)
T (ng/ml) 0,6 (0,4) 0,73 (0,4) 4,98 (2,56)
TEBG (nmol/l) 57,8 (21,7) 67,4(33,9) 46,75( (13,7)
FTI 0,04 (0,04) 0,04 (0,03) 41,8 (26,6)
P (ng/ml) 1,08 (1,23) 4,53 (5,73) -
E (ng/ml) 0,066 (0,058) 0,19 (0,10) -
DHEA= Dihidroepiandrosterone; AD: Androstenodione; LH: Luteinizing hormone; T= Testosterone; TEBG=Testosterone binding globuline; FIT= Free testosterone; P= Progesterone; E= Estradiol.
From Udry (1990).
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Dahl RE (2004), in Adolescent Brain Development: vulnerabilities and opportunities, Annals NYAS, Vol. 1021, pp. 1-22
Mandela’s kids study in South Africa:
born within a week difference!!
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STAGES OF HUMAN BRAIN
DEVELOPMENT
From Nelson Ch A (2004), Annals
NYAS, 1021, 105-109.
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Development of synaptic density in sensory and frontal regions. The lefthand graph shows the mean synaptic density in the primary auditory cortes (red circles), in the primary visual cortex (green circles) and in the prefrontal cortex (PFC: middle frontal gyrus, crosses), in postmortem human brains at different ages. The X axis shows the conceptual age in days from 200 postconception to 10.000 days post conception (aprox. 27 years). Synaptic density increases in all three regions in early chlidhood but synaptogenesis is most prolonged in the PFC. This is further demonstrated on the right graph which shows the difference in synaptic density between the auditory cortex and the middle frontal gyrus (purple cicles) plotted against conceptual age. The line represent the best fit for the data. Although peak synaptic density in the auditory cortex occurs early (aprox. three months after birth) the peak synaptic density at PFC occurs significantly later.
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Scanning adolescent’s brains
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EXPLORING
BRAIN CHANGES
WITH MAGNETIC
RESONANCE
IMAGING (MRI)
SCANS
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Toga AW, Thompson PM and Sowell ER (2006), Trends in
Neurosciences, 29, 3, 148-159.
CHANGES ON CORTICAL THICKNESS (GRAY-MATTER DENSITY) IN
BOTH HEMISPHERES ACROSS LIFETIME.
Points correspond to regional measures taken on 176 individuals with
ages ranging from 7 to 87 years old.
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CHANGES IN GRAY MATTER DENSITY ON
CORTICAL REGIONS ACROSS AGES
Toga AW, Thompson PM and Sowell ER (2006), Trends in
Neurosciences, 29, 3, 148-159.
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Toga AW, Thompson PM and Sowell ER (2006), Trends in Neurosciences, 29, 3, 148-159.
Trajectory of cortical gray-matter density in13 children scanned logitudinally every two years. The
units used are gray-matter density defined as the proportion of tissue segmenting as gray matter
within a 15 mm–diameter sphere centered at each point on the cortical surface. This measure ranges from 0 to 1 and is highly correlated with cortical thickness.
Mechanism?: Synaptic pruning?; Myelinization?; Fine tuning?.....
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BRAIN DEVELOPMENT TROUGH CHILDHOOD AND
ADOLESCENCE: MRI MEASURES
Total volume and white matter changes obtained from 145 healthy
individuals (89 males, 56 females, age range 4,2 to 21,6 years). 65 were subjected to a second scan and 30 to a third scan. The total
increase in white matter was 12,4%. From Giedd JN et al (1999)
Nature Neuroscience, 2, 861-863).
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Sex differences in age-
related gray matter
changes in a range of
cortical regions:
predicted MRI volumes, with 95% confidence intervals, of cortical gray matter in frontal, parietal, temporal and occipital lobes from males and females aged 4 to 22 years. Gray matter at the frontal
cortex peaks at the aprox age
of puberty: 11 years in girls and
12 years in boys. The peak at the temporal cortex is not attained till 16 years. Puberty rather than age per se may be the trigger of these neuroanatomical changes (From Giedd JN et al (1999) Nature Neuroscience, 2, 861-863).
BRAIN DEVELOPMENT TROUGH
CHILDHOOD AND ADOLESCENCE: MRI MEASURES
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From Giedd JN (2004), Annals NYAS, 1021, 77-85
Ongoing Brain Imaging Project at the Child Psychiatry Branch, the
National Institute of Mental Health, Bethesda, Washington.
Results from 329 scans from 95 males and 66 females (N Total = 161), plus neuropsychological testing, at aprox. 2 years intervals
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From Giedd JN (2004), Annals NYAS, 1021, 77-85
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From Giedd JN (2004), Annals NYAS, 1021, 77-85
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
Subjects:
- 16 children (7-11 years old; seven females)
- 13 adolescents (13-17 years old; six females)
- 12 adults (23-29 years old; six females )
Payment: 50 $ for participating + 25 $ in variable earnings!!
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Neural systems for reward
and addiction: from actions, to
habits to compulsions.
Everitt BJ and Robbins TW (2005) Nature
Neuroscience, 8, 1481-9.
Green arrows: Glutamate
Orange arrows: Dopamine
Pink arrows: GABA
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
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Galvan A et al (2006), The Journal of Neuroscience, 26(25), 6885-92.
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Risky choices: blending of higher sensitivity/maturation of limbic structures with delayed prefrontal maturation
Impulsiveness: prefrontal protracted development alone
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Using A Go-NoGo Task with Fearful/Neutral faces
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From Blakemore SJ (2008), Nature Reviews Neuroscience, 9, 267-277
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Regions of the social brain: Medial prefrontal cortex (mPFC) and the temporo-
parietal junction, which are both involved inb thinking about mental states; the posterior superior temporal sulcus (pSTS), activated by observing faces and biological motions; the inferior frontal gyrus IFG) and the interparietal sulcus. Othe regions on the medial surface involved in social cognition include the amygdala, the anterior cingulate cortex (ACC) and the anterior insula (AI). From Blakemore SJ (2008) Nature Reviews Neuroscience, 9, 267-277
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Animation tasks to
study mentalizing
(A): participants watch silent animations in
which two triangles move around in such a way that they seem to
have mental states. Autistic children do no
generate appropiate terms to describe the patterns of movement
of the triangles. The regions of the social
brain (B) including the PFC (top panel), the temporal poles (middle
pannel) and the superior temporal
sulcus (bottom) are activated when healthy participants observe
mentalizing animations relative to control
tasks that do no evoke mental attributions.
(Castelli F et al (2000), Neuroimage, 12, 314-325).
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Madurative and Environmental Inputs: from early
maltreatment to drug/toxic insults
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Pathways to individual aggressiveness
Frans De Waal (2000): Multiple sources of individual aggression, Science, 289, 586-90.
Different weights depending on interactions along vital itineraires!!!
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THE HYPOTHALAMIC-PITUITARY-
GONADAL AXIS: Hormonal steps and negative feedback loop.
RELATIONSHIPS OF ANDROGENIC STEROIDS WITH REPRODUCTIVE
FUNCTION, SEXUAL BEHAVIOR
AND AGGRESSION.
Late adolescence-youth upsurge
of violent behavior in humans (males mainly!).
.
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The discrete
character of
high-lethality
of youth
violence
FE Zimring (2004),
in J Devine, J Gilligan, KA Miczeck, R
Shaikh and D. Pfaff (Eds), Youth violence:
scientific
approaches to
prevention, Annals NYAS, 1036, 290-299.
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ANDROGENIC STEROIDS AND AGGRESSION
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NEUROHORMONES AND AGGRESSION
Aggression-enhancers: Aggression-dampening:
Androgens Serotonin
Vasopressine Corticoids
P substance Oxitocine
Dopamine Opioids
Noradrenaline Adenosine
Cholecystocinin Y neuropeptide
Insulin… Anandamides …..
Neuroregulators with differential actions:
GABA ( ; ) : Defensive attacks/fear; Offensive attacks
Progestagen/Estrogens: variations on aggressive outputs depending on ratios
Others (Glicine, Glutamate, NO, intracellular messengers…)
BUT!
But!!: Subtle variations depending on Aggression Modalities for several neuroregulators.
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GENES AND AGGRESSIVENESS: links and pathways
- Mutations leading to neural malfunction (Uncommon)
(MAOA data…., but dozens of other markers!!…)
- Genetical “templates” for temperamental traits (Common)
Impulsivity
Sensation seeking
Fearfulness Threshold for aggression
Irritability
Empathy…
- Genetic “templates” for physiological traits (Common)
Corpulence
Heart rate
Cortisol Threshold for aggression
Testosterone
Serotonin function…
Heritability estimates: 0,7/0,8
(Twin/adoption studies)
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Temperamental traits/ High-order personality factors.
Temperamental traits:
fearfulness, novelty-,
seeking, aggressiveness, empathy, altruism,
extraversion, persistence, conservatism, religiosity,
resilience…
Two views of the relationships between genes and personality (modified from D. Hamer (2004), Rethinking behavior genetics, Science, 298, 71-72). A. Early studies looked for linear relationships between gene markers and temperamental traits or high-order personality factors. B. Reality is likely to be far more complex with gene networks interacting with environmental inputs impacting on brain development and leaving enduring neural dispositions that, in turn, influence behavioral, cognitive and affective styles (temperamental traits).
GENES AND TEMPERAMENT
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Annals NYAS (1996), 794, 224-237.
- recruitment: 1967-71 908 Ss. Versus 667 Matched Controls
- 1st. measures: 1987-88
- 2nd. measures: 1994 94% > 25 years old
A 27 years long study following maltreated infants:
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Annals NYAS (1996), 794, 224-237.
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Annals NYAS (1996), 794, 224-237.
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Annals NYAS (1996), 794, 224-237.
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Science (2002), 297, 851-53.
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Caspi A et al (2002), Science, 297, 851-53.
A New Zealand cohort of 1037
children (52% male) were followed
triannually during 23 years, from 3 to
26 years-old, recording medical,
physical and psychological conditions.
8% suffered maltreatment, 28%
probable maltreatment and 64% no
maltreatment at all. At the end, 96%
of the initial sample was reached.
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Caspi et al (2002), Science, 297, 851-53.
Early maltreatment
and MAO genotype:
long term results with different
violent-related
measures.
Male results, also confirmed in females
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Temperamental traits/ High-order personality factors.
Temperamental traits:
fearfulness, novelty-,
seeking, aggressiveness, empathy, sociability,
persistence, conservatism, religiosity, altruism,
resilience…
Two views of the relationships between genes and personality (modified from D. Hamer (2004), Rethinking behavior genetics, Science, 298, 71-72). A. Early studies looked for linear relationships between gene markers and temperamental traits or high-order personality factors. B. Reality is likely to be far more complex with gene networks interacting with environmental inputs impacting on brain development and leaving enduring neural dispositions that, in turn, influence behavioral, cognitive and affective styles (temperamental traits).
GENES AND TEMPERAMENT
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Chromosomes Genes RNA’s Proteins/Peptides
Humans: 20.000 genes
> 100.000 proteins/peptides (>50% active in the brain)
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Burmeister M, McInnis MG and Zollner S (2008), Nature Review Genetics, 9, 527-540.
Gene-environment interactions in psychiatric diseases
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GENES AND PSYCHIATRIC DISEASES
Genes code for proteins and are associated with
biological processes …, they do’nt relate directly, howewer, to psychological traits, cognitive functions
or behavioural symptomatology…,
DNA variants (genic and nongenic) can be strongly
linked to psychiatric vulnerabilities through specified
neuromolecular systems!!!.
Pathological cognition,
affect and behavior
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McGowan PO et al (2009), Nature Neuroscience, 12, 3, 342-348.
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McGowan PO et al (2009), Nature Neuroscience, 12, 3, 342-348.
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Nestler EJ et al (2002), Neuron, 34, 13-25.
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Cronic stress and vulnerability to disease: molecular
and cellular pathways
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Developmental pathways and stress vulnerability: from early
separation distress to the “well-groomed” child
MATERNAL CARE MEDIATES
LONG-TERM TOUGHENING EFFECTS OF POSTNATAL
HANDLING
Sapolsky RM (1997), Science, 277, 1620-1621.
Separation distress
pionnering experiments:
- Harlow
- Levine
- Suomi…
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Science, (1997), 277, 1659-62.
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Liu et al (1997), Science, 277, 1659-62.
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Liu et al (1997), Science, 277, 1659-62.
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Liu et al (1997), Science, 277, 1659-62.
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Liu et al (1997), Science, 277, 1659-62.
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Hyman SE (2009), Nature Neuroscience,
12, 3, 241-242.
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Moffit TE, Caspi A, Farrington T and Milne BJ (2002) Development and
Psychopathology, 14, 179-207.
The Dunedin (New Zealand) longitudinal study of a cohort of 1037 children
(477 males), from 3 to 26 years old: a minority (10%) explained for most of violent acts and offenses across maturation.
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Vinding E (2004) On the nature and nurture of antisocial behavior and violence, in J Devine, J Gilligan, KA Miczeck, R Shaikh and D. Pfaff (Eds), Youth violence: scientific approaches to prevention, Annals NYAS, 1036, 267-277.
An ongoing study of antisocial behavior in more than 7000 twin children.
Heritabilities for callous/unemotional kids versus children without these traits.
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Science (2002), 295, 2468-71.
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Johnson JG et al (2002), Science, 295, 2468-71.
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Johnson JG et al (2002), Science, 295, 2468-71.
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N=1517 (12-15 years old) N= 1239 (81,7%) 984 (80,3%)
Self-reports, Caregiver reports, Census data.
Bingenheimer JB, Brennan RT and Earls FG (2005), Science, 308, 1323-26.
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Bingenheimer JB, Brennan RT and Earls FG (2005), Science, 308, 1323-26.
Variables at start that
show differences between adolescents
subsequently exposed vs. nonexposed to
gun-linked violence.
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Bingenheimer JB, Brennan RT and Earls FG (2005), Science, 308, 1323-26.
Individual
“propensity”
scores established by a
regression model
fitting 48 start
variables
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ADOLESCENT AND YOUTH RISK AND PROTECTIVE FACTORS
FOR SUBSEQUENT ANTISOCIAL BEHAVIOR
Risk factors Protective factors
Uncontrolled temperament, age 3 Shyness
Impulsive traits by ages 8-10 Inhibited temperament
Hyperactive traits, age 13 Intelligence
Callous traits by ages 7-12 Close relations with adults
Low IQ Good achievement at school
Poor academic achievement Sports achievements
Major depression at age 14 Non antisocial peers…
Oppositional defiant behavior by ages 7-12
Conduct disorder by ages 9-16
Substance abuse by ages 8-12
Poor parenting and supervision
Abuse under age 12
Association with a deviant peer group…
From Fonagy P (2004), Annals
NYAS, 1036,181-200.
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80% of adolescents navigate through ADOLESCENCE
TRANSITIONS (from puberty to adult responsabilitIes) without
major problems
END OF ADOLESCENCE?: Stabilized sleep chronotypes closing the typical
delayed pattern: around 19,5 years old in women and 21 years old in men.